-
2
-
-
29244486514
-
Autoimmunity and pulmonary hypertension: A perspective
-
Nicolls MR, Taraseviciene-Stewart L, Rai PR, Badesch DB, Voelkel NF. Autoimmunity and pulmonary hypertension: a perspective. Eur Respir J. 2005;26:1110-1118.
-
(2005)
Eur Respir J.
, vol.26
, pp. 1110-1118
-
-
Nicolls, M.R.1
Taraseviciene-Stewart, L.2
Rai, P.R.3
Badesch, D.B.4
Voelkel, N.F.5
-
3
-
-
70450175633
-
Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension
-
Angelini DJ, Su Q, Yamaji-Kegan K, Fan C, Teng X, Hassoun PM, Yang SC, Champion HC, Tuder RM, Johns RA. Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension. Am J Respir Cell Mol Biol. 2009;41:553-561.
-
(2009)
Am J Respir Cell Mol Biol.
, vol.41
, pp. 553-561
-
-
Angelini, D.J.1
Su, Q.2
Yamaji-Kegan, K.3
Fan, C.4
Teng, X.5
Hassoun, P.M.6
Yang, S.C.7
Champion, H.C.8
Tuder, R.M.9
Johns, R.A.10
-
4
-
-
84856802817
-
Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension
-
Perros F, Dorfmüller P, Montani D, Hammad H, Waelput W, Girerd B, Raymond N, Mercier O, Mussot S, Cohen-Kaminsky S, Humbert M, Lambrecht BN. Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012;185:311-321.
-
(2012)
Am J Respir Crit Care Med.
, vol.185
, pp. 311-321
-
-
Perros, F.1
Dorfmüller, P.2
Montani, D.3
Hammad, H.4
Waelput, W.5
Girerd, B.6
Raymond, N.7
Mercier, O.8
Mussot, S.9
Cohen-Kaminsky, S.10
Humbert, M.11
Lambrecht, B.N.12
-
5
-
-
80052459025
-
Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension
-
Sutendra G, Dromparis P, Bonnet S, Haromy A, McMurtry MS, Bleackley RC, Michelakis ED. Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension. J Mol Med (Berl). 2011;89:771-783.
-
(2011)
J Mol Med (Berl).
, vol.89
, pp. 771-783
-
-
Sutendra, G.1
Dromparis, P.2
Bonnet, S.3
Haromy, A.4
McMurtry, M.S.5
Bleackley, R.C.6
Michelakis, E.D.7
-
6
-
-
84864522564
-
Modern age pathology of pulmonary arterial hypertension
-
Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM. Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012;186:261-272.
-
(2012)
Am J Respir Crit Care Med.
, vol.186
, pp. 261-272
-
-
Stacher, E.1
Graham, B.B.2
Hunt, J.M.3
Gandjeva, A.4
Groshong, S.D.5
McLaughlin, V.V.6
Jessup, M.7
Grizzle, W.E.8
Aldred, M.A.9
Cool, C.D.10
Tuder, R.M.11
-
7
-
-
80053571093
-
Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension
-
Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, Gera L, Patterson AJ, Agrawal R, Rabinovitch M, Ambler K, Long CS, Voelkel NF, Nicolls MR. Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circ Res. 2011;109:867-879.
-
(2011)
Circ Res.
, vol.109
, pp. 867-879
-
-
Tamosiuniene, R.1
Tian, W.2
Dhillon, G.3
Wang, L.4
Sung, Y.K.5
Gera, L.6
Patterson, A.J.7
Agrawal, R.8
Rabinovitch, M.9
Ambler, K.10
Long, C.S.11
Voelkel, N.F.12
Nicolls, M.R.13
-
8
-
-
0028948189
-
Reciprocal induction of tumor necrosis factor-alpha and interleukin-1 beta activity mediates fibronectin synthesis in coronary artery smooth muscle cells
-
Molossi S, Clausell N, Rabinovitch M. Reciprocal induction of tumor necrosis factor-alpha and interleukin-1 beta activity mediates fibronectin synthesis in coronary artery smooth muscle cells. J Cell Physiol. 1995;163:19-29.
-
(1995)
J Cell Physiol.
, vol.163
, pp. 19-29
-
-
Molossi, S.1
Clausell, N.2
Rabinovitch, M.3
-
9
-
-
0030940521
-
Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease
-
Jones PL, Cowan KN, Rabinovitch M. Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease. Am J Pathol. 1997;150:1349-1360.
-
(1997)
Am J Pathol.
, vol.150
, pp. 1349-1360
-
-
Jones, P.L.1
Cowan, K.N.2
Rabinovitch, M.3
-
10
-
-
80053351689
-
Krüppellike factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension
-
Courboulin A, Tremblay VL, Barrier M, Meloche J, Jacob MH, Chapolard M, Bisserier M, Paulin R, Lambert C, Provencher S, Bonnet S. Krüppellike factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension. Respir Res. 2011;12:128.
-
(2011)
Respir Res.
, vol.12
, pp. 128
-
-
Courboulin, A.1
Tremblay, V.L.2
Barrier, M.3
Meloche, J.4
Jacob, M.H.5
Chapolard, M.6
Bisserier, M.7
Paulin, R.8
Lambert, C.9
Provencher, S.10
Bonnet, S.11
-
11
-
-
0029062419
-
Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension
-
Humbert M, Monti G, Brenot F, Sitbon O, Portier A, Grangeot-Keros L, Duroux P, Galanaud P, Simonneau G, Emilie D. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med. 1995;151:1628-1631.
-
(1995)
Am J Respir Crit Care Med.
, vol.151
, pp. 1628-1631
-
-
Humbert, M.1
Monti, G.2
Brenot, F.3
Sitbon, O.4
Portier, A.5
Grangeot-Keros, L.6
Duroux, P.7
Galanaud, P.8
Simonneau, G.9
Emilie, D.10
-
12
-
-
77956390581
-
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension
-
Soon E, Holmes AM, Treacy CM, Doughty NJ, Southgate L, Machado RD, Trembath RC, Jennings S, Barker L, Nicklin P, Walker C, Budd DC, Pepke-Zaba J, Morrell NW. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation. 2010;122:920-927.
-
(2010)
Circulation.
, vol.122
, pp. 920-927
-
-
Soon, E.1
Holmes, A.M.2
Treacy, C.M.3
Doughty, N.J.4
Southgate, L.5
Machado, R.D.6
Trembath, R.C.7
Jennings, S.8
Barker, L.9
Nicklin, P.10
Walker, C.11
Budd, D.C.12
Pepke-Zaba, J.13
Morrell, N.W.14
-
13
-
-
36248952716
-
Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension
-
Sanchez O, Marcos E, Perros F, Fadel E, Tu L, Humbert M, Dartevelle P, Simonneau G, Adnot S, Eddahibi S. Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2007;176:1041-1047.
-
(2007)
Am J Respir Crit Care Med.
, vol.176
, pp. 1041-1047
-
-
Sanchez, O.1
Marcos, E.2
Perros, F.3
Fadel, E.4
Tu, L.5
Humbert, M.6
Dartevelle, P.7
Simonneau, G.8
Adnot, S.9
Eddahibi, S.10
-
14
-
-
0037092565
-
CX(3)C chemokine fractalkine in pulmonary arterial hypertension
-
Balabanian K, Foussat A, Dorfmüller P, Durand-Gasselin I, Capel F, Bouchet- Delbos L, Portier A, Marfaing-Koka A, Krzysiek R, Rimaniol AC, Simonneau G, Emilie D, Humbert M. CX(3)C chemokine fractalkine in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2002;165:1419-1425.
-
(2002)
Am J Respir Crit Care Med.
, vol.165
, pp. 1419-1425
-
-
Balabanian, K.1
Foussat, A.2
Dorfmüller, P.3
Durand-Gasselin, I.4
Capel, F.5
Bouchet- Delbos, L.6
Portier, A.7
Marfaing-Koka, A.8
Krzysiek, R.9
Rimaniol, A.C.10
Simonneau, G.11
Emilie, D.12
Humbert, M.13
-
15
-
-
34248209543
-
Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension
-
Perros F, Dorfmüller P, Souza R, Durand-Gasselin I, Godot V, Capel F, Adnot S, Eddahibi S, Mazmanian M, Fadel E, Hervé P, Simonneau G, Emilie D, Humbert M. Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Eur Respir J. 2007;29:937-943.
-
(2007)
Eur Respir J.
, vol.29
, pp. 937-943
-
-
Perros, F.1
Dorfmüller, P.2
Souza, R.3
Durand-Gasselin, I.4
Godot, V.5
Capel, F.6
Adnot, S.7
Eddahibi, S.8
Mazmanian, M.9
Fadel, E.10
Hervé, P.11
Simonneau, G.12
Emilie, D.13
Humbert, M.14
-
16
-
-
84895529835
-
Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension
-
Cracowski JL, Chabot F, Labarère J, Faure P, Degano B, Schwebel C, Chaouat A, Reynaud-Gaubert M, Cracowski C, Sitbon O, Yaici A, Simonneau G, Humbert M. Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension. Eur Respir J. 2014;43:915-917.
-
(2014)
Eur Respir J.
