메뉴 건너뛰기




Volumn 4, Issue 3, 2010, Pages 358-362

Metastasis suppression by adiponectin: LKB1 rises up to the challenge

Author keywords

Adiponectin; AMPK; Cancer; Invasion; LKB1; Migration; S6K

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADIPONECTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; P70S6 KINASE; PROTEIN KINASE; PROTEIN KINASE LKB1; UNCLASSIFIED DRUG;

EID: 77956477076     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.4.3.11541     Document Type: Note
Times cited : (51)

References (52)
  • 1
    • 33751252276 scopus 로고    scopus 로고
    • Cancer Metastasis: Building a framework
    • Gupta GP, Massague J. Cancer Metastasis: Building a framework. Cell 2006; 127:679-95.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 2
    • 33947537241 scopus 로고    scopus 로고
    • Mechanisms of disease: Adipokines and breast cancer - Endocrine and paracrine mechanisms that connect adiposity and breast cancer
    • DOI 10.1038/ncpendmet0456, PII NCPENDMET0456
    • Schaffler A, Scholmerich J, Buechler C. Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Clin Pract Endocrinol Metab 2007; 3:345-54. (Pubitemid 46474652)
    • (2007) Nature Clinical Practice Endocrinology and Metabolism , vol.3 , Issue.4 , pp. 345-354
    • Schaffler, A.1    Scholmerich, J.2    Buechler, C.3
  • 3
    • 0141892161 scopus 로고    scopus 로고
    • Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions
    • DOI 10.1002/path.1430
    • Manabe Y, Toda S, Miyazaki K, Sugihara H. Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions. J Pathol 2003; 201:221-8. (Pubitemid 37258933)
    • (2003) Journal of Pathology , vol.201 , Issue.2 , pp. 221-228
    • Manabe, Y.1    Toda, S.2    Miyazaki, K.3    Sugihara, H.4
  • 4
    • 0142103807 scopus 로고    scopus 로고
    • Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of ant apoptotic transcriptional programs and proto-oncogene stabilization
    • Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, et al. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of ant apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene 2003; 22:6408-23.
    • (2003) Oncogene , vol.22 , pp. 6408-6423
    • Iyengar, P.1    Combs, T.P.2    Shah, S.J.3    Gouon-Evans, V.4    Pollard, J.W.5    Albanese, C.6
  • 5
    • 0026682506 scopus 로고
    • Capacity of adipose tissue to promote growth and metastasis of a murine mammary carcinoma: Effect of estrogen and progesterone
    • Elliott BE, Tam SP, Dexter D, Chen ZQ. Capacity of adipose tissue to promote growth and metastasis of a murine mammary carcinoma: effect of estrogen and progesterone. Int J Cancer 1992; 51:416-24.
    • (1992) Int J Cancer , vol.51 , pp. 416-424
    • Elliott, B.E.1    Tam, S.P.2    Dexter, D.3    Chen, Z.Q.4
  • 8
    • 33745106287 scopus 로고    scopus 로고
    • Molecular links between obesity and breast cancer
    • DOI 10.1677/erc.1.00729
    • Lorincz AM, Sukumar S. Molecular links between obesity and breast cancer. Endocrine-Related Cancer 2006; 13:279-92. (Pubitemid 43886659)
    • (2006) Endocrine-Related Cancer , vol.13 , Issue.2 , pp. 279-292
    • Lorincz, A.M.1    Sukumar, S.2
  • 9
    • 40349108448 scopus 로고    scopus 로고
    • Adiponectin in relation to malignancies: A review of existing basic research and clinical evidence
    • Barb D, Williams CJ, Neuwirth AK, Mantzoros CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 2007; 86:858-66.
    • (2007) Am J Clin Nutr , vol.86 , pp. 858-866
    • Barb, D.1    Williams, C.J.2    Neuwirth, A.K.3    Mantzoros, C.S.4
  • 10
    • 34547741589 scopus 로고    scopus 로고
    • Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
    • DOI 10.1677/ERC-06-0068
    • Vona-Davis L, Rose DP. Adipokines as endocrine, paracrine and autocrine factors in breast cancer risk and progression. Endocrine-Related Cancer 2007; 14:189-206. (Pubitemid 47242622)
    • (2007) Endocrine-Related Cancer , vol.14 , Issue.2 , pp. 189-206
    • Vona-Davis, L.1    Rose, D.P.2
  • 11
  • 12
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270:26746-9.
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 13
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • DOI 10.1074/jbc.271.18.10697
    • Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271:10697-703. (Pubitemid 26145805)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.18 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 15
