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Volumn 122, Issue 14, 2013, Pages e12-e22

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; MICRORNA; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR LMO2; TRANSCRIPTION FACTOR LYL1; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

EID: 84887650018     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-03-490425     Document Type: Article
Times cited : (118)

References (55)
  • 1
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000; 404(6774):193-197.
    • (2000) Nature , vol.404 , Issue.6774 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 2
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91(5):661-672.
    • (1997) Cell , vol.91 , Issue.5 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 3
    • 20244387299 scopus 로고    scopus 로고
    • Identification of Flt31 lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
    • Adolfsson J, Mansson R, Buza-Vidas N, et al. Identification of Flt31 lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell. 2005;121(2):295-306.
    • (2005) Cell , vol.121 , Issue.2 , pp. 295-306
    • Adolfsson, J.1    Mansson, R.2    Buza-Vidas, N.3
  • 4
    • 66549084876 scopus 로고    scopus 로고
    • Bloodomics Consortium. A HaemAtlas: Characterizing gene expression in differentiated human blood cells
    • Watkins NA, Gusnanto A, de Bono B, et al; Bloodomics Consortium. A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood. 2009;113(19):e1-e9.
    • (2009) Blood , vol.113 , Issue.19 , pp. e1-e9
    • Watkins, N.A.1    Gusnanto, A.2    De Bono, B.3
  • 5
    • 78651486442 scopus 로고    scopus 로고
    • Densely interconnected transcriptional circuits control cell states in human hematopoiesis
    • Novershtern N, Subramanian A, Lawton LN, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309.
    • (2011) Cell , vol.144 , Issue.2 , pp. 296-309
    • Novershtern, N.1    Subramanian, A.2    Lawton, L.N.3
  • 6
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5): 861-872.
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 7
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 2010;463(7284):1035-1041.
    • (2010) Nature , vol.463 , Issue.7284 , pp. 1035-1041
    • Vierbuchen, T.1    Ostermeier, A.2    Pang, Z.P.3    Kokubu, Y.4    Sudhof, T.C.5    Wernig, M.6
  • 8
    • 39349096526 scopus 로고    scopus 로고
    • Hematopoiesis: An evolving paradigm for stem cell biology
    • Orkin SH, Zon LI. Hematopoiesis: An evolving paradigm for stem cell biology. Cell. 2008;132(4): 631-644.
    • (2008) Cell , vol.132 , Issue.4 , pp. 631-644
    • Orkin, S.H.1    Zon, L.I.2
  • 9
    • 36749094041 scopus 로고    scopus 로고
    • Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development
    • Pimanda JE, Ottersbach K, Knezevic K, et al. Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci USA. 2007; 104(45):17692-17697.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.45 , pp. 17692-17697
    • Pimanda, J.E.1    Ottersbach, K.2    Knezevic, K.3
  • 10
    • 1942425445 scopus 로고    scopus 로고
    • SCL is required for normal function of short-Term repopulating hematopoietic stem cells
    • Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG. SCL is required for normal function of short-Term repopulating hematopoietic stem cells. Blood. 2004;103(9):3342-3348.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3342-3348
    • Curtis, D.J.1    Hall, M.A.2    Van, S.L.J.3    Robb, L.4    Jane, S.M.5    Begley, C.G.6
  • 11
    • 2342451948 scopus 로고    scopus 로고
    • AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
    • Ichikawa M, Asai T, Saito T, et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med. 2004;10(3):299-304.
    • (2004) Nat Med , vol.10 , Issue.3 , pp. 299-304
    • Ichikawa, M.1    Asai, T.2    Saito, T.3
  • 12
    • 77957348625 scopus 로고    scopus 로고
    • Combinatorial transcriptional control in blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators
    • Wilson NK, Foster SD, Wang X, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010;7(4):532-544.
