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Volumn 9, Issue 6, 2014, Pages 609-628

Epigenetic mechanisms in COPD: Implications for pathogenesis and drug discovery

Author keywords

Biomarker; Chronic obstructive pulmonary disease; DNA methyltransferase inhibitors; DNA modification; Emphysema; Histone deacetylase activators; Polycomb

Indexed keywords

HISTONE DEACETYLASE; MICRORNA; POLYCOMB GROUP PROTEIN; UNTRANSLATED RNA; DNA; HISTONE;

EID: 84901251854     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2014.913020     Document Type: Review
Times cited : (45)

References (148)
  • 1
    • 69549084350 scopus 로고    scopus 로고
    • WHO.). Global Strategy For Diagnosis Management And Prevention Of COPD. Available from [cited 13 January 2014]
    • WHO. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for Diagnosis, Management, and Prevention of COPD. 2013. Available from: Http://www. goldcopd.org/uploads/users/files/ GOLD-Report-2013-Feb20.pdf [cited 13 January 2014]
    • (2013) Global Initiative for Chronic Obstructive Lung Disease (GOLD
  • 2
    • 77249136293 scopus 로고    scopus 로고
    • WHO. Fact sheet N-315. Available from [cited 13 January 2014]
    • WHO. Chronic obstructive pulmonary disease (COPD). 2013. Fact sheet N-315. Available from: Http:// www.who.int/mediacentre/factsheets/ fs315/en/ [cited 13 January 2014]
    • (2013) Chronic Obstructive Pulmonary Disease (COPD
  • 3
    • 54149090275 scopus 로고    scopus 로고
    • WHO update. 2013. Available from [cited 13 January 2014]
    • WHO. The global burden of disease: 2004 update. 2013. Available from: Http://www.who.int/healthinfo/ global-burden-disease/ GBD-report-2004update- full.pdf [cited 13 January 2014]
    • (2004) The Global Burden of Disease
  • 6
    • 84886793202 scopus 로고    scopus 로고
    • Comorbidities and health status in individuals with and without copd in five latin american cities: The platino study
    • Lopez Varela MV, Montes de Oca M, Halbert R, et al. Comorbidities and health status in individuals with and without COPD in five latin american cities: The PLATINO study. Arch Bronconeumol 2013;49(11):468-74
    • (2013) Arch Bronconeumol , vol.49 , Issue.11 , pp. 468-474
    • Lopez Varela, M.V.1    Montes De Oca, M.2    Halbert, R.3
  • 7
    • 0003661910 scopus 로고    scopus 로고
    • WHO. Available from [cited 11 September 2012]
    • WHO. World health statistics 2008. 2008. Available from: Http://www.who. int/whosis/whostat/EN-WHS08-Full.pdf [cited 11 September 2012]
    • (2008) World Health Statistics , vol.2008
  • 8
    • 84901256434 scopus 로고    scopus 로고
    • WHO Available from cited 14 January 2014]
    • WHO. Projections of mortality and causes of death, 2015 and 2030. Available from: Http://www.who.int/ entity/healthinfo/global-burden-disease/ GHE-DthGlobal-Proj-2015-2030.xls [cited 14 January 2014]
    • Projections of Mortality and Causes of Death 2015 and 2030
  • 11
    • 69149102202 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease in non-smokers
    • Salvi SS, Barnes PJ. Chronic obstructive pulmonary disease in non-smokers. Lancet 2009;374(9691):733-43
    • (2009) Lancet , vol.374 , Issue.9691 , pp. 733-743
    • Salvi, S.S.1    Barnes, P.J.2
  • 12
    • 84901265670 scopus 로고    scopus 로고
    • Occupational exposure to vapors, gases, dusts and fumes and mortality in relation to chronic obstructive pulmonary disease among Swedish construction workers-A longitudinal cohort study
    • Epub ahead of print]
    • Toren K, Jarvholm B. Occupational exposure to vapors, gases, dusts and fumes and mortality in relation to chronic obstructive pulmonary disease among Swedish construction workers-A longitudinal cohort study. Chest 2013. [Epub ahead of print]
    • (2013) Chest
    • Toren, K.1    Jarvholm, B.2
  • 13
  • 14
    • 78349287385 scopus 로고    scopus 로고
    • Sex-related differences in copd in five latin american cities: The platino study
    • Lopez Varela MV, Montes de Oca M, Halbert RJ, et al. Sex-related differences in COPD in five Latin American cities: The PLATINO study. Eur Respir J 2010;36(5):1034-41
    • (2010) Eur Respir J , vol.36 , Issue.5 , pp. 1034-1041
    • Lopez Varela, M.V.1    Montes De Oca, M.2    Halbert, R.J.3
  • 16
    • 80051822790 scopus 로고    scopus 로고
    • Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and african american race in the copdgene study
    • Foreman MG, Zhang L, Murphy J, et al. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med 2011;184(4):414-20
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.4 , pp. 414-420
    • Foreman, M.G.1    Zhang, L.2    Murphy, J.3
  • 17
    • 84878135234 scopus 로고    scopus 로고
    • Human immunodeficiency virusassociated obstructive lung diseases
    • Gingo MR, Morris A, Crothers K. Human immunodeficiency virusassociated obstructive lung diseases. Clin Chest Med 2013;34(2):273-82
    • (2013) Clin Chest Med , vol.34 , Issue.2 , pp. 273-282
    • Gingo, M.R.1    Morris, A.2    Crothers, K.3
  • 18
    • 84861475738 scopus 로고    scopus 로고
    • Pulmonary tuberculosis and delay in anti-Tuberculous treatment are important risk factors for chronic obstructive pulmonary disease
    • Lee CH, Lee MC, Lin HH, et al. Pulmonary tuberculosis and delay in anti-Tuberculous treatment are important risk factors for chronic obstructive pulmonary disease. PLoS One 2012;7(5):e37978
    • (2012) PLoS One , vol.7 , Issue.5
    • Lee, C.H.1    Lee, M.C.2    Lin, H.H.3
  • 19
    • 84884236470 scopus 로고    scopus 로고
    • United Nations DoEaSA, Population Division Revision, Volume I: Comprehensive Tables ST/ESA/SER.A/ 336. Available from [cited 18 February 2014]
    • United Nations DoEaSA, Population Division. World Population Prospects: The 2012 Revision, Volume I: Comprehensive Tables ST/ESA/SER.A/ 336. 2013. Available from: Http://esa.un. org/wpp/Documentation/pdf/ WPP2012-Volume-I- Comprehensive-Tables.pdf [cited 18 February 2014]
    • (2013) World Population Prospects: The 2012
  • 20
    • 84884236470 scopus 로고    scopus 로고
    • United Nations DoEaSA, Population Division Volume II: Demographic Profiles. ST/ESA/SER.A/ 345. Available from [cited 18 February 2014]