, vol.43
, pp. 915-917
-
-
Cracowski, J.L.1
Chabot, F.2
Labarère, J.3
Faure, P.4
Degano, B.5
Schwebel, C.6
Chaouat, A.7
Reynaud-Gaubert, M.8
Cracowski, C.9
Sitbon, O.10
Yaici, A.11
Simonneau, G.12
Humbert, M.13
-
17
-
-
0037084245
-
Chemokine RANTES in severe pulmonary arterial hypertension
-
Dorfmüller P, Zarka V, Durand-Gasselin I, Monti G, Balabanian K, Garcia G, Capron F, Coulomb-Lherminé A, Marfaing-Koka A, Simonneau G, Emilie D, Humbert M. Chemokine RANTES in severe pulmonary arterial hypertension. Am J Respir Crit Care Med. 2002;165:534-539.
-
(2002)
Am J Respir Crit Care Med.
, vol.165
, pp. 534-539
-
-
Dorfmüller, P.1
Zarka, V.2
Durand-Gasselin, I.3
Monti, G.4
Balabanian, K.5
Garcia, G.6
Capron, F.7
Coulomb-Lherminé, A.8
Marfaing-Koka, A.9
Simonneau, G.10
Emilie, D.11
Humbert, M.12
-
18
-
-
84895553338
-
Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension
-
Heresi GA, Aytekin M, Hammel JP, Wang S, Chatterjee S, Dweik RA. Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension. Eur Respir J. 2014;43:912-914.
-
(2014)
Eur Respir J.
, vol.43
, pp. 912-914
-
-
Heresi, G.A.1
Aytekin, M.2
Hammel, J.P.3
Wang, S.4
Chatterjee, S.5
Dweik, R.A.6
-
19
-
-
39549087002
-
Pulmonary arterial remodeling induced by a Th2 immune response
-
Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, Taraseviciene-Stewart L, Voelkel NF, Rabinovitch M, Grunig E, Grunig G. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med. 2008;205:361-372.
-
(2008)
J Exp Med.
, vol.205
, pp. 361-372
-
-
Daley, E.1
Emson, C.2
Guignabert, C.3
De Waal Malefyt, R.4
Louten, J.5
Kurup, V.P.6
Hogaboam, C.7
Taraseviciene-Stewart, L.8
Voelkel, N.F.9
Rabinovitch, M.10
Grunig, E.11
Grunig, G.12
-
20
-
-
77957035915
-
Dysregulation of the IL-13 receptor system: A novel pathomechanism in pulmonary arterial hypertension
-
Hecker M, Zaslona Z, Kwapiszewska G, et al. Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2010;182:805-818.
-
(2010)
Am J Respir Crit Care Med.
, vol.182
, pp. 805-818
-
-
Hecker, M.1
Zaslona, Z.2
Kwapiszewska, G.3
-
21
-
-
84897011026
-
Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: A complex interplay
-
Huertas A, Perros F, Tu L, Cohen-Kaminsky S, Montani D, Dorfmüller P, Guignabert C, Humbert M. Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: a complex interplay. Circulation. 2014;129:1332-1340.
-
(2014)
Circulation.
, vol.129
, pp. 1332-1340
-
-
Huertas, A.1
Perros, F.2
Tu, L.3
Cohen-Kaminsky, S.4
Montani, D.5
Dorfmüller, P.6
Guignabert, C.7
Humbert, M.8
-
22
-
-
84898839855
-
Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension
-
Ricard N, Tu L, Le Hiress M, Huertas A, Phan C, Thuillet R, Sattler C, Fadel E, Seferian A, Montani D, Dorfmüller P, Humbert M, Guignabert C. Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension. Circulation. 2014;129:1586-1597.
-
(2014)
Circulation.
, vol.129
, pp. 1586-1597
-
-
Ricard, N.1
Tu, L.2
Le Hiress, M.3
Huertas, A.4
Phan, C.5
Thuillet, R.6
Sattler, C.7
Fadel, E.8
Seferian, A.9
Montani, D.10
Dorfmüller, P.11
Humbert, M.12
Guignabert, C.13
-
23
-
-
65549143164
-
Common and distinct pathways for cellular activities in FGF-2 signaling induced by IL-1beta in corneal endothelial cells
-
Lee JG, Kay EP. Common and distinct pathways for cellular activities in FGF-2 signaling induced by IL-1beta in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2009;50:2067-2076.
-
(2009)
Invest Ophthalmol Vis Sci.
, vol.50
, pp. 2067-2076
-
-
Lee, J.G.1
Kay, E.P.2
-
24
-
-
65649128937
-
Endothelialderived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
-
Izikki M, Guignabert C, Fadel E, Humbert M, Tu L, Zadigue P, Dartevelle P, Simonneau G, Adnot S, Maitre B, Raffestin B, Eddahibi S. Endothelialderived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J Clin Invest. 2009;119:512-523.
-
(2009)
J Clin Invest.
, vol.119
, pp. 512-523
-
-
Izikki, M.1
Guignabert, C.2
Fadel, E.3
Humbert, M.4
Tu, L.5
Zadigue, P.6
Dartevelle, P.7
Simonneau, G.8
Adnot, S.9
Maitre, B.10
Raffestin, B.11
Eddahibi, S.12
-
25
-
-
84872078405
-
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
-
Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med. 2013;19:74-82.
-
(2013)
Nat Med.
, vol.19
, pp. 74-82
-
-
Kim, J.1
Kang, Y.2
Kojima, Y.3
Lighthouse, J.K.4
Hu, X.5
Aldred, M.A.6
McLean, D.L.7
Park, H.8
Comhair, S.A.9
Greif, D.M.10
Erzurum, S.C.11
Chun, H.J.12
-
26
-
-
59849118025
-
Interleukin-6 overexpression induces pulmonary hypertension
-
28p following 244
-
Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, Waxman AB. Interleukin-6 overexpression induces pulmonary hypertension. Circ Res. 2009;104:236-244, 28p following 244.
-
(2009)
Circ Res.
, vol.104
, pp. 236-244
-
-
Steiner, M.K.1
Syrkina, O.L.2
Kolliputi, N.3
Mark, E.J.4
Hales, C.A.5
Waxman, A.B.6
-
27
-
-
61549104663
-
Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
-
Savale L, Tu L, Rideau D, Izziki M, Maitre B, Adnot S, Eddahibi S. Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Respir Res. 2009;10:6.
-
(2009)
Respir Res.
, vol.10
, pp. 6
-
-
Savale, L.1
Tu, L.2
Rideau, D.3
Izziki, M.4
Maitre, B.5
Adnot, S.6
Eddahibi, S.7
-
28
-
-
84867131487
-
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents
-
Tu L, De Man FS, Girerd B, Huertas A, Chaumais MC, Lecerf F, François C, Perros F, Dorfmüller P, Fadel E, Montani D, Eddahibi S, Humbert M, Guignabert C. A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents. Am J Respir Crit Care Med. 2012;186:666-676.
-
(2012)
Am J Respir Crit Care Med.
, vol.186
, pp. 666-676
-
-
Tu, L.1
De Man, F.S.2
Girerd, B.3
Huertas, A.4
Chaumais, M.C.5
Lecerf, F.6
François, C.7
Perros, F.8
Dorfmüller, P.9
Fadel, E.10
Montani, D.11
Eddahibi, S.12
Humbert, M.13
Guignabert, C.14
-
29
-
-
80052348254
-
Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
-
Alastalo TP, Li M, Perez Vde J, Pham D, Sawada H, Wang JK, Koskenvuo M, Wang L, Freeman BA, Chang HY, Rabinovitch M. Disruption of PPARγ/β- catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. J Clin Invest. 2011;121:3735-3746.
-
(2011)
J Clin Invest.
, vol.121
, pp. 3735-3746
-
-
Alastalo, T.P.1
Li, M.2
Perez Vde, J.3
Pham, D.4
Sawada, H.5
Wang, J.K.6
Koskenvuo, M.7
Wang, L.8
Freeman, B.A.9
Chang, H.Y.10
Rabinovitch, M.11
-
30
-
-
0033838125
-
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
-
Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, Kalachikov S, Cayanis E, Fischer SG, Barst RJ, Hodge SE, Knowles JA. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet. 2000;67:737-744.
-
(2000)
Am J Hum Genet.
, vol.67
, pp. 737-744
-
-
Deng, Z.1
Morse, J.H.2
Slager, S.L.3
Cuervo, N.4
Moore, K.J.5
Venetos, G.6
Kalachikov, S.7
Cayanis, E.8
Fischer, S.G.9
Barst, R.J.10
Hodge, S.E.11
Knowles, J.A.12
-
31
-
-
0033817459
-
Heterozygous germline mutations in bmpr2, encoding a tgf-beta receptor, cause familial primary pulmonary hypertension
-
Lane KB, Machado RD, Pauciulo MW, Thomson JR, Loyd JE III, Nichols WC, Trembath RC. Heterozygous germline mutations in bmpr2, encoding a tgf-beta receptor, cause familial primary pulmonary hypertension. Nat Genet. 2000;26:81-84
-
(2000)
Nat Genet.
, vol.26
, pp. 81-84
-
-
Lane, K.B.1
Machado, R.D.2
Pauciulo, M.W.3
Thomson, J.R.4
Loyd III, J.5
Nichols, W.C.6
Trembath, R.C.7
-
32
-
-
0037046175
-
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
-
Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation. 2002;105:1672-1678.
-
(2002)
Circulation.
