Modern age pathology of pulmonary arterial hypertension

American Journal of Respiratory and Critical Care Medicine

Volumn 186, Issue 3, 2012, Pages 261-272

  Stacher, Elvira ^a,b,c   Graham, Brian B ^c   Hunt, James M ^c   Gandjeva, Aneta ^c   Groshong, Steve D ^d   McLaughlin, Vallerie V ^e   Jessup, Marsha ^e   Grizzle, William E ^f   Aldred, Michaela A ^g   Cool, Carlyne D ^c   Tuder, Rubin M ^c  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^e UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^f University of Alabama at Birmingham   (United States)

^g CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Inflammation; Pulmonary circulation; Vessel remodeling

Indexed keywords

ADULT; AGED; AIRWAY REMODELING; ANTIHYPERTENSIVE THERAPY; ARTERIAL WALL THICKNESS; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LUNG HEMODYNAMICS; LUNG LESION; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; TREATMENT RESPONSE; VASCULITIS;

ADULT; AGED; AIRWAY REMODELING; ANALYSIS OF VARIANCE; ANTIHYPERTENSIVE AGENTS; COHORT STUDIES; EPOPROSTENOL; FEMALE; HUMANS; HYPERTENSION, PULMONARY; INFLAMMATION; LUNG; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PULMONARY ARTERY; SEX DISTRIBUTION;

EID: 84864522564     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201201-0164OC     Document Type: Article

References (23)

1. Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004;351:1425-1436.
2. D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991;115:343-349.
3. Heath D, Edwards JE. The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects. Circulation 1958;18:533-547.
4. Wagenvoort CA, Wagenvoort N. Primary pulmonary hypertension: a pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation 1970;42:1163-1184.
5. Rabinovitch M, Haworth SG, Castaneda AR, Nadas AS, Reid LM. Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease. Circulation 1978;58:1107-1122. (Pubitemid 9091993)
6. Wagenvoort CA. Lung biopsy specimens in the evaluation of pulmonary vascular disease. Chest 1980;77:614-625. (Pubitemid 10101563)
7. Wagenvoort CA. The pathology of primary pulmonary hypertension. J Pathol 1970;101:i.
8. Yamaki S, Horiuchi T, Takahashi T. Pulmonary changes in congenital heart disease with Down's syndrome: their significance as a cause of postoperative respiratory failure. Thorax 1985;40:380-386. (Pubitemid 15053478)
9. Bjornsson J, Edwards WD. Primary pulmonary hypertension: a histopathologic study of 80 cases. Mayo Clin Proc 1985;60:16-25. (Pubitemid 15199621)
10. Pietra GG, Edwards WD, Kay JM, Rich S, Kernis J, Schloo B, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry. Circulation 1989;80:1198-1206. (Pubitemid 19282508)
11. Chazova I, Loyd JE, Newman JH, Belenkov Y, Meyrick B. Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension. Am J Pathol 1995;146:389-397.
12. Overbeek MJ, Vonk MC, Boonstra A, Voskuyl AE, Vonk-Noordegraaf A, Smit EF, Dijkmans BA, Postmus PE, Mooi WJ, Heijdra Y, et al. Pulmonary arterial hypertension in limited cutaneous systemic sclerosis: a distinctive vasculopathy. Eur Respir J 2009;34:371-379.
13. Yi ES, Kim H, Ahn H, Strother J, Morris T, Masliah E, Hansen LA, Park K, Friedman PJ. Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study. Am J Respir Crit Care Med 2000;162:1577-1586.
14. Tuder RM, Marecki JC, Richter A, Fijalkowska I, Flores S. Pathology of pulmonary hypertension. Clin Chest Med 2007;28:23-42. (vii.). (Pubitemid 46335935)
15. Tuder RM. Pathology of pulmonary arterial hypertension. Semin Respir Crit Care Med 2009;30:376-385.
16. Tuder RM, Groshong SD, Cool CD. General features of non-neoplastic lung diseases. In: Mason RJ, Broaddus VC, Martin TR, King TE Jr, Schraufnagel DE, Murray JF, Nadel JA, editors. Murray & Nadel's textbook of respiratory medicine, 5th ed. Philadelphia: Saunders; 2009. pp. 314-329.
17. Tuder RM, Groves BM, Badesch DB, Voelkel NF. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 1994;144:275-285. (Pubitemid 24165948)
18. Girerd B, Montani D, Eyries M, Yaici A, Sztrymf B, Coulet F, Sitbon O, Simonneau G, Soubrier F, Humbert M. Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension. Respir Res 2010;11:73.
19. Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 2002;105:1672-1678. (Pubitemid 34298611)
20. Caslin AW, Heath D, Madden B, Yacoub M, Gosney JR, Smith P. The histopathology of 36 cases of plexogenic pulmonary arteriopathy. Histopathology 1990;16:9-19. (Pubitemid 20123330)
21. Achcar RO, Yung GL, Saffer H, Cool CD, Voelkel NF, Yi ES. Morphologic changes in explanted lungs after prostacyclin therapy for pulmonary hypertension. Eur J Med Res 2006;11:203-207.
22. Perros F, Dorfmuller P, Montani D, Hammad H, Waelput W, Girerd B, Raymond N, Mercier O, Mussot S, Cohen-Kaminsky S, et al. Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2012;185:311-321.
23. Hsia CC, Hyde DM, Ochs M, Weibel ER. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 2010;181:394-418.