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Volumn 45, Issue 2, 2014, Pages 485-492

Lipogenesis in cancer progression (review)

Author keywords

Epithelial to mesenchymal transition; Fatty acid synthase; Lipogenesis; Metastasis; Stearoyl coa desaturase 1

Indexed keywords

ACYL COENZYME A DESATURASE 1; FATTY ACID SYNTHASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84902584099     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2441     Document Type: Review
Times cited : (96)

References (102)
  • 1
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • Medes G, Thomas A and Weinhouse S: Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res 13: 27-29, 1953.
    • (1953) Cancer Res , vol.13 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 3
    • 62749188867 scopus 로고    scopus 로고
    • The role of the lipogenic pathway in the development of hepatic steatosis
    • Postic C and Girard J: The role of the lipogenic pathway in the development of hepatic steatosis. Diabetes Metab 34: 643-648, 2008.
    • (2008) Diabetes Metab , vol.34 , pp. 643-648
    • Postic, C.1    Girard, J.2
  • 4
    • 0029077405 scopus 로고
    • The regulation of stearoyl-CoA desaturase (SCD)
    • Ntambi JM: The regulation of stearoyl-CoA desaturase (SCD). Prog Lipid Res 34: 139-150, 1995.
    • (1995) Prog Lipid Res , vol.34 , pp. 139-150
    • Ntambi, J.M.1
  • 5
    • 77955690182 scopus 로고    scopus 로고
    • Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
    • Neuschwander-Tetri BA: Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 52: 774-788, 2010.
    • (2010) Hepatology , vol.52 , pp. 774-788
    • Neuschwander-Tetri, B.A.1
  • 6
    • 63849206613 scopus 로고    scopus 로고
    • AMP-activated protein kinase in the regulation of hepatic energy metabolism: From physiology to therapeutic perspectives
    • Oxf
    • Viollet B, Guigas B, Leclerc J, et al: AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) 196: 81-98, 2009.
    • (2009) Acta Physiol , vol.196 , pp. 81-98
    • Viollet, B.1    Guigas, B.2    Leclerc, J.3
  • 7
    • 33745196745 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase in the liver: A new strategy for the management of metabolic hepatic disorders
    • DOI 10.1113/jphysiol.2006.108506
    • Viollet B, Foretz M, Guigas B, et al: Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol 574: 41-53, 2006. (Pubitemid 43905795)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 41-53
    • Viollet, B.1    Foretz, M.2    Guigas, B.3    Horman, S.4    Dentin, R.5    Bertrand, L.6    Hue, L.7    Andreelli, F.8
  • 8
    • 0034002793 scopus 로고    scopus 로고
    • Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
    • Kuhajda FP: Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 16: 202-208, 2000.
    • (2000) Nutrition , vol.16 , pp. 202-208
    • Kuhajda, F.P.1
  • 9
    • 0026603188 scopus 로고
    • Prognostic significance of tumor phosphatidylcholine stearic acid level in breast carcinoma
    • Bougnoux P, Chajes V, Lanson M, et al: Prognostic significance of tumor phosphatidylcholine stearic acid level in breast carcinoma. Breast Cancer Res Treat 20: 185-194, 1992.
    • (1992) Breast Cancer Res Treat , vol.20 , pp. 185-194
    • Bougnoux, P.1    Chajes, V.2    Lanson, M.3
  • 10
    • 84861101004 scopus 로고    scopus 로고
    • An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway
    • Guo D, Reinitz F, Youssef M, et al: An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov 1: 442-456, 2011.
    • (2011) Cancer Discov , vol.1 , pp. 442-456
    • Guo, D.1    Reinitz, F.2    Youssef, M.3
  • 11
    • 84867627192 scopus 로고    scopus 로고
    • The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: Towards a stratification of malignancy
    • Nieva C, Marro M, Santana-Codina N, Rao S, Petrov D and Sierra A: The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: towards a stratification of malignancy. PLoS One 7: e46456, 2012.
