Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin

Biochemistry

Volumn 53, Issue 21, 2014, Pages 3392-3402

  Kosinová, Lucie ^a   Veverka, Václav ^a   Novotná, Pavlína ^b   Collinsová, Michaela ^a   Urbanová, Marie ^b   Moody, Nicholas R ^c   Turkenburg, Johan P ^c   Jiráček, Jiří ^a   Brzozowski, Andrzej M ^c   Žáková, Lenka ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHAINS; CONFORMATIONS; DIHEDRAL ANGLE; STABILIZATION;

AMINOISOBUTYRIC ACID; HUMAN INSULINS; N TERMINUS; RATIONAL DESIGN; SPECIFIC SITES; STRUCTURAL INSIGHTS;

INSULIN;

2 AMINO 2 METHYLPROPIONIC ACID; AMINO ACID; HUMAN INSULIN; INSULIN; INSULIN DERIVATIVE; INSULIN RECEPTOR; N METHYLALANINE; PROLINE;

ARTICLE; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROGEN BOND; LYMPHOCYTE; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

AMINOISOBUTYRIC ACIDS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

EID: 84901950333     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500073z     Document Type: Article

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