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Volumn 6, Issue 3, 2011, Pages

In vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS

Author keywords

[No Author keywords available]

Indexed keywords

SUPEROXIDE DISMUTASE; COPPER ZINC SUPEROXIDE DISMUTASE;

EID: 79952792761     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017910     Document Type: Article
Times cited : (59)

References (58)
  • 1
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, et al. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362: 59-62.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3    Figlewicz, D.A.4    Sapp, P.5
  • 2
    • 0029079993 scopus 로고
    • Motor neuron disease caused by mutations in superoxide dismutase 1
    • Wong PC, Borchelt DR, (1995) Motor neuron disease caused by mutations in superoxide dismutase 1. Curr Opin Neurol 8: 294-301.
    • (1995) Curr Opin Neurol , vol.8 , pp. 294-301
    • Wong, P.C.1    Borchelt, D.R.2
  • 3
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    • Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, et al. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264: 1772-1775.
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1    Pu, H.2    Chiu, A.Y.3    Dal Canto, M.C.4    Polchow, C.Y.5
  • 4
    • 33744798774 scopus 로고    scopus 로고
    • Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
    • Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, et al. (2006) Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia. Science 312: 1389-1392.
    • (2006) Science , vol.312 , pp. 1389-1392
    • Boillee, S.1    Yamanaka, K.2    Lobsiger, C.S.3    Copeland, N.G.4    Jenkins, N.A.5
  • 5
    • 33749056809 scopus 로고    scopus 로고
    • ALS: a disease of motor neurons and their nonneuronal neighbors
    • Boillee S, Vande Velde C, Cleveland DW, (2006) ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52: 39-59.
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillee, S.1    Vande Velde, C.2    Cleveland, D.W.3
  • 6
    • 34249670157 scopus 로고    scopus 로고
    • Glia cells in amyotrophic lateral sclerosis: new clues to understanding an old disease?
    • Neusch C, Bahr M, Schneider-Gold C, (2007) Glia cells in amyotrophic lateral sclerosis: new clues to understanding an old disease? Muscle Nerve 35: 712-724.
    • (2007) Muscle Nerve , vol.35 , pp. 712-724
    • Neusch, C.1    Bahr, M.2    Schneider-Gold, C.3
  • 7
    • 66749133370 scopus 로고    scopus 로고
    • Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS
    • Chattopadhyay M, Valentine JS, (2009) Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS. Antioxid Redox Signal 11: 1603-1614.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1603-1614
    • Chattopadhyay, M.1    Valentine, J.S.2
  • 9
    • 34547640096 scopus 로고    scopus 로고
    • Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis
    • Gruzman A, Wood WL, Alpert E, Prasad MD, Miller RG, et al. (2007) Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 104: 12524-12529.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12524-12529
    • Gruzman, A.1    Wood, W.L.2    Alpert, E.3    Prasad, M.D.4    Miller, R.G.5
  • 11
    • 33750478657 scopus 로고    scopus 로고
    • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    • Beers DR, Henkel JS, Xiao Q, Zhao W, Wang J, et al. (2006) Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 103: 16021-16026.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16021-16026
    • Beers, D.R.1    Henkel, J.S.2    Xiao, Q.3    Zhao, W.4    Wang, J.5
  • 12
    • 39749188753 scopus 로고    scopus 로고
    • Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
    • Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, et al. (2008) Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11: 251-253.
    • (2008) Nat Neurosci , vol.11 , pp. 251-253
    • Yamanaka, K.1    Chun, S.J.2    Boillee, S.3    Fujimori-Tonou, N.4    Yamashita, H.5
  • 13
    • 44649152645 scopus 로고    scopus 로고
    • Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
    • Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, et al. (2008) Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A 105: 7594-7599.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 7594-7599
    • Yamanaka, K.1    Boillee, S.2    Roberts, E.A.3    Garcia, M.L.4    McAlonis-Downes, M.5
  • 14
    • 39649089599 scopus 로고    scopus 로고
    • Glial cells not that supportive for motor neurons
    • Boillee S, Lobsiger CS, (2008) [Glial cells not that supportive for motor neurons]. Med Sci (Paris) 24: 124-126.
    • (2008) Med Sci (Paris) , vol.24 , pp. 124-126
    • Boillee, S.1    Lobsiger, C.S.2