    • (2012) PLoS One , vol.7
    • Nieva, C.1    Marro, M.2    Santana-Codina, N.3    Rao, S.4    Petrov, D.5    Sierra, A.6
  • 12
    • 0032532655 scopus 로고    scopus 로고
    • Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
    • Pizer ES, Chrest FJ, DiGiuseppe JA and Han WF: Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res 58: 4611-4615, 1998. (Pubitemid 28480625)
    • (1998) Cancer Research , vol.58 , Issue.20 , pp. 4611-4615
    • Pizer, E.S.1    Chrest, F.J.2    DiGiuseppe, J.A.3    Han, W.F.4
  • 13
    • 46649083578 scopus 로고    scopus 로고
    • Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells
    • Horiguchi A, Asano T, Asano T, Ito K, Sumitomo M and Hayakawa M: Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. J Urol 180: 729-736, 2008.
    • (2008) J Urol , vol.180 , pp. 729-736
    • Horiguchi, A.1    Asano, T.2    Asano, T.3    Ito, K.4    Sumitomo, M.5    Hayakawa, M.6
  • 14
    • 41249090769 scopus 로고    scopus 로고
    • Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells
    • Ma J, Yan R, Zu X, et al: Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. J Biol Chem 283: 3418-3423, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 3418-3423
    • Ma, J.1    Yan, R.2    Zu, X.3
  • 15
    • 33744808464 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival
    • DOI 10.1158/0008-5472.CAN-05-1489
    • Chajes V, Cambot M, Moreau K, Lenoir GM and Joulin V: Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Cancer Res 66: 5287-5294, 2006. (Pubitemid 43844953)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5287-5294
    • Chajes, V.1    Cambot, M.2    Moreau, K.3    Lenoir, G.M.4    Joulin, V.5
  • 16
    • 23044482013 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the acetyl-Coa-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-05-0571
    • Brusselmans K, De Schrijver E, Verhoeven G and Swinnen JV: RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 65: 6719-6725, 2005. (Pubitemid 41060709)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6719-6725
    • Brusselmans, K.1    De Schrijver, E.2    Verhoeven, G.3    Swinnen, J.V.4
  • 17
    • 53249147804 scopus 로고    scopus 로고
    • Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells
    • Zhan Y, Ginanni N, Tota MR, et al: Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells. Clin Cancer Res 14: 5735-5742, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 5735-5742
    • Zhan, Y.1    Ginanni, N.2    Tota, M.R.3
  • 18
    • 13644263225 scopus 로고    scopus 로고
    • High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts
    • DOI 10.1016/j.bbalip.2004.11.015
    • Scaglia N, Caviglia JM and Igal RA: High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim Biophys Acta 1687: 141-151, 2005. (Pubitemid 40228994)
    • (2005) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol.1687 , Issue.1-3 , pp. 141-151
    • Scaglia, N.1    Matias, C.J.2    Ariel, I.R.3
  • 19
    • 69449099939 scopus 로고    scopus 로고
    • Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: Role of AMPK
    • Scaglia N, Chisholm JW and Igal RA: Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PloS One 4: e6812, 2009.
    • (2009) PloS One , vol.4
    • Scaglia, N.1    Chisholm, J.W.2    Igal, R.A.3
  • 20
    • 54049084951 scopus 로고    scopus 로고
    • Inhibition of stearoyl-CoA desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis
    • Scaglia N and Igal RA: Inhibition of stearoyl-CoA desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol 33: 839-850, 2008.
    • (2008) Int J Oncol , vol.33 , pp. 839-850
    • Scaglia, N.1    Igal, R.A.2
  • 21
    • 34249285532 scopus 로고    scopus 로고
    • Identification of Ras-related nuclear protein, targeting protein for Xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen
    • DOI 10.1158/0008-5472.CAN-06-4132
    • Morgan-Lappe SE, Tucker LA, Huang X, et al: Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res 67: 4390-4398, 2007. (Pubitemid 46815088)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4390-4398
    • Morgan-Lappe, S.E.1    Tucker, L.A.2    Huang, X.3    Zhang, Q.4    Sarthy, A.V.5    Zakula, D.6    Vernetti, L.7    Schurdak, M.8    Wang, J.9    Fesik, S.W.10
  • 22
    • 77649216053 scopus 로고    scopus 로고
    • EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
    • Guo D, Prins RM, Dang J, et al: EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Sci Signal 2: ra82, 2009.