, vol.105
, pp. 1672-1678
-
-
Atkinson, C.1
Stewart, S.2
Upton, P.D.3
Machado, R.4
Thomson, J.R.5
Trembath, R.C.6
Morrell, N.W.7
-
33
-
-
84873873522
-
Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene
-
Park SH, Chen WC, Hoffman C, Marsh LM, West J, Grunig G. Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene. PLoS One. 2013;8:e55180.
-
(2013)
PLoS One.
, vol.8
-
-
Park, S.H.1
Chen, W.C.2
Hoffman, C.3
Marsh, L.M.4
West, J.5
Grunig, G.6
-
34
-
-
84857987240
-
Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice
-
Mushaben EM, Hershey GK, Pauciulo MW, Nichols WC, Le Cras TD. Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice. PLoS One. 2012;7:e32468.
-
(2012)
PLoS One.
, vol.7
-
-
Mushaben, E.M.1
Hershey, G.K.2
Pauciulo, M.W.3
Nichols, W.C.4
Le Cras, T.D.5
-
35
-
-
84863280800
-
BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: Role of proinflammatory cytokines
-
Davies RJ, Holmes AM, Deighton J, Long L, Yang X, Barker L, Walker C, Budd DC, Upton PD, Morrell NW. BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines. Am J Physiol Lung Cell Mol Physiol. 2012;302:L604-L615.
-
(2012)
Am J Physiol Lung Cell Mol Physiol.
, vol.302
-
-
Davies, R.J.1
Holmes, A.M.2
Deighton, J.3
Long, L.4
Yang, X.5
Barker, L.6
Walker, C.7
Budd, D.C.8
Upton, P.D.9
Morrell, N.W.10
-
36
-
-
52449108680
-
Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice
-
Song Y, Coleman L, Shi J, Beppu H, Sato K, Walsh K, Loscalzo J, Zhang YY. Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am J Physiol Heart Circ Physiol. 2008;295:H677-H690.
-
(2008)
Am J Physiol Heart Circ Physiol.
, vol.295
-
-
Song, Y.1
Coleman, L.2
Shi, J.3
Beppu, H.4
Sato, K.5
Walsh, K.6
Loscalzo, J.7
Zhang, Y.Y.8
-
37
-
-
34447534205
-
Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
-
Hagen M, Fagan K, Steudel W, Carr M, Lane K, Rodman DM, West J. Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1473-L1479.
-
(2007)
Am J Physiol Lung Cell Mol Physiol.
, vol.292
-
-
Hagen, M.1
Fagan, K.2
Steudel, W.3
Carr, M.4
Lane, K.5
Rodman, D.M.6
West, J.7
-
38
-
-
84893783838
-
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
-
Sawada H, Saito T, Nickel NP, et al. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med. 2014;211:263-280.
-
(2014)
J Exp Med.
, vol.211
, pp. 263-280
-
-
Sawada, H.1
Saito, T.2
Nickel, N.P.3
-
39
-
-
0037111391
-
Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation
-
Hager-Theodorides AL, Outram SV, Shah DK, Sacedon R, Shrimpton RE, Vicente A, Varas A, Crompton T. Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J Immunol. 2002;169:5496-5504.
-
(2002)
J Immunol.
, vol.169
, pp. 5496-5504
-
-
Hager-Theodorides, A.L.1
Outram, S.V.2
Shah, D.K.3
Sacedon, R.4
Shrimpton, R.E.5
Vicente, A.6
Varas, A.7
Crompton, T.8
-
40
-
-
74249121391
-
Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg
-
Lu L, Ma J, Wang X, Wang J, Zhang F, Yu J, He G, Xu B, Brand DD, Horwitz DA, Shi W, Zheng SG. Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg. Eur J Immunol. 2010;40:142-152.
-
(2010)
Eur J Immunol.
, vol.40
, pp. 142-152
-
-
Lu, L.1
Ma, J.2
Wang, X.3
Wang, J.4
Zhang, F.5
Yu, J.6
He, G.7
Xu, B.8
Brand, D.D.9
Horwitz, D.A.10
Shi, W.11
Zheng, S.G.12
-
41
-
-
34250205557
-
Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling
-
Taraseviciene-Stewart L, Nicolls MR, Kraskauskas D, Scerbavicius R, Burns N, Cool C, Wood K, Parr JE, Boackle SA, Voelkel NF. Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Am J Respir Crit Care Med. 2007;175:1280-1289.
-
(2007)
Am J Respir Crit Care Med.
, vol.175
, pp. 1280-1289
-
-
Taraseviciene-Stewart, L.1
Nicolls, M.R.2
Kraskauskas, D.3
Scerbavicius, R.4
Burns, N.5
Cool, C.6
Wood, K.7
Parr, J.E.8
Boackle, S.A.9
Voelkel, N.F.10
-
42
-
-
30144444546
-
Interleukin-6 causes mild pulmonary hypertension and augments hypoxia-induced pulmonary hypertension in mice
-
Golembeski SM, West J, Tada Y, Fagan KA. Interleukin-6 causes mild pulmonary hypertension and augments hypoxia-induced pulmonary hypertension in mice. Chest. 2005;128:572S-573S.
-
(2005)
Chest.
, vol.128
-
-
Golembeski, S.M.1
West, J.2
Tada, Y.3
Fagan, K.A.4
-
43
-
-
0028861014
-
Pulmonary hypertension in rats. 2. Role of interleukin-6
-
Miyata M, Sakuma F, Yoshimura A, Ishikawa H, Nishimaki T, Kasukawa R. Pulmonary hypertension in rats. 2. Role of interleukin-6. Int Arch Allergy Immunol. 1995;108:287-291.
-
(1995)
Int Arch Allergy Immunol.
, vol.108
, pp. 287-291
-
-
Miyata, M.1
Sakuma, F.2
Yoshimura, A.3
Ishikawa, H.4
Nishimaki, T.5
Kasukawa, R.6
-
44
-
-
84873356279
-
Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension
-
Condliffe R, Pickworth JA, Hopkinson K, et al. Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension. Pulm Circ. 2012;2:21-27.
-
(2012)
Pulm Circ.
, vol.2
, pp. 21-27
-
-
Condliffe, R.1
Pickworth, J.A.2
Hopkinson, K.3
-
45
-
-
38749138478
-
Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension
-
Lawrie A, Waterman E, Southwood M, Evans D, Suntharalingam J, Francis S, Crossman D, Croucher P, Morrell N, Newman C. Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension. Am J Pathol. 2008;172:256-264.
-
(2008)
Am J Pathol.
, vol.172
, pp. 256-264
-
-
Lawrie, A.1
Waterman, E.2
Southwood, M.3
Evans, D.4
Suntharalingam, J.5
Francis, S.6
Crossman, D.7
Croucher, P.8
Morrell, N.9
Newman, C.10
-
46
-
-
84902962783
-
Mif/cd74-dependent interleukin-6 and monocyte chemoattractant protein-1 secretion by pulmonary endothelial cells in idiopathic pulmonary hypertension
-
Tu L, Huertas A, Le Hiress M, Ricard N, Phan C, Fadel E, Seferian A, Montani D, Simonneau G, Humbert M, Guignabert C. Mif/cd74-dependent interleukin-6 and monocyte chemoattractant protein-1 secretion by pulmonary endothelial cells in idiopathic pulmonary hypertension. Am Thorac Soc. 2013;187:A1739.
-
(2013)
Am Thorac Soc.
, vol.187
-
-
Tu, L.1
Huertas, A.2
Le Hiress, M.3
Ricard, N.4
Phan, C.5
Fadel, E.6
Seferian, A.7
Montani, D.8
Simonneau, G.9
Humbert, M.10
Guignabert, C.11
-
47
-
-
79952234493
-
P53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: Inhibitory effects of macrophage migration inhibitor factor
-
Damico R, Simms T, Kim BS, Tekeste Z, Amankwan H, Damarla M, Hassoun PM. p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. Am J Respir Cell Mol Biol. 2011;44:323-332.
-
(2011)
Am J Respir Cell Mol Biol.
, vol.44
, pp. 323-332
-
-
Damico, R.1
Simms, T.2
Kim, B.S.3
Tekeste, Z.4
Amankwan, H.5
Damarla, M.6
Hassoun, P.M.7
-
48
-
-
84872193648
-
Key roles of Src family tyrosine kinases in the integrity of the pulmonary vascular bed
-
Guignabert C, Montani D. Key roles of Src family tyrosine kinases in the integrity of the pulmonary vascular bed. Eur Respir J. 2013;41:3-4.
-
(2013)
Eur Respir J.
, vol.41
, pp. 3-4
-
-
Guignabert, C.1
Montani, D.2
-
49
-
-
12444285441
-
MIF signal transduction initiated by binding to CD74
-
Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R. MIF signal transduction initiated by binding to CD74. J Exp Med. 2003;197:1467-1476.
-
(2003)
J Exp Med.
, vol.197
, pp. 1467-1476
-
-
Leng, L.1
Metz, C.N.2
Fang, Y.3
Xu, J.4
Donnelly, S.5
Baugh, J.6
Delohery, T.7
Chen, Y.8
Mitchell, R.A.9
Bucala, R.10
-
50
-
-
84872202945
-
Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries
-
Nagaraj C, Tang B, Bálint Z, Wygrecka M, Hrzenjak A, Kwapiszewska G, Stacher E, Lindenmann J, Weir EK, Olschewski H, Olschewski A. Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries. Eur Respir J. 2013;41:85-95.
-
(2013)
Eur Respir J.
