Regulation and functional effects of ZNT8 in human pancreatic islets

Journal of Endocrinology

Volumn 214, Issue 2, 2012, Pages 225-232

  Lefebvre, Bruno ^a,b   Vandewalle, Brigitte ^a,b   Balavoine, Anne Sophie ^a,b   Queniat, Gurvan ^a,b   Moerman, Ericka ^a,b   Vantyghem, Marie Christine ^a,b,c   Gmyr, Valery ^a,b   Pawlowski, Valérie ^a,b   Kerr Conte, Julie ^a,b   Pattou, Francois ^a,b,c  

^a UNIV LILLE   (France)

^b Biotherapies for Diabetes ^*  (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LIPID; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; PALMITIC ACID; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER; ZINC TRANSPORTER 8;

ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; LIPOTOXICITY; METABOLIC STRESS; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM;

ADULT; CATION TRANSPORT PROTEINS; CELL DEATH; CELLS, CULTURED; CHELATING AGENTS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HUMANS; ISLETS OF LANGERHANS; LIPIDS; PALMITIC ACID; TRANSFECTION; ZINC;

EID: 84866280206     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0071     Document Type: Article

References (42)

1. Bancila V, Nikonenko I, Dunant Y & Bloc A, 2004 Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus. Journal of Neurochemistry 90 1243-1250.
2. Chen MD, Song YM & Lin PY, 2000 Zinc effects on hyperglycemia and hypoleptinemia in streptozotocin-induced diabetic mice. Hormone and Metabolic Research 32 107-109
3. Chimienti F, Devergnas S, Favier A & Seve M, 2004 Identification and cloning of a b-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53 2330-2337
4. Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vandewalle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A et al. 2006 In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. Journal of Cell Science 119 4199-4206
5. Cousins RJ, Blanchard RK, Moore JB, Cui L, Green CL, Liuzzi JP, Cao J & Bobo JA. 2003 Regulation of zinc metabolism and genomic outcomes. Journal of Nutrition 133 1521S-1526S.
6. Egefjord L, Jensen JL, Bang-Berthelsen CH, Petersen AB, Smidt K, Schmitz O, Karlsen AE, Pociot F, Chimienti F,Rungby J et al. 2009 Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in b-cell apoptosis? BMC Endocrine Disorder 9 7
7. Eide DJ. 2006 Zinc transporters and the cellular trafficking of zinc. Biochimica et Biophysica Acta 1763 711-722
8. El Muayed M, Billings LK, Raja MR, Zhang X, Park PJ, Newman MV, Kaufman DB, O'Halloran TV & Lowe Jr W.L., 2010 Acute cytokinemediated downregulation of the zinc transporter ZnT8 alters pancreatic b-cell function. Journal of Endocrinology 206 159-169
9. Emdin SO, Dodson GG, Cutfield JM & Cutfield SM. 1980 Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell. Diabetologia 19 174-182
10. Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK & Cohen DM. 2009 Down-regulation of ZnT8 expression in INS-1 rat pancreatic b cells reduces insulin content and glucose-inducible insulin secretion. PLoS ONE 4 e5679
11. Fujimoto S, Mukai E, Hamamoto Y, Takeda T, Takehiro M, Yamada Y & Seino Y. 2002 Prior exposure to high glucose augments depolarizationinduced insulin release by mitigating the decline of ATP level in rat islets. Endocrinology 143 213-221
12. Gyulkhandanyan AV, Lu H, Lee SC, Bhattacharjee A, Wijesekara N, Fox JE, MacDonald PE, Chimienti F, Dai FF & Wheeler MB. 2008 Investigation of transport mechanisms and regulation of intracellular Zn2C in pancreatic a-cells. Journal of Biological Chemistry 283 10184-10197
13. Huang L, Kirschke CP & Gitschier J. 2002 Functional characterization of a novel mammalian zinc transporter, ZnT6. Journal of Biological Chemistry 277 26389-26395
14. Ishihara H, Maechler P, Gjinovci A, Herrera PL & Wollheim CB, 2003 Islet β-cell secretion determines glucagon release from neighbouring α-cells. Nature Cell Biology 5 330-335
15. Islam MS & Loots du T, 2007 Diabetes, metallothionein, and zinc interactions: a review. Biofactors 29 203-212
16. Jansen J, Karges W & Rink L, 2009 Zinc and diabetes - clinical links and molecular mechanisms. Journal of Nutritional Biochemistry 20 399-417
17. Kahn SE, Hull RL & Utzschneider KM, 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444 840-846
18. Kambe T, Narita H, Yamaguchi-Iwai Y, Hirose J, Amano T, Sugiura N, Sasaki R, Mori K, Iwanaga T & Nagao M, 2002 Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic b cells. Journal of Biological Chemistry 277 19049-19055