  • 15
    • 35549006420 scopus 로고    scopus 로고
    • Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
    • Lobsiger CS, Cleveland DW, (2007) Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci 10: 1355-1360.
    • (2007) Nat Neurosci , vol.10 , pp. 1355-1360
    • Lobsiger, C.S.1    Cleveland, D.W.2
  • 16
    • 33344462702 scopus 로고    scopus 로고
    • Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
    • Pun S, Santos AF, Saxena S, Xu L, Caroni P, (2006) Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF. Nat Neurosci 9: 408-419.
    • (2006) Nat Neurosci , vol.9 , pp. 408-419
    • Pun, S.1    Santos, A.F.2    Saxena, S.3    Xu, L.4    Caroni, P.5
  • 17
    • 35349025311 scopus 로고    scopus 로고
    • Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
    • Hegedus J, Putman CT, Gordon T, (2007) Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 28: 154-164.
    • (2007) Neurobiol Dis , vol.28 , pp. 154-164
    • Hegedus, J.1    Putman, C.T.2    Gordon, T.3
  • 18
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, et al. (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8: 752-758.
    • (2005) Nat Neurosci , vol.8 , pp. 752-758
    • Davalos, D.1    Grutzendler, J.2    Yang, G.3    Kim, J.V.4    Zuo, Y.5
  • 19
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F, (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308: 1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 20
    • 77954398133 scopus 로고    scopus 로고
    • NO mediates microglial response to acute spinal cord injury under ATP control in vivo
    • Dibaj P, Nadrigny F, Steffens H, Scheller A, Hirrlinger J, et al. (2010) NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia 58: 1133-1144.
    • (2010) Glia , vol.58 , pp. 1133-1144
    • Dibaj, P.1    Nadrigny, F.2    Steffens, H.3    Scheller, A.4    Hirrlinger, J.5
  • 21
    • 77955369663 scopus 로고    scopus 로고
    • Long-lasting post-mortem activity of spinal microglia in situ in mice
    • Dibaj P, Steffens H, Nadrigny F, Neusch C, Kirchhoff F, et al. (2010) Long-lasting post-mortem activity of spinal microglia in situ in mice. J Neurosci Res 88: 2431-2440.
    • (2010) J Neurosci Res , vol.88 , pp. 2431-2440
    • Dibaj, P.1    Steffens, H.2    Nadrigny, F.3    Neusch, C.4    Kirchhoff, F.5
  • 22
    • 39749169771 scopus 로고    scopus 로고
    • Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy
    • Davalos D, Lee JK, Smith WB, Brinkman B, Ellisman MH, et al. (2008) Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods 169: 1-7.
    • (2008) J Neurosci Methods , vol.169 , pp. 1-7
    • Davalos, D.1    Lee, J.K.2    Smith, W.B.3    Brinkman, B.4    Ellisman, M.H.5
  • 23
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch UK, Kettenmann H, (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394.
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 24
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, et al. (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20: 4106-4114.
    • (2000) Mol Cell Biol , vol.20 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3    Sunshine, M.J.4    Kreutzberg, G.W.5
  • 25
    • 0033634813 scopus 로고    scopus 로고
    • Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    • Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, et al. (2000) Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28: 41-51.
    • (2000) Neuron , vol.28 , pp. 41-51
    • Feng, G.1    Mellor, R.H.2    Bernstein, M.3    Keller-Peck, C.4    Nguyen, Q.T.5
  • 26
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM, (2007) Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 10: 1538-1543.
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 27
    • 26244439673 scopus 로고    scopus 로고
    • Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice
    • Hirrlinger PG, Scheller A, Braun C, Quintela-Schneider M, Fuss B, et al. (2005) Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice. Mol Cell Neurosci 30: 291-303.
    • (2005) Mol Cell Neurosci , vol.30 , pp. 291-303
    • Hirrlinger, P.G.1    Scheller, A.2    Braun, C.3    Quintela-Schneider, M.4    Fuss, B.5
  • 29
    • 41149097086 scopus 로고    scopus 로고
    • ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
    • Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, et al. (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci 11: 420-422.
    • (2008) Nat Neurosci , vol.11 , pp. 420-422
    • Zhong, Z.1    Deane, R.2    Ali, Z.3    Parisi, M.4    Shapovalov, Y.5
  • 30
    • 0032125587 scopus 로고    scopus 로고
    • Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
