메뉴 건너뛰기




Volumn 129, Issue 12, 2014, Pages 1332-1340

Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: A complex interplay

Author keywords

[No Author keywords available]

Indexed keywords

FRACTALKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

EID: 84897011026     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.004555     Document Type: Article
Times cited : (144)

References (78)
  • 9
    • 84866618858 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms in pulmonary arterial hypertension
    • El Chami H, Hassoun PM. Immune and inflammatory mechanisms in pulmonary arterial hypertension. Prog Cardiovasc Dis. 2012;55:218-228.
    • (2012) Prog Cardiovasc Dis. , vol.55 , pp. 218-228
    • El Chami, H.1    Hassoun, P.M.2
  • 10
    • 63049136565 scopus 로고    scopus 로고
    • C-reactive protein: A new predictor of adverse outcome in pulmonary arterial hypertension
    • Quarck R, Nawrot T, Meyns B, Delcroix M. C-reactive protein: a new predictor of adverse outcome in pulmonary arterial hypertension. J Am Coll Cardiol. 2009;53:1211-1218.
    • (2009) J Am Coll Cardiol. , vol.53 , pp. 1211-1218
    • Quarck, R.1    Nawrot, T.2    Meyns, B.3    Delcroix, M.4
  • 12
    • 84864502492 scopus 로고    scopus 로고
    • Progress in pulmonary arterial hypertension pathology: Relighting a torch inside the tunnel
    • Dorfmüller P, Humbert M. Progress in pulmonary arterial hypertension pathology: relighting a torch inside the tunnel. Am J Respir Crit Care Med. 2012;186:210-212.
    • (2012) Am J Respir Crit Care Med. , vol.186 , pp. 210-212
    • Dorfmüller, P.1    Humbert, M.2
  • 19
    • 33746379082 scopus 로고    scopus 로고
    • Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension
    • Sanchez O, Sitbon O, Jaïs X, Simonneau G, Humbert M. Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension. Chest. 2006;130:182-189.
    • (2006) Chest. , vol.130 , pp. 182-189
    • Sanchez, O.1    Sitbon, O.2    Jaïs, X.3    Simonneau, G.4    Humbert, M.5
  • 20
    • 39749156384 scopus 로고    scopus 로고
    • Immunosuppressive therapy in lupus-and mixed connective tissue disease-associated pulmonary arterial hypertension: A retrospective analysis of twenty-three cases
    • Jais X, Launay D, Yaici A, Le Pavec J, Tchérakian C, Sitbon O, Simonneau G, Humbert M. Immunosuppressive therapy in lupus-and mixed connective tissue disease-associated pulmonary arterial hypertension: a retrospective analysis of twenty-three cases. Arthritis Rheum. 2008;58:521-531.
    • (2008) Arthritis Rheum. , vol.58 , pp. 521-531
    • Jais, X.1    Launay, D.2    Yaici, A.3    Le Pavec, J.4    Tchérakian, C.5    Sitbon, O.6    Simonneau, G.7    Humbert, M.8
  • 31
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 2010;11:7-13.
    • (2010) Nat Immunol. , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 32
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004;199:971-979.
    • (2004) J Exp Med. , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 34
    • 41349089311 scopus 로고    scopus 로고
    • Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension
    • Ulrich S, Nicolls MR, Taraseviciene L, Speich R, Voelkel N. Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension. Respiration. 2008;75:272-280.
    • (2008) Respiration. , vol.75 , pp. 272-280
    • Ulrich, S.1    Nicolls, M.R.2    Taraseviciene, L.3    Speich, R.4    Voelkel, N.5
  • 36
    • 35549004528 scopus 로고    scopus 로고
    • Balancing between immunity and tolerance: An interplay between dendritic cells, regulatory T cells, and effector T cells
    • Cools N, Ponsaerts P, Van Tendeloo VF, Berneman ZN. Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells. J Leukoc Biol. 2007;82:1365-1374.
