Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity

Biochemistry

Volumn 47, Issue 21, 2008, Pages 5858-5868

  Žáková, Lenka ^a   Kazdová, Ludmila ^b   Hančlová, Ivona ^a   Protivínská, Eva ^a   Šanda, Miloslav ^a   Buděšínský, Miloš ^a   Jiráček, Jiří ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOACTIVITY; CHEMICAL MODIFICATION;

BINDING AFFINITY; INSULIN ANALOGUES;

INSULIN;

INSULIN;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIPOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WISTAR RAT;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; HUMANS; INSULIN; LIPOGENESIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; RECEPTOR, INSULIN; SWINE;

RATTUS; RATTUS NORVEGICUS;

EID: 44349151121     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702086w     Document Type: Article

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