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Volumn 34, Issue 6 PART 2, 2008, Pages 643-648

The role of the lipogenic pathway in the development of hepatic steatosis

Author keywords

Hepatic steatosis; Insulin resistance; Lipogenesis; NAFLD; Review

Indexed keywords

LIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 62749188867     PISSN: 12623636     EISSN: 18781780     Source Type: Journal    
DOI: 10.1016/S1262-3636(08)74599-3     Document Type: Article
Times cited : (234)

References (54)
  • 1
    • 35448963836 scopus 로고    scopus 로고
    • Nonalcoholic Fatty liver disease as a complication of insulin resistance
    • Abdelmalek MF, Diehl AM. Nonalcoholic Fatty liver disease as a complication of insulin resistance. Med Clin North Am 2007;91:1125-49.
    • (2007) Med Clin North Am , vol.91 , pp. 1125-1149
    • Abdelmalek, M.F.1    Diehl, A.M.2
  • 2
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • Anderson N, Borlak J. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol Rev 2008;60:311-57.
    • (2008) Pharmacol Rev , vol.60 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 3
    • 35348900749 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Adams LA, Lindor KD. Nonalcoholic fatty liver disease. Ann Epidemiol 2007;17:863-9.
    • (2007) Ann Epidemiol , vol.17 , pp. 863-869
    • Adams, L.A.1    Lindor, K.D.2
  • 4
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297-307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6
  • 5
    • 3242745192 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    • Tiikkainen M, Hakkinen AM, Korsheninnikova E, Nyman T, Makimattila S, Yki-Jarvinen H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 2004;53:2169-76.
    • (2004) Diabetes , vol.53 , pp. 2169-2176
    • Tiikkainen, M.1    Hakkinen, A.M.2    Korsheninnikova, E.3    Nyman, T.4    Makimattila, S.5    Yki-Jarvinen, H.6
  • 8
    • 19944366619 scopus 로고    scopus 로고
    • Regulation of plasma triglycerides in insulin resistance and diabetes
    • Ginsberg HN, Zhang YL, Hernandez-Ono A. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res 2005;36:232-40.
    • (2005) Arch Med Res , vol.36 , pp. 232-240
    • Ginsberg, H.N.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 9
    • 0041314066 scopus 로고    scopus 로고
    • Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipasedeficient mice
    • Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, et al. Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipasedeficient mice. Endocrinology 2003;144:3456-62.
    • (2003) Endocrinology , vol.144 , pp. 3456-3462
    • Voshol, P.J.1    Haemmerle, G.2    Ouwens, D.M.3    Zimmermann, R.4    Zechner, R.5    Teusink, B.6
  • 10
    • 20544449419 scopus 로고    scopus 로고
    • Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart
    • Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, et al. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. Am J Physiol Endocrinol Metab 2005;289:E30-9.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Park, S.Y.1    Kim, H.J.2    Wang, S.3    Higashimori, T.4    Dong, J.5    Kim, Y.J.6
  • 11
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005;115:1343-51.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 12
    • 0036711553 scopus 로고    scopus 로고
    • New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose:a role for the transcription factor sterol regulatory element binding protein-1c
    • Foufelle F, Ferré P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose:a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 2002;366:377-91.
    • (2002) Biochem J , vol.366 , pp. 377-391
    • Foufelle, F.1    Ferré, P.2
  • 13
    • 0023644811 scopus 로고
    • Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver
    • Iynedjian PB, Ucla C, Mach B. Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver. J Biol Chem 1987;62:6032-8.
    • (1987) J Biol Chem , vol.62 , pp. 6032-6038
    • Iynedjian, P.B.1    Ucla, C.2    Mach, B.3
  • 14
    • 0023019274 scopus 로고
    • Transcriptional and posttranscriptional regulation of L-type pyruvate kinase gene expression in rat liver
    • Vaulont S, Munnich A, Decaux JF, Kahn A. Transcriptional and posttranscriptional regulation of L-type pyruvate kinase gene expression in rat liver. J Biol Chem 1986;261:7621-5.
