The Lipid Phenotype of Breast Cancer Cells Characterized by Raman Microspectroscopy: Towards a Stratification of Malignancy

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Nieva, Claudia ^a,b   Marro, Monica ^b   Santana Codina, Naiara ^a,c   Rao, Satish ^d   Petrov, Dmitri ^b,e   Sierra, Angels ^a  

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b ICFO INSTITUT DE CIENCIES FOTONIQUES   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; LIPID; PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ABCA1 GENE; ARTICLE; BREAST CANCER; CANCER CELL; CELL METABOLISM; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FAT CONTENT; FATTY ACID DESATURATION; GENE; GENE EXPRESSION; LIPID COMPOSITION; METASTASIS POTENTIAL; PARTIAL LEAST SQUARES REGRESSION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN CONTENT; RAMAN MICROSPECTROSCOPY; RAMAN SPECTROMETRY; SENSITIVITY AND SPECIFICITY; SREBP 1C GENE;

BREAST NEOPLASMS; CELL LINE, TUMOR; DISCRIMINANT ANALYSIS; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEAST-SQUARES ANALYSIS; LIPID METABOLISM; MICROSPECTROPHOTOMETRY; NEOPLASM METASTASIS; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; SPECTRUM ANALYSIS, RAMAN;

EID: 84867627192     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046456     Document Type: Article

