Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene

Brain Research

Volumn 819, Issue 1-2, 1999, Pages 120-131

  Warita, Hitoshi ^a   Itoyama, Yasuto ^a   Abe, Koji ^b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

ALS; Axonal transport; Dynein; Kinesin; SOD1; Transgenic mouse

Indexed keywords

ALANINE; COPPER ZINC SUPEROXIDE DISMUTASE; DYNEIN ADENOSINE TRIPHOSPHATASE; GLYCINE; KINESIN;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GASTROCNEMIUS MUSCLE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MALE; MYELINATED NERVE; NERVE FIBER TRANSPORT; NERVE LIGATION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; SCIATIC NERVE; SPINAL CORD MOTONEURON; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AXONAL TRANSPORT; CYTOPLASM; DYNEIN ATPASE; HUMANS; IMMUNOHISTOCHEMISTRY; KINESIN; LIGATION; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCLE, SKELETAL; MUTATION; PERIPHERAL NERVES; SCIATIC NERVE; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 0033585832     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01351-1     Document Type: Article

References (49)

1. Abe K., Aoki M., Kawagoe J., Yoshida T., Hattori A., Kogure K., Itoyama Y. Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke. 26:1995;1478-1489.
2. Abe K., Morita S., Kikuchi T., Itoyama Y. Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease. J. Neurosci. Res. 48:1997;63-70.
3. Abe K., Pan L.H., Watanabe M., Kato T., Itoyama Y. Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. Neurosci. Lett. 199:1995;152-154.
4. Aoki M., Ogasawara M., Matsubara Y., Narisawa K., Nakamura S., Itoyama Y., Abe K. Familial amyotrophic lateral sclerosis (ALS) in Japan associated with H46R mutation in Cu/Zn superoxide dismutase gene: a possible new subtype of familial ALS. J. Neurol. Sci. 126:1994;77-83.
5. Beckman J.S., Carson M., Smith C.D., Koppenol W.H. ALS, SOD and peroxynitrite. Nature. 364:1993;584.
6. Bowling A.C., Barkowski E.E., McKenna-Yasek D., Sapp P., Horvitz H.R., Beal M.F., Brown R.H. Jr. Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis. J. Neurochem. 64:1995;2366-2369.
7. Bradley W.G., Good P., Rasool C.G., Adelman L.S. Morphometric and biochemical studies of peripheral nerves in amyotrophic lateral sclerosis. Ann. Neurol. 14:1983;267-277.
8. Brady S. Motor-neuron diseases. Interfering with the runners. Nature. 375:1995;12-13.
9. Brady S.T. A novel brain ATPase with properties expected for the fast axonal transport motor. Nature. 317:1985;73-75.
10. Brady S.T. Molecular motors in the nervous system. Neuron. 7:1991;521-533.
11. Breuer A.C., Atkinson M.B. Fast axonal transport alterations in amyotrophic lateral sclerosis (ALS) and in parathyroid hormone (PTH)-treated axons. Cell Motil. Cytoskeleton. 10:1988;321-330.
12. Breuer A.C., Lynn M.P., Atkinson M.B., Chou S.M., Wilbourn A.J., Marks K.E., Culver J.E., Fleegler E.J. Fast axonal transport in amyotrophic lateral sclerosis: an intra-axonal organelle traffic analysis. Neurology. 37:1987;738-748.
13. Collard J.F., Côté F., Julien J.P. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature. 375:1995;61-64.
14. Côté F., Collard J.F., Julien J.P. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell. 73:1993;35-46.
15. Dal Canto M.C., Gurney M.E. Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis. Am. J. Pathol. 145:1994;1271-1279.
16. Dal Canto M.C., Gurney M.E. Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res. 676:1995;25-40.
17. Dal Canto M.C., Gurney M.E. A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis. Acta Neuropathol. (Berlin). 93:1997;537-550.
18. Delisle M.B., Carpenter S. Neurofibrillary axonal swellings and amyotrophic lateral sclerosis. J. Neurol. Sci. 63:1984;241-250.
19. Deng H.X., Hentati A., Tainer J.A., Iqbal Z., Cayabyab A., Hung W.Y., Getzoff E.D., Hu P., Herzfeldt B., Roos R.P., Warner C., Deng G., Soriano E., Smyth C., Parge H.E., Ahmed A., Roses A.D., Halliwell R.A., Periak-Vance M.A., Siddique T. Amyotrophic lateral sclerosis and structural defects in Cu, Zn superoxide dismutase. Science. 261:1993;1047-1051.
20. Eyer J., Cleveland D.W., Wong P.C., Peterson A.C. Pathogenesis of two axonopathies does not require axonal neurofilaments. Nature. 391:1998;584-587.
21. Ferrante R.J., Shinobu L.A., Schulz J.B., Matthews R.T., Thomas C.E., Kowall N.W., Gurney M.E., Beal M.F. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Ann. Neurol. 42:1997;326-334.