    • (1986) J Biol Chem , vol.261 , pp. 7621-7625
    • Vaulont, S.1    Munnich, A.2    Decaux, J.F.3    Kahn, A.4
  • 15
    • 0025058095 scopus 로고
    • Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age
    • Elshourbagy NA, Near JC, Kmetz PJ, Sathe GM, Southan C, Strickler JE, et al. Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age. J Biol Chem 1990;265:1430-5.
    • (1990) J Biol Chem , vol.265 , pp. 1430-1435
    • Elshourbagy, N.A.1    Near, J.C.2    Kmetz, P.J.3    Sathe, G.M.4    Southan, C.5    Strickler, J.E.6
  • 16
    • 0025299901 scopus 로고
    • Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liver
    • Katsurada A, Iritani N, Fukuda H, Matsumura Y, Nishimoto N, Noguchi T, et al. Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liver. Eur J Biochem 1990;190:435-41.
    • (1990) Eur J Biochem , vol.190 , pp. 435-441
    • Katsurada, A.1    Iritani, N.2    Fukuda, H.3    Matsumura, Y.4    Nishimoto, N.5    Noguchi, T.6
  • 17
    • 0024378504 scopus 로고
    • Effects of nutrients and insulin on transcriptional and post-transcriptional regulation of glucose-6-phosphate dehydrogenase synthesis in rat liver
    • Katsurada A, Iritani N, Fukuda H, Matsumura Y, Noguchi T, Tanaka T. Effects of nutrients and insulin on transcriptional and post-transcriptional regulation of glucose-6-phosphate dehydrogenase synthesis in rat liver. Biochim Biophys Acta 1989;1006:104-10.
    • (1989) Biochim Biophys Acta , vol.1006 , pp. 104-110
    • Katsurada, A.1    Iritani, N.2    Fukuda, H.3    Matsumura, Y.4    Noguchi, T.5    Tanaka, T.6
  • 18
    • 33646018341 scopus 로고    scopus 로고
    • Fatty acid elongases in mammals:their regulation and roles in metabolism
    • Jakobsson A, Westerberg R, Jacobsson A. Fatty acid elongases in mammals:their regulation and roles in metabolism. Prog Lipid Res 2006;45:237-49.
    • (2006) Prog Lipid Res , vol.45 , pp. 237-249
    • Jakobsson, A.1    Westerberg, R.2    Jacobsson, A.3
  • 19
    • 0026745069 scopus 로고
    • Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver
    • Ntambi JM. Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. J Biol Chem 1992;267:10925-30.
    • (1992) J Biol Chem , vol.267 , pp. 10925-10930
    • Ntambi, J.M.1
  • 20
    • 0345171460 scopus 로고    scopus 로고
    • Enzymes of triacylglycerol synthesis and their regulation
    • Coleman RA, Lee DP. Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 2004;43:134-76.
    • (2004) Prog Lipid Res , vol.43 , pp. 134-176
    • Coleman, R.A.1    Lee, D.P.2
  • 21
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance:lessons from genetically engineered mice
    • Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance:lessons from genetically engineered mice. J Clin Invest 2008;118:829-38.
    • (2008) J Clin Invest , vol.118 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 22
    • 33644654777 scopus 로고    scopus 로고
    • Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
    • Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest 2006;116:817-24.
    • (2006) J Clin Invest , vol.116 , pp. 817-824
    • Savage, D.B.1    Choi, C.S.2    Samuel, V.T.3    Liu, Z.X.4    Zhang, D.5    Wang, A.6
  • 25
    • 20144388684 scopus 로고    scopus 로고
    • Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1
    • Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, et al. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J Clin Invest 2005;115:1030-8.
    • (2005) J Clin Invest , vol.115 , pp. 1030-1038
    • Jiang, G.1    Li, Z.2    Liu, F.3    Ellsworth, K.4    Dallas-Yang, Q.5    Wu, M.6
  • 26
    • 33745212925 scopus 로고    scopus 로고
    • Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
    • Gutierrez-Juarez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP, et al. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest 2006;116:1686-95.
