Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxie rats

Journal of Clinical Investigation

Volumn 97, Issue 11, 1996, Pages 2491-2498

  Voelkel, Norbert F ^a   Tuder, Rubin M ^a   Wade, Kelly ^a   Höper, Marius ^a   Lepley, Robert A ^a   Goulet, Jennifer L ^b   Koller, Beverly H ^b   Fitzpatrick, Frank ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Arachidonate 5 lipoxygenase; Hypertension, pulmonary; Hypoxia; Leukotriene; Mice, knockout

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ANGIOTENSIN; ARACHIDONATE 5 LIPOXYGENASE; ENZYME ACTIVATOR; LEUKOTRIENE B4; MESSENGER RNA; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ENZYME LOCALIZATION; GENE DELETION; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; IMMUNOCHEMISTRY; IMMUNOHISTOLOGY; IN SITU HYBRIDIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; ISOLATED LUNG; LUNG BLOOD VESSEL; LUNG PERFUSION; LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; RAT;

ALTITUDE; ANGIOTENSIN II; ANIMALS; ANOXIA; ARACHIDONATE 5-LIPOXYGENASE; CARDIOMEGALY; CARRIER PROTEINS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INDOLES; INFLAMMATION; LIPOXYGENASE INHIBITORS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION;

EID: 0029936155     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118696     Document Type: Article

References (37)