    • United Nations DoEaSA, Population Division. World Population Prospects: The 2012 Revision, Volume II: Demographic Profiles. ST/ESA/SER.A/ 345. 2013. Available from: Http://esa.un. org/wpp/Documentation/pdf/ WPP2012-Volume-II- Demographic-Profiles.pdf [cited 18 February 2014]
    • (2013) World Population Prospects: The 2012 Revision
  • 21
    • 84863819831 scopus 로고    scopus 로고
    • Genes and chronic obstructive pulmonary disease
    • Foreman MG, Campos M, Celedon JC. Genes and chronic obstructive pulmonary disease. Med Clin North Am 2012;96(4):699-711
    • (2012) Med Clin North Am , vol.96 , Issue.4 , pp. 699-711
    • Foreman, M.G.1    Campos, M.2    Celedon, J.C.3
  • 22
    • 20744450475 scopus 로고    scopus 로고
    • Alpha1-Antitrypsin deficiency
    • Stoller JK, Aboussouan LS. Alpha1-Antitrypsin deficiency. Lancet 2005;365(9478):2225-36
    • (2005) Lancet , vol.365 , Issue.9478 , pp. 2225-2236
    • Stoller, J.K.1    Aboussouan, L.S.2
  • 23
    • 66149093072 scopus 로고    scopus 로고
    • The pathology of chronic obstructive pulmonary disease
    • Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 2009;4:435-59
    • (2009) Annu Rev Pathol , vol.4 , pp. 435-459
    • Hogg, J.C.1    Timens, W.2
  • 24
    • 84864776533 scopus 로고    scopus 로고
    • Pathogenesis of chronic obstructive pulmonary disease
    • Tuder RM, Petrache I. Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest 2012;122(8):2749-55
    • (2012) J Clin Invest , vol.122 , Issue.8 , pp. 2749-2755
    • Tuder, R.M.1    Petrache, I.2
  • 25
    • 84901265680 scopus 로고    scopus 로고
    • Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-beta
    • Epub ahead of print]
    • Schamberger AC, Mise N, Jia J, et al. Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-beta. Am J Respir Cell Mol Biol 2013. [Epub ahead of print]
    • (2013) Am J Respir Cell Mol Biol
    • Schamberger, A.C.1    Mise, N.2    Jia, J.3
  • 26
    • 83655190177 scopus 로고    scopus 로고
    • Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery
    • Heijink IH, Brandenburg SM, Postma DS, van Oosterhout AJ. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery. Eur Respir J 2012;39(2):419-28
    • (2012) Eur Respir J , vol.39 , Issue.2 , pp. 419-428
    • Heijink, I.H.1    Brandenburg, S.M.2    Postma, D.S.3    Van Oosterhout, A.J.4
  • 28
    • 0032576744 scopus 로고    scopus 로고
    • X inactivation in females with X-linked disease
    • DOI 10.1056/NEJM199801293380511
    • Puck JM, Willard HF. X inactivation in females with X-linked disease. N Engl J Med 1998;338(5):325-8 (Pubitemid 28065261
    • (1998) New England Journal of Medicine , vol.338 , Issue.5 , pp. 325-328
    • Puck, J.M.1    Willard, H.F.2
  • 29
    • 84864019015 scopus 로고    scopus 로고
    • Epigenetic variation during the adult lifespan: Cross-sectional and longitudinal data on monozygotic twin pairs
    • Talens RP, Christensen K, Putter H, et al. Epigenetic variation during the adult lifespan: Cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell 2012;11(4):694-703
    • (2012) Aging Cell , vol.11 , Issue.4 , pp. 694-703
    • Talens, R.P.1    Christensen, K.2    Putter, H.3
  • 31
    • 84857855590 scopus 로고    scopus 로고
    • Twin studies as a model for exploring the aetiology of autoimmune thyroid disease
    • Brix TH, Hegedus L. Twin studies as a model for exploring the aetiology of autoimmune thyroid disease. Clin Endocrinol (Oxf) 2012;76(4):457-64
    • (2012) Clin Endocrinol (Oxf , vol.76 , Issue.4 , pp. 457-464
    • Brix, T.H.1    Hegedus, L.2
  • 32
    • 84870698653 scopus 로고    scopus 로고
    • Asthma discordance in twins is linked to epigenetic modifications of T cells
    • Runyon RS, Cachola LM, Rajeshuni N, et al. Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One 2012;7(11):e48796
    • (2012) PLoS One , vol.7 , Issue.11
    • Runyon, R.S.1    Cachola, L.M.2    Rajeshuni, N.3
  • 33
    • 0031777437 scopus 로고    scopus 로고
    • Segregation analysis of pulmonary function among families in the Framingham Study
    • Givelber RJ, Couropmitree NN, Gottlieb DJ, et al. Segregation analysis of pulmonary function among families in the Framingham Study. Am J Respir Crit Care Med 1998;157(5 Pt 1):1445-51
    • (1998) Am J Respir Crit Care Med , vol.157 , Issue.5 PART 1 , pp. 1445-1451
    • Givelber, R.J.1    Couropmitree, N.N.2    Gottlieb, D.J.3
  • 34
    • 0017800258 scopus 로고
    • Studies of the familial aggregation of chronic bronchitis and obstructive airways disease
    • Tager I, Tishler PV, Rosner B, et al. Studies of the familial aggregation of chronic bronchitis and obstructive airways disease. Int J Epidemiol 1978;7(1):55-62 (Pubitemid 8328482
    • (1978) International Journal of Epidemiology , vol.7 , Issue.1 , pp. 55-62
    • Tager, I.A.1    Tishler, P.V.2    Rosner, B.3
  • 36
    • 33144482007 scopus 로고    scopus 로고
    • Reduced histone deacetylase in COPD: Clinical implications
    • DOI 10.1378/chest.129.1.151
    • Barnes PJ. Reduced histone deacetylase in COPD: Clinical implications. Chest 2006;129(1):151-5 (Pubitemid 43265256
    • (2006) Chest , vol.129 , Issue.1 , pp. 151-155
    • Barnes, P.J.1
  • 37
    • 36849024085 scopus 로고    scopus 로고
    • Epigenetic regulation of airway inflammation
    • DOI 10.1016/j.coi.2007.07.016, PII S0952791507001306, Autoimmunity / Allergy and Hypersenditivity
    • Adcock IM, Tsaprouni L, Bhavsar P, Ito K. Epigenetic regulation of airway inflammation. Curr Opin Immunol 2007;19(6):694-700 (Pubitemid 350236802
    • (2007) Current Opinion in Immunology , vol.19 , Issue.6 , pp. 694-700
    • Adcock, I.M.1    Tsaprouni, L.2    Bhavsar, P.3    Ito, K.4
  • 38
    • 14744285888 scopus 로고    scopus 로고
    • Histone acetylation and deacetylation: Importance in inflammatory lung diseases
    • DOI 10.1183/09031936.05.00117504
    • Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: Importance in inflammatory lung diseases. Eur Respir J 2005;25(3):552-63 (Pubitemid 40331188
    • (2005) European Respiratory Journal , vol.25 , Issue.3 , pp. 552-563
    • Barnes, P.J.1    Adcock, I.M.2    Ito, K.3
  • 39
    • 0036733675 scopus 로고    scopus 로고
    • Chromatin modification and epigenetic reprogramming in mammalian development
    • DOI 10.1038/nrg887
    • Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 2002;3(9):662-73 (Pubitemid 34984255
    • (2002) Nature Reviews Genetics , vol.3 , Issue.9 , pp. 662-673
    • Li, E.1
  • 40
    • 84857381360 scopus 로고    scopus 로고
    • Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function
    • Qiu W, Baccarelli A, Carey VJ, et al. Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function. Am J Respir Crit Care Med 2012;185(4):373-81
    • (2012) Am J Respir Crit Care Med , vol.185 , Issue.4 , pp. 373-381
    • Qiu, W.1    Baccarelli, A.2    Carey, V.J.3
  • 41
    • 77954086478 scopus 로고    scopus 로고
    • Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
    • Liu F, Killian JK, Yang M, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 2010;29(25):3650-64
    • (2010) Oncogene , vol.29 , Issue.25 , pp. 3650-3664
    • Liu, F.1    Killian, J.K.2    Yang, M.3
  • 42
    • 84855839546 scopus 로고    scopus 로고
    • Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers
    • Monick MM, Beach SR, Plume J, et al. Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet 2012;159B(2):141-51
    • (2012) Am J Med Genet B Neuropsychiatr Genet , vol.159 B , Issue.2 , pp. 141-151
    • Monick, M.M.1    Beach, S.R.2    Plume, J.3
  • 43
    • 84901277610 scopus 로고    scopus 로고
    • Dna methylation is globally disrupted and associated with expression changes in copd small airways
    • Epub ahead of print]
    • Vucic EA, Chari R, Thu KL, et al. DNA methylation is globally disrupted and associated with expression changes in COPD small airways. Am J Respir Cell Mol Biol 2013. [Epub ahead of print]
    • (2013) Am J Respir Cell Mol Biol
    • Vucic, E.A.1    Chari, R.2    Thu, K.L.3
  • 44
    • 67349118349 scopus 로고    scopus 로고
    • Inhalation of cigarette smoke induces regions of altered dna methylation (rams) in sencar mouse lung
    • Phillips JM, Goodman JI. Inhalation of cigarette smoke induces regions of altered DNA methylation (RAMs) in SENCAR mouse lung. Toxicology 2009;260(1-3):7-15
    • (2009) Toxicology , vol.260 , Issue.1-3 , pp. 7-15
    • Phillips, J.M.1    Goodman, J.I.2
  • 45
    • 69249132169 scopus 로고    scopus 로고
    • Prenatal tobacco smoke exposure affects global and gene-specific dna methylation
    • Breton CV, Byun HM, Wenten M, et al. Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med 2009;180(5):462-7
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.5 , pp. 462-467
    • Breton, C.V.1    Byun, H.M.2    Wenten, M.3
  • 46
    • 84894242124 scopus 로고    scopus 로고
    • Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents
    • Hollams EM, de Klerk NH, Holt PG, Sly PD. Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents. Am J Respir Crit Care Med 2014;189(4):401-7
    • (2014) Am J Respir Crit Care Med , vol.189 , Issue.4 , pp. 401-407
    • Hollams, E.M.1    De Klerk, N.H.2    Holt, P.G.3    Sly, P.D.4
  • 48
    • 84863509978 scopus 로고    scopus 로고
    • Cigarette smoking behaviors and time since quitting are associated with differential dna methylation across the human genome
    • Wan ES, Qiu W, Baccarelli A, et al. Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet 2012;21(13):3073-82
    • (2012) Hum Mol Genet , vol.21 , Issue.13 , pp. 3073-3082
    • Wan, E.S.1    Qiu, W.2    Baccarelli, A.3
  • 49
    • 79953706343 scopus 로고    scopus 로고
    • Tobacco-smoking-related differential DNA methylation: 27K discovery and replication
    • Breitling LP, Yang R, Korn B, et al. Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet 2011;88(4):450-7
    • (2011) Am J Hum Genet , vol.88 , Issue.4 , pp. 450-457
    • Breitling, L.P.1    Yang, R.2    Korn, B.3
  • 50
    • 84863806469 scopus 로고    scopus 로고
    • Association of cigarette smoking and crp levels with dna methylation in alpha-1 antitrypsin deficiency
    • Siedlinski M, Klanderman B, Sandhaus RA, et al. Association of cigarette smoking and CRP levels with DNA methylation in alpha-1 antitrypsin deficiency. Epigenetics 2012;7(7):720-8
    • (2012) Epigenetics , vol.7 , Issue.7 , pp. 720-728
    • Siedlinski, M.1    Klanderman, B.2    Sandhaus, R.A.3
  • 51
    • 84890025789 scopus 로고    scopus 로고
    • Histone deacetylase 6-mediated selective autophagy regulates copdassociated cilia dysfunction
    • Lam HC, Cloonan SM, Bhashyam AR, et al. Histone deacetylase 6-mediated selective autophagy regulates COPDassociated cilia dysfunction. J Clin Invest 2013;123(12):5212-30
    • (2013) J Clin Invest , vol.123 , Issue.12 , pp. 5212-5230
    • Lam, H.C.1    Cloonan, S.M.2    Bhashyam, A.R.3
  • 52
    • 35148873511 scopus 로고    scopus 로고
    • Cigarette smoke induces demethylation of prometastatic oncogene synucleingamma in lung cancer cells by downregulation of dnmt3b
    • Liu H, Zhou Y, Boggs SE, et al. Cigarette smoke induces demethylation of prometastatic oncogene synucleingamma in lung cancer cells by downregulation of DNMT3B. Oncogene 2007;26(40):5900-10
    • (2007) Oncogene , vol.26 , Issue.40 , pp. 5900-5910
    • Liu, H.1    Zhou, Y.2    Boggs, S.E.3
  • 53
    • 33846111256 scopus 로고    scopus 로고
    • Alteration of dna methyltransferases contributes to 5'cpg methylation and poor prognosis in lung cancer
    • Lin RK, Hsu HS, Chang JW, et al. Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung cancer 2007;55(2):205-13
    • (2007) Lung Cancer , vol.55 , Issue.2 , pp. 205-213
    • Lin, R.K.1    Hsu, H.S.2    Chang, J.W.3
  • 54
    • 76649112380 scopus 로고    scopus 로고
    • The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients
    • Lin RK, Hsieh YS, Lin P, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest 2010;120(2):521-32
    • (2010) J Clin Invest , vol.120 , Issue.2 , pp. 521-532
    • Lin, R.K.1    Hsieh, Y.S.2    Lin, P.3
  • 55
    • 84888001513 scopus 로고    scopus 로고
    • A new world of polycombs: Unexpected partnerships and emerging functions
    • Schwartz YB, Pirrotta V. A new world of Polycombs: Unexpected partnerships and emerging functions. Nat Rev Genet 2013;14(12):853-64
    • (2013) Nat Rev Genet , vol.14 , Issue.12 , pp. 853-864
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 56
    • 84876871047 scopus 로고    scopus 로고
    • Occupying chromatin: Polycomb mechanisms for getting to genomic targets stopping transcriptional traffic and staying put
