Toward the active conformation of insulin: Stereospecific modulation of a structural switch in the B chain

Journal of Biological Chemistry

Volumn 281, Issue 34, 2006, Pages 24900-24909

  Hua, Qing Xin ^a   Nakagawa, Satoe ^b   Hu, Shi Quan ^a   Jia, Wenhua ^a   Wang, Shuhua ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENUATION; CONFORMATIONS; HORMONES; ISOMERS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

CONFORMATIONAL FLUCTUATIONS; ISOMERIC ANALOGS; RECEPTOR BINDING; STEREOSPECIFIC MODULATION;

INSULIN;

GLYCINE; INSULIN; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; BETA CHAIN; BINDING ASSAY; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; RECEPTOR BINDING; STEREOSPECIFICITY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; HUMANS; INSULIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, INSULIN;

EID: 33747670241     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602691200     Document Type: Article

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