Decoding the cryptic active conformation of a Protein by synthetic photoscanning. Insulin inserts a detachable arm between receptor domains

Journal of Biological Chemistry

Volumn 284, Issue 21, 2009, Pages 14597-14608

  Xu, Bin ^a   Huang, Kun ^a   Chu, Ying Chi ^b   Hu, Shi Quan ^a   Nakagawa, Satoe ^c   Wang, Shuhua ^a   Wang, Run Ying ^b   Whittaker, Jonathan ^a   Katsoyannis, Panayotis G ^b   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZIDO DERIVATIVES; BINDING DOMAIN; CANONICAL STRUCTURE; CHEMICAL SYNTHESIS; COMPLEX NETWORKS; FITNESS LANDSCAPE; FUNCTIONAL SURFACES; GROUND-STATE STRUCTURES; HEXAMERS; INSULIN GENE; INSULIN RECEPTORS; N-TERMINAL; PHOTOCROSS-LINKING; PHOTOPRODUCTS; RECEPTOR BINDING; RECEPTOR DOMAINS; STRUCTURAL INFORMATION;

BINDING SITES; CONFORMATIONS; PROBES; PROTEIN FOLDING; SYNTHESIS (CHEMICAL);

INSULIN;

AZIDE; INSULIN; CHYMOTRYPSIN; CROSS LINKING REAGENT; INSULIN RECEPTOR;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BETA CHAIN; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HORMONE BINDING; INSULIN BINDING; MOLECULAR EVOLUTION; MOLECULAR IMAGING; MUTAGENESIS; PANCREAS ISLET BETA CELL; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN FOLDING; PROTEIN FUNCTION; RECEPTOR BINDING; STEREOSPECIFICITY; STRUCTURE ANALYSIS; SYNTHETIC PHOTOSCANNING; ALLOSTERISM; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; LIGHT; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; RADIATION EXPOSURE; SWINE;

VERTEBRATA;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; CHYMOTRYPSIN; CROSS-LINKING REAGENTS; HUMANS; INSULIN; LIGHT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE MAPPING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN; SUS SCROFA;

EID: 67649827251     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900087200     Document Type: Article

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