References (55)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide. IARC CancerBase Lyon, France: International Agency for Research on Cancer.
2. American Cancer Society: Cancer Facts and Figures 2010 (2010) Atlanta.
3. Sleeman J, Steeg PS, (2010) Cancer metastasis as a therapeutic target. Eur J Cancer 46: 1177-1180.
4. Weil RJ, Palmieri DC, Bronder JL, Stark AM, Steeg PS, (2005) Breast cancer metastasis to the central nervous system. Am J Pathol 167: 913-920.
5. Rodenhiser D, Andrews JD, Vandenberg TA, Chambers AF, (2011) Gene signatures of breast cancer progression and metastasis. Breast Cancer Res 13: 201-208.
6. Guedj M, Marisa L, de Reynies A, Orsetti B, Schiappa R, et al. (2012) A refined molecular taxonomy of breast cancer. Oncogene 31: 1196-1206.
7. Brough R, Frankum JR, Sims D, Mackay A, Mendes-Pereira AM, et al. (2011) Functional viability profiles of breast cancer. 1: 261-273.
8. Kasaian K, Jones S JM, (2011) A new frontier in personalized cancer therapy: mapping molecular changes. Future oncology 7: 873-894.
9. Koppenol WH, Bounds PL, Dang CV, (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325-37.
10. Bayley JP, Devilee P, (2012) The Warburg effect in 2012. Curr Opin Oncol 24: 62-7.
11. Simpson NE, Tryndyak VP, Beland FA, Pogribny IP, (2012) An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression. Breast Cancer Res Treat 133: 959-68.
12. Hu H, Deng C, Yang T, Dong Q, Chen Y, et al. (2011) Proteomics revisits the cancer metabolome. Expert Rev Proteomics 8: 505-33.
13. Vazquez-Martin A, Colomer R, Brunet J, Lupu R, Menendez JA, (2008) Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif 41: 59-85.
14. Hilvo M, Denkert C, Lehtinen L, Müller B, Brockmöller S, et al. (2011) Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res 71: 3236-45.
15. Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, et al. (2011) An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery 1: 442-456.
16. Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, et al. (2011) PGC1α promotes tumor growth by inducing gene expression programs supporting Lipogenesis. Cancer Res 71: 6888-98.
17. Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, et al. (2010) De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res 70: 8117-26.
18. Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, et al. (2011) Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology 140: 1071-83.
19. Vedin L-L, Lewandowski SA, Parini P, Gustafsson JA, Steffensen KR, (2009) The oxysterol receptor LXR inhibits proliferation of human breast cancer cells. Carcinogenesis 30: 575-579.
20. Freudiger CW, Min W, Saar BG, Lu S, Holtom GR, et al. (2008) Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science 322: 1857-1861.
21. Popp J, Krafft DC, Mayerhöfer T, (2011) Modern Raman spectroscopy for biomedical applications. A variety of Raman spectroscopical techniques on the threshold of biomedical applications. Optik and Photonik 6: 24-28.
22. Min W, Freudiger CW, Lu S, Xie XS, (2011) Coherent nonlinear optical imaging: beyond fluorescence microscopy. Annu Rev Phys Chem 62: 507-30.
23. Fen MB, Xanthopoulos P, Pyrgiotakis G, Grobmyer SR, Pardalos PM, et al. (2011) Raman Spectroscopy for Clinical Oncology. Advances in Optical Technologies doi:10.1155/2011/213783.
24. Pichardo-Molina JL, Frausto-Reyes C, Barbosa-García O, Huerta-Franco R, González-Trujillo JL, et al. (2007) Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients. Lasers med sci 22: 239-236.
25. Lieber CA, Nethercott HE, Kabeer MH, (2010) Cancer field effects in normal tissues revealed by Raman spectroscopy. Biomed Opt Express 1: 975-982.
26. Jackson JE (1991) A User's Guide to Principal Components. New York: Wiley.
27. Westerhuis JA, Hoefsloot HCJ, Smit S, Vis DJ, Smilde AK, et al. (2008) Assessment of PLS-DA cross validation. Metabolomics 4: 81-89.
28. Sarrió D, Rodriguez-Pinilla SM, Hardisson D, Cano A, Moreno-Bueno G, et al. (2008) Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res 68: 989-97.
29. Mikhailyuk I, Razzhivin A, (2003) Background subtraction in experimental data arrays illustrated by the exemple of Raman spectra and fluorescent gel electrophoresis paterns. Instrum Exp Tech 46: 765-769.
30. Bocklitz T, Walter A, Hartmann K, Rösch P, Popp J, (2011) How to pre-process Raman spectra for reliable and stable models?. Analytica Chimica Acta 704: 47-56.
31. Zelcer N, Hong C, Boyadjian R, Tontonoz P, (2009) LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor. Science 325: 100-104.
32. Rawson RB, (2003) The SREBP pathway-insights from Insigs and insects. Nature Rev Mol Cell Biol 4: 631-640.
33. Voss MJ, Möller MF, Powe DG, Niggemann B, Zänker KS, et al. (2011) Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism. BMC Cancer 11: 158.
34. Rudolph MC, Monks J, Burns V, Phistry M, Marians R, et al. (2010) Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium. AJP - Endo 299: 918-927.
35. Van de Sande T, De Schrijver E, Heyns W, Verhoeven G, Swinnen JV, (2002) Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res 62: 642-646.
36. Porstmannm T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, et al. (2005) PKB/AKT induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24: 6465-6481.
37. Agelopoulos K, Greve B, Schmidt H, Pospisil H, Kurtz S, et al. (2010) Selective regain of egfr gene copies in CD44+/CD24-/low breast cancer cellular model MDA-MB-468. BMC Cancer 10: 78.
38. Jones RG, Thompson CB, (2009) Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 23: 537-548.
39. Cairns RA, Harris IS, Mak TW, (2011) Regulation of cancer cell metabolism. Nature Reviews 11: 85-95.
40. Antalis CJ, Arnold T, Rasool T, Lee B, Buhman KK, et al. (2010) High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation. Breast Cancer Res Treat 122: 661-670.
41. Antalis CJ, Uchida A, Buhman KK, Siddiqui RA, (2011) Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification. Clin Exp Metastases 28: 733-741.
42. Diaz G, Melisa M, Batetta B, Angius F, Falchi AM, (2008) Hydrophobic characterization of intracellular lipids in situ by Nile Red red/yellow emission ratio. Micron 39: 819-824.
43. Menendez J, Lupu R, (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nature reviews 7: 763-777.
44. Knowles LM, Smith JW, (2007) Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer. BMC Genomics 8: 168.
45. Movasaghi Z, Rehman S, Rehman IU, (2007) Raman spectroscopy of biological tissues. Appl spectrosc reviews 42: 493-541.
46. García-Flores AF, Raniero L, Canevari RA, Jalkanen KJ, Bitar RA, et al. (2011) High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer. Theor Chem Acc 130: 1231-1238.
47. Moreno-Bueno G, Portillo F, Cano A, (2008) Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27: 6958-6969.
48. Polyak K, Weinberg RA, (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273.
49. Tomaskovic-Crook E, Thompson EW, Thiery JP, (2009) Epithelial to mesenchymal transition and breast cancer. Breast Cancer Research 11: 213.
50. Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, et al. (2011) Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 121: 2750-2767.
51. Tavassoli F, Devilee P (2003) WHO Classification of Tumors. Pathology & Genetics: Tumors of the breast and female genital organs. Lyon (France): IARC Pres.
52. Hartsuiker L, Zeijen NJ, Terstappen LW, Otto C, (2010) A comparison of breast cancer tumor cells with varying expression of the Her2/neu receptor by Raman microspectroscopic imaging. Analyst 135: 3220-3226.
53. Raniero L, Canevari RA, Ramalho LNZ, Ramalho FS, dos Santos EAP, et al. (2011) In and ex vivo breast disease study by Raman spectroscopy. Theor Chem Acc 130: 1239-1247.
54. Rehman S, Movasaghi Z, Tucker AT, Joel SP, Darr JA, et al. (2007) Raman spectroscopic analysis of reast cancer tissues: identifying differences between normal, invasive ductal carcinoma and ductal carcinoma in situ of the breast tissue. J Raman Spectrosc 38: 1345-1351.
55. Pichardo-Molina JL, Frausto-Reyes C, Barbosa-García O, Huerta-Franco R, González-Trujillo G, et al. (2007) Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients. Lasers Med Sci 22: 229-236.