The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer

Breast Cancer Research and Treatment

Volumn 122, Issue 1, 2010, Pages 105-110

  McIntyre, Emmet ^a   Blackburn, Edith ^a   Brown, Philip J ^a   Johnson, Colin G ^a   Gullick, William J ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

Author keywords

Breast cancer; ErbB; Growth factor; Growth factor receptor; Prognosis

Indexed keywords

AMPHIREGULIN; BETACELLULIN; CYCLOPHOSPHAMIDE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPIREGULIN; FLUOROURACIL; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; METHOTREXATE; NEU DIFFERENTIATION FACTOR; NEUREGULIN 1ALPHA; NEUREGULIN 2ALPHA; NEUREGULIN 2BETA; NEUREGULIN 4; TAMOXIFEN; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; AREG PROTEIN, HUMAN; BTC PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; EPGN PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR DERIVATIVE; EPIGEN; ERBB2 PROTEIN, HUMAN; ERBB4 PROTEIN, HUMAN; GLYCOPROTEIN; GROWTH FACTOR RECEPTOR; LIGAND; SIGNAL PEPTIDE; TUMOR PROTEIN;

ARTICLE; BREAST CANCER; BREAST SURGERY; CANCER RADIOTHERAPY; CANCER RELAPSE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; BIOSYNTHESIS; BREAST TUMOR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTIGENE FAMILY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTO ONCOGENE;

BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; EPIDERMAL GROWTH FACTOR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, ERBB; GENES, ERBB-1; GENES, ERBB-2; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MULTIGENE FAMILY; NEOPLASM PROTEINS; NEUREGULINS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; RECEPTORS, GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; BETACELLULIN; EGF FAMILY OF PROTEINS; EPIGEN; RECEPTOR, ERBB-4;

EID: 77953544706     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0536-5     Document Type: Article

References (18)

1. RA Stein JV Staros 2006 Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis BMC Evol Biol 6 79 10.1186/1471-2148-6-79 17026767 (Pubitemid 44612714)
2. NV Hayes WJ Gullick 2008 The Neuregulin family of genes and their multiple splice variants in breast cancer J Mammary Gland Biol Neoplasia 13 205 214 10.1007/s10911-008-9078-4 18415007
3. M Sundvall K Iljin S Kilpinen H Sara OP Kallioniemi K Elenius 2008 Role of ErbB4 in breast cancer J Mammary Gland Biol Neoplasia 13 259 268 10.1007/s10911-008-9079-3 18454307
4. Lemmon MA (2009) Ligand-induced receptor dimerisation. Exp Cell Res 315:638-648
5. CG Johnson JP Goldman WJ Gullick 2004 Simulating intracellular processes using object-oriented computational modelling Prog Biophys Mol Biol 86 379 406 10.1016/j.pbiomolbio.2003.11.001 15302205 (Pubitemid 39081524)
6. M Scaltriti J Baselga 2006 The epidermal growth factor receptor pathway: a model for targeted therapy Clin Cancer Res 12 5268 5272 10.1158/1078-0432.CCR- 05-1554 1:CAS:528:DC%2BD28XpvFShs74%3D 17000658 (Pubitemid 44497237)
7. BS Kochupurakkai D Harari A Di-Segni G Maik-Rachline L Lyass G Gur G Kerber A Citri S Lavi R Eilam V Chalifa-Caspi Z Eshhar E Pikarsky R Pinkas-Kramarski SS Bacuss Y Yarden 2005 Epigen the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity J Biol Chem 280 8503 8512 10.1074/jbc.M413919200 (Pubitemid 40349755)
8. H Toyoda T Komurasaki D Uchida Y Takayama T Isobe Y Okuyama K Hanada 1995 Epiregulin: A novel epidermal growth factor with mitogenic activity for rat primary hepaocytes J Biol Chem 270 7495 7500 10.1074/jbc.270.13.7495 1:CAS:528:DyaK2MXkvVOjsLc%3D 7706296
9. WJ Gullick JJ Marsden N Whittle B Ward L Bobrow MD Waterfield 1986 Expression of epidermal growth factor receptors on cervical, ovarian and vulval carcinomas Cancer Res 46 285 292 1:CAS:528:DyaL28XmtlalsA%3D%3D 2998607
10. WJ Gullick MS Berger PLP Bennett JB Rothbard MD Waterfield 1987 Expression of the c-erbB-2 protein in normal and transformed cells Int J Cancer 40 246 254 10.1002/ijc.2910400221 1:CAS:528:DyaL2sXltlWrtro%3D 3301694
11. T Rajkumar U Majhi V Malligarjuna V Shantha WJ Gullick 1995 Prevalence of c-erbB-3 expression in squamous cell carcinomas of the cervix as determined by the monoclonal antibody RTJ-2 Int J Oncol 6 105 109 1:CAS:528:DyaK2MXjsF2jsrY%3D
12. R Srinivasan R Poulsom HC Hurst WJ Gullick 1998 Expression of the HER4/c-erbB-4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types J Pathol 185 236 245 10.1002/(SICI)1096- 9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7 1:CAS:528:DyaK1cXlsVOitLg%3D 9771476 (Pubitemid 28320044)
13. T Saeki C-F Qi G Johnson WJ Gullick E Tahara N Normanno F Ciardiello N Kenney K Stromberg DS Salomon 1992 Differential immunohistochemical detection of amphiregulin and cripto in normal and malignant human colon Cancer Res 52 3467 3473 1:CAS:528:DyaK38XlsVyhsLw%3D 1596904
14. K Chobotava I Spyropolou J Carver S Manek JK Heath WJ Gullick DH Barlow IL Sargent HJ Mardon 2002 Heparin binding epidermal growth factor and its receptors mediate implantation of the human blastocyst Mech Dev 119 137 144 10.1016/S0925-4773(02)00342-8 (Pubitemid 35430103)
15. R Srinivasan E Benton F McCormick WJ Gullick 1999 Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta and Betacellulin, in normal endometrium and endometrial cancer Clin Cancer Res 5 2877 2883 1:STN:280: DC%2BD3c%2FgsFOnug%3D%3D 10537356
16. N Normanno C-F Qi WJ Gullick G Persico Y Yarden D Wen G Plowman N Kenny G Johnson N Kim R Brandt I Soarez RB Dickson DS Salomon 1993 Expression of Amphiregulin, cripto-1 and Heregulin alpha in human breast cancer cells Int J Oncol 2 903 911 1:CAS:528:DyaK3sXkvFamtrY%3D
17. M Dunn P Sinha R Campbell E Blackburn N Levinson R Rampaul T Bates S Humphreys W Gullick 2004 Co-expression of Neuregulin 1, 2, 3 and 4 in human breast cancer J Pathol 203 672 680 10.1002/path.1561 1:CAS:528: DC%2BD2cXlsVWkurw%3D 15141382 (Pubitemid 38714104)
18. NVL Hayes E Blackburn LV Smart M Boyle G Russell T Frost B Morgan AJ Baines WJ Gullick 2007 Identification and characterisation of novel spliced variants of NRG4 in prostate cancer Clin Cancer Res 13 3147 3155 10.1158/1078-0432.CCR-06-2237 1:CAS:528:DC%2BD2sXmtVajtbg%3D 17545517 (Pubitemid 46944896)