Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis

Brain Pathology

Volumn 21, Issue 1, 2011, Pages 1-15

  Sunico, Carmen R ^a,d   Domínguez, Germán ^a   García Verdugo, José Manuel ^b   Osta, Rosario ^c   Montero, Fernando ^a   Moreno López, Bernardo ^a  

^a UNIVERSITY OF CÁDIZ   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSIDAD DE ZARAGOZA   (Spain)

^d BURNHAM INSTITUTE   (United States)

Author keywords

hypoglossal motoneurons; myosin light chain phosphorylation; nitric oxide; SOD1G93A mice; synaptic alterations

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL SIZE; CELL SWELLING; CELL VACUOLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE COURSE; EXCITOTOXICITY; FEMALE; MALE; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NONHUMAN; PATHOGENESIS; SYNAPSE VESICLE;

AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MOTOR NEURONS; NERVE DEGENERATION; NITRIC OXIDE; SUPEROXIDE DISMUTASE; SYNAPSES; VESICULAR GLUTAMATE TRANSPORT PROTEIN 2; VESICULAR INHIBITORY AMINO ACID TRANSPORT PROTEINS;

EID: 78650017783     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2010.00417.x     Document Type: Article

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