    • Simon JA, Kingston RE. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell 2013;49(5):808-24
    • (2013) Mol Cell , vol.49 , Issue.5 , pp. 808-824
    • Simon, J.A.1    Kingston, R.E.2
  • 57
    • 51049098953 scopus 로고    scopus 로고
    • Runx3 methylation reveals that bladder tumors are older in patients with a history of smoking
    • Wolff EM, Liang G, Cortez CC, et al. RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. Cancer Res 2008;68(15):6208-14
    • (2008) Cancer Res , vol.68 , Issue.15 , pp. 6208-6214
    • Wolff, E.M.1    Liang, G.2    Cortez, C.C.3
  • 58
    • 84874631435 scopus 로고    scopus 로고
    • Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis
    • Xi S, Xu H, Shan J, et al. Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis. J Clin Invest 2013;123(3):1241-61
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 1241-1261
    • Xi, S.1    Xu, H.2    Shan, J.3
  • 59
    • 84896707487 scopus 로고    scopus 로고
    • Dna methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes
    • Hascher A, Haase AK, Hebestreit K, et al. DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes. Clin Cancer Res 2014;20(4):814-26
    • (2014) Clin Cancer Res , vol.20 , Issue.4 , pp. 814-826
    • Hascher, A.1    Haase, A.K.2    Hebestreit, K.3
  • 60
    • 84885183510 scopus 로고    scopus 로고
    • Aerosolised 5-Azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model
    • Reed MD, Tellez CS, Grimes MJ, et al. Aerosolised 5-Azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model. Br J Cancer 2013;109(7):1775-81
    • (2013) Br J Cancer , vol.109 , Issue.7 , pp. 1775-1781
    • Reed, M.D.1    Tellez, C.S.2    Grimes, M.J.3
  • 61
    • 33846805947 scopus 로고    scopus 로고
    • Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-κB activation in normal human bronchial epithelial cells
    • DOI 10.1038/sj.onc.1209829, PII 1209829
    • Syed DN, Afaq F, Kweon MH, et al. Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells. Oncogene 2007;26(5):673-82 (Pubitemid 46204247
    • (2007) Oncogene , vol.26 , Issue.5 , pp. 673-682
    • Syed, D.N.1    Afaq, F.2    Kweon, M.-H.3    Hadi, N.4    Bhatia, N.5    Spiegelman, V.S.6    Mukhtar, H.7
  • 62
    • 70349628613 scopus 로고    scopus 로고
    • Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats
    • Chan KH, Ho SP, Yeung SC, et al. Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats. Respir Med 2009;103(11):1746-54
    • (2009) Respir Med , vol.103 , Issue.11 , pp. 1746-1754
    • Chan, K.H.1    Ho, S.P.2    Yeung, S.C.3
  • 63
    • 84886808679 scopus 로고    scopus 로고
    • Chromatin proteins and modifications as drug targets
    • Helin K, Dhanak D. Chromatin proteins and modifications as drug targets. Nature 2013;502(7472):480-8
    • (2013) Nature , vol.502 , Issue.7472 , pp. 480-488
    • Helin, K.1    Dhanak, D.2
  • 64
    • 0042528729 scopus 로고    scopus 로고
    • Heterochromatin and epigenetic control of gene expression
    • DOI 10.1126/science.1086887
    • Grewal SI, Moazed D. Heterochromatin and epigenetic control of gene expression. Science 2003;301(5634):798-802 (Pubitemid 36962612
    • (2003) Science , vol.301 , Issue.5634 , pp. 798-802
    • Grewal, S.I.S.1    Moazed, D.2
  • 65
    • 84855956247 scopus 로고    scopus 로고
    • Epigenetics and the environment: Emerging patterns and implications
    • Feil R, Fraga MF. Epigenetics and the environment: Emerging patterns and implications. Nat Rev Genet 2011;13(2):97-109
    • (2011) Nat Rev Genet , vol.13 , Issue.2 , pp. 97-109
    • Feil, R.1    Fraga, M.F.2
  • 66
    • 18544383099 scopus 로고    scopus 로고
    • Increased expression of nuclear factor-kappab in bronchial biopsies from smokers and patients with copd
    • Di Stefano A, Caramori G, Oates T, et al. Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J 2002;20(3):556-63
    • (2002) Eur Respir J , vol.20 , Issue.3 , pp. 556-563
    • Di Stefano, A.1    Caramori, G.2    Oates, T.3
  • 69
    • 33745728358 scopus 로고    scopus 로고
    • Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
    • Yang SR, Chida AS, Bauter MR, et al. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol 2006;291(1):L46-57
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291 , Issue.1
    • Yang, S.R.1    Chida, A.S.2    Bauter, M.R.3
  • 70
    • 0036066957 scopus 로고    scopus 로고
    • Oxidative stress an TNF-α induce histone acetylation and NF-κB/AP-1 activation in alveolar epithelial cells: Potential mechanism in gene transcription in lung inflammation
    • DOI 10.1023/A:1015905010086
    • Rahman I, Gilmour PS, Jimenez LA, MacNee W. Oxidative stress and TNF-Alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: Potential mechanism in gene transcription in lung inflammation. Mol Cell Biochem 2002;234-235(1-2):239-48 (Pubitemid 34777863
    • (2002) Molecular and Cellular Biochemistry , vol.234-235 , pp. 239-248
    • Rahman, I.1    Gilmour, P.S.2    Jimenez, L.A.3    MacNee, W.4
  • 71
    • 84856409891 scopus 로고    scopus 로고
    • Mitogen-And stress-Activated kinase 1 (MSK1) regulates cigarette smokeinduced histone modifications on NF-kappaB-dependent genes
    • Sundar IK, Chung S, Hwang JW, et al. Mitogen-And stress-Activated kinase 1 (MSK1) regulates cigarette smokeinduced histone modifications on NF-kappaB-dependent genes. PLoS One 2012;7(2):e31378
    • (2012) PLoS One , vol.7 , Issue.2
    • Sundar, I.K.1    Chung, S.2    Hwang, J.W.3
  • 72
    • 0034802887 scopus 로고    scopus 로고
    • The p65 (rela) subunit of nf-κb interacts with the histone deacetylase (hdac) corepressors hdac1 and hdac2 to negatively regulate gene expression
    • DOI 10.1128/MCB.21.20.7065-7077.2001
    • Ashburner BP, Westerheide SD, Baldwin AS Jr. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 2001;21(20):7065-77 (Pubitemid 32916079
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.20 , pp. 7065-7077
    • Ashburner, B.P.1    Westerheide, S.D.2    Baldwin Jr., A.S.3
  • 73
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-κB action regulated by reversible acetylation
    • DOI 10.1126/science.1062374
