-
1
-
-
84883720120
-
Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia
-
Van Vlierberghe P, Ambesi-Impiombato A, De Keersmaecker K, et al. Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia. Blood 2013; 122:74-82.
-
(2013)
Blood
, vol.122
, pp. 74-82
-
-
Van Vlierberghe, P.1
Ambesi-Impiombato, A.2
De Keersmaecker, K.3
-
3
-
-
84862907593
-
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
-
Zhang J, Ding L, Holmfeldt L, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012; 481:157-163.
-
(2012)
Nature
, vol.481
, pp. 157-163
-
-
Zhang, J.1
Ding, L.2
Holmfeldt, L.3
-
4
-
-
84873084751
-
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
-
De Keersmaecker K, Atak ZK, Li N, et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet 2013; 45:186-190.
-
(2013)
Nat Genet
, vol.45
, pp. 186-190
-
-
De Keersmaecker, K.1
Atak, Z.K.2
Li, N.3
-
5
-
-
84875158235
-
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL
-
Tzoneva G, Perez-Garcia A, Carpenter Z, et al. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med 2013; 19:368-371.
-
(2013)
Nat Med
, vol.19
, pp. 368-371
-
-
Tzoneva, G.1
Perez-Garcia, A.2
Carpenter, Z.3
-
6
-
-
77958124683
-
Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia
-
Tremblay CS, Hoang T, Hoang T. Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia. Prog Mol Biol Transl Sci 2010; 92:121-156.
-
(2010)
Prog Mol Biol Transl Sci
, vol.92
, pp. 121-156
-
-
Tremblay, C.S.1
Hoang, T.2
Hoang, T.3
-
7
-
-
57149118627
-
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia
-
Mullighan CG, Phillips LA, Su X, et al. Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 2008; 322:1377-1380.
-
(2008)
Science
, vol.322
, pp. 1377-1380
-
-
Mullighan, C.G.1
Phillips, L.A.2
Su, X.3
-
8
-
-
84894304555
-
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
-
Corces-Zimmerman MR, Hong WJ, Weissman IL, et al. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A 2014; 111:2548-2553.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 2548-2553
-
-
Corces-Zimmerman, M.R.1
Hong, W.J.2
Weissman, I.L.3
-
9
-
-
84894245627
-
Identification of preleukaemic haematopoietic stem cells in acute leukaemia
-
Shlush LI, Zandi S, Mitchell A, et al. Identification of preleukaemic haematopoietic stem cells in acute leukaemia. Nature 2014; 506:328-333.
-
(2014)
Nature
, vol.506
, pp. 328-333
-
-
Shlush, L.I.1
Zandi, S.2
Mitchell, A.3
-
10
-
-
79955711142
-
Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse
-
Clappier E, Gerby B, Sigaux F, et al. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J Exp Med 2011; 208:653-661.
-
(2011)
J Exp Med
, vol.208
, pp. 653-661
-
-
Clappier, E.1
Gerby, B.2
Sigaux, F.3
-
11
-
-
79953735093
-
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
-
Homminga I, Pieters R, Langerak AW, et al. Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell 2011; 19:484-497.
-
(2011)
Cancer Cell
, vol.19
, pp. 484-497
-
-
Homminga, I.1
Pieters, R.2
Langerak, A.W.3
-
12
-
-
84892577298
-
Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have nonrearranged T-cell receptors
-
Zuurbier L, Gutierrez A, Mullighan CG, et al. Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have nonrearranged T-cell receptors. Haematologica 2014; 99:94-102.
-
(2014)
Haematologica
, vol.99
, pp. 94-102
-
-
Zuurbier, L.1
Gutierrez, A.2
Mullighan, C.G.3
-
13
-
-
80052706223
-
Cell of origin strongly influences genetic selection in a mouse model of T-ALL
-
Berquam-Vrieze KE, Nannapaneni K, Brett BT, et al. Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood 2011; 118:4646-4656.
