Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Lassen, Louise Berkhoudt ^a   Ballarín González, Borja ^a   Schmitz, Alexander ^a,b   Füchtbauer, Annette ^a   Pedersen, Finn Skou ^a   Füchtbauer, Ernst Martin ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ADULTHOOD; AGE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL EXPANSION; CELL MATURATION; CONTROLLED STUDY; DNA MODIFICATION; EMBRYO; FERTILITY; FLOW CYTOMETRY; GCSF GENE; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INSERTION; GENE OVEREXPRESSION; GENETIC VARIABILITY; GFI1 GENE; GRANULOCYTE; GRANULOCYTOSIS; HETEROZYGOSITY; HOMOZYGOSITY; LATENT PERIOD; LETHALITY; LONG TERMINAL REPEAT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE N RAS; RASGRP1 GENE; RETROVIRUS; SOS1 GENE; SPLEEN; SURVIVAL TIME; T LYMPHOCYTE; THYMUS; UPREGULATION; WILD TYPE;

ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, LETHAL; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HOMOZYGOTE; LEUKOCYTOSIS; MICE; MICE, TRANSGENIC; MYELOID CELLS; PHENOTYPE; PROTO-ONCOGENE PROTEINS P21(RAS); RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; SOS1 PROTEIN; SPLEEN; T-LYMPHOCYTES; THYMOCYTES; TRANSCRIPTION FACTORS; WEIGHT LOSS;

ANIMALIA; MUS;

EID: 84864450119     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042216     Document Type: Article

References (38)

1. Ohba Y, Kurokawa K, Matsuda M, ((2003)) Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J 22:: 859--869.
2. Vetter IR, Wittinghofer A, ((2001)) The guanine nucleotide-binding switch in three dimensions. Science 294:: 1299--1304.
3. Schubbert S, Shannon K, Bollag G, ((2007)) Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 7:: 295--308.
4. Alvarado Y, Giles FJ, ((2007)) Ras as a therapeutic target in hematologic malignancies. Expert Opin Emerg Drugs 12:: 271--284.
5. Byrne JL, Marshall CJ, ((1998)) The molecular pathophysiology of myeloid leukaemias: Ras revisited. Br J Haematol 100:: 256--264.
6. Bos JL, ((1989)) ras oncogenes in human cancer. a review. Cancer Res 49:: 4682--4689.
7. Umanoff H, Edelmann W, Pellicer A, Kucherlapati R, ((1995)) The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A 92:: 1709--1713.
8. Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, et al. ((2000)) Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene 19:: 2951--2956.
9. Esteban LM, Vicario-Abejon C, Fernandez-Salguero P, Fernandez-Medarde A, Swaminathan N, et al. ((2001)) Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol Cell Biol 21:: 1444--1452.
10. Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, et al. ((1997)) K-ras is essential for the development of the mouse embryo. Oncogene 15:: 1151--1159.
11. Potenza N, Vecchione C, Notte A, De Rienzo A, Rosica A, et al. ((2005)) Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep 6:: 432--437.
12. Perez de Castro I, Diaz R, Malumbres M, Hernandez MI, Jagirdar J, et al. ((2003)) Mice deficient for N-ras: impaired antiviral immune response and T-cell function. Cancer Res 63:: 1615--1622.
13. MacKenzie KL, Dolnikov A, Millington M, Shounan Y, Symonds G, ((1999)) Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. Blood 93:: 2043--2056.
14. Parikh C, Subrahmanyam R, Ren R, ((2006)) Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice. Blood 108:: 2349--2357.
15. Parikh C, Subrahmanyam R, Ren R, ((2007)) Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice. Cancer Res 67:: 7139--7146.
16. Wang J, Liu Y, Li Z, Wang Z, Tan LX, et al. ((2011)) Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 118:: 368--379.
17. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, et al. ((2011)) Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood 117:: 2022--2032.
18. Wang J, Liu Y, Li Z, Du J, Ryu MJ, et al. ((2010)) Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 116:: 5991--6002.
19. Wang J, Liu Y, Tan LX, Lo JC, Du J, et al. ((2011)) Distinct requirements of hematopoietic stem cell activity and Nras G12D signaling in different cell types during leukemogenesis. Cell Cycle 10:: 2836--2839.
20. Mangues R, Seidman I, Gordon JW, Pellicer A, ((1992)) Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice. Oncogene 7:: 2073--2076.
21. Martin-Hernandez J, Sorensen AB, Pedersen FS, ((2001)) Murine leukemia virus proviral insertions between the N-ras and unr genes in B-cell lymphoma DNA affect the expression of N-ras only. J Virol 75:: 11907--11912.
22. Feola DJ, Garvy BA, Cory TJ, Birket SE, Hoy H, et al. ((2010)) Azithromycin alters macrophage phenotype and pulmonary compartmentalization during lung infection with Pseudomonas. Antimicrob Agents Chemother 54:: 2437--2447.
23. Lagasse E, Weissman IL, ((1996)) Flow cytometric identification of murine neutrophils and monocytes. J Immunol Methods 197:: 139--150.
24. Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, et al. ((1994)) Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84:: 1737--1746.
25. Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC, ((1996)) Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity 5:: 491--501.
26. Karsunky H, Zeng H, Schmidt T, Zevnik B, Kluge R, et al. ((2002)) Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet 30:: 295--300.
27. de la Luz Sierra M, Sakakibara S, Gasperini P, Salvucci O, Jiang K, et al. ((2010)) The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1. Blood 115:: 3970--3979.
28. Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, et al. ((2003)) Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112:: 685--695.
29. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A, ((2005)) A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol 25:: 4426--4441.
30. Zhang J, Lodish HF, ((2005)) Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. Proc Natl Acad Sci U S A 102:: 14605--14610.
31. Demetri GD, Ernst TJ, Pratt ES 2nd, Zenzie BW, Rheinwald JG, et al ((1990)) Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes. J Clin Invest 86:: 1261--1269.
32. Gough NM, Metcalf D, Gough J, Grail D, Dunn AR, ((1985)) Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. EMBO J 4:: 645--653.
33. Morris ES, MacDonald KP, Kuns RD, Morris HM, Banovic T, et al. ((2009)) Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation. Nat Med 15:: 436--441.
34. Vellenga E, Rambaldi A, Ernst TJ, Ostapovicz D, Griffin JD, ((1988)) Independent regulation of M-CSF and G-CSF gene expression in human monocytes. Blood 71:: 1529--1532.
35. Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T, ((1994)) Notch1 is essential for postimplantation development in mice. Genes Dev 8:: 707--719.
36. Lovmand J, Sorensen AB, Schmidt J, Ostergaard M, Luz A, et al. ((1998)) B-Cell lymphoma induction by akv murine leukemia viruses harboring one or both copies of the tandem repeat in the U3 enhancer. J Virol 72:: 5745--5756.
37. Wertz K, Füchtbauer E-M, ((1994)) B6D2F1- An improved mouse hybrid strain for the production of ES cell germ line chimeras. Transgenics 1:: 277--280.
38. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, et al. ((1996)) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93:: 5860--5865.