The structure of a mutant insulin uncouples receptor binding from protein allostery: An electrostatic block to the tr transition

Journal of Biological Chemistry

Volumn 283, Issue 30, 2008, Pages 21198-21210

  Wan, Zhu Li ^a   Huang, Kun ^a   Hu, Shi Quan ^a   Whittaker, Jonathan ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; INSULIN; MAMMALS; MONOMERS; PHENOLS; ZINC;

ACTIVE SPECIES; ALLOSTERY; BINDING ACTIVITIES; CONFORMATIONAL CHANGES; CONFORMATIONAL STATES; HEXAMER; HEXAMERS; IN CONTROLS; INSULIN HEXAMER; INSULIN MONOMERS; OPTICAL SPECTROSCOPIES; POSITIVE CHARGES; PROTEIN SURFACES; RECEPTOR BINDINGS; SIDE CHAINS; TYPE STRUCTURES; WILD TYPES;

HORMONES;

ARGININE; HISTIDINE; INSULIN; PHENOL; ZINC;

ABSORPTION SPECTROPHOTOMETRY; ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLIZATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR BINDING; WILD TYPE; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; ELECTRICITY; GENETICS; METHODOLOGY; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

EUTHERIA; VERTEBRATA;

ALLOSTERIC SITE; ARGININE; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HUMANS; HYDROGEN-ION CONCENTRATION; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PROTEIN BINDING; ZINC;

EID: 48149093031     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800235200     Document Type: Article

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