    • (2009) Sci Signal , vol.2
    • Guo, D.1    Prins, R.M.2    Dang, J.3
  • 23
    • 28644439593 scopus 로고    scopus 로고
    • Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer
    • DOI 10.1074/mcp.M400221-MCP200
    • Zhang D, Tai LK, Wong LL, Chiu LL, Sethi SK and Koay ES: Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer. Mol Cell Proteomics 4: 1686-1696, 2005. (Pubitemid 41749262)
    • (2005) Molecular and Cellular Proteomics , vol.4 , Issue.11 , pp. 1686-1696
    • Zhang, D.1    Tai, L.K.2    Wong, L.L.3    Chiu, L.-L.4    Sethi, S.K.5    Koay, E.S.C.6
  • 24
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • DOI 10.1038/sj.onc.1208802, PII 1208802
    • Porstmann T, Griffiths B, Chung YL, et al: PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24: 6465-6481, 2005. (Pubitemid 41486630)
    • (2005) Oncogene , vol.24 , Issue.43 , pp. 6465-6481
    • Porstmann, T.1    Griffiths, B.2    Chung, Y.-L.3    Delpuech, O.4    Griffiths, J.R.5    Downward, J.6    Schulze, A.7
  • 25
    • 19944374798 scopus 로고    scopus 로고
    • Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    • DOI 10.1038/sj.onc.1208463
    • Wang HQ, Altomare DA, Skele KL, et al: Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene 24: 3574-3582, 2005. (Pubitemid 40756227)
    • (2005) Oncogene , vol.24 , Issue.22 , pp. 3574-3582
    • Wang, H.Q.1    Altomare, D.A.2    Skele, K.L.3    Poulikakos, P.I.4    Kuhajda, F.P.5    Di, C.A.6    Testa, J.R.7
  • 27
    • 30844448578 scopus 로고    scopus 로고
    • KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
    • DOI 10.1194/jlr.M500154-JLR200
    • Chang Y, Wang J, Lu X, Thewke DP and Mason RJ: KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells. J Lipid Res 46: 2624-2635, 2005. (Pubitemid 43107474)
    • (2005) Journal of Lipid Research , vol.46 , Issue.12 , pp. 2624-2635
    • Chang, Y.1    Wang, J.2    Lu, X.3    Thewke, D.P.4    Mason, R.J.5
  • 30
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M, Mimori K, Yokobori T, et al: Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 101: 293-299, 2010.
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3
  • 31
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 32
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 33
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A and Pintzas A: Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 1796: 75-90, 2009.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 35
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle E, Sancho E, Franci C, et al: The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2: 84-89, 2000.
    • (2000) Nat Cell Biol , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3
  • 36
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell JE Jr: Transcription factors as targets for cancer therapy. Nature reviews. Cancer 2: 740-749, 2002.