1. Reeves, J.T., and N.F. Voelkel. 1989. Mechanisms of chronic pulmonary hypertension: Basic considerations. In Pulmonary Circulation. C.A. Wagenvoort and H. Denolin, editors. Elsevier Science Publishing Co., New York. 27-39.
2. Tuder, R.M., B. Groves, D.B. Badesch, and N.F. Voelkel. 1994. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am. J Pathol. 144:275-285.
3. Ono, S., J.Y. Westcott, and N.F. Voelkel. 1992. PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats. J. Appl. Physiol. 73:1084-1092.
4. Voelkel, N.F., R.M. Tuder, J. Bridges, and W.P. Arend. 1994. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am. J. Respir. Cell Mol. Biol. 11:664-675.
5. Voelkel, N.F. 1993. Pulmonary hypertension: from phenomenology to a molecular understanding of disease mechanisms. In Ion Flux in Pulmonary Vascular Control. E. K. Weir, editor. Plenum Press, New York. 1-14.
6. Wagenvoort, C.A., and N. Wagenvoort. 1977. Pathology of Pulmonary Hypertension. Elsevier Science Publishing Co., New York. 345 pp.
7. D'Alonzo, G.E., R.J. Barst, S.M. Ayers, E.H. Bergofsky, B.H. Brundage, K.M. Detre, A.P. Fishman, R.M. Goldring, B.M. Groves, J.T. Kernis, et al. 1991. Survival in patients with primary pulmonary hypertension. Ann. Intern. Med. 115:343-349.
8. Stenmark, K.R., M.L. Morganroth, N.F. Voelkel, R.C. Murphy, P.M. Henson, M.M. Mathias, and J.T. Reeves. 1985. Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension. Am. J. Physiol 248:H859-H866.
9. Morganroth, M.L., K.R. Stenmark, K.G. Morris, R.C. Murphy, M. Mathias, J.T. Reeves, and N.F. Voelkel. 1985. Diethylcarbamazine inhibits acute and chronic hypoxic pulmonary hypertension in awake rats. Am. Rev. Respir. Dis. 131:488-492.
10. Voelkel, N.F., T.J. McDonnell, S.W. Chang, M. Bugnitz, J.Y. Westcott, and K.R. Stenmark. 1987. The future for drugs affecting the lipoxygenase pathway in the treatment of pulmonary hypertension and ARDS. IBC Tech. Serv. 1-11.
11. Kaneko, S., N. Ueda, T. Tonai, T. Maruyama, T. Yoshimoto, and S. Uamamoto. 1987. Arachidonate 5-lipoxygenase of porcine leukocytes studied by enzyme immunoassay using monoclonal antibodies. J Biol. Chem. 262:6741-6745.
12. 4 hydrolase in cells and tissues lacking 5-lipoxygenase. In Cell-cell Interactions in the Release of Inflammatory Mediators. P.Y.-K. Wong and C. N. Serhan, editors. Plenum Press, New York. 307-315.
13. 4 synthesized by polymorphonuclear leukocytes. J. Biol. Chem. 261:16466-16472.
14. Nishida, M., T. Kuzuya, S. Hoshida, Y. Kim, A. Kitabatake, T. Kamada, and M. Tada. 1990. Polymorphonuclear leukocytes induced vasoconstriction in isolated canine coronary arteries. Circ. Res. 66:253-258.
15. Sala, A., G. Rossoni, F. Buccellati, F. Berti, G. Folco, and J. Maclouf. 1993. Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. Br. J. Pharmacol. 110:1206-1212.
16. Karakurum, M., R. Shreeniwas, J. Chen, D. Pinsky, S.-D. Yan, M. Anderson, K. Sunouchi, J. Major, K. Kuwabara, A. Rot, R. Nowygrod, and D. Stern. 1994. Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J. Clin. Invest. 93:1564-1570.
17. Shreeniwas, R., S. Koga, M. Karakurum, K. Pinsky, E. Kaiser, J. Brett, B.A. Wolitzky, C. Norton, J. Plocinski, W. Benjamin, D.K. Burns, A. Goldstein, and D. Stern. 1992. Hypoxia-mediated induction of endothelial cell interleukin-1α. J. Clin. Invest. 90:2333-2339.
18. Ford-Hutchinson, A.W. 1990. Modification of the lipoxygenase pathway of arachidonic acid metabolism. In Advances in Prostaglandin, Thromboxane and Leukotriene Research. B. Samuelsson, S.-E. Dahlén, J. Fritsch, and P. Hedqvist, editors. Raven Press Ltd., New York. 161-169.
19. Ford-Hutchinson, A.W., M. Gresser, and R.N. Young. 1994. 5-lipoxygenase. Annu. Rev. Biochem. 63:383-417.
20. Kargman, S., P.J. Vickers, and J.F. Evans. 1992. A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells. J. Cell Biol. 119:1701-1709.
21. Funk, C.D., H. Gunne, H. Steiner, T. Izumi, and B. Samuelsson. 1989. Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell system. Proc. Natl. Acad. Sci USA. 86:2592-2596.
22. Goulet, J.L., J.N. Snouwaert, A.M. Latour, T.M. Coffman, and B.H. Koller. 1994. Altered inflammatory responses in leukotriene-deficient mice. Proc. Natl. Acad. Sci. USA. 51:12852-12856.
23. Halbower, A.C., R.J. Mason, S.H. Abman, and R.M. Tuder. 1994. Agarose infiltration improves morphology of cryostat sections of lung. Lab. Invest. 71:149-153.
24. Lepley, R.A., and F.A. Fitzpatrick. 1994. 5-lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. J Biol. Chem. 269:24163-24168.
25. 4 in rat lung: comparison of GM/MS, RIA, and EIA. Prostaglandins, 32: 857-873.
26. Chang, S.-W., and N.F. Voelkel. 1991. The isolated perfused lung preparation as a research tool. In Comparative Biology of the Normal Lung. R.A. Parent, editor. CRC Press, Boca Raton, FL. 587-613.
27. Tuder, R.M., B.E. Flook, and N.F. Voelkel. 1995. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J. Clin. Invest. 95:1798-1807.
28. Boado, R.J., W.M. Pardridge, H.V. Vinters, and K.L. Black. 1992. Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family. Proc. Natl. Acad. Sci. USA. 89:9044-9048.
29. Coffey, M., M. Peters-Golden, J.C. Fantone, III, and P.H.S. Sporn. 1992. Membrane association of active 5-lipoxygenase in resting cells. J Biol. Chem. 267:570-576.
30. Cornfield, D.N., T. Stevens, I.F. McMurtry, S.H. Abman, and D.M. Rodman. 1993. Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells. Am. J. Physiol. 265:L53-L56.
31. McMurtry, I.F., A.B. Davidson, J.T. Reeves, and R.F. Grover. 1976. Inhibition of hypoxic pulmonary vasoconstriction by calcium agonists in isolated rat lungs. Circ. Res. 38:99-104.
32. Voelkel, N.F., S.W. Chang, T.J. McDonnell, and J. Haynes. 1987. Role of membrane lipids in the control of normal vascular tone. Am. Rev. Respir. Dis. 136:214-217.
33. McDonnell, T.J., J.Y. Westcott, J. Czartolomna, and N.F. Voelkel. 1990. Role of peptidoleukotrienes in hypoxic pulmonary vasoconstriction in rats. Am. J. Physiol. 259:H751-H758.
34. Voelkel, N.F., K. Lobel, J.Y. Westcott, and T.J. Burke. 1995. Nitric oxide-related vasoconstriction in lungs perfused with red cell lysate. FASEB J. 9:379-386.
35. Post, J.M., J.R. Hume, S.L. Archer, and E.K. Weir. 1992. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol. 262:C882-C890.
36. Yuan, X.-J., W.F. Goldman, M.L. Tod, L.J. Rubin, and M.P. Blauslein. 1993. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am. J. Physiol. 264:L116-L123.
37. Weir, E.K., and S.L. Archer. 1995. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J. 9:183-189.