    • (2010) Cell Stem Cell , vol.7 , Issue.4 , pp. 532-544
    • Wilson, N.K.1    Foster, S.D.2    Wang, X.3
  • 13
    • 84877930760 scopus 로고    scopus 로고
    • Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia
    • Diffner E, Beck D, Gudgin E, et al. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood. 2013;121(12): 2289-2300.
    • (2013) Blood , vol.121 , Issue.12 , pp. 2289-2300
    • Diffner, E.1    Beck, D.2    Gudgin, E.3
  • 14
    • 58049191558 scopus 로고    scopus 로고
    • Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
    • Cui K, Zang C, Roh TY, et al. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell. 2009;4(1): 80-93.
    • (2009) Cell Stem Cell , vol.4 , Issue.1 , pp. 80-93
    • Cui, K.1    Zang, C.2    Roh, T.Y.3
  • 16
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium
    • Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M; ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012; 489(7414):57-74.
    • (2012) Nature , vol.489 , Issue.7414 , pp. 57-74
    • Bernstein, B.E.1    Birney, E.2    Dunham, I.3    Green, E.D.4    Gunter, C.5    Snyder, M.6
  • 17
    • 53849146020 scopus 로고    scopus 로고
    • Model-based analysis of ChIP-Seq (MACS)
    • Zhang Y, Liu T, Meyer CA, et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137.
    • (2008) Genome Biol , vol.9 , Issue.9 , pp. R137
    • Zhang, Y.1    Liu, T.2    Meyer, C.A.3
  • 18
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz S, Benner C, Spann N, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010; 38(4):576-589.
    • (2010) Mol Cell , vol.38 , Issue.4 , pp. 576-589
    • Heinz, S.1    Benner, C.2    Spann, N.3
  • 19
    • 0028685490 scopus 로고
    • Fitting a mixture model by expectation maximization to discover motifs in biopolymers
    • Bailey TL, Elkan C. Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc Int Conf Intell Syst Mol Biol. 1994;2:28-36.
    • (1994) Proc Int Conf Intell Syst Mol Biol , vol.2 , pp. 28-36
    • Bailey, T.L.1    Elkan, C.2
  • 20
    • 38549096565 scopus 로고    scopus 로고
    • JASPAR, the open access database of transcription factorbinding profiles: New content and tools in the 2008 update
    • Database issue
    • Bryne JC, Valen E, Tang MH, et al. JASPAR, the open access database of transcription factorbinding profiles: new content and tools in the 2008 update. Nucleic Acids Res. 2008;36(Database issue):D102-D106.
    • (2008) Nucleic Acids Res , vol.36 , pp. D102-D106
    • Bryne, J.C.1    Valen, E.2    Tang, M.H.3
  • 21
    • 79953300078 scopus 로고    scopus 로고
    • FIMO: Scanning for occurrences of a given motif
    • Grant CE, Bailey TL, Noble WS. FIMO: scanning for occurrences of a given motif. Bioinformatics. 2011;27(7):1017-1018.
    • (2011) Bioinformatics , vol.27 , Issue.7 , pp. 1017-1018
    • Grant, C.E.1    Bailey, T.L.2    Noble, W.S.3
  • 22
    • 77952214662 scopus 로고    scopus 로고
    • GREAT improves functional interpretation of cis-regulatory regions
    • McLean CY, Bristor D, Hiller M, et al. GREAT improves functional interpretation of cis-regulatory regions. Nat Biotechnol. 2010;28(5):495-501.
    • (2010) Nat Biotechnol , vol.28 , Issue.5 , pp. 495-501
    • McLean, C.Y.1    Bristor, D.2    Hiller, M.3
  • 23
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledgebased approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: A knowledgebased approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545-15550.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 24
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009;25(9):1105-1111.
    • (2009) Bioinformatics , vol.25 , Issue.9 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 26
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15-20.
