-
1
-
-
0034002793
-
Fatty acid synthase and human cancer: New perspectives on its role in tumor biology
-
Kuhajda FP. Fatty acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 2000;16:202-8.
-
(2000)
Nutrition
, vol.16
, pp. 202-208
-
-
Kuhajda, F.P.1
-
2
-
-
2342538485
-
Aberrant mRNA translation in cancer pathogenesis: An old concept revisited comes finally of age
-
Pandolfi PP. Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age. Oncogene 2004;23:3134-7.
-
(2004)
Oncogene
, vol.23
, pp. 3134-3137
-
-
Pandolfi, P.P.1
-
3
-
-
2942544833
-
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells
-
Abdulov S, Li S, Mochalek V, et al. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 2004;5:553-63.
-
(2004)
Cancer Cell
, vol.5
, pp. 553-563
-
-
Abdulov, S.1
Li, S.2
Mochalek, V.3
-
4
-
-
0347318052
-
The AMP-activated protein kinase cascade: A unifying system for energy control
-
Carling D. The AMP-activated protein kinase cascade: a unifying system for energy control. Trends Biochem Sci 2004;29:18-24.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 18-24
-
-
Carling, D.1
-
5
-
-
0024322304
-
The allosteric transition of glycogen phosphorylase
-
Barford D, Johnson LN. The allosteric transition of glycogen phosphorylase. Nature 1989;340:609-16.
-
(1989)
Nature
, vol.340
, pp. 609-616
-
-
Barford, D.1
Johnson, L.N.2
-
6
-
-
0021318683
-
The role of fructose 2,6-bisphosphate in the regulation of carbohydrate metabolism
-
Claus TH, El-Maghrabi MR, Regen DM, et al. The role of fructose 2,6-bisphosphate in the regulation of carbohydrate metabolism. Curr Top Cell Regul 1984; 23:57-86.
-
(1984)
Curr Top Cell Regul
, vol.23
, pp. 57-86
-
-
Claus, T.H.1
El-Maghrabi, M.R.2
Regen, D.M.3
-
7
-
-
0037224448
-
Different sensitivities of mutants and chimeric forms of human muscle and liver fructose-I,6-bisphosphatases towards AMP
-
Rakus D, Tillmann H, Wysocki R, Ulaszewski S, Eschrich K, Dzugaj A. Different sensitivities of mutants and chimeric forms of human muscle and liver fructose-I,6-bisphosphatases towards AMP. Biol Chem 2003;384:51-8.
-
(2003)
Biol Chem
, vol.384
, pp. 51-58
-
-
Rakus, D.1
Tillmann, H.2
Wysocki, R.3
Ulaszewski, S.4
Eschrich, K.5
Dzugaj, A.6
-
8
-
-
0037524354
-
LKB1, a protein kinase regulating cell proliferation and polarity
-
Boudeau J, Sapkota G, Alessi DR. LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett 2003;546:159-65.
-
(2003)
FEBS Lett
, vol.546
, pp. 159-165
-
-
Boudeau, J.1
Sapkota, G.2
Alessi, D.R.3
-
9
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley SA, Boudeau J, Reid JL, et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003;2:28.1-28.16.
-
(2003)
J Biol
, vol.2
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
-
10
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods A, Johnstone SR, Dickerson K, et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003;13:2004-8.
-
(2003)
Curr Biol
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
-
11
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano JM, Goransson O, Toth R, et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 2004;23: 833-43.
-
(2004)
EMBO J
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
-
12
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 2004;101:3329-35.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
-
13
-
-
0344081177
-
Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status
-
Hardie DG. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003;144:5179-83.
-
(2003)
Endocrinology
, vol.144
, pp. 5179-5183
-
-
Hardie, D.G.1
-
14
-
-
0023642627
-
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
-
Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 1987;223:217-22.
-
(1987)
FEBS Lett
, vol.223
, pp. 217-222
-
-
Carling, D.1
Zammit, V.A.2
Hardie, D.G.3
-
15
-
-
0023789884
-
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase
-
Munday MR, Cambell DG, Carling D, Hardie DG. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur J Biochem 1988;175:331-8.
-
(1988)
Eur J Biochem
, vol.175
, pp. 331-338
-
-
Munday, M.R.1
Cambell, D.G.2
Carling, D.3
Hardie, D.G.4
-
16
-
-
0025310576
-
Regulation of HMG-CoA reductase: Identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver
-
Clarke PR, Hardie DG. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J 1990;9:2439-46.
