메뉴 건너뛰기




Volumn 122, Issue 1, 2013, Pages 74-82

Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

BCL 11 B PROTEIN; CD8 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DNA METHYLTRANSFERASE 3A; FBXW 7 PROTEIN; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; L SELECTIN; MICROSOMAL AMINOPEPTIDASE; NOTCH1 RECEPTOR; PROTEIN P53; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; WT1 PROTEIN; MEMBRANE PROTEIN;

EID: 84883720120     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-03-491092     Document Type: Article
Times cited : (127)

References (54)
  • 2
    • 0027938776 scopus 로고
    • Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias
    • Hebert J, Cayuela JM, Berkeley J, Sigaux F. Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood. 1994;84(12):4038-4044.
    • (1994) Blood , vol.84 , Issue.12 , pp. 4038-4044
    • Hebert, J.1    Cayuela, J.M.2    Berkeley, J.3    Sigaux, F.4
  • 4
    • 84867179824 scopus 로고    scopus 로고
    • The molecular basis of T cell acute lymphoblastic leukemia
    • Van Vlierberghe P, Ferrando A. The molecular basis of T cell acute lymphoblastic leukemia. J Clin Invest.2012;122(10):3398-3406.
    • (2012) J Clin Invest , vol.122 , Issue.10 , pp. 3398-3406
    • Van Vlierberghe, P.1    Ferrando, A.2
  • 5
    • 84873084751 scopus 로고    scopus 로고
    • Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
    • De Keersmaecker K, Atak ZK, Li N, et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet.2013;45(2):186-190.
    • (2013) Nat Genet , vol.45 , Issue.2 , pp. 186-190
    • De Keersmaecker, K.1    Atak, Z.K.2    Li, N.3
  • 6
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang J, Ding L, Holmfeldt L, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature.2012;481(7380):157-163.
    • (2012) Nature , vol.481 , Issue.7380 , pp. 157-163
    • Zhang, J.1    Ding, L.2    Holmfeldt, L.3
  • 7
    • 79953735093 scopus 로고    scopus 로고
    • Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
    • Homminga I, Pieters R, Langerak AW, et al. Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell.2011;19(4):484-497.
    • (2011) Cancer Cell , vol.19 , Issue.4 , pp. 484-497
    • Homminga, I.1    Pieters, R.2    Langerak, A.W.3
  • 9
    • 47149084727 scopus 로고    scopus 로고
    • The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia
    • Van Vlierberghe P, van Grotel M, Tchinda J, et al. The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Blood.2008;111(9):4668-4680.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4668-4680
    • Van Vlierberghe, P.1    Van Grotel, M.2    Tchinda, J.3
  • 10
    • 58749095816 scopus 로고    scopus 로고
    • Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia
    • Coustan-Smith E, Mullighan CG, Onciu M, et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol.2009;10(2):147-156.
    • (2009) Lancet Oncol , vol.10 , Issue.2 , pp. 147-156
    • Coustan-Smith, E.1    Mullighan, C.G.2    Onciu, M.3
  • 11
    • 84855508998 scopus 로고    scopus 로고
    • ETV6 mutations in early immature human T cell leukemias
    • Van Vlierberghe P, Ambesi-Impiombato A, Perez-Garcia A, et al. ETV6 mutations in early immature human T cell leukemias. J Exp Med.2011;208(13):2571- 2579.
    • (2011) J Exp Med , vol.208 , Issue.13 , pp. 2571-2579
    • Van Vlierberghe, P.1    Ambesi-Impiombato, A.2    Perez-Garcia, A.3
  • 12
    • 77956240492 scopus 로고    scopus 로고
    • Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia
    • Gutierrez A, Dahlberg SE, Neuberg DS, et al. Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol.2010;28(24):3816-3823.
    • (2010) J Clin Oncol , vol.28 , Issue.24 , pp. 3816-3823
    • Gutierrez, A.1    Dahlberg, S.E.2    Neuberg, D.S.3
  • 14
    • 73949110789 scopus 로고    scopus 로고
    • T-cell acute lymphoblastic leukemia in adults: Clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)
    • Marks DI, Paietta EM, Moorman AV, et al. T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993). Blood.2009;114(25):5136-5145.