    • Hall ED, Oostveen JA, Gurney ME, (1998) Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. Glia 23: 249-256.
    • (1998) Glia , vol.23 , pp. 249-256
    • Hall, E.D.1    Oostveen, J.A.2    Gurney, M.E.3
  • 32
    • 20244390181 scopus 로고    scopus 로고
    • The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse
    • Fischer LR, Culver DG, Davis AA, Tennant P, Wang M, et al. (2005) The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse. Neurobiol Dis 19: 293-300.
    • (2005) Neurobiol Dis , vol.19 , pp. 293-300
    • Fischer, L.R.1    Culver, D.G.2    Davis, A.A.3    Tennant, P.4    Wang, M.5
  • 33
    • 73949128974 scopus 로고    scopus 로고
    • Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    • Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, et al. (2009) Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A 106: 20960-20965.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20960-20965
    • Chiu, I.M.1    Phatnani, H.2    Kuligowski, M.3    Tapia, J.C.4    Carrasco, M.A.5
  • 34
    • 0029004898 scopus 로고
    • Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
    • Collard JF, Cote F, Julien JP, (1995) Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 375: 61-64.
    • (1995) Nature , vol.375 , pp. 61-64
    • Collard, J.F.1    Cote, F.2    Julien, J.P.3
  • 35
    • 0033366384 scopus 로고    scopus 로고
    • Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
    • Williamson TL, Cleveland DW, (1999) Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat Neurosci 2: 50-56.
    • (1999) Nat Neurosci , vol.2 , pp. 50-56
    • Williamson, T.L.1    Cleveland, D.W.2
  • 36
    • 66449103829 scopus 로고    scopus 로고
    • A comparative analysis of the encapsulated end-organs of mammalian skeletal muscles and of their sensory nerve endings
    • Banks RW, Hulliger M, Saed HH, Stacey MJ, (2009) A comparative analysis of the encapsulated end-organs of mammalian skeletal muscles and of their sensory nerve endings. J Anat 214: 859-887.
    • (2009) J Anat , vol.214 , pp. 859-887
    • Banks, R.W.1    Hulliger, M.2    Saed, H.H.3    Stacey, M.J.4
  • 37
    • 51349143226 scopus 로고    scopus 로고
    • Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia
    • Hoffmann A, Hofmann F, Just I, Lehnardt S, Hanisch UK, et al. (2008) Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia. Glia 56: 1162-1175.
    • (2008) Glia , vol.56 , pp. 1162-1175
    • Hoffmann, A.1    Hofmann, F.2    Just, I.3    Lehnardt, S.4    Hanisch, U.K.5
  • 38
    • 33845259342 scopus 로고    scopus 로고
    • The P2Y12 receptor regulates microglial activation by extracellular nucleotides
    • Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, et al. (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9: 1512-1519.
    • (2006) Nat Neurosci , vol.9 , pp. 1512-1519
    • Haynes, S.E.1    Hollopeter, G.2    Yang, G.3    Kurpius, D.4    Dailey, M.E.5
  • 39
    • 58149335525 scopus 로고    scopus 로고
    • ATP and NO dually control migration of microglia to nerve lesions
    • Duan Y, Sahley CL, Muller KJ, (2009) ATP and NO dually control migration of microglia to nerve lesions. Dev Neurobiol 69: 60-72.
    • (2009) Dev Neurobiol , vol.69 , pp. 60-72
    • Duan, Y.1    Sahley, C.L.2    Muller, K.J.3
  • 40
    • 70449732762 scopus 로고    scopus 로고
    • The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis
    • D'Ambrosi N, Finocchi P, Apolloni S, Cozzolino M, Ferri A, et al. (2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis. J Immunol 183: 4648-4656.
    • (2009) J Immunol , vol.183 , pp. 4648-4656
    • D'Ambrosi, N.1    Finocchi, P.2    Apolloni, S.3    Cozzolino, M.4    Ferri, A.5
  • 41
    • 34548233140 scopus 로고    scopus 로고
    • Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    • Xiao Q, Zhao W, Beers DR, Yen AA, Xie W, et al. (2007) Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. J Neurochem 102: 2008-2019.
    • (2007) J Neurochem , vol.102 , pp. 2008-2019
    • Xiao, Q.1    Zhao, W.2    Beers, D.R.3    Yen, A.A.4    Xie, W.5
  • 42
    • 77953491018 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice
    • Chen K, Northington FJ, Martin LJ, (2009) Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice. Brain Struct Funct.
    • (2009) Brain Struct Funct
    • Chen, K.1    Northington, F.J.2    Martin, L.J.3
  • 43
    • 0033018506 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Almer G, Vukosavic S, Romero N, Przedborski S, (1999) Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 72: 2415-2425.
    • (1999) J Neurochem , vol.72 , pp. 2415-2425
    • Almer, G.1    Vukosavic, S.2    Romero, N.3    Przedborski, S.4
  • 45