    • (2002) Nature Reviews. Cancer , vol.2 , pp. 740-749
    • Darnell Jr., J.E.1
  • 37
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • DOI 10.1111/j.1349-7006.2007.00550.x
    • Moustakas A and Heldin CH: Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 98: 1512-1520, 2007. (Pubitemid 47308444)
    • (2007) Cancer Science , vol.98 , Issue.10 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.-H.2
  • 38
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • DOI 10.1056/NEJM200005043421807
    • Blobe GC, Schiemann WP and Lodish HF: Role of transforming growth factor beta in human disease. N Engl J Med 342: 1350-1358, 2000. (Pubitemid 30408720)
    • (2000) New England Journal of Medicine , vol.342 , Issue.18 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 39
    • 0027960448 scopus 로고
    • Mitogen inactivation of glycogen synthase kinase-3beta in intact cells via serine 9 phosphorylation
    • Stambolic V and Woodgett JR: Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. Biochem J 303: 701-704, 1994. (Pubitemid 24325998)
    • (1994) Biochemical Journal , vol.303 , Issue.3 , pp. 701-704
    • Stambolic, V.1    Woodgett, J.R.2
  • 40
    • 5444230567 scopus 로고    scopus 로고
    • Transcriptional regulation of cadherins during development and carcinogenesis
    • DOI 10.1387/ijdb.041794hp, Invasion in Cancer and Embryonic Development
    • Peinado H, Portillo F and Cano A: Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol 48: 365-375, 2004. (Pubitemid 39360388)
    • (2004) International Journal of Developmental Biology , vol.48 , Issue.5-6 , pp. 365-375
    • Peinado, H.1    Portillo, F.2    Cano, A.3
  • 41
    • 7744246985 scopus 로고    scopus 로고
    • The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF
    • DOI 10.1016/j.devcel.2004.08.022, PII S1534580704003363
    • Hamada F and Bienz M: The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell 7: 677-685, 2004. (Pubitemid 39462688)
    • (2004) Developmental Cell , vol.7 , Issue.5 , pp. 677-685
    • Hamada, F.1    Bienz, M.2
  • 44
    • 0031877634 scopus 로고    scopus 로고
    • Modulation of epithelial cell adhesion in gastrointestinal homeostasis
    • Efstathiou JA and Pignatelli M: Modulation of epithelial cell adhesion in gastrointestinal homeostasis. Am J Pathol 153: 341-347, 1998. (Pubitemid 28373644)
    • (1998) American Journal of Pathology , vol.153 , Issue.2 , pp. 341-347
    • Efstathiou, J.A.1    Pignatelli, M.2
  • 45
    • 0033620790 scopus 로고    scopus 로고
    • E-cadherin-catenin: More than a 'sticky' molecular complex
    • DOI 10.1016/S0140-6736(99)90055-7
    • Wijnhoven BP and Pignatelli M: E-cadherin-catenin: more than a 'sticky' molecular complex. Lancet 354: 356-357, 1999. (Pubitemid 29355748)
    • (1999) Lancet , vol.354 , Issue.9176 , pp. 356-357
    • Wijnhoven, B.P.L.1    Pignatelli, M.2
  • 47
    • 0037194578 scopus 로고    scopus 로고
    • Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers
    • DOI 10.1038/sj.onc.1205755
    • Takahashi M, Tsunoda T, Seiki M, Nakamura Y and Furukawa Y: Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene 21: 5861-5867, 2002. (Pubitemid 35007236)
    • (2002) Oncogene , vol.21 , Issue.38 , pp. 5861-5867
    • Takahashi, M.1    Tsunoda, T.2    Seiki, M.3    Nakamura, Y.4    Furukawa, Y.5
  • 48
    • 84878333224 scopus 로고    scopus 로고
    • Pitfalls in outcome prediction of breast cancer
    • Rakha EA: Pitfalls in outcome prediction of breast cancer. J Clin Pathol 66: 458-464, 2013.
    • (2013) J Clin Pathol , vol.66 , pp. 458-464
    • Rakha, E.A.1
  • 49
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum LZ, Witters LA, Pasternack GR and Kuhajda FP: Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 3: 2115-2120, 1997. (Pubitemid 27505140)
    • (1997) Clinical Cancer Research , vol.3 , Issue.11 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 50
    • 0028875706 scopus 로고
    • OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate
    • Epstein JI, Carmichael M and Partin AW: OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate. Urology 45: 81-86, 1995.
    • (1995) Urology , vol.45 , pp. 81-86
    • Epstein, J.I.1    Carmichael, M.2    Partin, A.W.3
  • 51
    • 33747807398 scopus 로고    scopus 로고
    • Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
    • DOI 10.1210/en.2006-0486
    • Lupu R and Menendez JA: Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators? Endocrinology 147: 4056-4066, 2006. (Pubitemid 44274975)
    • (2006) Endocrinology , vol.147 , Issue.9 , pp. 4056-4066
    • Lupu, R.1    Menendez, J.A.2
  • 52
    • 84885634420 scopus 로고    scopus 로고
    • Defining a prognostic marker panel for patients with ovarian serous carcinoma effusion
    • Davidson B, Smith Y, Nesland JM, Kaern J, Reich R and Trope CG: Defining a prognostic marker panel for patients with ovarian serous carcinoma effusion. Hum Pathol 44: 2449-2460, 2013.