    • (2009) Blood , vol.114 , Issue.25 , pp. 5136-5145
    • Marks, D.I.1    Paietta, E.M.2    Moorman, A.V.3
  • 16
    • 33747842275 scopus 로고    scopus 로고
    • Comparative gene marker selection suite
    • DOI 10.1093/bioinformatics/btl196
    • Gould J, Getz G, Monti S, Reich M, Mesirov JP. Comparative gene marker selection suite. Bioinformatics. 2006;22(15):1924-1925. (Pubitemid 44283041)
    • (2006) Bioinformatics , vol.22 , Issue.15 , pp. 1924-1925
    • Gould, J.1    Getz, G.2    Monti, S.3    Reich, M.4    Mesirov, J.P.5
  • 18
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med.2010;363(25):2424-2433.
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 19
    • 80054035931 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in pediatric acute leukemia
    • Andersson AK, Miller DW, Lynch JA, et al. IDH1 and IDH2 mutations in pediatric acute leukemia. Leukemia.2011;25(10):1570-1577.
    • (2011) Leukemia , vol.25 , Issue.10 , pp. 1570-1577
    • Andersson, A.K.1    Miller, D.W.2    Lynch, J.A.3
  • 20
    • 80053385665 scopus 로고    scopus 로고
    • Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
    • Zenatti PP, Ribeiro D, Li W, et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet.2011;43(10):932-939.
    • (2011) Nat Genet , vol.43 , Issue.10 , pp. 932-939
    • Zenatti, P.P.1    Ribeiro, D.2    Li, W.3
  • 22
    • 77950299929 scopus 로고    scopus 로고
    • PHF6 mutations in T-cell acute lymphoblastic leukemia
    • Van Vlierberghe P, Palomero T, Khiabanian H, et al. PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet.2010;42(4):338-342.
    • (2010) Nat Genet , vol.42 , Issue.4 , pp. 338-342
    • Van Vlierberghe, P.1    Palomero, T.2    Khiabanian, H.3
  • 23
    • 78149348102 scopus 로고    scopus 로고
    • The TLX1 oncogene drives aneuploidy in T cell transformation
    • De Keersmaecker K, Real PJ, Gatta GD, et al. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med.2010;16(11):1321-1327.
    • (2010) Nat Med , vol.16 , Issue.11 , pp. 1321-1327
    • De Keersmaecker, K.1    Real, P.J.2    Gatta, G.D.3
  • 24
    • 70349232830 scopus 로고    scopus 로고
    • WT1 mutations in T-ALL
    • Tosello V, Mansour MR, Barnes K, et al. WT1 mutations in T-ALL. Blood.2009;114(5):1038-1045.
    • (2009) Blood , vol.114 , Issue.5 , pp. 1038-1045
    • Tosello, V.1    Mansour, M.R.2    Barnes, K.3
  • 25
    • 84856747744 scopus 로고    scopus 로고
    • Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
    • Ntziachristos P, Tsirigos A, Van Vlierberghe P, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med.2012;18(2):298-301.
    • (2012) Nat Med , vol.18 , Issue.2 , pp. 298-301
    • Ntziachristos, P.1    Tsirigos, A.2    Van Vlierberghe, P.3
  • 26
    • 84862776920 scopus 로고    scopus 로고
    • Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL
    • Della Gatta G, Palomero T, Perez-Garcia A, et al. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nat Med.2012;18(3):436-440.
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 436-440
    • Della Gatta, G.1    Palomero, T.2    Perez-Garcia, A.3
  • 29
    • 0031015557 scopus 로고    scopus 로고
    • The lasso method for variable selection in the cox model
    • DOI 10.1002/(SICI)1097-0258(19970228)16:4<385
    • Tibshirani R. The lasso method for variable selection in the Cox model. Stat Med. 1997;16(4):385-395. (Pubitemid 27073009)
    • (1997) Statistics in Medicine , vol.16 , Issue.4 , pp. 385-395
    • Tibshirani, R.1
  • 31
    • 84855793253 scopus 로고    scopus 로고
    • Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: Results of the Tokyo Children's Cancer Study Group Study L99-15
    • Inukai T, Kiyokawa N, Campana D, et al. Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15. Br J Haematol.2012;156(3):358-365.
