Insulin analog with additional disulfide bond has increased stability and preserved activity

Protein Science

Volumn 22, Issue 3, 2013, Pages 296-305

  Vinther, Tine N ^a,b   Norrman, Mathias ^a   Ribel, Ulla ^a   Huus, Kasper ^a   Schlein, Morten ^a   Steensgaard, Dorte B ^a   Pedersen, Thomas Å ^a   Pettersson, Ingrid ^a   Ludvigsen, Svend ^a   Kjeldsen, Thomas ^a   Jensen, Knud J ^b   Hubálek, František ^a  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Disulfide; Evolution; Insulin; Protein design; Stability; Yeast

Indexed keywords

INSULIN; INSULIN RECEPTOR; ZINC;

ARTICLE; DISULFIDE BOND; DRUG STABILITY; DRUG STRUCTURE; PRIORITY JOURNAL; TEMPERATURE;

ADIPOCYTES; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD; BIOLOGICAL TRANSPORT; BLOOD GLUCOSE; CELLS, CULTURED; CYSTINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN, REGULAR, HUMAN; MUTANT PROTEINS; PROTEIN CONFORMATION; PROTEIN STABILITY; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; ZINC;

RATTUS; VERTEBRATA;

EID: 84878301058     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2211     Document Type: Article

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