-
(2011)
Blood
, vol.118
, pp. 4646-4656
-
-
Berquam-Vrieze, K.E.1
Nannapaneni, K.2
Brett, B.T.3
-
14
-
-
34347385398
-
Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL
-
Dik WA, Nadel B, Przybylski GK, et al. Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL. Blood 2007; 110:388-392.
-
(2007)
Blood
, vol.110
, pp. 388-392
-
-
Dik, W.A.1
Nadel, B.2
Przybylski, G.K.3
-
15
-
-
84880993951
-
Breakpoint sites disclose the role of the V(D) J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia
-
Larmonie NS, Dik WA, Meijerink JP, et al. Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia. Haematologica 2013; 98:1173-1184.
-
(2013)
Haematologica
, vol.98
, pp. 1173-1184
-
-
Larmonie, N.S.1
Dik, W.A.2
Meijerink, J.P.3
-
16
-
-
84897550064
-
Gene therapy for Wiskott-Aldrich syndrome: Long-term efficacy and genotoxicity
-
Braun CJ, Boztug K, Paruzynski A, et al. Gene therapy for Wiskott-Aldrich syndrome: long-term efficacy and genotoxicity. Sci Transl Med 2014; 6:227-33.
-
(2014)
Sci Transl Med
, vol.6
, pp. 227-233
-
-
Braun, C.J.1
Boztug, K.2
Paruzynski, A.3
-
17
-
-
76749097260
-
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal
-
McCormack MP, Young LF, Vasudevan S, et al. The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science 2010; 327:879-883.
-
(2010)
Science
, vol.327
, pp. 879-883
-
-
McCormack, M.P.1
Young, L.F.2
Vasudevan, S.3
-
18
-
-
77953079694
-
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes
-
Tremblay M, Tremblay CS, Herblot S, et al. Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev 2010; 24:1093-1105.
-
(2010)
Genes Dev
, vol.24
, pp. 1093-1105
-
-
Tremblay, M.1
Tremblay, C.S.2
Herblot, S.3
-
19
-
-
84876571061
-
Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia
-
Cleveland SM, Smith S, Tripathi R, et al. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 2013; 31:882-894.
-
(2013)
Stem Cells
, vol.31
, pp. 882-894
-
-
Cleveland, S.M.1
Smith, S.2
Tripathi, R.3
-
20
-
-
84902293435
-
LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways
-
Smith S, Tripathi R, Goodings C, et al. LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS One 2014; 9:e85883.
-
(2014)
PLoS One
, vol.9
-
-
Smith, S.1
Tripathi, R.2
Goodings, C.3
-
21
-
-
84865109759
-
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
-
Sanda T, Lawton LN, Barrasa MI, et al. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell 2012; 22:209-221.
-
(2012)
Cancer Cell
, vol.22
, pp. 209-221
-
-
Sanda, T.1
Lawton, L.N.2
Barrasa, M.I.3
-
22
-
-
77957348625
-
Combinatorial transcriptional control in blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators
-
Wilson NK, Foster SD, Wang X, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 2010; 7:532-544.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 532-544
-
-
Wilson, N.K.1
Foster, S.D.2
Wang, X.3
-
23
-
-
84884263191
-
The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia
-
Mansour MR, Sanda T, Lawton LN, et al. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med 2013; 210:1545-1557.
-
(2013)
J Exp Med
, vol.210
, pp. 1545-1557
-
-
Mansour, M.R.1
Sanda, T.2
Lawton, L.N.3
-
24
-
-
84880263370
-
Novel TAL1 targets beyond proteincoding genes: Identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia
-
Correia NC, Durinck K, Leite AP, et al. Novel TAL1 targets beyond proteincoding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia. Leukemia 2013; 27:1603-1606.
-
(2013)
Leukemia
, vol.27
, pp. 1603-1606
-
-
Correia, N.C.1
Durinck, K.2
Leite, A.P.3
-
25
-
-
84887650018
-
Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes
-
Beck D, Thoms JA, Perera D, et al. Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes. Blood 2013; 122:e12-e22.
-
(2013)
Blood
, vol.122
-
-
Beck, D.1
Thoms, J.A.2
Perera, D.3
-
26
-
-
78149348102
-
The TLX1 oncogene drives aneuploidy in T cell transformation
-
De Keersmaecker K, Real PJ, Della Gatta G, et al. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med 2010; 16:1321-1328.