22. Figlewicz D.A., Krizus A., Martinoli M.G., Meininger V., Dib M., Rouleau G.A., Julien J.P. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum. Mol. Genet. 3:1994;1757-1761.
23. Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.X., Chen W., Zhai P., Sufit R.L., Siddique T. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science. 264:1994;1772-1775.
24. Hirano A., Donnenfeld H., Sasaki S., Nakano I. Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 43:1984;461-470.
25. Hirokawa N. The molecular mechanism of organelle transport along microtubules: the identification and characterization of KIFs (kinesin superfamily proteins). Cell Struct. Funct. 21:1996;357-367.
26. Hirokawa N. Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science. 279:1998;519-526.
27. Hirokawa N., Sato-Yoshitake R., Kobayashi N., Pfister K.K., Bloom G.S., Brady S.T. Kinesin associates with anterogradely transported membranous organelles in vivo. J. Cell Biol. 114:1991;295-302.
28. Hirokawa N., Sato-Yoshitake R., Yoshida T., Kawashima T. Brain dynein (MAP1C) localizes on both anterogradely and retrogradely transported membranous organelles in vivo. J. Cell Biol. 111:1990;1027-1037.
29. Hurd D.D., Saxton W.M. Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila. Genetics. 144:1996;1075-1085.
30. Kennel P.F., Finiels F., Revah F., Mallet J. Neuromuscular function impairment is not caused by motor neurone loss in FALS mice: an electromyographic study. Neuroreport. 7:1996;1427-1431.
31. Lee M.K., Marszalek J.R., Cleveland D.W. A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron. 13:1994;975-988.
32. Lye R.J., Porter M.E., Scholey J.M., McIntosh J.R. Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans. Cell. 51:1987;309-318.
33. Marszalek J.R., Williamson T.L., Lee M.K., Xu Z., Hoffman P.N., Becher M.W., Crawford T.O., Cleveland D.W. Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J. Cell Biol. 135:1996;711-724.
34. Paschal B.M., Vallee R.B. Retrograde transport by the microtubule-associated protein MAP 1C. Nature. 330:1987;181-183.
35. Pramatarova A., Figlewicz D.A., Krizus A., Han F.Y., Ceballos-Picot I., Nicole A., Dib M., Meininger V., Brown R.H., Rouleau G.A. Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis. Am. J. Hum. Genet. 56:1995;592-596.
36. Reaume A.G., Elliott J.L., Hoffman E.K., Kowall N.W., Ferrante R.J., Siwek D.F., Wilcox H.M., Flood D.G., Beal M.F., Brown R.H. Jr., Scott R.W., Snider W.D. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet. 13:1996;43-47.
37. Ripps M.E., Huntley G.W., Hof P.R., Morrison J.H., Gordon J.W. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 92:1995;689-693.
38. Rooke K., Figlewicz D.A., Han F.Y., Rouleau G.A. Analysis of the KSP repeat of the neurofilament heavy subunit in familial amyotrophic lateral sclerosis. Neurology. 46:1996;789-790.
39. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., Deng H.X. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 364:1993;59-62.
40. Rouleau G.A., Clark A.W., Rooke K., Pramatarova A., Krizus A., Suchowersky O., Julien J.P., Figlewicz D. SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis. Ann. Neurol. 39:1996;128-131.
41. Sasaki S., Iwata M. Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis. Neurology. 47:1996;535-540.
42. Schmidt M.L., Carden M.J., Lee V.M., Trojanowski J.Q. Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls. Lab. Invest. 56:1987;282-294.
43. Tu P.H., Raju P., Robinson K.A., Gurney M.E., Trojanowski J.Q., Lee V.M. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc. Natl. Acad. Sci. U.S.A. 93:1996;3155-3160.
44. Vale R.D., Reese T.S., Sheetz M.P. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell. 42:1985;39-50.
45. Vallee R.B., Bloom G.S. Mechanisms of fast and slow axonal transport. Annu. Rev. Neurosci. 14:1991;59-92.
46. Vechio J.D., Bruijn L.I., Xu Z., Brown R.H. Jr., Cleveland D.W. Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis. Ann. Neurol. 40:1996;603-610.
47. Wong P.C., Pardo C.A., Borchelt D.R., Lee M.K., Copeland N.G., Jenkins N.A., Sisodia S.S., Cleveland D.W., Price D.L. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 14:1995;1105-1116.
48. Xu Z., Cork L.C., Griffin J.W., Cleveland D.W. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell. 73:1993;23-33.
49. Zhang B., Tu P., Abtahian F., Trojanowski J.Q., Lee V.M.Y. Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J. Cell Biol. 139:1997;1307-1315.