    • (2013) Hum Pathol , vol.44 , pp. 2449-2460
    • Davidson, B.1    Smith, Y.2    Nesland, J.M.3    Kaern, J.4    Reich, R.5    Trope, C.G.6
  • 53
    • 0142106795 scopus 로고    scopus 로고
    • Increased Fatty Acid Synthase Expression and Activity During Progression of Prostate Cancer in the TRAMP Model
    • DOI 10.1002/pros.10297
    • Pflug BR, Pecher SM, Brink AW, Nelson JB and Foster BA: Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model. Prostate 57: 245-254, 2003. (Pubitemid 37267807)
    • (2003) Prostate , vol.57 , Issue.3 , pp. 245-254
    • Pflug, B.R.1    Pecher, S.M.2    Brink, A.W.3    Nelson, J.B.4    Foster, B.A.5
  • 55
    • 63649099458 scopus 로고    scopus 로고
    • Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer
    • Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, et al: Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst 101: 519-532, 2009.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 519-532
    • Migita, T.1    Ruiz, S.2    Fornari, A.3    Fiorentino, M.4    Priolo, C.5    Zadra, G.6
  • 56
    • 0030936232 scopus 로고    scopus 로고
    • Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP
    • Swinnen JV, Esquenet M, Goossens K, Heyns W and Verhoeven G: Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res 57: 1086-1090, 1997. (Pubitemid 27138606)
    • (1997) Cancer Research , vol.57 , Issue.6 , pp. 1086-1090
    • Swinnen, J.V.1    Esquenet, M.2    Goossens, K.3    Heyns, W.4    Verhoeven, G.5
  • 57
    • 0034791515 scopus 로고    scopus 로고
    • Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway
    • DOI 10.1210/me.15.10.1817
    • Heemers H, Maes B, Foufelle F, Heyns W, Verhoeven G and Swinnen JV: Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway. Mol Endocrinol 15: 1817-1828, 2001. (Pubitemid 32939311)
    • (2001) Molecular Endocrinology , vol.15 , Issue.10 , pp. 1817-1828
    • Heemers, H.1    Maes, B.2    Foufelle, F.3    Heyns, W.4    Verhoeven, G.5    Swinnen, J.V.6
  • 58
    • 0036469122 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
    • Van de Sande T, De Schrijver E, Heyns W, Verhoeven G and Swinnen JV: Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res 62: 642-646, 2002. (Pubitemid 34126933)
    • (2002) Cancer Research , vol.62 , Issue.3 , pp. 642-646
    • Van De, S.T.1    De Schrijver, E.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 60
    • 77957128212 scopus 로고    scopus 로고
    • HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase
    • Selvendiran K, Ahmed S, Dayton A, et al: HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Mol Cancer Res 8: 1188-1197, 2010.
    • (2010) Mol Cancer Res , vol.8 , pp. 1188-1197
    • Selvendiran, K.1    Ahmed, S.2    Dayton, A.3
  • 61
    • 79960693011 scopus 로고    scopus 로고
    • The anti-cancer effects of (-)-epigal-locatechin-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells
    • Hsu YC and Liou YM: The anti-cancer effects of (-)-epigal-locatechin-3- gallate on the signaling pathways associated with membrane receptors in MCF-7 cells. J Cell Physiol 226: 2721-2730, 2011.
    • (2011) J Cell Physiol , vol.226 , pp. 2721-2730
    • Hsu, Y.C.1    Liou, Y.M.2
  • 64
    • 84874091667 scopus 로고    scopus 로고
    • Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells
    • Lee JS, Yoon IS, Lee MS, et al: Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells. Biol Pharm Bull 36: 316-325, 2013.