    • (2012) Br J Haematol , vol.156 , Issue.3 , pp. 358-365
    • Inukai, T.1    Kiyokawa, N.2    Campana, D.3
  • 32
    • 79952095577 scopus 로고    scopus 로고
    • Modern therapy of acute lymphoblastic leukemia
    • Bassan R, Hoelzer D. Modern therapy of acute lymphoblastic leukemia. J Clin Oncol.2011;29(5):532-543.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 532-543
    • Bassan, R.1    Hoelzer, D.2
  • 34
    • 84863353013 scopus 로고    scopus 로고
    • Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia
    • Yang YL, Hsiao CC, Chen HY, et al. Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia. Pediatr Blood Cancer.2012;58(6):846-851.
    • (2012) Pediatr Blood Cancer , vol.58 , Issue.6 , pp. 846-851
    • Yang, Y.L.1    Hsiao, C.C.2    Chen, H.Y.3
  • 35
    • 84863975116 scopus 로고    scopus 로고
    • Clinical impact of NOTCH1 and/or FBXW7 mutations, FLASH deletion, and TCR status in pediatric T-cell lymphoblastic lymphoma
    • Callens C, Baleydier F, Lengline E, et al. Clinical impact of NOTCH1 and/or FBXW7 mutations, FLASH deletion, and TCR status in pediatric T-cell lymphoblastic lymphoma. J Clin Oncol.2012;30(16):1966-1973.
    • (2012) J Clin Oncol , vol.30 , Issue.16 , pp. 1966-1973
    • Callens, C.1    Baleydier, F.2    Lengline, E.3
  • 36
    • 70149087158 scopus 로고    scopus 로고
    • High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
    • Gutierrez A, Sanda T, Grebliunaite R, et al. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood.2009;114(3):647-650.
    • (2009) Blood , vol.114 , Issue.3 , pp. 647-650
    • Gutierrez, A.1    Sanda, T.2    Grebliunaite, R.3
  • 38
    • 33747608619 scopus 로고    scopus 로고
    • Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast
    • DOI 10.1038/sj.leu.2404302, PII 2404302
    • Graux C, Cools J, Michaux L, Vandenberghe P, Hagemeijer A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia. 2006;20(9):1496-1510. (Pubitemid 44264091)
    • (2006) Leukemia , vol.20 , Issue.9 , pp. 1496-1510
    • Graux, C.1    Cools, J.2    Michaux, L.3    Vandenberghe, P.4    Hagemeijer, A.5
  • 39
    • 0028091651 scopus 로고
    • Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia
    • Diccianni MB, Yu J, Hsiao M, Mukherjee S, Shao LE, Yu AL. Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia. Blood. 1994;84(9):3105-3112. (Pubitemid 24328104)
    • (1994) Blood , vol.84 , Issue.9 , pp. 3105-3112
    • Diccianni, M.B.1    Yu, J.2    Hsiao, M.3    Mukherjee, S.4    Shao, L.-E.5    Yu, A.L.6
  • 40
    • 80051828388 scopus 로고    scopus 로고
    • Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia
    • Hof J, Krentz S, van Schewick C, et al. Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia. J Clin Oncol.2011;29(23):3185-3193.
    • (2011) J Clin Oncol , vol.29 , Issue.23 , pp. 3185-3193
    • Hof, J.1    Krentz, S.2    Van Schewick, C.3
  • 41
    • 73949121255 scopus 로고    scopus 로고
    • Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: A comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia
    • Krieger D, Moericke A, Oschlies I, Zimmermann M, Schrappe M, Reiter A, Burkhardt B. Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia. Haematologica.2010;95(1):158-162.
    • (2010) Haematologica , vol.95 , Issue.1 , pp. 158-162
    • Krieger, D.1    Moericke, A.2    Oschlies, I.3    Zimmermann, M.4    Schrappe, M.5    Reiter, A.6    Burkhardt, B.7
  • 42
    • 33747155025 scopus 로고    scopus 로고
    • Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    • DOI 10.1182/blood-2005-12-4956
    • Breit S, Stanulla M, Flohr T, et al. Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood. 2006;108(4):1151-1157. (Pubitemid 44232009)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1151-1157
    • Breit, S.1    Stanulla, M.2    Flohr, T.3    Schrappe, M.4    Ludwig, W.-D.5    Tolle, G.6    Happich, M.7    Muckenthaler, M.U.8    Kulozik, A.E.9
  • 43
    • 78650311120 scopus 로고    scopus 로고
    • NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951
    • EORTC-CLG
    • Clappier E, Collette S, Grardel N, et al EORTC-CLG. NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951. Leukemia.2010;24(12):2023-2031.
