Non-equivalent role of inter- and intramolecular hydrogen bonds in the insulin dimer interface

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36968-36977

  Antolíková, Emília ^a   Žáková, Lenka ^a   Turkenburg, Johan P ^b   Watson, Christopher J ^b   Hančlová, Ivona ^a   Šanda, Miloslav ^a   Cooper, Alan ^c   Kraus, Tomáš ^a   Brzozowski, A Marek ^b   Jiráček, Jiří ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE HYDROGENS; BINDING AFFINITIES; C TERMINUS; DIMER INTERFACE; HEXAMERS; HIGH CONCENTRATION; INSULIN ANALOGUES; INSULIN RECEPTORS; INTRAMOLECULAR HYDROGEN BOND; INTRAMOLECULAR HYDROGEN BONDING; ISOTHERMAL MICROCALORIMETRY; N-METHYLATION; PEPTIDE BONDS; SOLUTION EQUILIBRIUM;

ALKYLATION; AMIDES; BINDING ENERGY; DIMERIZATION; DIMERS; HYDROGEN; HYDROGEN BONDS; METHYLATION;

INSULIN;

AMIDE; DIMER; HYDROGEN; INSULIN; INSULIN DERIVATIVE; INSULIN RECEPTOR; OLIGOMER; PEPTIDE; PHENYLALANINE; TYROSINE;

ANIMAL TISSUE; ARTICLE; BETA CHAIN; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIMERIZATION; HUMAN; HYDROGEN BOND; MALE; MICROCALORIMETRY; MOLECULAR INTERACTION; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN STRUCTURE; RAT; RECEPTOR BINDING;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; INSULIN, REGULAR, PORK; METHYLATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; SWINE;

EID: 80054682157     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.265249     Document Type: Article

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