    • (2013) Biol Pharm Bull , vol.36 , pp. 316-325
    • Lee, J.S.1    Yoon, I.S.2    Lee, M.S.3
  • 65
    • 0034718771 scopus 로고    scopus 로고
    • Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway
    • Swinnen JV, Heemers H, Deboel L, Foufelle F, Heyns W and Verhoeven G: Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Oncogene 19: 5173-5181, 2000.
    • (2000) Oncogene , vol.19 , pp. 5173-5181
    • Swinnen, J.V.1    Heemers, H.2    Deboel, L.3    Foufelle, F.4    Heyns, W.5    Verhoeven, G.6
  • 66
    • 0033963942 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism
    • Oskouian B: Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. Cancer Lett 149: 43-51, 2000.
    • (2000) Cancer Lett , vol.149 , pp. 43-51
    • Oskouian, B.1
  • 67
    • 0037226462 scopus 로고    scopus 로고
    • Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis
    • Kumar-Sinha C, Ignatoski KW, Lippman ME, Ethier SP and Chinnaiyan AM: Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res 63: 132-139, 2003. (Pubitemid 36070431)
    • (2003) Cancer Research , vol.63 , Issue.1 , pp. 132-139
    • Kumar-Sinha, C.1    Ignatoski, K.W.2    Lippman, M.E.3    Ethier, S.P.4    Chinnaiyan, A.M.5
  • 71
    • 33748188459 scopus 로고    scopus 로고
    • Epidermal growth factor receptor biology in head and neck cancer
    • DOI 10.1200/JCO.2005.04.8306
    • Kalyankrishna S and Grandis JR: Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol 24: 2666-2672, 2006. (Pubitemid 46622088)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.17 , pp. 2666-2672
    • Kalyankrishna, S.1    Grandis, J.R.2
  • 72
    • 34249902824 scopus 로고    scopus 로고
    • RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells
    • DOI 10.1111/j.1349-7006.2007.00485.x
    • Qiu Z, Huang C, Sun J, et al: RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci 98: 1099-1106, 2007. (Pubitemid 46865397)
    • (2007) Cancer Science , vol.98 , Issue.7 , pp. 1099-1106
    • Qiu, Z.1    Huang, C.2    Sun, J.3    Qiu, W.4    Zhang, J.5    Li, H.6    Jiang, T.7    Huang, K.8    Cao, J.9
  • 73
    • 48649096861 scopus 로고    scopus 로고
    • Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma
    • Horiguchi A, Asano T, Asano T, Ito K, Sumitomo M and Hayakawa M: Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. J Urol 180: 1137-1140, 2008.
    • (2008) J Urol , vol.180 , pp. 1137-1140
    • Horiguchi, A.1    Asano, T.2    Asano, T.3    Ito, K.4    Sumitomo, M.5    Hayakawa, M.6
  • 74
    • 0033808261 scopus 로고    scopus 로고
    • The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung
    • Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H, Heimburger DC, et al: The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol 31: 1068-1073, 2000.
    • (2000) Hum Pathol , vol.31 , pp. 1068-1073
    • Piyathilake, C.J.1    Frost, A.R.2    Manne, U.3    Bell, W.C.4    Weiss, H.5    Heimburger, D.C.6
  • 75
    • 57349175482 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
    • Carvalho MA, Zecchin KG, Seguin F, et al: Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int J Cancer 123: 2557-2565, 2008.
    • (2008) Int J Cancer , vol.123 , pp. 2557-2565
    • Carvalho, M.A.1    Zecchin, K.G.2    Seguin, F.3
  • 76
    • 77954842328 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice
    • Murata S, Yanagisawa K, Fukunaga K, et al: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. Cancer Sci 101: 1861-1865, 2010.
    • (2010) Cancer Sci , vol.101 , pp. 1861-1865
    • Murata, S.1    Yanagisawa, K.2    Fukunaga, K.3
  • 77
    • 84858265438 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer
    • Zaytseva YY, Rychahou PG, Gulhati P, et al: Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res 72: 1504-1517, 2012.
    • (2012) Cancer Res , vol.72 , pp. 1504-1517
    • Zaytseva, Y.Y.1    Rychahou, P.G.2    Gulhati, P.3
  • 81
    • 84872262047 scopus 로고    scopus 로고
    • Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells
    • Mauvoisin D, Charfi C, Lounis AM, Rassart E and Mounier C: Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells. Cancer Sci 104: 36-42, 2013.