    • (2010) Leukemia , vol.24 , Issue.12 , pp. 2023-2031
    • Clappier, E.1    Collette, S.2    Grardel, N.3
  • 44
    • 78650305754 scopus 로고    scopus 로고
    • The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function
    • Kox C, Zimmermann M, Stanulla M, et al. The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function. Leukemia.2010;24(12):2005-2013.
    • (2010) Leukemia , vol.24 , Issue.12 , pp. 2005-2013
    • Kox, C.1    Zimmermann, M.2    Stanulla, M.3
  • 45
    • 78650307928 scopus 로고    scopus 로고
    • NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols
    • Zuurbier L, Homminga I, Calvert V, et al. NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols. Leukemia.2010;24(12):2014-2022.
    • (2010) Leukemia , vol.24 , Issue.12 , pp. 2014-2022
    • Zuurbier, L.1    Homminga, I.2    Calvert, V.3
  • 46
    • 81055149624 scopus 로고    scopus 로고
    • Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: A GRAALL study
    • Group for Research on Adult Acute Lymphoblastic Leukemia
    • Ben Abdelali R, Asnafi V, Leguay T, et al Group for Research on Adult Acute Lymphoblastic Leukemia. Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study. Blood.2011;118(19):5099-5107.
    • (2011) Blood , vol.118 , Issue.19 , pp. 5099-5107
    • Ben Abdelali, R.1    Asnafi, V.2    Leguay, T.3
  • 47
    • 70349334513 scopus 로고    scopus 로고
    • Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol
    • Mansour MR, Sulis ML, Duke V, et al. Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol. J Clin Oncol.2009;27(26):4352-4356.
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4352-4356
    • Mansour, M.R.1    Sulis, M.L.2    Duke, V.3
  • 48
    • 70349642839 scopus 로고    scopus 로고
    • Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia
    • Baldus CD, Thibaut J, Goekbuget N, et al. Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia. Haematologica.2009;94(10):1383-1390.
    • (2009) Haematologica , vol.94 , Issue.10 , pp. 1383-1390
    • Baldus, C.D.1    Thibaut, J.2    Goekbuget, N.3
  • 49
    • 65449135968 scopus 로고    scopus 로고
    • NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): A Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
    • Asnafi V, Buzyn A, Le Noir S, et al. NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study. Blood.2009;113(17):3918-3924.
    • (2009) Blood , vol.113 , Issue.17 , pp. 3918-3924
    • Asnafi, V.1    Buzyn, A.2    Le Noir, S.3
  • 50
    • 84878442961 scopus 로고    scopus 로고
    • NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia
    • published online ahead of print January 24, 2013
    • Bandapalli OR, Zimmermann M, Kox C, et al. NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia [published online ahead of print January 24, 2013]. Haematologica.
    • Haematologica
    • Bandapalli, O.R.1    Zimmermann, M.2    Kox, C.3
  • 51
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML study group Ulm
    • DOI 10.1182/blood-2002-05-1440
    • Fröhling S, Schlenk RF, Breitruck J, et al AML Study Group Ulm. Acute myeloid leukemia. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood. 2002;100(13):4372-4380. (Pubitemid 35434129)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3    Benner, A.4    Kreitmeier, S.5    Tobis, K.6    Dohner, H.7    Dohner, K.8
  • 52
    • 84862502902 scopus 로고    scopus 로고
    • Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
    • Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, et al. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood.2012;119(24):5824- 5831.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5824-5831
    • Ribeiro, A.F.1    Pratcorona, M.2    Erpelinck-Verschueren, C.3
  • 53
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med.2012;366(12):1079-1089.
    • (2012) N Engl J Med , vol.366 , Issue.12 , pp. 1079-1089
    • Patel, J.P.1    Gönen, M.2    Figueroa, M.E.3
  • 54
    • 84873732313 scopus 로고    scopus 로고
    • The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL
    • Grossmann V, Haferlach C, Weissmann S, et al. The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Genes Chromosomes Cancer.2013;52(4): 410-422.
    • (2013) Genes Chromosomes Cancer , vol.52 , Issue.4 , pp. 410-422
    • Grossmann, V.1    Haferlach, C.2    Weissmann, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.