메뉴 건너뛰기




Volumn 304, Issue 2, 2013, Pages

IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension

Author keywords

Animal model; Arginase; Inflammation; Pulmonary vascular disease

Indexed keywords

ARGINASE; ARGINASE 2; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA2; NITRIC OXIDE; RECOMBINANT INTERLEUKIN 13; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84872416060     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00101.2012     Document Type: Article
Times cited : (43)

References (46)
  • 3
    • 84861894074 scopus 로고    scopus 로고
    • High expression of IL-13 receptor alpha2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis
    • Barderas R, Bartolome RA, Fernandez-Acenero MJ, Torres S, Casal JI. High expression of IL-13 receptor alpha2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis. Cancer Res 72: 2780-2790, 2012.
    • (2012) Cancer Res , vol.72 , pp. 2780-2790
    • Barderas, R.1    Bartolome, R.A.2    Fernandez-Acenero, M.J.3    Torres, S.4    Casal, J.I.5
  • 4
    • 71949117652 scopus 로고    scopus 로고
    • Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase
    • Chen B, Calvert AE, Cui H, Nelin LD. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase. Am J Physiol Lung Cell Mol Physiol 297: L1151-L1159, 2009.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297
    • Chen, B.1    Calvert, A.E.2    Cui, H.3    Nelin, L.D.4
  • 5
    • 84864543610 scopus 로고    scopus 로고
    • Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells
    • Chen B, Calvert AE, Meng X, Nelin LD. Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 47: 218-226, 2012.
    • (2012) Am J Respir Cell Mol Biol , vol.47 , pp. 218-226
    • Chen, B.1    Calvert, A.E.2    Meng, X.3    Nelin, L.D.4
  • 9
    • 30044449492 scopus 로고    scopus 로고
    • IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    • Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 12: 99-106, 2006.
    • (2006) Nat Med , vol.12 , pp. 99-106
    • Fichtner-Feigl, S.1    Strober, W.2    Kawakami, K.3    Puri, R.K.4    Kitani, A.5
  • 10
    • 57249094020 scopus 로고    scopus 로고
    • IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis
    • Fichtner-Feigl S, Young CA, Kitani A, Geissler EK, Schlitt HJ, Strober W. IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 135: 2003-2013, 2013.
    • (2013) Gastroenterology , vol.135 , pp. 2003-2013
    • Fichtner-Feigl, S.1    Young, C.A.2    Kitani, A.3    Geissler, E.K.4    Schlitt, H.J.5    Strober, W.6
  • 11
    • 72249115096 scopus 로고    scopus 로고
    • A novel role of interleukin- 13 receptor alpha2 in pancreatic cancer invasion and metastasis
    • Fujisawa T, Joshi B, Nakajima A, Puri RK. A novel role of interleukin- 13 receptor alpha2 in pancreatic cancer invasion and metastasis. Cancer Res 69: 8678-8685, 2009.
    • (2009) Cancer Res , vol.69 , pp. 8678-8685
    • Fujisawa, T.1    Joshi, B.2    Nakajima, A.3    Puri, R.K.4
  • 12
    • 17044393596 scopus 로고    scopus 로고
    • Gene expression profiling identifies IL-13 receptor alpha 2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin
    • Gonzalez-Moreno O, Calvo A, Joshi BH, Abasolo I, Leland P, Wang Z, Montuenga L, Puri RK, Green JE. Gene expression profiling identifies IL-13 receptor alpha 2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin. Int J Cancer 114: 870-878, 2005.
    • (2005) Int J Cancer , vol.114 , pp. 870-878
    • Gonzalez-Moreno, O.1    Calvo, A.2    Joshi, B.H.3    Abasolo, I.4    Leland, P.5    Wang, Z.6    Montuenga, L.7    Puri, R.K.8    Green, J.E.9
  • 13
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity 32: 593-604, 2010.
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 17
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signaling pathways: An evolving web
    • Hershey GK. IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 111: 677-691, 2003.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 677-691
    • Hershey, G.K.1
  • 18
    • 0035957368 scopus 로고    scopus 로고
    • Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation
    • Ignarro LJ, Buga GM, Wei LH, Bauer PM, Wu G, del Soldato P. Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc Natl Acad Sci USA 98: 4202-4208, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4202-4208
    • Ignarro, L.J.1    Buga, G.M.2    Wei, L.H.3    Bauer, P.M.4    Wu, G.5    del Soldato, P.6
  • 19
    • 0035676884 scopus 로고    scopus 로고
    • Pulmonary vascular remodeling: A target for therapeutic intervention in pulmonary hypertension
    • Jeffery TK, Wanstall JC. Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension. Pharmacol Ther 92: 1-20, 2001.
    • (2001) Pharmacol Ther , vol.92 , pp. 1-20
    • Jeffery, T.K.1    Wanstall, J.C.2
  • 21
    • 33749005099 scopus 로고    scopus 로고
    • Interleukin- 13 receptor alpha2 chain: A potential biomarker and molecular target for ovarian cancer therapy
    • Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK. Interleukin- 13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy. Cancer 107: 1407-1418, 2006.
    • (2006) Cancer , vol.107 , pp. 1407-1418
    • Kioi, M.1    Kawakami, M.2    Shimamura, T.3    Husain, S.R.4    Puri, R.K.5
  • 23
    • 9644268915 scopus 로고    scopus 로고
    • Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease
    • Mentink-Kane MM, Wynn TA. Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. Immunol Rev 202: 191-202, 2004.
    • (2004) Immunol Rev , vol.202 , pp. 191-202
    • Mentink-Kane, M.M.1    Wynn, T.A.2
  • 24
    • 0020570619 scopus 로고
    • Pulmonary hypertension. Anatomic and physiologic correlates
    • Meyrick B, Reid L. Pulmonary hypertension. Anatomic and physiologic correlates. Clin Chest Med 4: 199-217, 1983.
    • (1983) Clin Chest Med , vol.4 , pp. 199-217
    • Meyrick, B.1    Reid, L.2
  • 25
    • 84872373694 scopus 로고    scopus 로고
    • Resistin-like molecule (RELM)-alpha and beta are allergen-induced cytokines with potent remodeling activity in the murine lung (Abstract)
    • Mishra A, DeBrosse CW, Rothenberg ME. Resistin-like molecule (RELM)-alpha and beta are allergen-induced cytokines with potent remodeling activity in the murine lung (Abstract). J Allergy Clin Immunol 113: S185, 2004.
    • (2004) J Allergy Clin Immunol , vol.113
    • Mishra, A.1    Debrosse, C.W.2    Rothenberg, M.E.3
  • 27
    • 70350303578 scopus 로고    scopus 로고
    • Recent advances in arginine metabolism: Roles and regulation of the arginases
    • Morris SM Jr. Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol 157: 922-930, 2009.
    • (2009) Br J Pharmacol , vol.157 , pp. 922-930
    • Morris Jr., S.M.1
  • 28
    • 41549154142 scopus 로고    scopus 로고
    • Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: Implications in pulmonary arterial hypertension
    • Mukhopadhyay S, Shah M, Xu F, Patel K, Tuder RM, Sehgal PB. Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 294: L449-L468, 2008.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Mukhopadhyay, S.1    Shah, M.2    Xu, F.3    Patel, K.4    Tuder, R.M.5    Sehgal, P.B.6
  • 29
    • 0033214545 scopus 로고    scopus 로고
    • Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells
    • Munder M, Eichmann K, Moran JM, Centeno F, Soler G, Modolell M. Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol 163: 3771-3777, 1999.
    • (1999) J Immunol , vol.163 , pp. 3771-3777
    • Munder, M.1    Eichmann, K.2    Moran, J.M.3    Centeno, F.4    Soler, G.5    Modolell, M.6
  • 31
    • 84856258774 scopus 로고    scopus 로고
    • An interleukin 13 receptor alpha 2-specific peptide homes to human Glioblastoma multiforme xenografts
    • Pandya H, Gibo DM, Garg S, Kridel S, Debinski W. An interleukin 13 receptor alpha 2-specific peptide homes to human Glioblastoma multiforme xenografts. Neuro Oncol 14: 6-18, 2011.
    • (2011) Neuro Oncol , vol.14 , pp. 6-18
    • Pandya, H.1    Gibo, D.M.2    Garg, S.3    Kridel, S.4    Debinski, W.5
  • 35
    • 79955772251 scopus 로고    scopus 로고
    • Early macrophage recruitment and alternative activation are critical for the later development of hypoxiainduced pulmonary hypertension
    • Vergadi E, Chang MS, Lee C, Liang OD, Liu X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S. Early macrophage recruitment and alternative activation are critical for the later development of hypoxiainduced pulmonary hypertension. Circulation 123: 1986-1995, 2011.
    • (2011) Circulation , vol.123 , pp. 1986-1995
    • Vergadi, E.1    Chang, M.S.2    Lee, C.3    Liang, O.D.4    Liu, X.5    Fernandez-Gonzalez, A.6    Mitsialis, S.A.7    Kourembanas, S.8
  • 39
    • 0037775352 scopus 로고    scopus 로고
    • IL13 effector functions
    • Wynn TA. IL13 effector functions. Annu Rev Immunol 21: 425-456, 2003.
    • (2003) Annu Rev Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 40
    • 0029900905 scopus 로고    scopus 로고
    • Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
    • Xia Y, Dawson VL, Dawson TM, Snyder SH, Zweier JL. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci USA 93: 6770-6774, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6770-6774
    • Xia, Y.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4    Zweier, J.L.5
  • 44
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103: 779-788, 1999.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6    Zhang, Y.7    Elias, J.A.8
  • 46
    • 33644769084 scopus 로고    scopus 로고
    • The arginine-arginase balance in asthma and lung inflammation
    • Zimmermann N, Rothenberg ME. The arginine-arginase balance in asthma and lung inflammation. Eur J Pharmacol 533: 253-262, 2006.
    • (2006) Eur J Pharmacol , vol.533 , pp. 253-262
    • Zimmermann, N.1    Rothenberg, M.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.