    • (2013) Cancer Sci , vol.104 , pp. 36-42
    • Mauvoisin, D.1    Charfi, C.2    Lounis, A.M.3    Rassart, E.4    Mounier, C.5
  • 82
    • 0015502078 scopus 로고
    • Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate
    • Goodridge AG: Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate. J Biol Chem 247: 6946-6952, 1972.
    • (1972) J Biol Chem , vol.247 , pp. 6946-6952
    • Goodridge, A.G.1
  • 83
    • 0028972789 scopus 로고
    • Fatty acid proportions in cholesterol esters and risk of premature death from cancer in middle aged French men
    • Zureik M, Ducimetiere P, Warnet JM and Orssaud G: Fatty acid proportions in cholesterol esters and risk of premature death from cancer in middle aged French men. BMJ 311: 1251-1254, 1995.
    • (1995) BMJ , vol.311 , pp. 1251-1254
    • Zureik, M.1    Ducimetiere, P.2    Warnet, J.M.3    Orssaud, G.4
  • 84
    • 0030948322 scopus 로고    scopus 로고
    • Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis
    • Petrek JA, Hudgins LC, Ho M, Bajorunas DR and Hirsch J: Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis. J Clin Oncol 15: 1377-1384, 1997. (Pubitemid 27167369)
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.4 , pp. 1377-1384
    • Petrek, J.A.1    Hudgins, L.C.2    Ho, M.3    Bajorunas, D.R.4    Hirsch, J.5
  • 85
    • 0029123907 scopus 로고
    • Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease
    • Zhu ZR, Agren J, Mannisto S, et al: Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease. Nutr Cancer 24: 151-160, 1995.
    • (1995) Nutr Cancer , vol.24 , pp. 151-160
    • Zhu, Z.R.1    Agren, J.2    Mannisto, S.3
  • 86
    • 2642645431 scopus 로고    scopus 로고
    • Tissue stores of individual monounsaturated fatty acids and breast cancer: The EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer
    • Simonsen NR, Fernandez-Crehuet Navajas J, Martin-Moreno JM, et al: Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Am J Clin Nutr 68: 134-141, 1998.
    • (1998) Am J Clin Nutr , vol.68 , pp. 134-141
    • Simonsen, N.R.1    Fernandez-Crehuet Navajas, J.2    Martin-Moreno, J.M.3
  • 87
    • 78650510746 scopus 로고    scopus 로고
    • Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-beta-induced epithelial-mesenchymal transition
    • Lamouille S and Derynck R: Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-beta-induced epithelial-mesenchymal transition. Cells Tissues Organs 193: 8-22, 2011.
    • (2011) Cells Tissues Organs , vol.193 , pp. 8-22
    • Lamouille, S.1    Derynck, R.2
  • 89
    • 84884558970 scopus 로고    scopus 로고
    • Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins
    • Rios-Esteves J and Resh MD: Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep 4: 1072-1081, 2013.
    • (2013) Cell Rep , vol.4 , pp. 1072-1081
    • Rios-Esteves, J.1    Resh, M.D.2
  • 91
    • 77953544706 scopus 로고    scopus 로고
    • The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer
    • McIntyre E, Blackburn E, Brown PJ, Johnson CG and Gullick WJ: The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer. Breast Cancer Res Treat 122: 105-110, 2010.
    • (2010) Breast Cancer Res Treat , vol.122 , pp. 105-110
    • McIntyre, E.1    Blackburn, E.2    Brown, P.J.3    Johnson, C.G.4    Gullick, W.J.5
  • 92
    • 34249876936 scopus 로고    scopus 로고
    • HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: The 'fat features' of the 'Mediterranean diet' as an 'anti-HER2 cocktail'
    • Menendez JA, Vazquez-Martin A, Ropero S, Colomer R and Lupu R: HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the 'fat features' of the 'Mediterranean diet' as an 'anti-HER2 cocktail'. Clin Transl Oncol 8: 812-820, 2006.
