Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men

Diabetologia

Volumn 47, Issue 2, 2004, Pages 204-213

  Leung, N ^a   Sakaue, T ^a   Carpentier, A ^b   Uffelman, K ^a   Giacca, A ^a   Lewis, G F ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Disposition index; NEFA; Pancreatic beta cell

Indexed keywords

FATTY ACID; GLUCOSE; HEPARIN; INSULIN; INTRALIPID;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETIC OBESITY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; INTERMETHOD COMPARISON; LIPID BLOOD LEVEL; MALE; PANCREAS ISLET BETA CELL; PANCREAS SECRETION; PRIORITY JOURNAL;

BLOOD GLUCOSE; C-PEPTIDE; FASTING; FAT EMULSIONS, INTRAVENOUS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HEPARIN; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; OBESITY; PATIENT SELECTION; TRIGLYCERIDES;

EID: 1542285102     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1301-7     Document Type: Article

References (44)

1. DeFronzo RA, Bonadonna RC, Ferrannini E (1992) Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15:318-368
2. Taylor SI, Accili D, Imai Y (1994) Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM? Diabetes 43:735-740
3. Polonsky KS (1995) Lilly lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research. Diabetes 44:705-717
4. Porte D Jr (1991) Banting lecture 1990. Beta-cells in type II diabetes mellitus. Diabetes 40:166-180
5. Polonsky KS, Sturis J, Bell GI (1996) Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med 334:777-783
6. Bruning JC, Michael MD, Winnay JN et al. (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2:559-569
7. Leahy JL, Bonner-Weir S, Weir GC (1992) Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care 15:442-455
8. Leahy JL, Cooper HE, Deal DA, Weir GC (1986) Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J Clin Invest 77:908-915
9. Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir S (1981) Islet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes 30:590-595
10. Bonner-Weir S, Trent DF, Weir GC (1983) Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 71:1544-1553
11. Rossetti L, Shulman GI, Zawalich W, DeFronzo RA (1987) Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 80:1037-1044
12. Leahy JL, Cooper HE, Weir GC (1987) Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions. Diabetes 36:459-464
13. Kergoat M, Bailbe D, Portha B (1987) Insulin treatment improves glucose-induced insulin release in rats with NIDDM induced by streptozocin. Diabetes 36:971-977
14. Leahy JL, Weir GC (1991) Beta-cell dysfunction in hyperglycaemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level. Diabetologia 34:640-647
15. Vague P, Moulin JP (1982) The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia. Metabolism 31:139-142
16. Boden G, Ruiz J, Kim CJ, Chen X (1996) Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects. Am J Physiol 270:E251-E258
17. Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA (1994) Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia 37:1025-1035
18. Flax H, Matthews DR, Levy JC, Coppack SW, Turner RC (1991) No glucotoxicity after 53 hours of 6.0 mmol/l hyperglycaemia in normal man. Diabetologia 34:570-575
19. Kahn SE, Bergman RN, Schwartz MW, Taborsky GJ Jr, Porte D Jr (1992) Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans. Am J Physiol 262:E518-E523
20. McGarry JD, Dobbins RL (1999) Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42:128-138
21. Charles MA, Eschwege E, Thibult N et al. (1997) The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia 40:1101-1106
22. Knowler WC, Pettitt DJ, Saad MF, Bennett PH (1990) Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab Rev 6:1-27
23. Lewis GF, Carpentier A, Adeli K, Giacca A (2002) Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23:201-229
24. Grill V, Qvigstad E (2000) Fatty acids and insulin secretion. Br J Nutr 83 [Suppl 1]:S79-S84
25. Prentki M, Joly E, El Assaad W, Roduit R (2002) Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51 [Suppl 3]:S405-S413
26. Poitout V, Robertson RP (2002) Minireview: secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology 143:339-342
27. Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF (2000) Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes 49:399-408
28. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
29. Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF (1999) Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol 276:E1055-E1066
30. Van Cauter E, Mestrez F, Sturis J, Polonsky KS (1992) Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41:368-377
31. Balent B, Goswami G, Goodloe G et al. (2002) Acute elevation of NEFA causes hyperinsulinemia without effect on insulin secretion rate in healthy human subjects. Ann NY Acad Sci 967:535-543
32. Byrne MM, Sturis J, Polonsky KS (1995) Insulin secretion and clearance during low-dose graded glucose infusion. Am J Physiol 268:E21-E27
33. Carpentier A, Giacca A, Lewis GF (2001) Effect of inreased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans. Diabetologia 44:1989-1997
34. Bergman RN, Phillips LS, Cobelli C (1981) Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68:1456-1467
35. Paolisso G, Tagliamonte MR, Rizzo MR et al. (1998) Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. Diabetologia 41:1127-1132
36. Santomauro AT, Boden G, Silva ME et al. (1999) Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes 48:1836-1841
37. Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M (1997) Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. Diabetes 46:393-400
38. Brun T, Roche E, Kim KH, Prentki M (1993) Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1). J Biol Chem 268: 18905-18911
39. Roche E, Assimacopoulos-Jeannet F, Witters LA et al. (1997) Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1). J Biol Chem 272:3091-3098
40. Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M (1997) Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1. J Biol Chem 272:1659-1664
41. Roche E, Farfari S, Witters LA et al. (1998) Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression. Diabetes 47:1086-1094
42. Jacqueminet S, Briaud I, Rouault C, Reach G, Poitout V (2000) Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism 49:532-536
43. Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V (2001) Lipotoxicity of the pancreatic beta cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50:315-321
44. Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP (2001) Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats. Diabetes 50:2481-2486