Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal motor neurons

Neurobiology of Disease

Volumn 7, Issue 4, 2000, Pages 274-285

  Dupuis, Luc ^a   De Tapia, Marc ^a   René, Frédérique ^a   Lutz Bucher, Bernadette ^a   Gordon, Jon W ^b   Mercken, Luc ^c   Pradier, Laurent ^c   Loeffler, Jean Philippe ^a  

^a CNRS   (France)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; GENE MUTATION; MOUSE; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; TRANSGENIC MOUSE;

EID: 0033826065     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0292     Document Type: Article

References (40)

1. Mitochondrial dysfunction in neurodegenerative diseases
2. Elevated 'hydroxyl radical' generation in vivo in an animal model of amyotrophic lateral sclerosis
3. Mechanisms of selective motor neuron death in ALS: Insights from transgenic mouse models of motor neuron disease
4. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
5. Amyotrophic lateral sclerosis: Lower motor neuron disease spreading to upper motor neurons
6. Oxidative stress and motor neurone disease
7. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis
8. Superoxide dismutase catalyzes nitration of tyrosines by peroxyrdtrite in the rod and head domains of neurofilament-L
9. Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries
10. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
11. Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis. Evidence for the implication of the p53-signaling pathway
12. Slow axonal transport of neurofilament proteins: Impairment by β,β'-iminodipropionitrile administration
13. Transgenic-animal model of familial amyotrophic lateral sclerosis
14. Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation
15. The mechanisms of fast and slow transport in neurons: Identification and characterization of the new kinesin superfamily motors
16. Neurofilaments and motor neuron disease
17. 3H]MK-801/NMDA binding sites in spinal cord
18. A role for amplified protein kinase C activity in the pathogenesis of amyotrophic lateral sclerosis
19. Aberrant RNA processing in a neurodegenerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis
20. Oxidative stress and a murine superoxide dismutase-1 mutation promoting amyotrophic lateral sclerosis alter neurosecretion in the hypothalamo-neurohypophyseal axis
21. Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice
22. Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
23. Redistribution of proteins of fast axonal transport following administration of β,β'-iminodipropionitrile: A quantitative autoradiographic study
24. Transgenic mice expressing an altered murine superoxide dismutase provide an animal model of amyotrophic lateral sclerosis
25. Mutations in Cu/Zn superoxide dismutase are associated with familial amyotrophic lateral sclerosis
26. Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis
27. Kinesin accumulation in chick spinal axonal swellings with β,β'-iminodipropionitrile (IDPN) intoxication
28. Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of hut an motor neuron disease
29. A high throughput screening for rarely transcribed differentially expressed genes
30. Abnormalities of protein kinases in neurodegenerative diseases
31. Selective impairment of anterograde axonal transport in the peripheral nerves fast of asymptomatic transgenic mice with a G93A mutant SOD1 gene
32. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
33. An adverse property of a famial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
34. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
35. KIF3/B: A heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport
36. Cloning and characterization of KAP3: A novel kinesin superfamily-associated protein of K1F3A/3B
37. Characterization of the KIF3C neural kinesin-like motor from mouse
38. Neurofilaments and orthograte transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation