Shortened Insulin Analogues: Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain

Biochemistry

Volumn 43, Issue 8, 2004, Pages 2323-2331

  Žáková, Lenka ^a   Barth, Tomislav ^a   Jiráček, Jiří ^a   Barthová, Jana ^b   Zórad, Štefan ^c  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOASSAY; BIOLOGICAL MEMBRANES; CATALYSIS; SYNTHESIS (CHEMICAL);

BINDING AFFINITY;

INSULIN;

HISTIDINE; INSULIN DERIVATIVE; INSULIN RECEPTOR; OCTAPEPTIDE; PHENYLALANINE; SYNTHETIC PEPTIDE; TRYPSIN; TYROSINE;

ADIPOCYTE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL MEMBRANE; CHEMICAL BOND; DRUG ACTIVITY; GLUCOSE TRANSPORT SYSTEM; IN VITRO STUDY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SUBSTITUTION; ANIMALS; BIOLOGICAL TRANSPORT; DEOXYGLUCOSE; HUMANS; HYDROGEN BONDING; INSULIN; MALE; METHYLATION; PEPTIDE FRAGMENTS; PHENYLALANINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; SWINE; TYROSINE;

ANIMALIA;

EID: 10744225006     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036001w     Document Type: Article

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