Spectroscopic evidence for preexisting T- and R-state insulin hexamer conformations

Proteins: Structure, Function and Genetics

Volumn 26, Issue 4, 1996, Pages 377-390

  Choi, Wonjae E ^a,d   Borchardt, Dan ^b   Kaarsholm, Niels C ^c   Brzovic, Peter S ^a,e   Dunn, Michael F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NOVO NORDISK A S   (Denmark)

^d JOSLIN DIABETES CENTER   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

allostery; half site reactivity; hexameric insulin; positive and negative cooperativity

Indexed keywords

INSULIN;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ANALYTIC METHOD; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SPECTROSCOPY;

ALLOSTERIC REGULATION; ANIONS; BIOPOLYMERS; COBALT; HUMANS; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0030457564     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(199612)26:4<377::AID-PROT2>3.0.CO;2-9     Document Type: Article

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