    • Chen L, Fischle W, Verdin E, Greene WC. Duration of nuclear NFkappaB action regulated by reversible acetylation. Science 2001;293(5535):1653-7 (Pubitemid 32807844
    • (2001) Science , vol.293 , Issue.5535 , pp. 1653-1657
    • Chen, L.-F.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 74
    • 0036203419 scopus 로고    scopus 로고
    • The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1
    • DOI 10.1016/S1097-2765(02)00477-X
    • Zhong H, May MJ, Jimi E, Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 2002;9(3):625-36 (Pubitemid 34273792
    • (2002) Molecular Cell , vol.9 , Issue.3 , pp. 625-636
    • Zhong, H.1    May, M.J.2    Jimi, E.3    Ghosh, S.4
  • 75
    • 84862788383 scopus 로고    scopus 로고
    • Histone deacetylase activity is decreased in peripheral blood monocytes in patients with COPD
    • Chen Y, Huang P, Ai W, et al. Histone deacetylase activity is decreased in peripheral blood monocytes in patients with COPD. J Inflamm 2012;9:10
    • (2012) J Inflamm , vol.9 , pp. 10
    • Chen, Y.1    Huang, P.2    Ai, W.3
  • 77
    • 79955090868 scopus 로고    scopus 로고
    • Patterns of inflammatory responses in large and small airways in smokers with and without chronic obstructive pulmonary disease
    • Isajevs S, Taivans I, Svirina D, et al. Patterns of inflammatory responses in large and small airways in smokers with and without chronic obstructive pulmonary disease. Respiration 2011;81(5):362-71
    • (2011) Respiration , vol.81 , Issue.5 , pp. 362-371
    • Isajevs, S.1    Taivans, I.2    Svirina, D.3
  • 79
    • 65249151877 scopus 로고    scopus 로고
    • Inhibition of PI3Kdelta restores glucocorticoid function in smokinginduced airway inflammation in mice
    • Marwick JA, Caramori G, Stevenson CS, et al. Inhibition of PI3Kdelta restores glucocorticoid function in smokinginduced airway inflammation in mice. Am J Respir Crit Care Med 2009;179(7):542-8
    • (2009) Am J Respir Crit Care Med , vol.179 , Issue.7 , pp. 542-548
    • Marwick, J.A.1    Caramori, G.2    Stevenson, C.S.3
  • 80
    • 80555124930 scopus 로고    scopus 로고
    • Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients
    • Malhotra D, Thimmulappa RK, Mercado N, et al. Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. J Clin Invest 2011;121(11):4289-302
    • (2011) J Clin Invest , vol.121 , Issue.11 , pp. 4289-4302
    • Malhotra, D.1    Thimmulappa, R.K.2    Mercado, N.3
  • 81
    • 84881521758 scopus 로고    scopus 로고
    • Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-kappab activation in copd
    • To M, Takagi D, Akashi K, et al. Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-kappaB activation in COPD. Chest 2013;144(2):515-21
    • (2013) Chest , vol.144 , Issue.2 , pp. 515-521
    • To, M.1    Takagi, D.2    Akashi, K.3
  • 82
    • 53649099660 scopus 로고    scopus 로고
    • Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
    • Goven D, Boutten A, Lecon-Malas V, et al. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax 2008;63(10):916-24
    • (2008) Thorax , vol.63 , Issue.10 , pp. 916-924
    • Goven, D.1    Boutten, A.2    Lecon-Malas, V.3
  • 83
    • 51849129227 scopus 로고    scopus 로고
    • Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
    • Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med 2008;178(6):592-604
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.6 , pp. 592-604
    • Malhotra, D.1    Thimmulappa, R.2    Navas-Acien, A.3
  • 84
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009;460(7255):587-91
    • (2009) Nature , vol.460 , Issue.7255 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 85
    • 84858797950 scopus 로고    scopus 로고
    • Sirtuins as regulators of metabolism and healthspan
    • Houtkooper RH, Pirinen E, Auwerx J. Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 2012;13(4):225-38
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.4 , pp. 225-238
    • Houtkooper, R.H.1    Pirinen, E.2    Auwerx, J.3
  • 86
    • 53249121556 scopus 로고    scopus 로고
    • Sirtuins-novel therapeutic targets to treat age-Associated diseases
    • Lavu S, Boss O, Elliott PJ, Lambert PD. Sirtuins-novel therapeutic targets to treat age-Associated diseases. Nat Rev Drug Discov 2008;7(10):841-53
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.10 , pp. 841-853
    • Lavu, S.1    Boss, O.2    Elliott, P.J.3    Lambert, P.D.4
  • 87
    • 77956180402 scopus 로고    scopus 로고
    • SIRT1 is a redox-sensitive deacetylase that is post-Translationally modified by oxidants and carbonyl stress
    • Caito S, Rajendrasozhan S, Cook S, et al. SIRT1 is a redox-sensitive deacetylase that is post-Translationally modified by oxidants and carbonyl stress. FASEB J 2010;24(9):3145-59
    • (2010) FASEB J , vol.24 , Issue.9 , pp. 3145-3159
    • Caito, S.1    Rajendrasozhan, S.2    Cook, S.3
  • 88
    • 77249158771 scopus 로고    scopus 로고
    • Sirt1 regulates oxidant-And cigarette smoke-induced enos acetylation in endothelial cells: Role of resveratrol
    • Arunachalam G, Yao H, Sundar IK, et al. SIRT1 regulates oxidant-And cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun 2010;393(1):66-72
    • (2010) Biochem Biophys Res Commun , vol.393 , Issue.1 , pp. 66-72
    • Arunachalam, G.1    Yao, H.2    Sundar, I.K.3
  • 89
    • 42649146208 scopus 로고    scopus 로고
    • SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
    • DOI 10.1164/rccm.200708-1269OC
    • Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177(8):861-70 (Pubitemid 351600664
    • (2008) American Journal of Respiratory and Critical Care Medicine , vol.177 , Issue.8 , pp. 861-870
    • Rajendrasozhan, S.1    Yang, S.-R.2    Kinnula, V.L.3    Rahman, I.4
  • 90
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
    • DOI 10.1038/sj.emboj.7600244
    • Yeung F, Hoberg JE, Ramsey CS, et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004;23(12):2369-80 (Pubitemid 38954844
    • (2004) EMBO Journal , vol.23 , Issue.12 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 91
    • 84875491560 scopus 로고    scopus 로고
    • Different patterns of lung sirtuin expression in smokers with and without chronic obstructive pulmonary disease
    • Isajevs S, Strazda G, Kopeika U, Taivans I. Different patterns of lung sirtuin expression in smokers with and without chronic obstructive pulmonary disease. Medicina (B Aires) 2012;48(10):552-7