    • 29444443348 scopus 로고    scopus 로고
    • Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
    • Urushitani M, Sik A, Sakurai T, Nukina N, Takahashi R, et al. (2006) Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci 9: 108-118.
    • (2006) Nat Neurosci , vol.9 , pp. 108-118
    • Urushitani, M.1    Sik, A.2    Sakurai, T.3    Nukina, N.4    Takahashi, R.5
  • 46
    • 73149105494 scopus 로고    scopus 로고
    • Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
    • Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, et al. (2010) Extracellular mutant SOD1 induces microglial-mediated motoneuron injury. Glia 58: 231-243.
    • (2010) Glia , vol.58 , pp. 231-243
    • Zhao, W.1    Beers, D.R.2    Henkel, J.S.3    Zhang, W.4    Urushitani, M.5
  • 47
    • 33847783428 scopus 로고    scopus 로고
    • Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene
    • Fendrick SE, Xue QS, Streit WJ, (2007) Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene. J Neuroinflammation 4: 9.
    • (2007) J Neuroinflammation , vol.4 , pp. 9
    • Fendrick, S.E.1    Xue, Q.S.2    Streit, W.J.3
  • 48
    • 28644436113 scopus 로고    scopus 로고
    • Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury
    • Bareyre FM, Kerschensteiner M, Misgeld T, Sanes JR, (2005) Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury. Nat Med 11: 1355-1360.
    • (2005) Nat Med , vol.11 , pp. 1355-1360
    • Bareyre, F.M.1    Kerschensteiner, M.2    Misgeld, T.3    Sanes, J.R.4
  • 50
    • 31544466262 scopus 로고    scopus 로고
    • Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis
    • Boven LA, Van Meurs M, Van Zwam M, Wierenga-Wolf A, Hintzen RQ, et al. (2006) Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis. Brain 129: 517-526.
    • (2006) Brain , vol.129 , pp. 517-526
    • Boven, L.A.1    van Meurs, M.2    van Zwam, M.3    Wierenga-Wolf, A.4    Hintzen, R.Q.5
  • 51
    • 77349114038 scopus 로고    scopus 로고
    • Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
    • Graber DJ, Hickey WF, Harris BT, (2010) Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis. J Neuroinflammation 7: 8.
    • (2010) J Neuroinflammation , vol.7 , pp. 8
    • Graber, D.J.1    Hickey, W.F.2    Harris, B.T.3
  • 52
    • 48949120504 scopus 로고    scopus 로고
    • Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis
    • Hegedus J, Putman CT, Tyreman N, Gordon T, (2008) Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis. J Physiol 586: 3337-3351.
    • (2008) J Physiol , vol.586 , pp. 3337-3351
    • Hegedus, J.1    Putman, C.T.2    Tyreman, N.3    Gordon, T.4
  • 53
    • 33748261830 scopus 로고    scopus 로고
    • Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
    • Gould TW, Buss RR, Vinsant S, Prevette D, Sun W, et al. (2006) Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci 26: 8774-8786.
    • (2006) J Neurosci , vol.26 , pp. 8774-8786
    • Gould, T.W.1    Buss, R.R.2    Vinsant, S.3    Prevette, D.4    Sun, W.5
  • 54
    • 23744445580 scopus 로고    scopus 로고
    • A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
    • Schaefer AM, Sanes JR, Lichtman JW, (2005) A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis. J Comp Neurol 490: 209-219.
    • (2005) J Comp Neurol , vol.490 , pp. 209-219
    • Schaefer, A.M.1    Sanes, J.R.2    Lichtman, J.W.3
  • 55
    • 0345742771 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
    • Fischer LR, Culver DG, Tennant P, Davis AA, Wang M, et al. (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol 185: 232-240.
    • (2004) Exp Neurol , vol.185 , pp. 232-240
    • Fischer, L.R.1    Culver, D.G.2    Tennant, P.3    Davis, A.A.4    Wang, M.5
  • 56
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Bruijn LI, Miller TM, Cleveland DW, (2004) Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 27: 723-749.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 57
    • 74049164709 scopus 로고    scopus 로고
    • Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
    • Ilieva H, Polymenidou M, Cleveland DW, (2009) Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 187: 761-772.
    • (2009) J Cell Biol , vol.187 , pp. 761-772
    • Ilieva, H.1    Polymenidou, M.2    Cleveland, D.W.3
  • 58
    • 70350075024 scopus 로고    scopus 로고
    • Genetics of motor neuron disorders: new insights into pathogenic mechanisms
    • Dion PA, Daoud H, Rouleau GA, (2009) Genetics of motor neuron disorders: new insights into pathogenic mechanisms. Nat Rev Genet 10: 769-782.
    • (2009) Nat Rev Genet , vol.10 , pp. 769-782
    • Dion, P.A.1    Daoud, H.2    Rouleau, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.