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 27
    • 84861963461 scopus 로고    scopus 로고
    • DoRiNA: A database of RNA interactions in posttranscriptional regulation
    • Database issue
    • Anders G, Mackowiak SD, Jens M, et al. doRiNA: A database of RNA interactions in posttranscriptional regulation. Nucleic Acids Res. 2012;40(Database issue):D180-D186.
    • (2012) Nucleic Acids Res , vol.40 , pp. D180-D186
    • Anders, G.1    Mackowiak, S.D.2    Jens, M.3
  • 28
    • 38649099445 scopus 로고    scopus 로고
    • Highresolution mapping and characterization of open chromatin across the genome
    • Boyle AP, Davis S, Shulha HP, et al. Highresolution mapping and characterization of open chromatin across the genome. Cell. 2008;132(2): 311-322.
    • (2008) Cell , vol.132 , Issue.2 , pp. 311-322
    • Boyle, A.P.1    Davis, S.2    Shulha, H.P.3
  • 29
    • 84856704764 scopus 로고    scopus 로고
    • A transcription factor collective defines cardiac cell fate and reflects lineage history
    • Junion G, Spivakov M, Girardot C, et al. A transcription factor collective defines cardiac cell fate and reflects lineage history. Cell. 2012; 148(3):473-486.
    • (2012) Cell , vol.148 , Issue.3 , pp. 473-486
    • Junion, G.1    Spivakov, M.2    Girardot, C.3
  • 30
    • 77954842706 scopus 로고    scopus 로고
    • Gene regulatory networks governing haematopoietic stem cell development and identity
    • Pimanda JE, Gottgens B. Gene regulatory networks governing haematopoietic stem cell development and identity. Int J Dev Biol. 2010; 54(6-7):1201-1211.
    • (2010) Int J Dev Biol , vol.54 , Issue.6-7 , pp. 1201-1211
    • Pimanda, J.E.1    Gottgens, B.2
  • 31
    • 79955883317 scopus 로고    scopus 로고
    • Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators
    • Tijssen MR, Cvejic A, Joshi A, et al. Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5): 597-609.
    • (2011) Dev Cell , vol.20 , Issue.5 , pp. 597-609
    • Tijssen, M.R.1    Cvejic, A.2    Joshi, A.3
  • 32
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: Establishing competence for gene expression
    • Zaret KS, Carroll JS. Pioneer transcription factors: Establishing competence for gene expression. Genes Dev. 2011;25(21):2227-2241.
    • (2011) Genes Dev , vol.25 , Issue.21 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 33
    • 0028872728 scopus 로고
    • Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative
    • Adams CC, Workman JL. Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative. Mol Cell Biol. 1995;15(3): 1405-1421.
    • (1995) Mol Cell Biol , vol.15 , Issue.3 , pp. 1405-1421
    • Adams, C.C.1    Workman, J.L.2
  • 34
    • 0036216109 scopus 로고    scopus 로고
    • Chromatin structure and gene regulation in the immune system
    • Smale ST, Fisher AG. Chromatin structure and gene regulation in the immune system. Annu Rev Immunol. 2002;20:427-462.
    • (2002) Annu Rev Immunol , vol.20 , pp. 427-462
    • Smale, S.T.1    Fisher, A.G.2
  • 35
    • 78650758676 scopus 로고    scopus 로고
    • Histone H3K27ac separates active from poised enhancers and predicts developmental state
    • Creyghton MP, Cheng AW, Welstead GG, et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci USA. 2010;107(50): 21931-21936.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.50 , pp. 21931-21936
    • Creyghton, M.P.1    Cheng, A.W.2    Welstead, G.G.3
  • 36
    • 38349165800 scopus 로고    scopus 로고
    • Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCLregulated enhancer
    • Nottingham WT, Jarratt A, Burgess M, et al. Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCLregulated enhancer. Blood. 2007;110(13): 4188-4197.