-
(2010)
Nat Med
, vol.16
, pp. 1321-1328
-
-
De Keersmaecker, K.1
Real, P.J.2
Della Gatta, G.3
-
27
-
-
84887605442
-
MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia
-
Loosveld M, Bonnet M, Gon S, et al. MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer 2014; 53:52-66.
-
(2014)
Genes Chromosomes Cancer
, vol.53
, pp. 52-66
-
-
Loosveld, M.1
Bonnet, M.2
Gon, S.3
-
28
-
-
84873732313
-
The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL
-
Grossmann V, Haferlach C, Weissmann S, et al. The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Genes Chromosomes Cancer 2013; 52:410-422.
-
(2013)
Genes Chromosomes Cancer
, vol.52
, pp. 410-422
-
-
Grossmann, V.1
Haferlach, C.2
Weissmann, S.3
-
29
-
-
84879177403
-
The role of chromatin modifiers in normal and malignant hematopoiesis
-
Butler JS, Dent SY. The role of chromatin modifiers in normal and malignant hematopoiesis. Blood 2013; 121:3076-3084.
-
(2013)
Blood
, vol.121
, pp. 3076-3084
-
-
Butler, J.S.1
Dent, S.Y.2
-
30
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
Challen GA, Sun D, Jeong M, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2012; 44:23-31.
-
(2012)
Nat Genet
, vol.44
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
-
31
-
-
84891372425
-
Large conserved domains of low DNA methylation maintained by Dnmt3a
-
Jeong M, Sun D, Luo M, et al. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet 2014; 46:17-23.
-
(2014)
Nat Genet
, vol.46
, pp. 17-23
-
-
Jeong, M.1
Sun, D.2
Luo, M.3
-
32
-
-
84866378702
-
The role of mutations in epigenetic regulators in myeloid malignancies
-
Shih AH, Abdel-Wahab O, Patel JP, et al. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer 2012; 12:599-612.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 599-612
-
-
Shih, A.H.1
Abdel-Wahab, O.2
Patel, J.P.3
-
33
-
-
84856477048
-
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia
-
Fried I, Bodner C, Pichler MM, et al. Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia. Haematologica 2012; 97:246-250.
-
(2012)
Haematologica
, vol.97
, pp. 246-250
-
-
Fried, I.1
Bodner, C.2
Pichler, M.M.3
-
34
-
-
84862776906
-
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
-
Ding L, Ley TJ, Larson DE, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 2012; 481:506-510.
-
(2012)
Nature
, vol.481
, pp. 506-510
-
-
Ding, L.1
Ley, T.J.2
Larson, D.E.3
-
35
-
-
84864255882
-
The origin and evolution of mutations in acute myeloid leukemia
-
Welch JS, Ley TJ, Link DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 2012; 150:264-278.
-
(2012)
Cell
, vol.150
, pp. 264-278
-
-
Welch, J.S.1
Ley, T.J.2
Link, D.C.3
-
36
-
-
84856747744
-
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
-
Ntziachristos P, Tsirigos A, Van Vlierberghe P, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med 2012; 18:298-301.
-
(2012)
Nat Med
, vol.18
, pp. 298-301
-
-
Ntziachristos, P.1
Tsirigos, A.2
Van Vlierberghe, P.3
-
37
-
-
84859295400
-
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
-
Simon C, Chagraoui J, Krosl J, et al. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev 2012; 26:651-656.
-
(2012)
Genes Dev
, vol.26
, pp. 651-656
-
-
Simon, C.1
Chagraoui, J.2
Krosl, J.3
-
38
-
-
33646870495
-
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
-
Bracken AP, Dietrich N, Pasini D, et al. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006; 20:1123-1136.