    • (2012) Medicina (B Aires , vol.48 , Issue.10 , pp. 552-557
    • Isajevs, S.1    Strazda, G.2    Kopeika, U.3    Taivans, I.4
  • 92
    • 84861831957 scopus 로고    scopus 로고
    • SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
    • Yao H, Chung S, Hwang JW, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest 2012;122(6):2032-45
    • (2012) J Clin Invest , vol.122 , Issue.6 , pp. 2032-2045
    • Yao, H.1    Chung, S.2    Hwang, J.W.3
  • 93
    • 70349324812 scopus 로고    scopus 로고
    • A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
    • Nakamaru Y, Vuppusetty C, Wada H, et al. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 2009;23(9):2810-19
    • (2009) FASEB J , vol.23 , Issue.9 , pp. 2810-2819
    • Nakamaru, Y.1    Vuppusetty, C.2    Wada, H.3
  • 94
    • 84886997569 scopus 로고    scopus 로고
    • SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD
    • Yao H, Hwang JW, Sundar IK, et al. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol 2013;305(9):L615-24
    • (2013) Am J Physiol Lung Cell Mol Physiol , vol.305 , Issue.9
    • Yao, H.1    Hwang, J.W.2    Sundar, I.K.3
  • 95
    • 79953651813 scopus 로고    scopus 로고
    • Candidate genes for COPD in two large data sets
    • Bakke PS, Zhu G, Gulsvik A, et al. Candidate genes for COPD in two large data sets. Eur Respir J 2011;37(2):255-63
    • (2011) Eur Respir J , vol.37 , Issue.2 , pp. 255-263
    • Bakke, P.S.1    Zhu, G.2    Gulsvik, A.3
  • 96
    • 84893401717 scopus 로고    scopus 로고
    • Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
    • Takasaka N, Araya J, Hara H, et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol 2014;192(3):958-68
    • (2014) J Immunol , vol.192 , Issue.3 , pp. 958-968
    • Takasaka, N.1    Araya, J.2    Hara, H.3
  • 97
    • 84884614312 scopus 로고    scopus 로고
    • Histone 3.3 participates in a selfsustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease
    • Barrero CA, Perez-Leal O, Aksoy M, et al. Histone 3.3 participates in a selfsustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013;188(6):673-83
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.6 , pp. 673-683
    • Barrero, C.A.1    Perez-Leal, O.2    Aksoy, M.3
  • 98
    • 84893873979 scopus 로고    scopus 로고
    • Cigarette smoke induces distinct histone modifications in lung cells: Implications for the pathogenesis of COPD and lung cancer
    • Sundar IK, Nevid MZ, Friedman AE, Rahman I. Cigarette smoke induces distinct histone modifications in lung cells: Implications for the pathogenesis of COPD and lung cancer. J Proteome Res 2014;13(2):982-96
    • (2014) J Proteome Res , vol.13 , Issue.2 , pp. 982-996
    • Sundar, I.K.1    Nevid, M.Z.2    Friedman, A.E.3    Rahman, I.4
  • 99
    • 65949116604 scopus 로고    scopus 로고
    • Tobacco smoke induces polycombmediated repression of Dickkopf-1 in lung cancer cells
    • Hussain M, Rao M, Humphries AE, et al. Tobacco smoke induces polycombmediated repression of Dickkopf-1 in lung cancer cells. Cancer Res 2009;69(8):3570-8
    • (2009) Cancer Res , vol.69 , Issue.8 , pp. 3570-3578
    • Hussain, M.1    Rao, M.2    Humphries, A.E.3
  • 100
    • 65849427529 scopus 로고    scopus 로고
    • Glucocorticoid resistance in inflammatory diseases
    • Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet 2009;373(9678):1905-17
    • (2009) Lancet , vol.373 , Issue.9678 , pp. 1905-1917
    • Barnes, P.J.1    Adcock, I.M.2
  • 101
    • 84875225940 scopus 로고    scopus 로고
    • Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
    • Barnes PJ. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 2013;131(3):636-45
    • (2013) J Allergy Clin Immunol , vol.131 , Issue.3 , pp. 636-645
    • Barnes, P.J.1
  • 103
    • 77958173826 scopus 로고    scopus 로고
    • Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
    • To Y, Ito K, Kizawa Y, et al. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182(7):897-904
    • (2010) Am J Respir Crit Care Med , vol.182 , Issue.7 , pp. 897-904
    • To, Y.1    Ito, K.2    Kizawa, Y.3
  • 104
    • 66049156186 scopus 로고    scopus 로고
    • Low-dose theophylline enhances the antiinflammatory effects of steroids during exacerbations of COPD
    • Cosio BG, Iglesias A, Rios A, et al. Low-dose theophylline enhances the antiinflammatory effects of steroids during exacerbations of COPD. Thorax 2009;64(5):424-9
    • (2009) Thorax , vol.64 , Issue.5 , pp. 424-429
    • Cosio, B.G.1    Iglesias, A.2    Rios, A.3
  • 105
    • 77953310216 scopus 로고    scopus 로고
    • Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in copd
    • Ford PA, Durham AL, Russell RE, et al. Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest 2010;137(6):1338-44
    • (2010) Chest , vol.137 , Issue.6 , pp. 1338-1344
    • Ford, P.A.1    Durham, A.L.2    Russell, R.E.3
  • 106
    • 79955002992 scopus 로고    scopus 로고
    • Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-delta
    • Mercado N, To Y, Ito K, Barnes PJ. Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-delta. J Pharmacol Exp Ther 2011;337(2):465-70
    • (2011) J Pharmacol Exp Ther , vol.337 , Issue.2 , pp. 465-470
    • Mercado, N.1    To, Y.2    Ito, K.3    Barnes, P.J.4
  • 107
    • 84879019868 scopus 로고    scopus 로고
    • A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition
    • Kobayashi Y, Wada H, Rossios C, et al. A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition. Br J Pharmacol 2013;169(5):1024-34
    • (2013) Br J Pharmacol , vol.169 , Issue.5 , pp. 1024-1034
    • Kobayashi, Y.1    Wada, H.2    Rossios, C.3
  • 108
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the antiinflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the antiinflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41(1):40-59
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.1 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 109
    • 51249121642 scopus 로고    scopus 로고
    • Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2
    • Meja KK, Rajendrasozhan S, Adenuga D, et al. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol 2008;39(3):312-23