    • (2007) Blood , vol.110 , Issue.13 , pp. 4188-4197
    • Nottingham, W.T.1    Jarratt, A.2    Burgess, M.3
  • 37
    • 34249037850 scopus 로고    scopus 로고
    • A Gata2 intronic enhancer confers its pan-endotheliaspecific regulation
    • Khandekar M, Brandt W, Zhou Y, et al. A Gata2 intronic enhancer confers its pan-endotheliaspecific regulation. Development. 2007;134(9): 1703-1712.
    • (2007) Development , vol.134 , Issue.9 , pp. 1703-1712
    • Khandekar, M.1    Brandt, W.2    Zhou, Y.3
  • 38
    • 35148870447 scopus 로고    scopus 로고
    • The SCL 140 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins
    • Ogilvy S, Ferreira R, Piltz SG, Bowen JM, Gottgens B, Green AR. The SCL 140 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins. Mol Cell Biol. 2007;27(20): 7206-7219.
    • (2007) Mol Cell Biol , vol.27 , Issue.20 , pp. 7206-7219
    • Ogilvy, S.1    Ferreira, R.2    Piltz, S.G.3    Bowen, J.M.4    Gottgens, B.5    Green, A.R.6
  • 39
    • 67349199007 scopus 로고    scopus 로고
    • Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors
    • Landry JR, Bonadies N, Kinston S, et al. Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors. Blood. 2009;113(23): 5783-5792.
    • (2009) Blood , vol.113 , Issue.23 , pp. 5783-5792
    • Landry, J.R.1    Bonadies, N.2    Kinston, S.3
  • 40
    • 33847419981 scopus 로고    scopus 로고
    • The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype
    • Chan WY, Follows GA, Lacaud G, et al. The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype. Blood. 2007;109(5):1908-1916.
    • (2007) Blood , vol.109 , Issue.5 , pp. 1908-1916
    • Chan, W.Y.1    Follows, G.A.2    Lacaud, G.3
  • 41
    • 79959825899 scopus 로고    scopus 로고
    • ERG promotes T-Acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer
    • Thoms JA, Birger Y, Foster S, et al. ERG promotes T-Acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Blood. 2011;117(26): 7079-7089.
    • (2011) Blood , vol.117 , Issue.26 , pp. 7079-7089
    • Thoms, J.A.1    Birger, Y.2    Foster, S.3
  • 42
    • 78751523598 scopus 로고    scopus 로고
    • MicroRNA-146a disrupts hematopoietic differentiation and survival
    • Starczynowski DT, Kuchenbauer F, Wegrzyn J, et al. MicroRNA-146a disrupts hematopoietic differentiation and survival. Exp Hematol. 2011; 39(2):167-178.
    • (2011) Exp Hematol , vol.39 , Issue.2 , pp. 167-178
    • Starczynowski, D.T.1    Kuchenbauer, F.2    Wegrzyn, J.3
  • 43
    • 80055092199 scopus 로고    scopus 로고
    • MicroRNA expression and regulation in human, chimpanzee, and macaque brains
    • Hu HY, Guo S, Xi J, et al. MicroRNA expression and regulation in human, chimpanzee, and macaque brains. PLoS Genet. 2011;7(10): E1002327.
    • (2011) PLoS Genet , vol.7 , Issue.10 , pp. e1002327
    • Hu, H.Y.1    Guo, S.2    Xi, J.3
  • 44
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon U. Network motifs: Theory and experimental approaches. Nat Rev Genet. 2007;8(6):450-461.
    • (2007) Nat Rev Genet , vol.8 , Issue.6 , pp. 450-461
    • Alon, U.1
  • 45
    • 84055200841 scopus 로고    scopus 로고
    • Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
    • Pang WW, Price EA, Sahoo D, et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA. 2011;108(50):20012-20017.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.50 , pp. 20012-20017
    • Pang, W.W.1    Price, E.A.2    Sahoo, D.3
  • 46
    • 78650444882 scopus 로고    scopus 로고
    • Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
    • Gentles AJ, Plevritis SK, Majeti R, Alizadeh AA. Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA. 2010;304(24): 2706-2715.
