Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis

Volumn 9, Issue 1, 2008, Pages 24-34

  Parkhouse, Wade S ^a   Cunningham, Lori ^a   McFee, Ingrid ^a   Litt Miller, Jennifer M ^a   Whitney, Darryl ^a   Pelech, Steven L ^b,c   Krieger, Charles ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Kinexus Bioinformatics Corporation   (Canada)

Author keywords

Amyotrophic lateral sclerosis; Protein kinases; Retrograde transport; Skeletal muscle

Indexed keywords

FLUOROGOLD; MUTANT PROTEIN; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOUSE; MUSCLE ATROPHY; MUSCLE DENERVATION; NERVE FIBER; NEUROMUSCULAR DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; NEUROMUSCULAR DISEASES; SUPEROXIDE DISMUTASE;

EID: 39349101214     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/17482960701725646     Document Type: Article

References (29)

1. Gurney, M. E., Pu, H., Chiu, A. Y., Canto, M. C. Dal, Polchow, C. Y. and Alexander, D. D. (1994) Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation. Science, 264, pp. 1772-1775.
2. Boillee, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A. and Kassiotis, G. (2006) Onset and progression in inherited ALS determined by motor neurons and microglia. Science, 312, pp. 1389-1392.
3. Mohajeri, M. H., Figlewicz, D. A. and Bohn, M. C. (1998) Selective loss of motor neurons innervating the medial gastrocnemius muscle in a mouse model of amyotrophic lateral sclerosis. Exp Neurol, 50, pp. 329-336.
4. Ligon, L. A., LaMonte, B. H., Wallace, K. E., Weber, N., Kalb, R. G. and Holzbaur, E. L. F. (2005) Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons. Neuroreport, 6, pp. 533-536.
5. Atkin, J. D., Scott, R. L., West, J. M., Lopes, E., Quah, A. K. J. and Cheema, S. S. (2005) Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis. Neuromusc Dis, 15, pp. 377-388.
6. Kong, J. and Xu, Z. (1998) Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing mutant SOD1. J Neurosci, 18, pp. 3241-3250.
7. Fischer, L. R., Culver, D. G., Tennant, P., Davis, A. A., Wang, M. and Castellano-Sanchez, A. (2004) Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man. Exp Neurol, 185, pp. 232-240.
8. Derave, W., Bosch, L. van den, Lemmens, G., Eijnde, B. O., Robberecht, W. and Hespel, P. (2003) Skeletal muscle properties in a transgenic mouse model for amytrophic lateral sclerosis: Effects of creatine treatment. Neurobiol Dis, 13, pp. 264-272.
9. Leger, B., Vergani, L., Soraru, G., Hespel, P., Gobelet, C. and D'Ascenzio, C. (2006) Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1. FASEB J, 20, pp. 583-585.
10. Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L. and Stitt, T. N. (2004) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/PKB/mTOR and PI(3)K/PKB/GSK3 pathways. Nat Cell Biol, 3, pp. 1009-1013.
11. Li, M., Li, C. and Parkhouse, W. S. (2003) Age-related differences in the des IGF-I-mediated activation of PKB-1 and p70 S6K in mouse skeletal muscle. Mech Ageing Dev, 124, pp. 771-778.
12. Dudek, S. M. and Fields, R. D. (2001) Mitogen-activated protein kinase/ extracellular signal-regulated kinase activation in somatodendritic compartments: Roles of action potentials, frequency, and mode of calcium entry. J Neurosci, 21, pp. 1-5.
13. Hu, J. H., Chernoff, K., Pelech, S. and Krieger, C. (2003) Protein kinase and protein phosphatase expression in the central nervous system of G93A mSOD overexpressing mice. J Neurochem, 85, pp. 422-431.
14. Zhang, H., Shi, X., Zhang, Q. J., Hampong, M., Paddon, H. and Wahyuningsih, D. (2002) Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem, 277, pp. 43648-43658.
15. Covault, J. and Sanes, J. R. (1986) Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle. J Cell Biol, 102, pp. 716-730.
16. Feeney, S. J., McKelvie, P. A., Austin, L., Jean-Francois, M. J., Kapsa, R. and Tombs, S. M. (2001) Presymptomatic motor neuron loss and reactive astrocytosis in the SOD1 mouse model of amyotrophic lateral sclerosis. Muscle Nerve, 24, pp. 1510-1519.
17. Frey, D., Schneider, C., Xu, L., Borg, J., Spooren, W. and Caroni, P. (2000) Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motor neuron diseases. J Neurosci, 20, pp. 2534-2542.
18. Kieran, D., Hafezparast, M., Bohnert, S., Dick, J. R. T., Martin, J. and Schiavo, G. (2005) A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J Cell Biol, 169, pp. 561-567.
19. Li, S., Wang, X., Klee, C. B. and Krieger, C. (2004) Overexpressed mutant G93A superoxide dismutase protects calcineurin from inactivation. Mol Brain Res, 125, pp. 156-161.
20. Jaarsma, D., Haasdijk, E. D., Grashorn, J. A. C., Hawkins, R., van Duijn, W. and Verspaget, H. W. (2000) Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration and premature motor neuron death and accelerates motor neuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1. Neurobiol Dis, 7, pp. 623-643.
21. Sanes, J. R., Schachner, M. and Covault, J. (1986) Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and heparin sulphate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle. J Cell Biol, 102, pp. 420-431.
22. Cashman, N. R., Covault, J., Wollman, R. L. and Sanes, J. R. (1987) Neural cell adhesion molecule in normal, denervated, and myopathic human muscle. Ann Neurol, 21, pp. 481-489.
23. Tews, D. S., Goebel, H. H., Schneider, I., Gunkel, A., Stennert, E. and Neiss, W. F. (1997) Expression profile of stress proteins, intermediate filaments, and adhesion molecules in experimentally denervated and re-innervated rat facial muscle. Exp Neurol, 146, pp. 125-134.
24. Schoser, B. G., Wehling, S. and Blottner, D. (2001) Cell death and apoptosis-related proteins in muscle biopsies of sporadic amyotrophic lateral sclerosis and polyneuropathy. Muscle Nerve, 24, pp. 1083-1089.
25. Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L. and Bauerlein, R. (2001) PKB/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol, 3, pp. 1014-1019.
26. Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L. and Stitt, T. N. (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/PKB/mTOR and PI(3)K/PKB/GSK3 pathways. Nat Cell Biol, 3, pp. 1009-1013.
27. Dobrowolny, G., Giacinti, C., Pelosi, L., Nicoletti, C., Winn, N. and Barberi, L. (2005) Muscle expression of local Igf-1 isoform protects motor neurons in an ALS mouse model. J Cell Biol, 168, pp. 193-199.
28. Kaspar, B. K., Llado, J., Sherkat, N., Rothstein, J. D. and Gage, F. H. (2003) Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science, 301, pp. 839-842.
29. Boillee, S. and Cleveland, D. W. (2004) Gene therapy for ALS delivers. Trends Neurosci, 27, pp. 235-238.