-
(1990)
EMBO J
, vol.9
, pp. 2439-2446
-
-
Clarke, P.R.1
Hardie, D.G.2
-
17
-
-
0037025356
-
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR signaling)
-
Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR signaling). J Biol Chem 2002;277:23977-80.
-
(2002)
J Biol Chem
, vol.277
, pp. 23977-23980
-
-
Bolster, D.R.1
Crozier, S.J.2
Kimball, S.R.3
Jefferson, L.S.4
-
18
-
-
0037143449
-
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
-
Horman S, Browne G, Krause U, et al. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol 2002;12:1419-23.
-
(2002)
Curr Biol
, vol.12
, pp. 1419-1423
-
-
Horman, S.1
Browne, G.2
Krause, U.3
-
19
-
-
16844373065
-
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
-
Browne GJ, Finn SG, Proud CG. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. Oncogene 2004;23:3151-71.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Browne, G.J.1
Finn, S.G.2
Proud, C.G.3
-
20
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-90.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
21
-
-
0028301959
-
Fatty acid synthesis: A potential selective target for antineoplastic therapy
-
Kuhajda FP, Jenner K, Wood FD, et al. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci U S A 1994;91:6379-83.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 6379-6383
-
-
Kuhajda, F.P.1
Jenner, K.2
Wood, F.D.3
-
22
-
-
0038418257
-
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis in LNCaP prostate cancer cells
-
De Schrijver E, Brusselmans K, Heyns W, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis in LNCaP prostate cancer cells. Cancer Res 2003;63:3799-804.
-
(2003)
Cancer Res
, vol.63
, pp. 3799-3804
-
-
De Schrijver, E.1
Brusselmans, K.2
Heyns, W.3
Verhoeven, G.4
Swinnen, J.V.5
-
23
-
-
2542458153
-
Potential antitumor effects of statins
-
Jakobisiak M, Golab J. Potential antitumor effects of statins (Review). Int J Oncol 2003;23:1055-69.
-
(2003)
Int J Oncol
, vol.23
, pp. 1055-1069
-
-
Jakobisiak, M.1
Golab, J.2
-
24
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004;23:3151-71.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
25
-
-
2342489456
-
eIF-4E expression and its role in malignancies and metastases
-
De Benedetti A, Graff JR. eIF-4E expression and its role in malignancies and metastases. Oncogene 2004; 23:189-99.
-
(2004)
Oncogene
, vol.23
, pp. 189-199
-
-
De Benedetti, A.1
Graff, J.R.2
-
26
-
-
85047689953
-
5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
-
Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-Aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 1995;229:558-65.
-
(1995)
Eur J Biochem
, vol.229
, pp. 558-565
-
-
Corton, J.M.1
Gillespie, J.G.2
Hawley, S.A.3
Hardie, D.G.4
-
27
-
-
0029743674
-
Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP
-
Swinnen JV, Van Veldhoven PP, Esquenet M, Heyns W, Verhoeven G. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology 1996; 137:4468-74.
-
(1996)
Endocrinology
, vol.137
, pp. 4468-4474
-
-
Swinnen, J.V.1
Van Veldhoven, P.P.2
Esquenet, M.3
Heyns, W.4
Verhoeven, G.5
-
28
-
-
0030936232
-
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP
-
Swinnen JV, Esquenet M, Goossens K, Heyns W, Verhoeven G. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res 1997;57:1086-90.
-
(1997)
Cancer Res
, vol.57
, pp. 1086-1090
-
-
Swinnen, J.V.1
Esquenet, M.2
Goossens, K.3
Heyns, W.4
Verhoeven, G.5
-
29
-
-
0037323828
-
AMP-activated protein kinase and hepatic genes involved in glucose metabolism
-
Ferré P, Azzout-Marniche D, Foufelle F. AMP-activated protein kinase and hepatic genes involved in glucose metabolism. Biochem Soc Trans 2003;31:220-3.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 220-223
-
-
Ferré, P.1
Azzout-Marniche, D.2
Foufelle, F.3
-
30
-
-
0344838439
-
Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
-
Swinnen JV, Van Veldhoven PP, Timmermans L, et al. Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun 2003;302:898-903.
-
(2003)
Biochem Biophys Res Commun
, vol.302
, pp. 898-903
-
-
Swinnen, J.V.1
Van Veldhoven, P.P.2
Timmermans, L.3
-
31
-
-
0033559856
-
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
-
Muoio DM, Seefeld K, Witters LA, Coleman RA. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 1999;338:783-91.