    • (2006) J Clin Invest , vol.116 , pp. 1686-1695
    • Gutierrez-Juarez, R.1    Pocai, A.2    Mulas, C.3    Ono, H.4    Bhanot, S.5    Monia, B.P.6
  • 27
    • 33748655454 scopus 로고    scopus 로고
    • Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    • Chu K, Miyazaki M, Man WC, Ntambi JM. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol 2006;26:6786-98.
    • (2006) Mol Cell Biol , vol.26 , pp. 6786-6798
    • Chu, K.1    Miyazaki, M.2    Man, W.C.3    Ntambi, J.M.4
  • 28
    • 34948904815 scopus 로고    scopus 로고
    • Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
    • Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, et al. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med 2007;13:1193-202.
    • (2007) Nat Med , vol.13 , pp. 1193-1202
    • Matsuzaka, T.1    Shimano, H.2    Yahagi, N.3    Kato, T.4    Atsumi, A.5    Yamamoto, T.6
  • 29
    • 43249127067 scopus 로고    scopus 로고
    • Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    • Flowers MT, Ntambi JM. Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr Opin Lipidol 2008;19:248-56.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 248-256
    • Flowers, M.T.1    Ntambi, J.M.2
  • 30
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry JD, Brown NF. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 1997;244:1-14.
    • (1997) Eur J Biochem , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 31
    • 36448991861 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    • Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab 2007;6:484-96.
    • (2007) Cell Metab , vol.6 , pp. 484-496
    • Miyazaki, M.1    Flowers, M.T.2    Sampath, H.3    Chu, K.4    Otzelberger, C.5    Liu, X.6
  • 32
    • 14544289119 scopus 로고    scopus 로고
    • Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein- 1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver
    • Dentin R, Girard J, Postic C. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein- 1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie 2005;87:81-6.
    • (2005) Biochimie , vol.87 , pp. 81-86
    • Dentin, R.1    Girard, J.2    Postic, C.3
  • 33
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 2006;116:607-14.
    • (2006) J Clin Invest , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 34
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of SREBP-1c transcription and stimulation of fatty acid synthesis in liver
    • Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of SREBP-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci USA 2004;101:11245-50.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 35
    • 33845587711 scopus 로고    scopus 로고
    • Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice
    • Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab 2007;5:73-9.
    • (2007) Cell Metab , vol.5 , pp. 73-79
    • Chen, W.1    Chen, G.2    Head, D.L.3    Mangelsdorf, D.J.4    Russell, D.W.5
  • 37
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X recep-tor agonists in mice with selective deficiency of sterol regulatory element- binding protein-1c
    • Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. Diminished hepatic response to fasting/refeeding and liver X recep-tor agonists in mice with selective deficiency of sterol regulatory element- binding protein-1c. J Biol Chem 2002;277:9520-8.
    • (2002) J Biol Chem , vol.277 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6
  • 38
    • 2442489891 scopus 로고    scopus 로고
    • Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression
    • Dentin R, Pegorier JP, Benhamed F, Foufelle F, Ferre P, Fauveau V, et al. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 2004;279(19):20314-26.
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 20314-20326
    • Dentin, R.1    Pegorier, J.P.2    Benhamed, F.3    Foufelle, F.4    Ferre, P.5    Fauveau, V.6
  • 39
    • 33847006599 scopus 로고    scopus 로고
    • The Liver X Receptor (LXR) and Hepatic Lipogenesis: The carbohydrate-response element-binding protein is a target gene of LXR
    • Cha JY, Repa JJ. The Liver X Receptor (LXR) and Hepatic Lipogenesis: The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 2007;282:743-51.
    • (2007) J Biol Chem , vol.282 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 40
    • 40549125618 scopus 로고    scopus 로고
    • ChREBP, but not LXRs, is required for the induction of glucose- regulated genes in mouse liver
    • Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, et al. ChREBP, but not LXRs, is required for the induction of glucose- regulated genes in mouse liver. J Clin Invest 2008;118:956-64.
