Structural integrity of the B24 site in human insulin is important for hormone functionality

Journal of Biological Chemistry

Volumn 288, Issue 15, 2013, Pages 10230-10240

  Žáková, Lenka ^a   Kletvíková, Emília ^a   Veverka, Václav ^a   Lepšík, Martin ^a   Watson, Christopher J ^b   Turkenburg, Johan P ^b   Jiráček, Jiří ^a   Brzozowski, Andrzej M ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN INSULINS; INSULIN RECEPTORS; RECEPTOR BINDING; RECEPTOR-BOUND STRUCTURES;

STRUCTURAL INTEGRITY;

INSULIN;

AMINO ACID; HISTIDINE; HUMAN INSULIN; INSULIN DERIVATIVE; INSULIN RECEPTOR; PHENYLALANINE; TYROSINE;

ARTICLE; BETA CHAIN; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HYDROPHOBICITY; IC 50; ISOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SYNTHESIS; RECEPTOR BINDING; STRUCTURE ANALYSIS;

BINDING SITES; HUMANS; INSULIN; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, INSULIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876262581     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.448050     Document Type: Article

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