    • 0029836585 scopus 로고    scopus 로고
    • Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma
    • Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem 1996; 120:803-12. (Pubitemid 26385421)
    • (1996) Journal of Biochemistry , vol.120 , Issue.4 , pp. 803-812
    • Nakano, Y.1    Tobe, T.2    Choi-Miura, N.-H.3    Mazda, T.4    Tomita, M.5
  • 19
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines and inflammation
    • Fantuzzi G. Adipose tissue, adipokines and inflammation. J Allergy Clin Immunol 2005; 115:911-9.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 20
    • 2942687834 scopus 로고    scopus 로고
    • Adiponectin: A novel adipokine linking adipocytes and vascular function
    • Goldstein BJ, Scalia R. Adiponectin: A novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 2004; 89:2563-8.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2563-2568
    • Goldstein, B.J.1    Scalia, R.2
  • 21
    • 24044538551 scopus 로고    scopus 로고
    • Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner
    • Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, et al. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem 2005; 280:18341-7.
    • (2005) J Biol Chem , vol.280 , pp. 18341-18347
    • Wang, Y.1    Lam, K.S.2    Xu, J.Y.3    Lu, G.4    Xu, L.Y.5    Cooper, G.J.6
  • 23
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423:762-9.
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1    Kamon, J.2    Ito, Y.3    Tsuchida, A.4    Yokomizo, T.5    Kita, S.6
  • 24
    • 3142761477 scopus 로고    scopus 로고
    • T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    • Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 2004; 101:10308-13.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10308-10313
    • Hug, C.1    Wang, J.2    Ahmad, N.S.3    Bogan, J.S.4    Tsao, T.S.5    Lodish, H.F.6
  • 25
    • 21244500596 scopus 로고    scopus 로고
    • Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics
    • Chen MB, McAinch AJ, Macaulay SL, Castelli LA, O'Brien PE, Dixon JB, et al. Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. J Clin Endocrinol Metab 2005; 90:3665-72.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3665-3672
    • Chen, M.B.1    McAinch, A.J.2    Macaulay, S.L.3    Castelli, L.A.4    O'Brien, P.E.5    Dixon, J.B.6
  • 28
    • 33646497663 scopus 로고    scopus 로고
    • Serum adiponectin and leptin levels in Taiwanese breast cancer patients
    • Chen DC, Chung YF, Yeh YT, Chaung HC, Kuo FC, Fu OY, et al. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 2006; 237:109-14.
    • (2006) Cancer Lett , vol.237 , pp. 109-114
    • Chen, D.C.1    Chung, Y.F.2    Yeh, Y.T.3    Chaung, H.C.4    Kuo, F.C.5    Fu, O.Y.6
  • 31
    • 33845806853 scopus 로고    scopus 로고
    • Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    • Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, et al. Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res 2006; 66:11462-70.
    • (2006) Cancer Res , vol.66 , pp. 11462-11470
    • Wang, Y.1    Lam, J.B.2    Lam, K.S.3    Liu, J.4    Lam, M.C.5    Hoo, R.L.6
  • 32
    • 33947589720 scopus 로고    scopus 로고
    • Antiproliferative effect of adiponectin on MCF7 breast cancer cells: A potential hormonal link between obesity and cancer
    • Arditi JD, Venihaki M, Karalis KP, Chrousos GP. Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer. Horm Metab Res 2007; 39:9-13.
    • (2007) Horm Metab Res , vol.39 , pp. 9-13
    • Arditi, J.D.1    Venihaki, M.2    Karalis, K.P.3    Chrousos, G.P.4
  • 33
    • 34047141622 scopus 로고    scopus 로고
    • Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells
    • Takahata C, Miyoshi Y, Irahara N, Taguchi T, Tamaki Y, Noguchi S. Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells. Cancer Lett 2007; 250:229-36.
    • (2007) Cancer Lett , vol.250 , pp. 229-236
    • Takahata, C.1    Miyoshi, Y.2    Irahara, N.3    Taguchi, T.4    Tamaki, Y.5    Noguchi, S.6
  • 36
    • 52649088765 scopus 로고    scopus 로고
    • Adiponectin and leptin expression in primary ductal breast cancer and in adjacent healthy epithelial and myoepithelial tissue
    • Jarde T, Caldefie-Chezet F, Damez M, Mishellany F, Perrone D, Penault-Llorca F, et al. Adiponectin and leptin expression in primary ductal breast cancer and in adjacent healthy epithelial and myoepithelial tissue. Histopathology 2008; 53:484-7.
    • (2008) Histopathology , vol.53 , pp. 484-487
