The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro

Diabetologia

Volumn 52, Issue 7, 2009, Pages 1352-1362

  Scholz, H ^a   Lund, T ^a   Dahle, M K ^a   Collins, J L ^b   Korsgren, O ^c   Wang, J E ^a   Foss, A ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b GLAXOSMITHKLINE   (United States)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chemokines; Cytokines; GW3965; Human islets; Inflammatory mediators; Liver X receptor; Tissue factor

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; HISTONE; INSULIN; INTERLEUKIN 8; LIVER X RECEPTOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDOREDUCTASE; THROMBOPLASTIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA HISTONE INTERACTION; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; GRAFT SURVIVAL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INSULIN RELEASE; LEUKOCYTE; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; BENZOIC ACIDS; BENZYLAMINES; BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CHEMOKINE CCL2; CHOLESTEROL; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; HOMEOSTASIS; HUMANS; INSULIN; INTERLEUKIN-8; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; LIPOPOLYSACCHARIDES; MALE; METHYLPREDNISOLONE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; THROMBOPLASTIN; TISSUE DONORS;

EID: 67349112811     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1366-z     Document Type: Article

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