-
(1999)
Biochem J
, vol.338
, pp. 783-791
-
-
Muoio, D.M.1
Seefeld, K.2
Witters, L.A.3
Coleman, R.A.4
-
32
-
-
0035992276
-
The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma
-
Shen Z, Wen XF, Lan F, Shen ZZ, Shao ZM. The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res 2002;8:2085-90.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2085-2090
-
-
Shen, Z.1
Wen, X.F.2
Lan, F.3
Shen, Z.Z.4
Shao, Z.M.5
-
33
-
-
0036239832
-
HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis
-
Wong WW, Dimitroulakos J, Minden MD, Penn LZ. HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 2002;16:509-19.
-
(2002)
Leukemia
, vol.16
, pp. 509-519
-
-
Wong, W.W.1
Dimitroulakos, J.2
Minden, M.D.3
Penn, L.Z.4
-
34
-
-
0035109048
-
Caloric restriction and cancer
-
Tokyo
-
Kritchevsky D. Caloric restriction and cancer. J Nutr Sci Vitaminol (Tokyo) 2001;47:13-9.
-
(2001)
J Nutr Sci Vitaminol
, vol.47
, pp. 13-19
-
-
Kritchevsky, D.1
-
35
-
-
0042023373
-
Energy restriction and the risk of spontaneous mammary tumors in mice: A meta-analysis
-
Dirx MJM, Zeegers MPA, Dagnelie PC, Van den Bogaard T, Van den Brandt PA. Energy restriction and the risk of spontaneous mammary tumors in mice: a meta-analysis. Int J Cancer 2003;106:755-70.
-
(2003)
Int J Cancer
, vol.106
, pp. 755-770
-
-
Dirx, M.J.M.1
Zeegers, M.P.A.2
Dagnelie, P.C.3
Van Den Bogaard, T.4
Van Den Brandt, P.A.5
-
36
-
-
0036307179
-
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
-
Buhl ES, Jessen N, Pold R, et al. Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes 2002;51: 2199-206.
-
(2002)
Diabetes
, vol.51
, pp. 2199-2206
-
-
Buhl, E.S.1
Jessen, N.2
Pold, R.3
-
37
-
-
0033016641
-
Liver AMP-activated protein kinase and acetyl-CoA carboxylase during and after exercise
-
Carlson CL, Winder WW. Liver AMP-activated protein kinase and acetyl-CoA carboxylase during and after exercise. J Appl Physiol 1999;86:669-74.
-
(1999)
J Appl Physiol
, vol.86
, pp. 669-674
-
-
Carlson, C.L.1
Winder, W.W.2
-
38
-
-
0032704115
-
Chronic activation of 5′ AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
-
Holmes BF, Kurth-Kraczek EJ, Winder WW. Chronic activation of 5′ AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. J Appl Physiol 1999;87:1990-5.
-
(1999)
J Appl Physiol
, vol.87
, pp. 1990-1995
-
-
Holmes, B.F.1
Kurth-Kraczek, E.J.2
Winder, W.W.3
-
39
-
-
0033949848
-
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
-
Winder WW, Holmes BF, Rubinck DS, Jensen EB, Chen M, Holloszy JO. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol 2000;88:2219-26.
-
(2000)
J Appl Physiol
, vol.88
, pp. 2219-2226
-
-
Winder, W.W.1
Holmes, B.F.2
Rubinck, D.S.3
Jensen, E.B.4
Chen, M.5
Holloszy, J.O.6
-
40
-
-
0030951598
-
Physical activity and the risk of breast cancer
-
Thune I, Brenn T, Lund E, Gaard M. Physical activity and the risk of breast cancer. New Engl J Med 1997;336:1269-75.
-
(1997)
New Engl J Med
, vol.336
, pp. 1269-1275
-
-
Thune, I.1
Brenn, T.2
Lund, E.3
Gaard, M.4
-
41
-
-
0036845140
-
Physical activity and cancer prevention: Etiologic evidence and biological mechanisms
-
Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 2002;132:3456-648.
-
(2002)
J Nutr
, vol.132
, pp. 3456-3648
-
-
Friedenreich, C.M.1
Orenstein, M.R.2
-
42
-
-
0025863078
-
AICA riboside: Safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent
-
Dixon R, Gourzis J, McDermott D, Fujitaki J, Dewland P, Gruber H. AICA riboside: safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent. J Clin Pharmacol 1991;31:342-7.
-
(1991)
J Clin Pharmacol
, vol.31
, pp. 342-347
-
-
Dixon, R.1
Gourzis, J.2
McDermott, D.3
Fujitaki, J.4
Dewland, P.5
Gruber, H.6
|