Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 5, 2010, Pages 1966-1970

  Jiráček, Jiří ^a   Žáková, Lenka ^a   Antolíková, Emília ^a   Watson, Christopher J ^b   Turkenburg, Johan P ^b   Dodson, Guy G ^b   Brzozowski, Andrzej M ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

turn; Diabetes; Peptide bond isomerisation; Protein; Structure

Indexed keywords

AMINO ACID; INSULIN DERIVATIVE; INSULIN RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA CHAIN; CHEMICAL BOND; CHIRALITY; CIS ISOMER; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; GENE INSERTION; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT;

ANTIGENS, CD; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RECEPTOR, INSULIN; STATIC ELECTRICITY;

EID: 76649083949     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911785107     Document Type: Article

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