, vol.41
, pp. 85-95
-
-
Nagaraj, C.1
Tang, B.2
Bálint, Z.3
Wygrecka, M.4
Hrzenjak, A.5
Kwapiszewska, G.6
Stacher, E.7
Lindenmann, J.8
Weir, E.K.9
Olschewski, H.10
Olschewski, A.11
-
51
-
-
34848917110
-
CD74: A new candidate target for the immunotherapy of B-cell neoplasms
-
Stein R, Mattes MJ, Cardillo TM, Hansen HJ, Chang CH, Burton J, Govindan S, Goldenberg DM. CD74: a new candidate target for the immunotherapy of B-cell neoplasms. Clin Cancer Res. 2007;13:5556s-5563s.
-
(2007)
Clin Cancer Res.
, vol.13
-
-
Stein, R.1
Mattes, M.J.2
Cardillo, T.M.3
Hansen, H.J.4
Chang, C.H.5
Burton, J.6
Govindan, S.7
Goldenberg, D.M.8
-
52
-
-
80051615782
-
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension
-
Tu L, Dewachter L, Gore B, Fadel E, Dartevelle P, Simonneau G, Humbert M, Eddahibi S, Guignabert C. Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension. Am J Respir Cell Mol Biol. 2011;45:311-322.
-
(2011)
Am J Respir Cell Mol Biol.
, vol.45
, pp. 311-322
-
-
Tu, L.1
Dewachter, L.2
Gore, B.3
Fadel, E.4
Dartevelle, P.5
Simonneau, G.6
Humbert, M.7
Eddahibi, S.8
Guignabert, C.9
-
53
-
-
34249066942
-
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
-
Bernhagen J, Krohn R, Lue H, et al. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007;13:587-596.
-
(2007)
Nat Med.
, vol.13
, pp. 587-596
-
-
Bernhagen, J.1
Krohn, R.2
Lue, H.3
-
54
-
-
84856773010
-
Macrophage migration inhibitory factor contributes to hypoxic pulmonary vasoconstriction in rats
-
Zhang B, Luo Y, Liu ML, Wang J, Xu DQ, Dong MQ, Liu Y, Xu M, Dong HY, Zhao PT, Gao YQ, Li ZC. Macrophage migration inhibitory factor contributes to hypoxic pulmonary vasoconstriction in rats. Microvasc Res. 2012;83:205-212.
-
(2012)
Microvasc Res.
, vol.83
, pp. 205-212
-
-
Zhang, B.1
Luo, Y.2
Liu, M.L.3
Wang, J.4
Xu, D.Q.5
Dong, M.Q.6
Liu, Y.7
Xu, M.8
Dong, H.Y.9
Zhao, P.T.10
Gao, Y.Q.11
Li, Z.C.12
-
55
-
-
84859063201
-
Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension
-
Zhang Y, Talwar A, Tsang D, Bruchfeld A, Sadoughi A, Hu M, Omonuwa K, Cheng KF, Al-Abed Y, Miller EJ. Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension. Mol Med. 2012;18:215-223.
-
(2012)
Mol Med.
, vol.18
, pp. 215-223
-
-
Zhang, Y.1
Talwar, A.2
Tsang, D.3
Bruchfeld, A.4
Sadoughi, A.5
Hu, M.6
Omonuwa, K.7
Cheng, K.F.8
Al-Abed, Y.9
Miller, E.J.10
-
56
-
-
84863069598
-
Role of macrophage migration inhibitory factor in the proliferation of smooth muscle cell in pulmonary hypertension
-
Zhang B, Shen M, Xu M, Liu LL, Luo Y, Xu DQ, Wang YX, Liu ML, Liu Y, Dong HY, Zhao PT, Li ZC. Role of macrophage migration inhibitory factor in the proliferation of smooth muscle cell in pulmonary hypertension. Mediators Inflamm. 2012;2012:840737.
-
(2012)
Mediators Inflamm.
, vol.2012
, pp. 840737
-
-
Zhang, B.1
Shen, M.2
Xu, M.3
Liu, L.L.4
Luo, Y.5
Xu, D.Q.6
Wang, Y.X.7
Liu, M.L.8
Liu, Y.9
Dong, H.Y.10
Zhao, P.T.11
Li, Z.C.12
-
57
-
-
84865498747
-
Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension
-
Ormiston ML, Chang C, Long LL, et al. Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension. Circulation. 2012;126:1099-1109.
-
(2012)
Circulation.
, vol.126
, pp. 1099-1109
-
-
Ormiston, M.L.1
Chang, C.2
Long, L.L.3
-
58
-
-
84872578985
-
Cytotoxic cells and granulysin in pulmonary arterial hypertension and pulmonary veno-occlusive disease
-
Perros F, Cohen-Kaminsky S, Gambaryan N, Girerd B, Raymond N, Klingelschmitt I, Huertas A, Mercier O, Fadel E, Simonneau G, Humbert M, Dorfmüller P, Montani D. Cytotoxic cells and granulysin in pulmonary arterial hypertension and pulmonary veno-occlusive disease. Am J Respir Crit Care Med. 2013;187:189-196.
-
(2013)
Am J Respir Crit Care Med.
, vol.187
, pp. 189-196
-
-
Perros, F.1
Cohen-Kaminsky, S.2
Gambaryan, N.3
Girerd, B.4
Raymond, N.5
Klingelschmitt, I.6
Huertas, A.7
Mercier, O.8
Fadel, E.9
Simonneau, G.10
Humbert, M.11
Dorfmüller, P.12
Montani, D.13
-
59
-
-
83355176600
-
Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice
-
Bauer EM, Zheng H, Comhair S, Erzurum S, Billiar TR, Bauer PM. Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One. 2011;6:e28578.
-
(2011)
PLoS One.
, vol.6
-
-
Bauer, E.M.1
Zheng, H.2
Comhair, S.3
Erzurum, S.4
Billiar, T.R.5
Bauer, P.M.6
-
60
-
-
84861914152
-
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma
-
Dib H, Tamby MC, Bussone G, Regent A, Berezné A, Lafine C, Broussard C, Simonneau G, Guillevin L, Witko-Sarsat V, Humbert M, Mouthon L. Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma. Eur Respir J. 2012;39:1405-1414.
-
(2012)
Eur Respir J.
, vol.39
, pp. 1405-1414
-
-
Dib, H.1
Tamby, M.C.2
Bussone, G.3
Regent, A.4
Berezné, A.5
Lafine, C.6
Broussard, C.7
Simonneau, G.8
Guillevin, L.9
Witko-Sarsat, V.10
Humbert, M.11
Mouthon, L.12
-
61
-
-
33845510782
-
Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension
-
Tamby MC, Humbert M, Guilpain P, Servettaz A, Dupin N, Christner JJ, Simonneau G, Fermanian J, Weill B, Guillevin L, Mouthon L. Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension. Eur Respir J. 2006;28:799-807.
-
(2006)
Eur Respir J.
, vol.28
, pp. 799-807
-
-
Tamby, M.C.1
Humbert, M.2
Guilpain, P.3
Servettaz, A.4
Dupin, N.5
Christner, J.J.6
Simonneau, G.7
Fermanian, J.8
Weill, B.9
Guillevin, L.10
Mouthon, L.11
-
62
-
-
0022979494
-
Antinuclear antibodies in primary pulmonary hypertension
-
Rich S, Kieras K, Hart K, Groves BM, Stobo JD, Brundage BH. Antinuclear antibodies in primary pulmonary hypertension. J Am Coll Cardiol. 1986;8:1307-1311.
-
(1986)
J Am Coll Cardiol.
, vol.8
, pp. 1307-1311
-
-
Rich, S.1
Kieras, K.2
Hart, K.3
Groves, B.M.4
Stobo, J.D.5
Brundage, B.H.6
-
63
-
-
24744455197
-
Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension
-
Tamby MC, Chanseaud Y, Humbert M, Fermanian J, Guilpain P, Garciade- la-Peña-Lefebvre P, Brunet S, Servettaz A, Weill B, Simonneau G, Guillevin L, Boissier MC, Mouthon L. Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension. Thorax. 2005;60:765-772.
-
(2005)
Thorax.
, vol.60
, pp. 765-772
-
-
Tamby, M.C.1
Chanseaud, Y.2
Humbert, M.3
Fermanian, J.4
Guilpain, P.5
Garciade-La-Peña-Lefebvre, P.6
Brunet, S.7
Servettaz, A.8
Weill, B.9
Simonneau, G.10
Guillevin, L.11
Boissier, M.C.12
Mouthon, L.13
-
64
-
-
0032523920
-
The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis
-
Bordron A, Dueymes M, Levy Y, Jamin C, Leroy JP, Piette JC, Shoenfeld Y, Youinou PY. The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis. J Clin Invest. 1998;101:2029-2035.
-
(1998)
J Clin Invest.
, vol.101
, pp. 2029-2035
-
-
Bordron, A.1
Dueymes, M.2
Levy, Y.3
Jamin, C.4
Leroy, J.P.5
Piette, J.C.6
Shoenfeld, Y.7
Youinou, P.Y.8
-
66
-
-
84886304083
-
Immunoglobulin G anti-endothelial cell antibodies: Inducers of endothelial cell apoptosis in pulmonary arterial hypertension?
-
Arends SJ, Damoiseaux JG, Duijvestijn AM, Debrus-Palmans L, Vroomen M, Boomars KA, Brunner-La Rocca HP, Reutelingsperger CP, Cohen Tervaert JW, van Paassen P. Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension?. Clin Exp Immunol. 2013;174:433-440.