    • (2007) J Leukoc Biol. , vol.82 , pp. 1365-1374
    • Cools, N.1    Ponsaerts, P.2    Van Tendeloo, V.F.3    Berneman, Z.N.4
  • 37
    • 0034890907 scopus 로고    scopus 로고
    • Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    • Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol. 2001;2:725-731.
    • (2001) Nat Immunol. , vol.2 , pp. 725-731
    • Akbari, O.1    Dekruyff, R.H.2    Umetsu, D.T.3
  • 39
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • Aloisi F, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol. 2006;6:205-217.
    • (2006) Nat Rev Immunol. , vol.6 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 41
    • 0034842962 scopus 로고    scopus 로고
    • Thyroid autoimmune disease: Demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers
    • Armengol MP, Juan M, Lucas-Martín A, Fernández-Figueras MT, Jaraquemada D, Gallart T, Pujol-Borrell R. Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am J Pathol. 2001;159:861-873.
    • (2001) Am J Pathol. , vol.159 , pp. 861-873
    • Armengol, M.P.1    Juan, M.2    Lucas-Martín, A.3    Fernández-Figueras, M.T.4    Jaraquemada, D.5    Gallart, T.6    Pujol-Borrell, R.7
  • 42
    • 0036231364 scopus 로고    scopus 로고
    • Thymic myoid cells and germinal center formation in myasthenia gravis; Possible roles in pathogenesis
    • Roxanis I, Micklem K, McConville J, Newsom-Davis J, Willcox N. Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesis. J Neuroimmunol. 2002;125:185-197.
    • (2002) J Neuroimmunol. , vol.125 , pp. 185-197
    • Roxanis, I.1    Micklem, K.2    McConville, J.3    Newsom-Davis, J.4    Willcox, N.5
  • 44
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • Serafini B, Rosicarelli B, Magliozzi R, Stigliano E, Aloisi F. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 2004;14:164-174.
    • (2004) Brain Pathol. , vol.14 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 45
    • 0021798878 scopus 로고
    • Immunohistological analysis of lung tissue from patients with cryptogenic fibrosing alveolitis suggesting local expression of immune hypersensitivity
    • Campbell DA, Poulter LW, Janossy G, du Bois RM. Immunohistological analysis of lung tissue from patients with cryptogenic fibrosing alveolitis suggesting local expression of immune hypersensitivity. Thorax. 1985;40:405-411.
    • (1985) Thorax. , vol.40 , pp. 405-411
    • Campbell, D.A.1    Poulter, L.W.2    Janossy, G.3    Du Bois, R.M.4
  • 46
    • 0036102947 scopus 로고    scopus 로고
    • Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease
    • Grant AJ, Goddard S, Ahmed-Choudhury J, Reynolds G, Jackson DG, Briskin M, Wu L, Hübscher SG, Adams DH. Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease. Am J Pathol. 2002;160:1445-1455.
    • (2002) Am J Pathol. , vol.160 , pp. 1445-1455
    • Grant, A.J.1    Goddard, S.2    Ahmed-Choudhury, J.3    Reynolds, G.4    Jackson, D.G.5    Briskin, M.6    Wu, L.7    Hübscher, S.G.8    Adams, D.H.9
  • 47
    • 0242600538 scopus 로고    scopus 로고
    • Naive T cell recruitment to nonlymphoid tissues: A role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis
    • Weninger W, Carlsen HS, Goodarzi M, Moazed F, Crowley MA, Baekkevold ES, Cavanagh LL, von Andrian UH. Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. J Immunol. 2003;170:4638-4648.
    • (2003) J Immunol. , vol.170 , pp. 4638-4648
    • Weninger, W.1    Carlsen, H.S.2    Goodarzi, M.3    Moazed, F.4    Crowley, M.A.5    Baekkevold, E.S.6    Cavanagh, L.L.7    Von Andrian, U.H.8
  • 48
    • 0035154624 scopus 로고    scopus 로고