    • (2008) Am J Respir Cell Mol Biol , vol.39 , Issue.3 , pp. 312-323
    • Meja, K.K.1    Rajendrasozhan, S.2    Adenuga, D.3
  • 110
    • 65549137218 scopus 로고    scopus 로고
    • Curcumin attenuates elastase-And cigarette smoke-induced pulmonary emphysema in mice
    • Suzuki M, Betsuyaku T, Ito Y, et al. Curcumin attenuates elastase-And cigarette smoke-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol 2009;296(4):L614-23
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296 , Issue.4
    • Suzuki, M.1    Betsuyaku, T.2    Ito, Y.3
  • 111
    • 79952439646 scopus 로고    scopus 로고
    • Decreased histone deacetylase 2 impairs nrf2 activation by oxidative stress
    • Mercado N, Thimmulappa R, Thomas CM, et al. Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun 2011;406(2):292-8
    • (2011) Biochem Biophys Res Commun , vol.406 , Issue.2 , pp. 292-298
    • Mercado, N.1    Thimmulappa, R.2    Thomas, C.M.3
  • 112
    • 84875139247 scopus 로고    scopus 로고
    • Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity
    • Guan SP, Tee W, Ng DS, et al. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br J Pharmacol 2013;168(7):1707-18
    • (2013) Br J Pharmacol , vol.168 , Issue.7 , pp. 1707-1718
    • Guan, S.P.1    Tee, W.2    Ng, D.S.3
  • 113
    • 79959429766 scopus 로고    scopus 로고
    • Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells
    • Kumar V, Kumar S, Hassan M, et al. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. J Med Chem 2011;54(12):4147-59
    • (2011) J Med Chem , vol.54 , Issue.12 , pp. 4147-4159
    • Kumar, V.1    Kumar, S.2    Hassan, M.3
  • 114
    • 33749049578 scopus 로고    scopus 로고
    • Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway
    • Hwang TL, Leu YL, Kao SH, et al. Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway. Free Radic Biol Med 2006;41(9):1433-41
    • (2006) Free Radic Biol Med , vol.41 , Issue.9 , pp. 1433-1441
    • Hwang, T.L.1    Leu, Y.L.2    Kao, S.H.3
  • 115
  • 116
    • 41549108838 scopus 로고    scopus 로고
    • Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
    • Kode A, Rajendrasozhan S, Caito S, et al. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008;294(3):L478-88
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294 , Issue.3
    • Kode, A.1    Rajendrasozhan, S.2    Caito, S.3
  • 117
    • 84891661882 scopus 로고    scopus 로고
    • Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease
    • Knobloch J, Wahl C, Feldmann M, et al. Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic Acid in chronic obstructive pulmonary disease. Basic Clin Pharmacol Toxicol 2014;114(2):202-9
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , Issue.2 , pp. 202-209
    • Knobloch, J.1    Wahl, C.2    Feldmann, M.3
  • 118
    • 78650806593 scopus 로고    scopus 로고
    • Suppression of inflammation by a synthetic histone mimic
    • Nicodeme E, Jeffrey KL, Schaefer U, et al. Suppression of inflammation by a synthetic histone mimic. Nature 2010;468(7327):1119-23
    • (2010) Nature , vol.468 , Issue.7327 , pp. 1119-1123
    • Nicodeme, E.1    Jeffrey, K.L.2    Schaefer, U.3
  • 119
    • 84869753078 scopus 로고    scopus 로고
    • Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of bet epigenetic signaling proteins
    • Lockwood WW, Zejnullahu K, Bradner JE, Varmus H. Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins. Proc Natl Acad Sci USA 2012;109(47):19408-13
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.47 , pp. 19408-19413
    • Lockwood, W.W.1    Zejnullahu, K.2    Bradner, J.E.3    Varmus, H.4
  • 120
    • 84888106365 scopus 로고    scopus 로고
    • Efficacy of bet bromodomain inhibition in kras-mutant non-small cell lung cancer
    • Shimamura T, Chen Z, Soucheray M, et al. Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. Clin Cancer Res 2013;19(22):6183-92
    • (2013) Clin Cancer Res , vol.19 , Issue.22 , pp. 6183-6192
    • Shimamura, T.1    Chen, Z.2    Soucheray, M.3
  • 122
    • 56949091456 scopus 로고    scopus 로고
    • Noncoding RNA in development
    • Amaral PP, Mattick JS. Noncoding RNA in development. Mamm Genome 2008;19(7-8):454-92
    • (2008) Mamm Genome , vol.19 , Issue.7-8 , pp. 454-492
    • Amaral, P.P.1    Mattick, J.S.2
  • 124
    • 58749097426 scopus 로고    scopus 로고
    • Small RNAs in transcriptional gene silencing and genome defence
    • Moazed D. Small RNAs in transcriptional gene silencing and genome defence. Nature 2009;457(7228):413-20
    • (2009) Nature , vol.457 , Issue.7228 , pp. 413-420
    • Moazed, D.1
  • 125
    • 84872533627 scopus 로고    scopus 로고
    • Rna interference in the nucleus: Roles for small rnas in transcription epigenetics and beyond
    • Castel SE, Martienssen RA. RNA interference in the nucleus: Roles for small RNAs in transcription, epigenetics and beyond. Nat Rev Genet 2013;14(2):100-12
    • (2013) Nat Rev Genet , vol.14 , Issue.2 , pp. 100-112
    • Castel, S.E.1    Martienssen, R.A.2
  • 126
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • DOI 10.1038/nature02871
    • Ambros V. The functions of animal microRNAs. Nature 2004;431(7006):350-5 (Pubitemid 39265675
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 128
    • 33845354027 scopus 로고    scopus 로고
    • Human let-7a miRNA blocks protein production on actively translating polyribosomes
    • DOI 10.1038/nsmb1173, PII NSMB1173
    • Nottrott S, Simard MJ, Richter JD. Human let-7a miRNA blocks protein production on actively translating polyribosomes. Nat Struct Mol Biol 2006;13(12):1108-14 (Pubitemid 44885922
    • (2006) Nature Structural and Molecular Biology , vol.13 , Issue.12 , pp. 1108-1114
    • Nottrott, S.1    Simard, M.J.2    Richter, J.D.3
  • 129
    • 32444436121 scopus 로고    scopus 로고
    • Short RNAs repress translation after initiation in mammalian cells
    • DOI 10.1016/j.molcel.2006.01.031, PII S1097276506000773
    • Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Mol Cell 2006;21(4):533-42 (Pubitemid 43228008
    • (2006) Molecular Cell , vol.21 , Issue.4 , pp. 533-542
    • Petersen, C.P.1    Bordeleau, M.-E.2    Pelletier, J.3    Sharp, P.A.4
  • 130
    • 77958533034 scopus 로고    scopus 로고
    • Micrornas in inflammatory lung disease-master regulators or target practice?