-
(2006)
Genes Dev
, vol.20
, pp. 1123-1136
-
-
Bracken, A.P.1
Dietrich, N.2
Pasini, D.3
-
39
-
-
84891740118
-
Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner
-
Xie H, Xu J, Hsu JH, et al. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell 2014; 14:68-80.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 68-80
-
-
Xie, H.1
Xu, J.2
Hsu, J.H.3
-
40
-
-
84891913160
-
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia
-
Piovan E, Yu J, Tosello V, et al. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. Cancer Cell 2013; 24:766-776.
-
(2013)
Cancer Cell
, vol.24
, pp. 766-776
-
-
Piovan, E.1
Yu, J.2
Tosello, V.3
-
41
-
-
37549010335
-
Launching the T-cell-lineage developmental programme
-
Rothenberg EV, Moore JE, Yui MA. Launching the T-cell-lineage developmental programme. Nat Rev Immunol 2008; 8:9-21.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 9-21
-
-
Rothenberg, E.V.1
Moore, J.E.2
Ma, Y.3
-
42
-
-
0035469821
-
Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by downregulating the cyclin-dependent kinase inhibitor p27(kip1)
-
Barata JT, Cardoso AA, Nadler LM, et al. Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by downregulating the cyclin-dependent kinase inhibitor p27(kip1). Blood 2001; 98:1524-1531.
-
(2001)
Blood
, vol.98
, pp. 1524-1531
-
-
Barata, J.T.1
Cardoso, A.A.2
Nadler, L.M.3
-
43
-
-
80053385665
-
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
-
Zenatti PP, Ribeiro D, Li W, et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet 2011; 43:932-939.
-
(2011)
Nat Genet
, vol.43
, pp. 932-939
-
-
Zenatti, P.P.1
Ribeiro, D.2
Li, W.3
-
44
-
-
84878596429
-
IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia
-
Ribeiro D, Melao A, Barata JT. IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia. Adv Biol Regul 2013; 53:211-222.
-
(2013)
Adv Biol Regul
, vol.53
, pp. 211-222
-
-
Ribeiro, D.1
Melao, A.2
Barata, J.T.3
-
45
-
-
84891303638
-
In vivo leukemogenic potential of an interleukin 7 receptor alpha chain mutant in hematopoietic stem and progenitor cells
-
Yokoyama K, Yokoyama N, Izawa K, et al. In vivo leukemogenic potential of an interleukin 7 receptor alpha chain mutant in hematopoietic stem and progenitor cells. Blood 2013; 122:4259-4263.
-
(2013)
Blood
, vol.122
, pp. 4259-4263
-
-
Yokoyama, K.1
Yokoyama, N.2
Izawa, K.3
-
46
-
-
79960414811
-
IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias
-
Silva A, Laranjeira AB, Martins LR, et al. IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias. Cancer Res 2011; 71:4780-4789.
-
(2011)
Cancer Res
, vol.71
, pp. 4780-4789
-
-
Silva, A.1
Laranjeira, A.B.2
Martins, L.R.3
-
47
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306:269-271.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
-
48
-
-
84865861232
-
Notch signaling expands a premalignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency
-
Blackburn JS, Liu S, Raiser DM, et al. Notch signaling expands a premalignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia 2012; 26:2069-2078.
-
(2012)
Leukemia
, vol.26
, pp. 2069-2078
-
-
Blackburn, J.S.1
Liu, S.2
Raiser, D.M.3
-
49
-
-
51349169034
-
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
-
Chiang MY, Xu L, Shestova O, et al. Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest 2008; 118:3181-3194.
-
(2008)
J Clin Invest
, vol.118
, pp. 3181-3194
-
-
Chiang, M.Y.1
Xu, L.2
Shestova, O.3
-
50
-
-
58149308526
-
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
-
Li X, Gounari F, Protopopov A, et al. Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. J Exp Med 2008; 205:2851-2861.
-
(2008)
J Exp Med
, vol.205
, pp. 2851-2861
-
-
Li, X.1
Gounari, F.2
Protopopov, A.3
-
51
-
-
84873578601
-
Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells
-
Chiang MY, Shestova O, Xu L, et al. Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood 2013; 121:905-917.
