Enhancing the T→R transition of insulin by helix-promoting sequence modifications at the N-terminal B-chain

Biological Chemistry

Volumn 381, Issue 2, 2000, Pages 127-133

  Shneine, Jewad ^a   Voswinkel, Marc ^a   Federwisch, Matthias ^a   Wollmer, Axel ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Allosterism; Circular dichroism; Ligands; N cap; Semisynthesis; Titration

Indexed keywords

INORGANIC COMPOUND; INSULIN; ION; PHENOL DERIVATIVE; COBALT; THIOCYANIC ACID DERIVATIVE; ZINC;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL MODIFICATION; HORMONE STRUCTURE; LIGAND BINDING; PRIORITY JOURNAL; STOICHIOMETRY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECT; HUMAN; METABOLISM; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; TITRIMETRY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CIRCULAR DICHROISM; COBALT; HUMANS; INSULIN; MODELS, CHEMICAL; PHENOLS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; THIOCYANATES; TITRIMETRY; ZINC;

EID: 0033624860     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2000.018     Document Type: Article

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