    • Jarde, T.1    Caldefie-Chezet, F.2    Damez, M.3    Mishellany, F.4    Perrone, D.5    Penault-Llorca, F.6
  • 37
    • 68049137624 scopus 로고    scopus 로고
    • LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells
    • Taliaferro-Smith L, Nagalingam A, Zhong D, Zhou W, Saxena NK, Sharma D. LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells. Oncogene 2009; 28:2621-33.
    • (2009) Oncogene , vol.28 , pp. 2621-2633
    • Taliaferro-Smith, L.1    Nagalingam, A.2    Zhong, D.3    Zhou, W.4    Saxena, N.K.5    Sharma, D.6
  • 38
    • 0031974516 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
    • Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998; 18:38-43.
    • (1998) Nat Genet , vol.18 , pp. 38-43
    • Jenne, D.E.1    Reimann, H.2    Nezu, J.3    Friedel, W.4    Loff, S.5    Jeschke, R.6
  • 39
    • 15044358594 scopus 로고    scopus 로고
    • New roles for the LKB1-AMPK pathway
    • Hardie DG. New roles for the LKB1-AMPK pathway. Curr Opin Cell Biol 2005; 17:167-73.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 167-173
    • Hardie, D.G.1
  • 41
    • 0035992276 scopus 로고    scopus 로고
    • The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma
    • Shen Z, Wen XF, Lan F, Shen ZZ, Shao ZM. The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res 2002; 8:2085-90.
    • (2002) Clin Cancer Res , vol.8 , pp. 2085-2090
    • Shen, Z.1    Wen, X.F.2    Lan, F.3    Shen, Z.Z.4    Shao, Z.M.5
  • 42
    • 0038614742 scopus 로고    scopus 로고
    • Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
    • Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, et al. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J 2003; 22:3062-72.
    • (2003) EMBO J , vol.22 , pp. 3062-3072
    • Baas, A.F.1    Boudeau, J.2    Sapkota, G.P.3    Smit, L.4    Medema, R.5    Morrice, N.A.6
  • 43
    • 0141753981 scopus 로고    scopus 로고
    • MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
    • Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, et al. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 2003; 22:5102-14.
    • (2003) EMBO J , vol.22 , pp. 5102-5114
    • Boudeau, J.1    Baas, A.F.2    Deak, M.3    Morrice, N.A.4    Kieloch, A.5    Schutkowski, M.6
  • 45
    • 0036499467 scopus 로고    scopus 로고
    • Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
    • Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi DR. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J 2002; 362:481-90.
    • (2002) Biochem J , vol.362 , pp. 481-490
    • Sapkota, G.P.1    Boudeau, J.2    Deak, M.3    Kieloch, A.4    Morrice, N.5    Alessi, D.R.6
  • 46
    • 0035375261 scopus 로고    scopus 로고
    • Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
    • Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, et al. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J Biol Chem 2001; 276:19469-82.
    • (2001) J Biol Chem , vol.276 , pp. 19469-19482
    • Sapkota, G.P.1    Kieloch, A.2    Lizcano, J.M.3    Lain, S.4    Arthur, J.S.5    Williams, M.R.6
  • 47
    • 56749176442 scopus 로고    scopus 로고
    • LKB1; linking cell structure and tumor suppression
    • Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene 2008; 27:6908-19.
    • (2008) Oncogene , vol.27 , pp. 6908-6919
    • Hezel, A.F.1    Bardeesy, N.2
  • 48
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway - New players upstream and downstream
    • Hardie DG. The AMP-activated protein kinase pathway - new players upstream and downstream. J Cell Sci 2004; 117:5479-87.
    • (2004) J Cell Sci , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 49
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001; 7:947-53.
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 50
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001; 98:2005-10.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3    Ebbets-Reed, D.4    Erickson, M.R.5    Yen, F.T.6
  • 51
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003; 112:91-100.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 52
    • 0037462684 scopus 로고    scopus 로고
    • Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
    • Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 2003; 278:2461-8.
    • (2003) J Biol Chem , vol.278 , pp. 2461-2468
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Imai, Y.4    Shimozawa, N.5    Hioki, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.