    • Oglesby IK, McElvaney NG, Greene CM. MicroRNAs in inflammatory lung disease-master regulators or target practice? Respir Res 2010;11:148
    • (2010) Respir Res , vol.11 , pp. 148
    • Oglesby, I.K.1    McElvaney, N.G.2    Greene, C.M.3
  • 131
    • 79952186298 scopus 로고    scopus 로고
    • Micrornas: The fine-Tuners of toll-like receptor signalling
    • O'Neill LA, Sheedy FJ, McCoy CE. MicroRNAs: The fine-Tuners of Toll-like receptor signalling. Nat Rev Immunol 2011;11(3):163-75
    • (2011) Nat Rev Immunol , vol.11 , Issue.3 , pp. 163-175
    • O'Neill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 132
    • 84856045106 scopus 로고    scopus 로고
    • Gene expression networks in copd: Microrna and mrna regulation
    • Ezzie ME, Crawford M, Cho JH, et al. Gene expression networks in COPD: MicroRNA and mRNA regulation. Thorax 2012;67(2):122-31
    • (2012) Thorax , vol.67 , Issue.2 , pp. 122-131
    • Ezzie, M.E.1    Crawford, M.2    Cho, J.H.3
  • 133
    • 79953304705 scopus 로고    scopus 로고
    • Microrna expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease
    • Van Pottelberge GR, Mestdagh P, Bracke KR, et al. MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011;183(7):898-906
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.7 , pp. 898-906
    • Van Pottelberge, G.R.1    Mestdagh, P.2    Bracke, K.R.3
  • 134
    • 84867814908 scopus 로고    scopus 로고
    • Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents
    • De Flora S, Balansky R, D'Agostini F, et al. Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents. Int J Cancer 2012;131(12):2763-73
    • (2012) Int J Cancer , vol.131 , Issue.12 , pp. 2763-2773
    • De Flora, S.1    Balansky, R.2    D'Agostini, F.3
  • 135
    • 70349315533 scopus 로고    scopus 로고
    • Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light
    • Izzotti A, Calin GA, Steele VE, et al. Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light. FASEB J 2009;23(9):3243-50
    • (2009) FASEB J , vol.23 , Issue.9 , pp. 3243-3250
    • Izzotti, A.1    Calin, G.A.2    Steele, V.E.3
  • 136
    • 74049134939 scopus 로고    scopus 로고
    • Mmp12, lung function, and copd in high-risk populations
    • Hunninghake GM, Cho MH, Tesfaigzi Y, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009;361(27):2599-608
    • (2009) N Engl J Med , vol.361 , Issue.27 , pp. 2599-2608
    • Hunninghake, G.M.1    Cho, M.H.2    Tesfaigzi, Y.3
  • 137
    • 84865597141 scopus 로고    scopus 로고
    • Cigarette smoking decreases global microRNA expression in human alveolar macrophages
    • Graff JW, Powers LS, Dickson AM, et al. Cigarette smoking decreases global microRNA expression in human alveolar macrophages. PLoS One 2012;7(8):e44066
    • (2012) PLoS One , vol.7 , Issue.8
    • Graff, J.W.1    Powers, L.S.2    Dickson, A.M.3
  • 138
    • 84891354115 scopus 로고    scopus 로고
    • Mir-638 regulates gene expression networks associated with emphysematous lung destruction
    • Christenson SA, Brandsma CA, Campbell JD, et al. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med 2013;5(12):114
    • (2013) Genome Med , vol.5 , Issue.12 , pp. 114
    • Christenson, S.A.1    Brandsma, C.A.2    Campbell, J.D.3
  • 139
    • 80052566074 scopus 로고    scopus 로고
    • Specific peripheral mirna profiles for distinguishing lung cancer from copd
    • Leidinger P, Keller A, Borries A, et al. Specific peripheral miRNA profiles for distinguishing lung cancer from COPD. Lung cancer 2011;74(1):41-7
    • (2011) Lung Cancer , vol.74 , Issue.1 , pp. 41-47
    • Leidinger, P.1    Keller, A.2    Borries, A.3
  • 140
    • 84862855868 scopus 로고    scopus 로고
    • Analysis of serum micro-rnas as potential biomarker in chronic obstructive pulmonary disease
    • Akbas F, Coskunpinar E, Aynaci E, et al. Analysis of serum micro-RNAs as potential biomarker in chronic obstructive pulmonary disease. Exp Lung Res 2012;38(6):286-94
    • (2012) Exp Lung Res , vol.38 , Issue.6 , pp. 286-294
    • Akbas, F.1    Coskunpinar, E.2    Aynaci, E.3
  • 141
    • 84872464917 scopus 로고    scopus 로고
    • Two panels of plasma micrornas as non-invasive biomarkers for prediction of recurrence in resectable nsclc
    • Sanfiorenzo C, Ilie MI, Belaid A, et al. Two panels of plasma microRNAs as non-invasive biomarkers for prediction of recurrence in resectable NSCLC. PLoS One 2013;8(1):e54596
    • (2013) PLoS One , vol.8 , Issue.1
    • Sanfiorenzo, C.1    Ilie, M.I.2    Belaid, A.3
  • 143
    • 84859911725 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation of the microrna-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    • Davalos V, Moutinho C, Villanueva A, et al. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 2012;31(16):2062-74
    • (2012) Oncogene , vol.31 , Issue.16 , pp. 2062-2074
    • Davalos, V.1    Moutinho, C.2    Villanueva, A.3
  • 144
    • 84900016577 scopus 로고    scopus 로고
    • Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells
    • Basma H, Gunji Y, Iwasawa S, et al. Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells. Am J Physiol Lung Cell Mol Physiol 2014;306(6):L552-65
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.306 , Issue.6
    • Basma, H.1    Gunji, Y.2    Iwasawa, S.3
  • 145
    • 80055016539 scopus 로고    scopus 로고
    • Epigenetic modifications of stem cells: A paradigm for the control of cardiac progenitor cells
    • Zhou Y, Kim J, Yuan X, Braun T. Epigenetic modifications of stem cells: A paradigm for the control of cardiac progenitor cells. Circ Res 2011;109(9):1067-81
    • (2011) Circ Res , vol.109 , Issue.9 , pp. 1067-1081
    • Zhou, Y.1    Kim, J.2    Yuan, X.3    Braun, T.4
  • 146
    • 84890451565 scopus 로고    scopus 로고
    • Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased dna damage and senescence
    • Paschalaki KE, Starke RD, Hu Y, et al. Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. Stem Cells 2013;31(12):2813-26
    • (2013) Stem Cells , vol.31 , Issue.12 , pp. 2813-2826
    • Paschalaki, K.E.1    Starke, R.D.2    Hu, Y.3
  • 147
    • 84894490851 scopus 로고    scopus 로고
    • A novel SIRT2 inhibitor with p53-dependent pro-Apoptotic activity in non-small-cell lung cancer
    • Hoffmann G, Breitenbuecher F, Schuler M, Ehrenhofer-Murray AE.A novel SIRT2 inhibitor with p53-dependent pro-Apoptotic activity in non-small-cell lung cancer. J Biol Chem 2014;289(8):5208-16
    • (2014) J Biol Chem , vol.289 , Issue.8 , pp. 5208-5216
    • Hoffmann, G.1    Breitenbuecher, F.2    Schuler, M.3    Ehrenhofer-Murray, A.E.4
  • 148
    • 84864722456 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in the treatment of cancer: Overview and perspectives
    • Giannini G, Cabri W, Fattorusso C, Rodriquez M. Histone deacetylase inhibitors in the treatment of cancer: Overview and perspectives. Future Med Chem 2012;4(11):1439-60
    • (2012) Future Med Chem , vol.4 , Issue.11 , pp. 1439-1460
    • Giannini, G.1    Cabri, W.2    Fattorusso, C.3    Rodriquez, M.4


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