    • (2010) JAMA , vol.304 , Issue.24 , pp. 2706-2715
    • Gentles, A.J.1    Plevritis, S.K.2    Majeti, R.3    Alizadeh, A.A.4
  • 47
    • 84865777819 scopus 로고    scopus 로고
    • ChIPseq guidelines and practices of the ENCODE and modENCODE consortia
    • Landt SG, Marinov GK, Kundaje A, et al. ChIPseq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012; 22(9):1813-1831.
    • (2012) Genome Res , vol.22 , Issue.9 , pp. 1813-1831
    • Landt, S.G.1    Marinov, G.K.2    Kundaje, A.3
  • 48
    • 34547692981 scopus 로고    scopus 로고
    • Long-Term propagation of distinct hematopoietic differentiation programs in vivo
    • Dykstra B, Kent D, Bowie M, et al. Long-Term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell. 2007;1(2):218-229.
    • (2007) Cell Stem Cell , vol.1 , Issue.2 , pp. 218-229
    • Dykstra, B.1    Kent, D.2    Bowie, M.3
  • 49
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert K, Takenaka K, Lechman ER, et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med. 2011; 17(9):1086-1093.
    • (2011) Nat Med , vol.17 , Issue.9 , pp. 1086-1093
    • Eppert, K.1    Takenaka, K.2    Lechman, E.R.3
  • 50
    • 32444446240 scopus 로고    scopus 로고
    • Gene regulatory networks and the evolution of animal body plans
    • Davidson EH, Erwin DH. Gene regulatory networks and the evolution of animal body plans. Science. 2006;311(5762):796-800.
    • (2006) Science , vol.311 , Issue.5762 , pp. 796-800
    • Davidson, E.H.1    Erwin, D.H.2
  • 51
    • 84866303839 scopus 로고    scopus 로고
    • A highthroughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals
    • Garber M, Yosef N, Goren A, et al. A highthroughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012;47(5): 810-822.
    • (2012) Mol Cell , vol.47 , Issue.5 , pp. 810-822
    • Garber, M.1    Yosef, N.2    Goren, A.3
  • 52
    • 67749132423 scopus 로고    scopus 로고
    • Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    • Chi SW, Zang JB, Mele A, Darnell RB. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 2009;460(7254):479-486.
    • (2009) Nature , vol.460 , Issue.7254 , pp. 479-486
    • Chi, S.W.1    Zang, J.B.2    Mele, A.3    Darnell, R.B.4
  • 53
    • 48449084118 scopus 로고    scopus 로고
    • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
    • Marson A, Levine SS, Cole MF, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008;134(3):521-533.
    • (2008) Cell , vol.134 , Issue.3 , pp. 521-533
    • Marson, A.1    Levine, S.S.2    Cole, M.F.3
  • 54
    • 49649086600 scopus 로고    scopus 로고
    • Fli1 acts at the top of the transcriptional network driving blood and endothelial development
    • Liu F, Walmsley M, Rodaway A, Patient R. Fli1 acts at the top of the transcriptional network driving blood and endothelial development. Curr Biol. 2008;18(16):1234-1240.
    • (2008) Curr Biol , vol.18 , Issue.16 , pp. 1234-1240
    • Liu, F.1    Walmsley, M.2    Rodaway, A.3    Patient, R.4
  • 55
    • 84878832501 scopus 로고    scopus 로고
    • Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence
    • Narula J, Williams CJ, Tiwari A, Marks-Bluth J, Pimanda JE, Igoshin OA. Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence. Dev Biol. 2013;379(2):258-269.
    • (2013) Dev Biol , vol.379 , Issue.2 , pp. 258-269
    • Narula, J.1    Williams, C.J.2    Tiwari, A.3    Marks-Bluth, J.4    Pimanda, J.E.5    Igoshin, O.A.6


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