-
(2013)
Clin Exp Immunol.
, vol.174
, pp. 433-440
-
-
Arends, S.J.1
Damoiseaux, J.G.2
Duijvestijn, A.M.3
Debrus-Palmans, L.4
Vroomen, M.5
Boomars, K.A.6
Brunner-La Rocca, H.P.7
Reutelingsperger, C.P.8
Cohen Tervaert, J.W.9
Van Paassen, P.10
-
67
-
-
0014667395
-
Thymus and reproduction: Sex-linked dysgenesia of the gonad after neonatal thymectomy in mice
-
Nishizuka Y, Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science. 1969;166:753-755.
-
(1969)
Science.
, vol.166
, pp. 753-755
-
-
Nishizuka, Y.1
Sakakura, T.2
-
68
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007;8:191-197.
-
(2007)
Nat Immunol.
, vol.8
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
69
-
-
2442484053
-
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
-
Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531-562.
-
(2004)
Annu Rev Immunol.
, vol.22
, pp. 531-562
-
-
Sakaguchi, S.1
-
70
-
-
84867136658
-
Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension
-
Huertas A, Tu L, Gambaryan N, Girerd B, Perros F, Montani D, Fabre D, Fadel E, Eddahibi S, Cohen-Kaminsky S, Guignabert C, Humbert M. Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension. Eur Respir J. 2012;40:895-904.
-
(2012)
Eur Respir J.
, vol.40
, pp. 895-904
-
-
Huertas, A.1
Tu, L.2
Gambaryan, N.3
Girerd, B.4
Perros, F.5
Montani, D.6
Fabre, D.7
Fadel, E.8
Eddahibi, S.9
Cohen-Kaminsky, S.10
Guignabert, C.11
Humbert, M.12
-
71
-
-
0026042115
-
Primary pulmonary hypertension in HIV infection
-
Speich R, Jenni R, Opravil M, Pfab M, Russi EW. Primary pulmonary hypertension in HIV infection. Chest. 1991;100:1268-1271.
-
(1991)
Chest.
, vol.100
, pp. 1268-1271
-
-
Speich, R.1
Jenni, R.2
Opravil, M.3
Pfab, M.4
Russi, E.W.5
-
72
-
-
67650128154
-
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression
-
Radstake TR, van Bon L, Broen J, Wenink M, Santegoets K, Deng Y, Hussaini A, Simms R, Cruikshank WW, Lafyatis R. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One. 2009;4:e5981.
-
(2009)
PLoS One.
, vol.4
-
-
Radstake, T.R.1
Van Bon, L.2
Broen, J.3
Wenink, M.4
Santegoets, K.5
Deng, Y.6
Hussaini, A.7
Simms, R.8
Cruikshank, W.W.9
Lafyatis, R.10
-
73
-
-
63149094153
-
Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus
-
Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C. Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunol. 2009;182:1689-1695.
-
(2009)
J Immunol.
, vol.182
, pp. 1689-1695
-
-
Bonelli, M.1
Savitskaya, A.2
Steiner, C.W.3
Rath, E.4
Smolen, J.S.5
Scheinecker, C.6
-
75
-
-
1842530436
-
CD4+ T-lymphocytopenia - A frequent finding in anti-SSA antibody seropositive patients with primary Sjögren's syndrome
-
Mandl T, Bredberg A, Jacobsson LT, Manthorpe R, Henriksson G. CD4+ T-lymphocytopenia - a frequent finding in anti-SSA antibody seropositive patients with primary Sjögren's syndrome. J Rheumatol. 2004;31:726-728.
-
(2004)
J Rheumatol.
, vol.31
, pp. 726-728
-
-
Mandl, T.1
Bredberg, A.2
Jacobsson, L.T.3
Manthorpe, R.4
Henriksson, G.5
-
76
-
-
33847696236
-
Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension
-
Perros F, Dorfmüller P, Souza R, Durand-Gasselin I, Mussot S, Mazmanian M, Hervé P, Emilie D, Simonneau G, Humbert M. Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension. Eur Respir J. 2007;29:462-468.
-
(2007)
Eur Respir J.
, vol.29
, pp. 462-468
-
-
Perros, F.1
Dorfmüller, P.2
Souza, R.3
Durand-Gasselin, I.4
Mussot, S.5
Mazmanian, M.6
Hervé, P.7
Emilie, D.8
Simonneau, G.9
Humbert, M.10
-
78
-
-
84860323260
-
Curing HIV-associated pulmonary arterial hypertension
-
Tcherakian C, Rivaud E, Zucman D, Metivier AC, Couderc LJ. Curing HIV-associated pulmonary arterial hypertension. Eur Respir J. 2012;39:1045-1046.
-
(2012)
Eur Respir J.
, vol.39
, pp. 1045-1046
-
-
Tcherakian, C.1
Rivaud, E.2
Zucman, D.3
Metivier, A.C.4
Couderc, L.J.5
-
79
-
-
73649092112
-
HIV-associated pulmonary arterial hypertension: Survival and prognostic factors in the modern therapeutic era
-
Degano B, Guillaume M, Savale L, Montani D, Jaïs X, Yaici A, Le Pavec J, Humbert M, Simonneau G, Sitbon O. HIV-associated pulmonary arterial hypertension: survival and prognostic factors in the modern therapeutic era. AIDS. 2010;24:67-75.
-
(2010)
AIDS
, vol.24
, pp. 67-75
-
-
Degano, B.1
Guillaume, M.2
Savale, L.3
Montani, D.4
Jaïs, X.5
Yaici, A.6
Le Pavec, J.7
Humbert, M.8
Simonneau, G.9
Sitbon, O.10
-
80
-
-
39749156384
-
Immunosuppressive therapy in lupus- and mixed connective tissue disease-associated pulmonary arterial hypertension: A retrospective analysis of twenty-three cases
-
Jais X, Launay D, Yaici A, Le Pavec J, Tchérakian C, Sitbon O, Simonneau G, Humbert M. Immunosuppressive therapy in lupus- and mixed connective tissue disease-associated pulmonary arterial hypertension: a retrospective analysis of twenty-three cases. Arthritis Rheum. 2008;58:521-531.
-
(2008)
Arthritis Rheum.
, vol.58
, pp. 521-531
-
-
Jais, X.1
Launay, D.2
Yaici, A.3
Le Pavec, J.4
Tchérakian, C.5
Sitbon, O.6
Simonneau, G.7
Humbert, M.8
-
81
-
-
84887271779
-
Bronchusassociated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies
-
Colvin KL, Cripe PJ, Ivy DD, Stenmark KR, Yeager ME. Bronchusassociated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies. Am J Respir Crit Care Med. 2013;188:1126-1136.
-
(2013)
Am J Respir Crit Care Med.
, vol.188
, pp. 1126-1136
-
-
Colvin, K.L.1
Cripe, P.J.2
Ivy, D.D.3
Stenmark, K.R.4
Yeager, M.E.5
-
82
-
-
0028282859
-
Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
-
Tuder RM, Groves B, Badesch DB, Voelkel NF. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol. 1994;144:275-285.
-
(1994)
Am J Pathol.
, vol.144
, pp. 275-285
-
-
Tuder, R.M.1
Groves, B.2
Badesch, D.B.3
Voelkel, N.F.4
-
83
-
-
84868283518
-
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension
-
Savai R, Pullamsetti SS, Kolbe J, et al. Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012;186:897-908.
-
(2012)
Am J Respir Crit Care Med.
, vol.186
, pp. 897-908
-
-
Savai, R.1
Pullamsetti, S.S.2
Kolbe, J.3
-
84
-
-
79954585526
-
A central role for CD68(+) macrophages in hepatopulmonary syndrome
-
Thenappan T, Goel A, Marsboom G, Fang YH, Toth PT, Zhang HJ, Kajimoto H, Hong Z, Paul J, Wietholt C, Pogoriler J, Piao L, Rehman J, Archer SL. A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion. Am J Respir Crit Care Med. 2011;183:1080-1091.
-
(2011)
Reversal by Macrophage Depletion. Am J Respir Crit Care Med.
, vol.183
, pp. 1080-1091
-
-
Thenappan, T.1
Goel, A.2
Marsboom, G.3
Fang, Y.H.4
Toth, P.T.5
Zhang, H.J.6
Kajimoto, H.7
Hong, Z.8
Paul, J.9
Wietholt, C.10
Pogoriler, J.11
Piao, L.12
Rehman, J.13
Archer, S.L.14
-
85
-
-
79955109384
-
Characteristics of interstitial fibrosis and inflammatory cell infiltration in right ventricles of systemic sclerosis-associated pulmonary arterial hypertension
-
pii: 604615
-
Overbeek MJ, Mouchaers KT, Niessen HM, Hadi AM, Kupreishvili K, Boonstra A, Voskuyl AE, Belien JA, Smit EF, Dijkmans BC, Vonk- Noordegraaf A, Grünberg K. Characteristics of interstitial fibrosis and inflammatory cell infiltration in right ventricles of systemic sclerosis-associated pulmonary arterial hypertension. Int J Rheumatol. 2010;2010:pii: 604615.
-
(2010)
Int J Rheumatol.