    • Adventitial infiltrates associated with advanced atherosclerotic plaques: Structural organization suggests generation of local humoral immune responses
    • Houtkamp MA, de Boer OJ, van der Loos CM, van der Wal AC, Becker AE. Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses. J Pathol. 2001;193:263-269.
    • (2001) J Pathol. , vol.193 , pp. 263-269
    • Houtkamp, M.A.1    De Boer, O.J.2    Van Der Loos, C.M.3    Van Der Wal, A.C.4    Becker, A.E.5
  • 51
    • 14044261259 scopus 로고    scopus 로고
    • In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium
    • Ghosh S, Steere AC, Stollar BD, Huber BT. In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium. J Immunol. 2005;174:2860-2869.
    • (2005) J Immunol. , vol.174 , pp. 2860-2869
    • Ghosh, S.1    Steere, A.C.2    Stollar, B.D.3    Huber, B.T.4
  • 54
    • 33646481327 scopus 로고    scopus 로고
    • Cutting edge: Nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis
    • Marchal-Sommé J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol. 2006;176:5735-5739.
    • (2006) J Immunol. , vol.176 , pp. 5735-5739
    • Marchal-Sommé, J.1    Uzunhan, Y.2    Marchand-Adam, S.3    Valeyre, D.4    Soumelis, V.5    Crestani, B.6    Soler, P.7
  • 56
    • 61549104663 scopus 로고    scopus 로고
    • Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
    • Savale L, Tu L, Rideau D, Izziki M, Maitre B, Adnot S, Eddahibi S. Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Respir Res. 2009;10:6.
    • (2009) Respir Res. , vol.10 , pp. 6
    • Savale, L.1    Tu, L.2    Rideau, D.3    Izziki, M.4    Maitre, B.5    Adnot, S.6    Eddahibi, S.7
  • 58
    • 0028676054 scopus 로고
    • Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline
    • Voelkel NF, Tuder RM, Bridges J, Arend WP. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am J Respir Cell Mol Biol. 1994;11:664-675.
    • (1994) Am J Respir Cell Mol Biol. , vol.11 , pp. 664-675
    • Voelkel, N.F.1    Tuder, R.M.2    Bridges, J.3    Arend, W.P.4
  • 59
    • 1642459098 scopus 로고    scopus 로고
    • Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis
    • Ma-Krupa W, Jeon MS, Spoerl S, Tedder TF, Goronzy JJ, Weyand CM. Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. J Exp Med. 2004;199:173-183.
    • (2004) J Exp Med. , vol.199 , pp. 173-183
    • Ma-Krupa, W.1    Jeon, M.S.2    Spoerl, S.3    Tedder, T.F.4    Goronzy, J.J.5    Weyand, C.M.6
  • 62
    • 83355176600 scopus 로고    scopus 로고
    • Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice
    • Bauer EM, Zheng H, Comhair S, Erzurum S, Billiar TR, Bauer PM. Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One. 2011;6:e28578.
    • (2011) PLoS One. , vol.6
    • Bauer, E.M.1    Zheng, H.2    Comhair, S.3    Erzurum, S.4    Billiar, T.R.5    Bauer, P.M.6
  • 71
    • 33748534188 scopus 로고    scopus 로고
    • Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats
    • Vajner L, Vytásek R, Lachmanová V, Uhlík J, Konrádová V, Novotná J, Hampl V, Herget J. Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats. Int J Exp Pathol. 2006;87:383-391.
    • (2006) Int J Exp Pathol. , vol.87 , pp. 383-391
    • Vajner, L.1    Vytásek, R.2    Lachmanová, V.3    Uhlík, J.4    Konrádová, V.5    Novotná, J.6    Hampl, V.7    Herget, J.8
  • 74
    • 4644290657 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med. 2004;351:1425-1436.
    • (2004) N Engl J Med. , vol.351 , pp. 1425-1436
    • Humbert, M.1    Sitbon, O.2    Simonneau, G.3
  • 77
    • 84874868372 scopus 로고    scopus 로고
    • Impression, sunset
    • Humbert M. Impression, sunset. Circulation. 2013;127:1098-1100.
    • (2013) Circulation. , vol.127 , pp. 1098-1100
    • Humbert, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.