-
(2013)
Blood
, vol.121
, pp. 905-917
-
-
Chiang, M.Y.1
Shestova, O.2
Xu, L.3
-
52
-
-
33746546368
-
C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng AP, Millholland JM, Yashiro-Ohtani Y, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev 2006; 20:2096-2109.
-
(2006)
Genes Dev
, vol.20
, pp. 2096-2109
-
-
Weng, A.P.1
Millholland, J.M.2
Yashiro-Ohtani, Y.3
-
53
-
-
84879364450
-
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
-
King B, Trimarchi T, Reavie L, et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 2013; 153:1552-1566.
-
(2013)
Cell
, vol.153
, pp. 1552-1566
-
-
King, B.1
Trimarchi, T.2
Reavie, L.3
-
54
-
-
34347369749
-
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
-
Chan SM, Weng AP, Tibshirani R, et al. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood 2007; 110:278-286.
-
(2007)
Blood
, vol.110
, pp. 278-286
-
-
Chan, S.M.1
Weng, A.P.2
Tibshirani, R.3
-
55
-
-
61849087835
-
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases
-
Joshi I, Minter LM, Telfer J, et al. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood 2009; 113:1689-1698.
-
(2009)
Blood
, vol.113
, pp. 1689-1698
-
-
Joshi, I.1
Minter, L.M.2
Telfer, J.3
-
56
-
-
84867602759
-
Therapeutic targeting of the cyclin D3:CDK4/ 6 complex in T cell leukemia
-
Sawai CM, Freund J, Oh P, et al. Therapeutic targeting of the cyclin D3:CDK4/ 6 complex in T cell leukemia. Cancer Cell 2012; 22:452-465.
-
(2012)
Cancer Cell
, vol.22
, pp. 452-465
-
-
Sawai, C.M.1
Freund, J.2
Oh, P.3
-
57
-
-
84902080598
-
Activity of the pan-class i phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia
-
doi: 10.1038/leu. 2013.369
-
Lonetti A, Antunes IL, Chiarini F, et al. Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia. Leukemia 2013. doi: 10.1038/leu. 2013.369.
-
(2013)
Leukemia
-
-
Lonetti, A.1
Antunes, I.L.2
Chiarini, F.3
-
58
-
-
84896076685
-
C-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells
-
Roderick JE, Tesell J, Shultz LD, et al. c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood 2014; 123:1040-1050.
-
(2014)
Blood
, vol.123
, pp. 1040-1050
-
-
Roderick, J.E.1
Tesell, J.2
Shultz, L.D.3
-
59
-
-
84896124109
-
Murine Pten T-ALL requires nonredundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and gammac/TCR signals for thymic exit
-
Hagenbeek TJ, Wu X, Choy L, et al. Murine Pten T-ALL requires nonredundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and gammac/TCR signals for thymic exit. Cancer Lett 2014; 346:237-248.
-
(2014)
Cancer Lett
, vol.346
, pp. 237-248
-
-
Hagenbeek, T.J.1
Wu, X.2
Choy, L.3
-
60
-
-
84861915311
-
High accuracy mutation detection in leukemia on a selected panel of cancer genes
-
Atak ZK, De Keersmaecker K, Gianfelici V, et al. High accuracy mutation detection in leukemia on a selected panel of cancer genes. Plos One 2012; 7:7; e38463.
-
(2012)
Plos One
, vol.77
-
-
Atak, Z.K.1
De Keersmaecker, K.2
Gianfelici, V.3
-
61
-
-
84889598519
-
Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
-
Li Q, Bohin N, Wen T, et al. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature 2013; 504:143-147.
-
(2013)
Nature
, vol.504
, pp. 143-147
-
-
Li, Q.1
Bohin, N.2
Wen, T.3
-
62
-
-
84864450119
-
Nras overexpression results in granulocytosis T-cell expansion and early lethality in mice
-
Lassen LB, Ballarin-Gonzalez B, Schmitz A, et al. Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice. PLoS One 2012; 7:e42216.
-
(2012)
PLoS One
, vol.7
-
-
Lassen, L.B.1
Ballarin-Gonzalez, B.2
Schmitz, A.3
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