, vol.2010
-
-
Overbeek, M.J.1
Mouchaers, K.T.2
Niessen, H.M.3
Hadi, A.M.4
Kupreishvili, K.5
Boonstra, A.6
Voskuyl, A.E.7
Belien, J.A.8
Smit, E.F.9
Dijkmans, B.C.10
Vonk- Noordegraaf, A.11
Grünberg, K.12
-
86
-
-
33144471139
-
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
-
Frid MG, Brunetti JA, Burke DL, Carpenter TC, Davie NJ, Reeves JT, Roedersheimer MT, van Rooijen N, Stenmark KR. Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol. 2006;168:659-669.
-
(2006)
Am J Pathol.
, vol.168
, pp. 659-669
-
-
Frid, M.G.1
Brunetti, J.A.2
Burke, D.L.3
Carpenter, T.C.4
Davie, N.J.5
Reeves, J.T.6
Roedersheimer, M.T.7
Van Rooijen, N.8
Stenmark, K.R.9
-
87
-
-
79955772251
-
Early macrophage recruitment and alternative activation are critical for the later development of hypoxiainduced pulmonary hypertension
-
Vergadi E, Chang MS, Lee C, Liang OD, Liu X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S. Early macrophage recruitment and alternative activation are critical for the later development of hypoxiainduced pulmonary hypertension. Circulation. 2011;123:1986-1995.
-
(2011)
Circulation.
, vol.123
, pp. 1986-1995
-
-
Vergadi, E.1
Chang, M.S.2
Lee, C.3
Liang, O.D.4
Liu, X.5
Fernandez-Gonzalez, A.6
Mitsialis, S.A.7
Kourembanas, S.8
-
88
-
-
84883849935
-
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension
-
Tian W, Jiang X, Tamosiuniene R, et al. Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med. 2013;5:200ra117.
-
(2013)
Sci Transl Med.
, vol.5
-
-
Tian, W.1
Jiang, X.2
Tamosiuniene, R.3
-
89
-
-
84902990488
-
Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development
-
Porter KM, Walp ER, Elms SC, Raynor R, Mitchell PO, Guidot DM, Sutliff RL. Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development. Pulm Circ. 2013;3:58-67.
-
(2013)
Pulm Circ.
, vol.3
, pp. 58-67
-
-
Porter, K.M.1
Walp, E.R.2
Elms, S.C.3
Raynor, R.4
Mitchell, P.O.5
Guidot, D.M.6
Sutliff, R.L.7
-
90
-
-
84874511371
-
Herpes virus infection is associated with vascular remodeling and pulmonary hypertension in idiopathic pulmonary fibrosis
-
Calabrese F, Kipar A, Lunardi F, Balestro E, Perissinotto E, Rossi E, Nannini N, Marulli G, Stewart JP, Rea F. Herpes virus infection is associated with vascular remodeling and pulmonary hypertension in idiopathic pulmonary fibrosis. PLoS One. 2013;8:e55715.
-
(2013)
PLoS One.
, vol.8
-
-
Calabrese, F.1
Kipar, A.2
Lunardi, F.3
Balestro, E.4
Perissinotto, E.5
Rossi, E.6
Nannini, N.7
Marulli, G.8
Stewart, J.P.9
Rea, F.10
-
91
-
-
84872037440
-
Activation of the unfolded protein response is associated with pulmonary hypertension
-
Yeager ME, Reddy MB, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Activation of the unfolded protein response is associated with pulmonary hypertension. Pulm Circ. 2012;2:229-240.
-
(2012)
Pulm Circ.
, vol.2
, pp. 229-240
-
-
Yeager, M.E.1
Reddy, M.B.2
Nguyen, C.M.3
Colvin, K.L.4
Ivy, D.D.5
Stenmark, K.R.6
-
92
-
-
77949725833
-
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
-
Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, Yu QC, Solomides CC, Morrisey EE, Khurana TS, Christofidou-Solomidou M, Simon MC. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest. 2010;120:827-839.
-
(2010)
J Clin Invest.
, vol.120
, pp. 827-839
-
-
Hickey, M.M.1
Richardson, T.2
Wang, T.3
Mosqueira, M.4
Arguiri, E.5
Yu, H.6
Yu, Q.C.7
Solomides, C.C.8
Morrisey, E.E.9
Khurana, T.S.10
Christofidou-Solomidou, M.11
Simon, M.C.12
-
93
-
-
80052667354
-
Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension
-
Li M, Riddle SR, Frid MG, et al. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol. 2011;187:2711-2722.
-
(2011)
J Immunol.
, vol.187
, pp. 2711-2722
-
-
Li, M.1
Riddle, S.R.2
Frid, M.G.3
-
94
-
-
84863622602
-
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis
-
Serezani CH, Kane S, Collins L, Morato-Marques M, Osterholzer JJ, Peters-Golden M. Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol. 2012;189:906-915.
-
(2012)
J Immunol.
, vol.189
, pp. 906-915
-
-
Serezani, C.H.1
Kane, S.2
Collins, L.3
Morato-Marques, M.4
Osterholzer, J.J.5
Peters-Golden, M.6
-
95
-
-
84857883847
-
Macrophage plasticity and polarization: In vivo veritas
-
Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122:787-795.
-
(2012)
J Clin Invest.
, vol.122
, pp. 787-795
-
-
Sica, A.1
Mantovani, A.2
-
96
-
-
84886102085
-
Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension
-
Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol. 2013;49:951-959.
-
(2013)
Am J Respir Cell Mol Biol.
, vol.49
, pp. 951-959
-
-
Graham, B.B.1
Chabon, J.2
Kumar, R.3
Kolosionek, E.4
Gebreab, L.5
Debella, E.6
Edwards, M.7
Diener, K.8
Shade, T.9
Bifeng, G.10
Bandeira, A.11
Butrous, G.12
Jones, K.13
Geraci, M.14
Tuder, R.M.15
-
98
-
-
42249084849
-
Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category
-
Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205:799-810.
-
(2008)
J Exp Med.
, vol.205
, pp. 799-810
-
-
Luger, D.1
Silver, P.B.2
Tang, J.3
Cua, D.4
Chen, Z.5
Iwakura, Y.6
Bowman, E.P.7
Sgambellone, N.M.8
Chan, C.C.9
Caspi, R.R.10
-
99
-
-
0034997949
-
Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension
-
Fujita M, Shannon JM, Irvin CG, Fagan KA, Cool C, Augustin A, Mason RJ. Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001;280:L39-L49.
-
(2001)
Am J Physiol Lung Cell Mol Physiol.
, vol.280
-
-
Fujita, M.1
Shannon, J.M.2
Irvin, C.G.3
Fagan, K.A.4
Cool, C.5
Augustin, A.6
Mason, R.J.7
-
100
-
-
79958031292
-
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension
-
Christmann RB, Hayes E, Pendergrass S, Padilla C, Farina G, Affandi AJ, Whitfield ML, Farber HW, Lafyatis R. Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum. 2011;63:1718-1728.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 1718-1728
-
-
Christmann, R.B.1
Hayes, E.2
Pendergrass, S.3
Padilla, C.4
Farina, G.5
Affandi, A.J.6
Whitfield, M.L.7
Farber, H.W.8
Lafyatis, R.9
-
101
-
-
84872416060
-
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension
-
Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013;304:L112-L124.
-
(2013)
Am J Physiol Lung Cell Mol Physiol.
, vol.304
-
-
Cho, W.K.1
Lee, C.M.2
Kang, M.J.3
Huang, Y.4
Giordano, F.J.5
Lee, P.J.6
Trow, T.K.7
Homer, R.J.8
Sessa, W.C.9
Elias, J.A.10
Lee, C.G.11
-
102
-
-
80052864064
-
Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions
-
Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M. Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions. Am J Pathol. 2011;179:1560-1572.
-
(2011)
Am J Pathol.
, vol.179
, pp. 1560-1572
-
-
Kim, Y.M.1
Haghighat, L.2
Spiekerkoetter, E.3
Sawada, H.4
Alvira, C.M.5
Wang, L.6
Acharya, S.7
Rodriguez-Colon, G.8
Orton, A.9
Zhao, M.10
Rabinovitch, M.11
-
103
-
-
0037192329
-
Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension
-
Zaidi SH, You XM, Ciura S, Husain M, Rabinovitch M. Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension. Circulation. 2002;105:516-521.
-
(2002)
Circulation.
, vol.105
, pp. 516-521
-
-
Zaidi, S.H.1
You, X.M.2
Ciura, S.3
Husain, M.4
Rabinovitch, M.5
-
104
-
-
0034126770
-
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor
-
Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, Rabinovitch M. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med. 2000;6:698-702.
-
(2000)
Nat Med.
, vol.6
, pp. 698-702
-
-
Cowan, K.N.1
Heilbut, A.2
Humpl, T.3
Lam, C.4
Ito, S.5
Rabinovitch, M.6
-
105
-
-
0031962711
-
Endothelial and serum factors which include apolipoprotein A1 tether elastin to smooth muscle cells inducing serine elastase activity via tyrosine kinase-mediated transcription and translation
-
Thompson K, Kobayashi J, Childs T, Wigle D, Rabinovitch M. Endothelial and serum factors which include apolipoprotein A1 tether elastin to smooth muscle cells inducing serine elastase activity via tyrosine kinase-mediated transcription and translation. J Cell Physiol. 1998;174:78-89.
-
(1998)
J Cell Physiol.