    • (2006) Clin Transl Oncol , vol.8 , pp. 812-820
    • Menendez, J.A.1    Vazquez-Martin, A.2    Ropero, S.3    Colomer, R.4    Lupu, R.5
  • 93
    • 33745923520 scopus 로고    scopus 로고
    • Expression of 'Spot 14' (THRSP) predicts disease free survival in invasive breast cancer: Immunohistochemical analysis of a new molecular marker
    • DOI 10.1007/s10549-005-9154-z
    • Wells WA, Schwartz GN, Morganelli PM, Cole BF, Gibson JJ and Kinlaw WB: Expression of 'Spot 14' (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker. Breast Cancer Res Treat 98: 231-240, 2006. (Pubitemid 44050774)
    • (2006) Breast Cancer Research and Treatment , vol.98 , Issue.2 , pp. 231-240
    • Wells, W.A.1    Schwartz, G.N.2    Morganelli, P.M.3    Cole, B.F.4    Gibson, J.J.5    Kinlaw, W.B.6
  • 94
    • 33747589441 scopus 로고    scopus 로고
    • Spot 14: A marker of aggressive breast cancer and a potential therapeutic target
    • DOI 10.1210/en.2006-0463
    • Kinlaw WB, Quinn JL, Wells WA, Roser-Jones C and Moncur JT: Spot 14: A marker of aggressive breast cancer and a potential therapeutic target. Endocrinology 147: 4048-4055, 2006. (Pubitemid 44268359)
    • (2006) Endocrinology , vol.147 , Issue.9 , pp. 4048-4055
    • Kinlaw, W.B.1    Quinn, J.L.2    Wells, W.A.3    Roser-Jones, C.4    Moncur, J.T.5
  • 97
    • 77956477076 scopus 로고    scopus 로고
    • Metastasis suppression by adiponectin: LKB1 rises up to the challenge
    • Saxena NK and Sharma D: Metastasis suppression by adiponectin: LKB1 rises up to the challenge. Cell Adh Migr 4: 358-362, 2010.
    • (2010) Cell Adh Migr , vol.4 , pp. 358-362
    • Saxena, N.K.1    Sharma, D.2
  • 98
    • 84855451705 scopus 로고    scopus 로고
    • Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis
    • Scott KE, Wheeler FB, Davis AL, Thomas MJ, Ntambi JM, Seals DF, et al: Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis. PloS One 7: e29761, 2012.
    • (2012) PloS One , vol.7
    • Scott, K.E.1    Wheeler, F.B.2    Davis, A.L.3    Thomas, M.J.4    Ntambi, J.M.5    Seals, D.F.6
  • 99
    • 33845904631 scopus 로고    scopus 로고
    • Mediterranean dietary traditions for the molecular treatment of human cancer: Anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9)
    • DOI 10.2174/138920106779116900
    • Menendez JA and Lupu R: Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9). Curr Pharm Biotechnol 7: 495-502, 2006. (Pubitemid 46017541)
    • (2006) Current Pharmaceutical Biotechnology , vol.7 , Issue.6 , pp. 495-502
    • Menendez, J.A.1    Lupu, R.2
  • 100
    • 0030666828 scopus 로고    scopus 로고
    • Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins
    • DOI 10.1073/pnas.94.24.12975
    • Swinnen JV, Ulrix W, Heyns W and Verhoeven G: Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins. Proc Natl Acad Sci USA 94: 12975-12980, 1997. (Pubitemid 27518461)
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.24 , pp. 12975-12980
    • Swinnen, J.V.1    Ulrix, W.2    Heyns, W.3    Verhoeven, G.4
  • 101
    • 84862908756 scopus 로고    scopus 로고
    • Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells
    • Huang WC, Li X, Liu J, Lin J and Chung LW: Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol Cancer Res 10: 133-142, 2012.
    • (2012) Mol Cancer Res , vol.10 , pp. 133-142
    • Huang, W.C.1    Li, X.2    Liu, J.3    Lin, J.4    Chung, L.W.5


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