Evolution of the insulin molecule: Insights into structure-activity and phylogenetic relationships

Peptides

Volumn 22, Issue 7, 2001, Pages 1183-1193

  Conlon, J Michael ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin; Phylogeny; Receptor binding; Structure activity; Vertebrate evolution

Indexed keywords

ASPARGINE A21; CYSTEINE; GLUTAMINE A5; GLUTAMYL A4; GLUTAMYL B13; GLYCINE A1; GLYCINE B23; GLYCINE B8; INSULIN; ISOLEUCINE A2; LEUCINE 13; LEUCINE 17; LEUCINE B11; LEUCINE B6; PHENYLALANINE B24; PHENYLALANINE B25; PROTEIN SUBUNIT; TYROSINE A19; TYROSINE A21; TYROSINE B26; UNCLASSIFIED DRUG; VALINE A3; VALINE B12;

AMINO ACID SEQUENCE; AMPHIBIA; BINDING SITE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ELASMOBRANCHII; HAGFISH; HUMAN; MOLECULAR EVOLUTION; MUTAGENESIS; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; RECEPTOR BINDING; REPTILE; REVIEW; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; VERTEBRATE; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; EVOLUTION, MOLECULAR; HUMANS; INSULIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHYLOGENY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034974365     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(01)00423-5     Document Type: Review

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