, vol.174
, pp. 78-89
-
-
Thompson, K.1
Kobayashi, J.2
Childs, T.3
Wigle, D.4
Rabinovitch, M.5
-
106
-
-
0029868471
-
Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor
-
Thompson K, Rabinovitch M. Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor. J Cell Physiol. 1996;166:495-505.
-
(1996)
J Cell Physiol.
, vol.166
, pp. 495-505
-
-
Thompson, K.1
Rabinovitch, M.2
-
108
-
-
0033960683
-
Cleavage of the fifth component of complement and generation of a functionally active C5b6-like complex by human leukocyte elastase
-
Vogt W. Cleavage of the fifth component of complement and generation of a functionally active C5b6-like complex by human leukocyte elastase. Immunobiology. 2000;201:470-477.
-
(2000)
Immunobiology.
, vol.201
, pp. 470-477
-
-
Vogt, W.1
-
109
-
-
33845953446
-
Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway
-
Butler MW, Robertson I, Greene CM, O'Neill SJ, Taggart CC, McElvaney NG. Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. J Biol Chem. 2006;281:34730-34735.
-
(2006)
J Biol Chem.
, vol.281
, pp. 34730-34735
-
-
Butler, M.W.1
Robertson, I.2
Greene, C.M.3
O'neill, S.J.4
Taggart, C.C.5
McElvaney, N.G.6
-
110
-
-
84881240287
-
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
-
Spiekerkoetter E, Tian X, Cai J, et al. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest. 2013;123:3600-3613.
-
(2013)
J Clin Invest.
, vol.123
, pp. 3600-3613
-
-
Spiekerkoetter, E.1
Tian, X.2
Cai, J.3
-
111
-
-
0022552509
-
Immunotherapy with bestatin for acute nonlymphocytic leukemia in adults
-
Ota K, Kurita S, Yamada K, Masaoka T, Uzuka Y, Ogawa N. Immunotherapy with bestatin for acute nonlymphocytic leukemia in adults. Cancer Immunol Immunother. 1986;23:5-10.
-
(1986)
Cancer Immunol Immunother.
, vol.23
, pp. 5-10
-
-
Ota, K.1
Kurita, S.2
Yamada, K.3
Masaoka, T.4
Uzuka, Y.5
Ogawa, N.6
-
112
-
-
0038364080
-
Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage i squamous-cell lung carcinoma
-
NK421 Lung Cancer Surgery Group
-
Ichinose Y, Genka K, Koike T, Kato H, Watanabe Y, Mori T, Iioka S, Sakuma A, Ohta M; NK421 Lung Cancer Surgery Group. Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma. J Natl Cancer Inst. 2003;95:605-610.
-
(2003)
J Natl Cancer Inst.
, vol.95
, pp. 605-610
-
-
Ichinose, Y.1
Genka, K.2
Koike, T.3
Kato, H.4
Watanabe, Y.5
Mori, T.6
Iioka, S.7
Sakuma, A.8
Ohta, M.9
-
113
-
-
84879237561
-
Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure
-
Barnes GD, Alam S, Carter G, Pedersen CM, Lee KM, Hubbard TJ, Veitch S, Jeong H, White A, Cruden NL, Huson L, Japp AG, Newby DE. Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure. Circ Heart Fail. 2013;6:482-491.
-
(2013)
Circ Heart Fail.
, vol.6
, pp. 482-491
-
-
Barnes, G.D.1
Alam, S.2
Carter, G.3
Pedersen, C.M.4
Lee, K.M.5
Hubbard, T.J.6
Veitch, S.7
Jeong, H.8
White, A.9
Cruden, N.L.10
Huson, L.11
Japp, A.G.12
Newby, D.E.13
-
114
-
-
33751507586
-
Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators
-
Cui T, Schopfer FJ, Zhang J, Chen K, Ichikawa T, Baker PR, Batthyany C, Chacko BK, Feng X, Patel RP, Agarwal A, Freeman BA, Chen YE. Nitrated fatty acids: endogenous anti-inflammatory signaling mediators. J Biol Chem. 2006;281:35686-35698.
-
(2006)
J Biol Chem.
, vol.281
, pp. 35686-35698
-
-
Cui, T.1
Schopfer, F.J.2
Zhang, J.3
Chen, K.4
Ichikawa, T.5
Baker, P.R.6
Batthyany, C.7
Chacko, B.K.8
Feng, X.9
Patel, R.P.10
Agarwal, A.11
Freeman, B.A.12
Chen, Y.E.13
-
115
-
-
77956254104
-
Redox signaling in inflammation: Interactions of endogenous electrophiles and mitochondria in cardiovascular disease
-
Koenitzer JR, Freeman BA. Redox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular disease. Ann N Y Acad Sci. 2010;1203:45-52.
-
(2010)
Ann N y Acad Sci.
, vol.1203
, pp. 45-52
-
-
Koenitzer, J.R.1
Freeman, B.A.2
-
116
-
-
0036893519
-
Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression
-
Fujita M, Mason RJ, Cool C, Shannon JM, Hara N, Fagan KA. Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression. J Appl Physiol (1985). 2002;93:2162-2170.
-
(2002)
J Appl Physiol (1985)
, vol.93
, pp. 2162-2170
-
-
Fujita, M.1
Mason, R.J.2
Cool, C.3
Shannon, J.M.4
Hara, N.5
Fagan, K.A.6
-
117
-
-
83455195470
-
Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension
-
Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M, McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M. Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension. BMC Immunol. 2011;12:67.
-
(2011)
BMC Immunol.
, vol.12
, pp. 67
-
-
Rabieyousefi, M.1
Soroosh, P.2
Satoh, K.3
Date, F.4
Ishii, N.5
Yamashita, M.6
Oka, M.7
McMurtry, I.F.8
Shimokawa, H.9
Nose, M.10
Sugamura, K.11
Ono, M.12
-
118
-
-
84868309560
-
Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization
-
Mizuno S, Farkas L, Al Husseini A, Farkas D, Gomez-Arroyo J, Kraskauskas D, Nicolls MR, Cool CD, Bogaard HJ, Voelkel NF. Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization. Am J Respir Cell Mol Biol. 2012;47:679-687.
-
(2012)
Am J Respir Cell Mol Biol.
, vol.47
, pp. 679-687
-
-
Mizuno, S.1
Farkas, L.2
Al Husseini, A.3
Farkas, D.4
Gomez-Arroyo, J.5
Kraskauskas, D.6
Nicolls, M.R.7
Cool, C.D.8
Bogaard, H.J.9
Voelkel, N.F.10
-
119
-
-
0028676054
-
Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline
-
Voelkel NF, Tuder RM, Bridges J, Arend WP. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am J Respir Cell Mol Biol. 1994;11:664-675.
-
(1994)
Am J Respir Cell Mol Biol.
, vol.11
, pp. 664-675
-
-
Voelkel, N.F.1
Tuder, R.M.2
Bridges, J.3
Arend, W.P.4
-
120
-
-
33748439778
-
Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats
-
Suzuki C, Takahashi M, Morimoto H, Izawa A, Ise H, Hongo M, Hoshikawa Y, Ito T, Miyashita H, Kobayashi E, Shimada K, Ikeda U. Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats. Biochem Biophys Res Commun. 2006;349:781-788.
-
(2006)
Biochem Biophys Res Commun.
, vol.349
, pp. 781-788
-
-
Suzuki, C.1
Takahashi, M.2
Morimoto, H.3
Izawa, A.4
Ise, H.5
Hongo, M.6
Hoshikawa, Y.7
Ito, T.8
Miyashita, H.9
Kobayashi, E.10
Shimada, K.11
Ikeda, U.12
-
121
-
-
79953690566
-
Dexamethasone reverses monocrotaline- induced pulmonary arterial hypertension in rats
-
Price LC, Montani D, Tcherakian C, Dorfmüller P, Souza R, Gambaryan N, Chaumais MC, Shao DM, Simonneau G, Howard LS, Adcock IM, Wort SJ, Humbert M, Perros F. Dexamethasone reverses monocrotaline- induced pulmonary arterial hypertension in rats. Eur Respir J. 2011;37:813-822.
-
(2011)
Eur Respir J.
, vol.37
, pp. 813-822
-
-
Price, L.C.1
Montani, D.2
Tcherakian, C.3
Dorfmüller, P.4
Souza, R.5
Gambaryan, N.6
Chaumais, M.C.7
Shao, D.M.8
Simonneau, G.9
Howard, L.S.10
Adcock, I.M.11
Wort, S.J.12
Humbert, M.13
Perros, F.14
-
122
-
-
80052448811
-
Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension
-
Wang W, Wang YL, Chen XY, Li YT, Hao W, Jin YP, Han B. Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension. Mol Biol Rep. 2011;38:3277-3284.
-
(2011)
Mol Biol Rep.
, vol.38
, pp. 3277-3284
-
-
Wang, W.1
Wang, Y.L.2
Chen, X.Y.3
Li, Y.T.4
Hao, W.5
Jin, Y.P.6
Han, B.7
-
123
-
-
0035131411
-
40-O-(2- hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats
-
Nishimura T, Faul JL, Berry GJ, Veve I, Pearl RG, Kao PN. 40-O-(2- hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med. 2001;163:498-502.
-
(2001)
Am J Respir Crit Care Med.