19. Kerr-Conte J, Vandewalle B, Moerman E, Lukowiak B, Gmyr V, Arnalsteen L, Caiazzo R, Sterkers A, Hubert T, VantyghemMC et al. 2010 Upgrading pretransplant human islet culture technology requires human serumcombined with media renewal. Transplantation 89 1154-1160
20. Lefebvre B, Vandewalle B, Longue J, Moerman E, Lukowiak B, Gmyr V, Maedler K, Kerr-conte J & Pattou F, 2010 Efficient gene delivery and silencing of mouse and human pancreatic islets. BMC Biotechnology 10 28
21. Lemaire K, Ravier MA, Schraenen A, Creemers JW, Van de Plas R, Granvik M, Van Lommel L, Waelkens E, Chimienti F, Rutter GA et al. 2009 Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. PNAS 106 14872-14877
22. Li X, Chen H & Epstein PN, 2004 Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species. Journal of Biological Chemistry 279 765-771
23. Liuzzi JP & Cousins RJ, 2004 Mammalian zinc transporters. Annual Review of Nutrition 24 151-172.
24. Liuzzi JP, Blanchard RK & Cousins RJ, 2001 Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. Journal of Nutrition 131 46-52.
25. Nabe K, Fujimoto S, Shimodahira M, Kominato R, Nishi Y, Funakoshi S, Mukai E, Yamada Y, Seino Y & Inagaki N, 2006 Diphenylhydantoin suppresses glucose-induced insulin release by decreasing cytoplasmic HC concentration in pancreatic islets. Endocrinology 147 2717-2727
26. Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K et al. 2009 Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 58 2070-2083
27. Palmiter RD & Findley SD, 1995 Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO Journal 14 639-649.
28. Petersen AB, Smidt K, Magnusson NE, Moore F, Egefjord L & Rungby J, 2011 siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells. APMIS: Acta Pathologica, Microbiologica et Immunologica Scandinavica 119 93-102
29. Pound LD, Sarkar SA, Benninger RK,Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW et al. 2009 Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochemical Journal 421 371-376
30. Roche E, Buteau J, Aniento I, Reig JA, Soria B & Prentki M, 1999 Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic b-cell line INS-1. Diabetes 48 2007-2014
31. Scott LJ, Mohlke KL, Bonnycastle LL,Willer CJ, Li Y, DurenWL, Erdos MR, Stringham HM, Chines PS, Jackson AU et al. 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316 1341-1345
32. Simon SF & Taylor CG, 2001 Dietary zinc supplementation attenuates hyperglycemia in db/db mice. Experimental Biology and Medicine 226 43-51.
33. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S et al. 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 881-885
34. Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, Jeppesen JB, Stoltenberg M, Culvenor JG, Tsatsanis A, Brock B et al. 2009 SLC30A3 responds to glucose- and zinc variations in b-cells and is critical for insulin production and in vivo glucose-metabolism during b-cell stress. PLoS ONE 4 5684
35. Tamaki M, Fujitani Y, Uchida T, Hirose T, Kawamori R & Watada H, 2009 Downregulation of ZnT8 expression in pancreatic b-cells of diabetic mice. Islets 1 124-128
36. Taylor CG, 2005 Zinc, the pancreas, and diabetes: insights from rodent studies and future directions. Biometals 18 305-312
37. Vandewalle B, Moerman E, Lefebvre B, Defrance F, Gmyr V, Lukowiak B, Kerr Conte J & Pattou F, 2008 PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets. Biochemical and Biophysical Research Communications 366 1096-1101
38. Vantyghem MC, Kerr-Conte J, Arnalsteen L, Sergent G, Defrance F, Gmyr V, Declerck N, Raverdy V, Vandewalle B, Pigny P et al. 2009 Primary graft function, metabolic control, and graft survival after islet transplantation. Diabetes Care 32 1473-1478
39. Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA &Wheeler MB, 2010 b Cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia 53 1656-1668
40. Yang J & Cherian MG, 1994 Protective effects of metallothionein on streptozotocin-induced diabetes in rats. Life Sciences 55 43-51.
41. Yang L, Li H, Yu T, Zhao H, Cherian MG, Cai L & Liu Y, 2008 Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. American Journal of Physiology. Endocrinology and Metabolism 294 E987-E992
42. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RMet al. 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316 1336-1341