    • (2008) J Clin Invest , vol.118 , pp. 956-964
    • Denechaud, P.D.1    Bossard, P.2    Lobaccaro, J.M.3    Millatt, L.4    Staels, B.5    Girard, J.6
  • 41
    • 0024372988 scopus 로고
    • Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture
    • Decaux JF, Antoine B, Kahn A. Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture. J Biol Chem 1989;264:11584-90.
    • (1989) J Biol Chem , vol.264 , pp. 11584-11590
    • Decaux, J.F.1    Antoine, B.2    Kahn, A.3
  • 42
    • 33749370739 scopus 로고    scopus 로고
    • Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice
    • Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, et al. Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice. Diabetes 2006;55:2159-70.
    • (2006) Diabetes , vol.55 , pp. 2159-2170
    • Dentin, R.1    Benhamed, F.2    Hainault, I.3    Fauveau, V.4    Foufelle, F.5    Dyck, J.R.6
  • 43
    • 33746536677 scopus 로고    scopus 로고
    • Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis
    • Uyeda K, Repa JJ. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 2006;4:107-10.
    • (2006) Cell Metab , vol.4 , pp. 107-110
    • Uyeda, K.1    Repa, J.J.2
  • 44
    • 0038561165 scopus 로고    scopus 로고
    • Xylulose 5- phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate- activated protein phosphatase in rat liver
    • Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. Xylulose 5- phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate- activated protein phosphatase in rat liver. Proc Natl Acad Sci USA 2003;100:5107-12.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5107-5112
    • Kabashima, T.1    Kawaguchi, T.2    Wadzinski, B.E.3    Uyeda, K.4
  • 45
    • 29644446917 scopus 로고    scopus 로고
    • Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism
    • Tsatsos NG, Towle HC. Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism. Biochem Biophys Res Commun 2006;340:449-56.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 449-456
    • Tsatsos, N.G.1    Towle, H.C.2
  • 46
    • 33745297834 scopus 로고    scopus 로고
    • Glucosedependent transcriptional regulation by an evolutionarily conserved glucose-sensing module
    • Li MV, Chang B, Imamura M, Poungvarin N, Chan L. Glucosedependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes 2006;55:1179-89.
    • (2006) Diabetes , vol.55 , pp. 1179-1189
    • Li, M.V.1    Chang, B.2    Imamura, M.3    Poungvarin, N.4    Chan, L.5
  • 47
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: modulation by nutrients and inflammation
    • Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 2008;118:2992-3002.
    • (2008) J Clin Invest , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 48
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007;45:1366-74.
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6
  • 50
    • 34347235098 scopus 로고    scopus 로고
    • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    • Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 2007;6: 69-78.
    • (2007) Cell Metab , vol.6 , pp. 69-78
    • Monetti, M.1    Levin, M.C.2    Watt, M.J.3    Sajan, M.P.4    Marmor, S.5    Hubbard, B.K.6
  • 51
    • 53149101726 scopus 로고    scopus 로고
    • Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
    • Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, et al. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res 2008;49:2038-44.
    • (2008) J Lipid Res , vol.49 , pp. 2038-2044
    • Minehira, K.1    Young, S.G.2    Villanueva, C.J.3    Yetukuri, L.4    Oresic, M.5    Hellerstein, M.K.6
  • 52
    • 35148881190 scopus 로고    scopus 로고
    • Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    • Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, et al. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med 2007;20:351-8.
    • (2007) Int J Mol Med , vol.20 , pp. 351-358
    • Kohjima, M.1    Enjoji, M.2    Higuchi, N.3    Kato, M.4    Kotoh, K.5    Yoshimoto, T.6
  • 53
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • (in press)
    • Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, et al. Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 2008 (in press).
    • (2008) Hepatol Res
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3    Tajiri, H.4    Tanaka, M.5    Yamashita, N.6
  • 54
    • 55049084785 scopus 로고    scopus 로고
    • Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP
    • (Paris)
    • Robichon C, Girard J, Postic C. Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP. Med Sci (Paris) 2008;24:841-6.
    • (2008) Med Sci , vol.24 , pp. 841-846
    • Robichon, C.1    Girard, J.2    Postic, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.