, vol.163
, pp. 498-502
-
-
Nishimura, T.1
Faul, J.L.2
Berry, G.J.3
Veve, I.4
Pearl, R.G.5
Kao, P.N.6
-
124
-
-
34547456414
-
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
-
Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, Hashimoto K, Bonnet SN, Michelakis ED. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A. 2007;104:11418-11423.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, pp. 11418-11423
-
-
Bonnet, S.1
Rochefort, G.2
Sutendra, G.3
Archer, S.L.4
Haromy, A.5
Webster, L.6
Hashimoto, K.7
Bonnet, S.N.8
Michelakis, E.D.9
-
125
-
-
33748703089
-
Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy
-
Koulmann N, Novel-Chaté V, Peinnequin A, Chapot R, Serrurier B, Simler N, Richard H, Ventura-Clapier R, Bigard X. Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy. Am J Respir Crit Care Med. 2006;174:699-705.
-
(2006)
Am J Respir Crit Care Med.
, vol.174
, pp. 699-705
-
-
Koulmann, N.1
Novel-Chaté, V.2
Peinnequin, A.3
Chapot, R.4
Serrurier, B.5
Simler, N.6
Richard, H.7
Ventura-Clapier, R.8
Bigard, X.9
-
126
-
-
84870279242
-
Inhibition of tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
-
Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW, Crossman DC, Newman CM, Kiely DG, Francis SE, Lawrie A. Inhibition of tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension. J Exp Med. 2012;209:1919-1935.
-
(2012)
J Exp Med.
, vol.209
, pp. 1919-1935
-
-
Hameed, A.G.1
Arnold, N.D.2
Chamberlain, J.3
Pickworth, J.A.4
Paiva, C.5
Dawson, S.6
Cross, S.7
Long, L.8
Zhao, L.9
Morrell, N.W.10
Crossman, D.C.11
Newman, C.M.12
Kiely, D.G.13
Francis, S.E.14
Lawrie, A.15
-
127
-
-
1942501625
-
Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats
-
Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang YY. Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol. 2004;286:H1775-H1784.
-
(2004)
Am J Physiol Heart Circ Physiol.
, vol.286
-
-
Jones, J.E.1
Walker, J.L.2
Song, Y.3
Weiss, N.4
Cardoso, W.V.5
Tuder, R.M.6
Loscalzo, J.7
Zhang, Y.Y.8
-
128
-
-
0029936155
-
Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
-
Voelkel NF, Tuder RM, Wade K, Höper M, Lepley RA, Goulet JL, Koller BH, Fitzpatrick F. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. J Clin Invest. 1996;97:2491-2498.
-
(1996)
J Clin Invest.
, vol.97
, pp. 2491-2498
-
-
Voelkel, N.F.1
Tuder, R.M.2
Wade, K.3
Höper, M.4
Lepley, R.A.5
Goulet, J.L.6
Koller, B.H.7
Fitzpatrick, F.8
-
129
-
-
0031063562
-
Role of leukotriene B4 in monocrotaline-induced pulmonary hypertension
-
Tabata T, Ono S, Song C, Noda M, Suzuki S, Tanita T, Fujimura S. [Role of leukotriene B4 in monocrotaline-induced pulmonary hypertension]. Nihon Kyobu Shikkan Gakkai Zasshi. 1997;35:160-166.
-
(1997)
Nihon Kyobu Shikkan Gakkai Zasshi.
, vol.35
, pp. 160-166
-
-
Tabata, T.1
Ono, S.2
Song, C.3
Noda, M.4
Suzuki, S.5
Tanita, T.6
Fujimura, S.7
-
130
-
-
77956550884
-
Schistosomiasis-induced experimental pulmonary hypertension: Role of interleukin-13 signaling
-
Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol. 2010;177:1549-1561.
-
(2010)
Am J Pathol.
, vol.177
, pp. 1549-1561
-
-
Graham, B.B.1
Mentink-Kane, M.M.2
El-Haddad, H.3
Purnell, S.4
Zhang, L.5
Zaiman, A.6
Redente, E.F.7
Riches, D.W.8
Hassoun, P.M.9
Bandeira, A.10
Champion, H.C.11
Butrous, G.12
Wynn, T.A.13
Tuder, R.M.14
-
131
-
-
84871720484
-
Monocrotalineinduced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-?B pathway in rats
-
Wang Q, Zuo XR, Wang YY, Xie WP, Wang H, Zhang M. Monocrotalineinduced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-?B pathway in rats. Vascul Pharmacol. 2013;58:71-77.
-
(2013)
Vascul Pharmacol.
, vol.58
, pp. 71-77
-
-
Wang, Q.1
Zuo, X.R.2
Wang, Y.Y.3
Xie, W.P.4
Wang, H.5
Zhang, M.6
-
132
-
-
43049101144
-
Effects of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension
-
Henriques-Coelho T, Brandão-Nogueira A, Moreira-Gonçalves D, Correia-Pinto J, Leite-Moreira AF. Effects of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension. Rev Port Cardiol. 2008;27:341-348.
-
(2008)
Rev Port Cardiol.
, vol.27
, pp. 341-348
-
-
Henriques-Coelho, T.1
Brandão-Nogueira, A.2
Moreira-Gonçalves, D.3
Correia-Pinto, J.4
Leite-Moreira, A.F.5
-
133
-
-
43049092988
-
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
-
Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest. 2008;118:1846-1857.
-
(2008)
J Clin Invest.
, vol.118
, pp. 1846-1857
-
-
Hansmann, G.1
De Jesus Perez, V.A.2
Alastalo, T.P.3
Alvira, C.M.4
Guignabert, C.5
Bekker, J.M.6
Schellong, S.7
Urashima, T.8
Wang, L.9
Morrell, N.W.10
Rabinovitch, M.11
-
134
-
-
66149144223
-
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation
-
Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL, Quertermous T. Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Am J Physiol Heart Circ Physiol. 2009;296:H1329-H1335.
-
(2009)
Am J Physiol Heart Circ Physiol.
, vol.296
-
-
Leeper, N.J.1
Tedesco, M.M.2
Kojima, Y.3
Schultz, G.M.4
Kundu, R.K.5
Ashley, E.A.6
Tsao, P.S.7
Dalman, R.L.8
Quertermous, T.9
-
135
-
-
51249104041
-
The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes
-
Mazzucotelli A, Ribet C, Castan-Laurell I, Daviaud D, Guigné C, Langin D, Valet P. The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes. Regul Pept. 2008;150:33-37.
-
(2008)
Regul Pept.
, vol.150
, pp. 33-37
-
-
Mazzucotelli, A.1
Ribet, C.2
Castan-Laurell, I.3
Daviaud, D.4
Guigné, C.5
Langin, D.6
Valet, P.7
-
136
-
-
0141997136
-
Fatal primary pulmonary hypertension in a 30-yr-old female with APECED syndrome
-
Korniszewski L, Kurzyna M, Stolarski B, Torbicki A, Smerdel A, Ploski R. Fatal primary pulmonary hypertension in a 30-yr-old female with APECED syndrome. Eur Respir J. 2003;22:709-711.
-
(2003)
Eur Respir J.
, vol.22
, pp. 709-711
-
-
Korniszewski, L.1
Kurzyna, M.2
Stolarski, B.3
Torbicki, A.4
Smerdel, A.5
Ploski, R.6
-
137
-
-
79959464127
-
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension
-
Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED. The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med. 2011;3:88ra55.
-
(2011)
Sci Transl Med.
, vol.3
-
-
Sutendra, G.1
Dromparis, P.2
Wright, P.3
Bonnet, S.4
Haromy, A.5
Hao, Z.6
McMurtry, M.S.7
Michalak, M.8
Vance, J.E.9
Sessa, W.C.10
Michelakis, E.D.11
-
139
-
-
84865297442
-
The inflammation highway: Metabolism accelerates inflammatory traffic in obesity
-
Johnson AR, Milner JJ, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev. 2012;249:218-238.
-
(2012)
Immunol Rev.
, vol.249
, pp. 218-238
-
-
Johnson, A.R.1
Milner, J.J.2
Makowski, L.3
-
140
-
-
27744519400
-
Fuel feeds function: Energy metabolism and the T-cell response
-
Fox CJ, Hammerman PS, Thompson CB. Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol. 2005;5:844-852.
-
(2005)
Nat Rev Immunol.
, vol.5
, pp. 844-852
-
-
Fox, C.J.1
Hammerman, P.S.2
Thompson, C.B.3
-
141
-
-
44349150953
-
Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation
-
van Raam BJ, Sluiter W, de Wit E, Roos D, Verhoeven AJ, Kuijpers TW. Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation. PLoS One. 2008;3:e2013.
-
(2008)
PLoS One.
, vol.3
-
-
Van Raam, B.J.1
Sluiter, W.2
De Wit, E.3
Roos, D.4
Verhoeven, A.J.5
Kuijpers, T.W.6
-
143
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796-1808.
-
(2003)
J Clin Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
144
-
-
59649112895
-
Insulin resistance in pulmonary arterial hypertension
-
Zamanian RT, Hansmann G, Snook S, Lilienfeld D, Rappaport KM, Reaven GM, Rabinovitch M, Doyle RL. Insulin resistance in pulmonary arterial hypertension. Eur Respir J. 2009;33:318-324.
-
(2009)
Eur Respir J.
, vol.33
, pp. 318-324
-
-
Zamanian, R.T.1
Hansmann, G.2
Snook, S.3
Lilienfeld, D.4
Rappaport, K.M.5
Reaven, G.M.6
Rabinovitch, M.7
Doyle, R.L.8
|