Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension

European Respiratory Journal

Volumn 40, Issue 4, 2012, Pages 895-904

  Huertas, Alice ^a   Tu, Ly ^a   Gambaryan, Natalia ^a   Girerd, Barbara ^a   Perros, Frédéric ^a   Montani, David ^a   Fabre, Dominique ^a   Fadel, Elie ^a   Eddahibi, Saadia ^a   Cohen Kaminsky, Sylvia ^a   Guignabert, Christophe ^a   Humbert, Marc ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b BICÊTRE HOSPITAL   (France)

Author keywords

Dysimmunity; Endothelial dysfunction; Leptin; Pulmonary arterial hypertension; Regulatory T lymphocytes

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; LEPTIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOGENESIS; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; REGULATORY T LYMPHOCYTE; SCLERODERMA; SCLERODERMA ASSOCIATED PULMONARY ARTERY HYPERTENSION; UPREGULATION;

ADULT; AGED; CASE-CONTROL STUDIES; ENDOTHELIAL CELLS; FEMALE; HUMANS; HYPERTENSION, PULMONARY; INFLAMMATION MEDIATORS; LEPTIN; MALE; MIDDLE AGED; PULMONARY ARTERY; RECEPTORS, LEPTIN; SCLERODERMA, SYSTEMIC; T-LYMPHOCYTES, REGULATORY;

EID: 84867136658     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00159911     Document Type: Article

References (27)

1. Simonneau G, Robbin IM, Beghetti M, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2009; 54: Suppl. 1, S43-S54.
2. Humbert M, Monti G, Brenot F, et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 1995; 151: 1628-1631.
3. Humbert M, Morrell NW, Archer SL, et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: Suppl. 12, 13S-24S. (Pubitemid 38759713)
4. Perros F, Dorfmüller P, Souza R, et al. Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension. Eur Respir J 2007; 29: 462-468. (Pubitemid 46372091)
5. Dorfmuller P, Perros F, Balabanian K, et al. Inflammation in pulmonary arterial hypertension. Eur Respir J 2003; 22: 358-363. (Pubitemid 36987011)
6. Tuder RM, Groves B, Badesch DB, et al. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 1994; 144: 275-285. (Pubitemid 24165948)
7. Tamby MC, Chanseaud Y, Humbert M, et al. Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension. Thorax 2005; 60: 765-772. (Pubitemid 41297897)
8. Terrier B, Tamby MC, Camoin L, et al. Identification of target antigens of antifibroblast antibodies in pulmonary arterial hypertension. Am J Respir Crit Care Med 2008; 177: 1128-1133.
9. Tamosiuniene R, Tian W, Dhillon G, et al. Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circ Res 2011; 109: 867-879.
10. Lam QL, Lu L. Role of leptin in immunity. Cell Mol Immunol 2007; 4: 1-13.
11. La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol 2004; 4: 371-379. (Pubitemid 38649279)
12. Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897-901. (Pubitemid 28410912)
13. Lam QL, Liu S, Cao X, et al. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol 2006; 36: 3118-3130. (Pubitemid 44932714)
14. Matarese G, Carrieri PB, La Cava A, et al. Leptin increase in multiple sclerosis associates with reduced number of CD4(1)CD251 regulatory T cells. Proc Natl Acad Sci USA 2005; 102: 5150-5155.
15. Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010; 11: 7-13.
16. Cool CD, Stewart JS, Wehareha P, et al. Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth. Am J Pathol 1999; 155: 411-419. (Pubitemid 29370391)
17. Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203: 1701-1711. (Pubitemid 44036276)
18. De Rosa V, Procaccini C, Calì G, et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 2007; 26: 241-255. (Pubitemid 46329441)
19. Tu L, Dewachter L, Gore B, et al. Autocrine FGF2 signaling contributes to altered endothelial phenotype in pulmonary hypertension. Am J Respir Cell Mol Biol 2011; 45: 311-322.
20. Bellmeyer A, Martino JM, Chandel NS, et al. Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med 2007; 175: 587-594. (Pubitemid 46438943)
21. Gavin MA, Torgerson TR, Houston E, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci USA 2006; 103: 6659-6664.
22. Wang J, Ioan-Facsinay A, van der Voort EI, et al. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007; 37: 129-138. (Pubitemid 46128793)
23. Shamsuzzaman AS, Winnicki M, Wolk R, et al. Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation 2004; 109: 2181-2185. (Pubitemid 38625394)
24. Gomez-Ambrosi J, Salvador J, Silva C, et al. Leptin therapy does not affect inflammatory markers. J Clin Endocrinol Metab 2005; 90: 3803. (Pubitemid 41014362)
25. Quarck R, Nawrot T, Meyns B, et al. C-reactive protein: a new predictor of adverse outcome in pulmonary arterial hypertension. J Am Coll Cardiol 2009; 53: 1211-1218.
26. Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004; 116: 337-350. (Pubitemid 38167322)
27. Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110: 1093-1103. (Pubitemid 35215890)