Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency

Epigenetics

Volumn 7, Issue 7, 2012, Pages 720-728

  Siedlinski, Mateusz ^a   Klanderman, Barbara ^b   Sandhaus, Robert A ^c   Barker, Alan F ^d   Brantly, Mark L ^e   Eden, Edward ^f   Gerard McElvaney, N ^g   Rennard, Stephen I ^h   Stocks, James M ⁱ   Stoller, James K ^j   Strange, Charlie ^k   Turino, Gerard M ^f   Campbell, Edward J ^l,m   DeMeo, Dawn L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b LABORATORY FOR MOLECULAR MEDICINE   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^f ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^g BEAUMONT HOSPITAL   (Ireland)

^h UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^j LERNER RESEARCH INSTITUTE   (United States)

^k MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^l INTERMOUNTAIN HEALTHCARE   (United States)

^m HerediLab Inc   (United States)

more..

Author keywords

68 kDa (TGFBI); Alpha 1 Antitrypsin (AAT) deficiency; Beta induced; C reactive protein (CRP); Chronic obstructive pulmonary disease (COPD); Illumina goldengate methylation cancer panel I; Methylation; Smoking behaviors; Transforming growth factor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BETA3; ADAMTS12 PROTEIN; C REACTIVE PROTEIN; EPHRIN RECEPTOR A3; JANUS KINASE 3; METALLOPROTEINASE; SLIT2 PROTEIN; TRANSCRIPTION FACTOR RUNX3; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADULT; AGE; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CASP6 GENE; CIGARETTE SMOKING; CPG ISLAND; DAPK1 GENE; DBC1 GENE; DCC GENE; DLK1 GENE; DNA METHYLATION; EYA4 GENE; FAT GENE; FEMALE; FRZB GENE; FZD9 GENE; GENE; GENETIC ASSOCIATION; HOMOZYGOSITY; HTR1B GENE; HUMAN; ISL1 GENE; KRT1 GENE; MAJOR CLINICAL STUDY; MALE; NR2F6 GENE; PHENOTYPE; PROTEIN BLOOD LEVEL; RAB32 GENE; RARB GENE; SCGB3A1 GENE; SERPINA1 GENE; SMOKING CESSATION;

NICOTIANA TABACUM;

EID: 84863806469     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.20319     Document Type: Article

References (26)

1. Wan ES, Silverman EK. Genetics of COPD and emphysema. Chest 2009; 136:859-66. PMID:19736190; http://dx.doi.org/10.1378/chest.09-0555.
2. Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, et al.; ICGN Investigators. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009; 5:1000421; PMID:19300482; http://dx.doi.org/10.1371/journal.pgen.1000421.
3. DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, et al. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet 2009; 85:493-502; PMID:19800047; http://dx.doi.org/10.1016/j.ajhg.2009.09.004.
4. Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet 2010; 42:200-202; PMID:20173748; http://dx.doi.org/10.1038/ng.535.
5. Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, et al.; Wellcome Trust Case Control Consortium. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010; 42:436-440; PMID:20418889; http://dx.doi.org/10.1038/ng.572.
6. Tobacco and Genetics Consortium. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010; 42:441-447; PMID:20418890; http://dx.doi.org/10.1038/ng.571.
7. Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, et al.; ENGAGE Consortium. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 2010; 42:448-453; PMID:20418888; http://dx.doi.org/10.1038/ng.573.
8. Demeo DL, Sandhaus RA, Barker AF, Brantly ML, Eden E, McElvaney NG, et al. Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. Thorax 2007; 62:806-813; PMID:17389752; http://dx.doi.org/10.1136/thx.2006.075846.
9. Dahl M, Vestbo J, Lange P, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 175:250-255; PMID:17053205; http://dx.doi.org/10.1164/rccm.200605-713OC.
10. Smith IM, Mydlarz WK, Mithani SK, Califano JA. DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage. Int J Cancer 2007; 121:1724-1728; PMID:17582607; http://dx.doi.org/10.1002/ijc.22889.
11. Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L, et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol 2012; 41:126-139; PMID:20846947; http://dx.doi.org/10.1093/ije/dyq154.
12. Laird PW. Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet 2010; 11:191-203; PMID:20125086; http://dx.doi.org/10.1038/nrg2732.
13. Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 2009; 5:1000602; PMID:19680444; http://dx.doi.org/10.1371/journal.pgen.1000602.
14. Breitling LP, Yang R, Korn B, Burwinkel B, Brenner H. Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet 2011; 88:450-457; PMID:21457905; http://dx.doi.org/10.1016/j.ajhg.2011.03.003.
15. Liu J, Morgan M, Hutchison K, Calhoun VD. A study of the influence of sex on genome wide methylation. PLoS One 2010; 5:10028; PMID:20386599; http://dx.doi.org/10.1371/journal.pone.0010028.
16. Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, et al. Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med 2010; 16:198-204; PMID:20098431; http://dx.doi.org/10.1038/nm.2088.
17. Chen YA, Choufani S, Ferreira JC, Grafodatskaya D, Butcher DT, Weksberg R. Sequence overlap between autosomal and sex-linked probes on the Illumina HumanMethylation27 microarray. Genomics 2011; 97:214-222; PMID:21211562; http://dx.doi.org/10.1016/j.ygeno.2010.12.004.
18. Bibikova M, Chudin E, Wu B, Zhou L, Garcia EW, Liu Y, et al. Human embryonic stem cells have a unique epigenetic signature. Genome Res 2006; 16:1075-1083; PMID:16899657; http://dx.doi.org/10.1101/gr.5319906.
19. Kim DH, Kim JS, Ji YI, Shim YM, Kim H, Han J, et al. Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer. Cancer Res 2003; 63:3743-3746; PMID:12839968.
20. Marsit CJ, Kim DH, Liu M, Hinds PW, Wiencke JK, Nelson HH, et al. Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence. Int J Cancer 2005; 114:219-223; PMID:15540210; http://dx.doi.org/10.1002/ijc.20714.
21. Satta R, Maloku E, Zhubi A, Pibiri F, Hajos M, Costa E, et al. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proc Natl Acad Sci USA 2008; 105:16356-16361; PMID:18852456; http://dx.doi.org/10.1073/pnas.0808699105.
22. Baccarelli A, Tarantini L, Wright RO, Bollati V, Litonjua AA, Zanobetti A, et al. Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study. Epigenetics 2010; 5:222-228; PMID:20305373; http://dx.doi.org/10.4161/epi.5.3.11377.
23. R Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing 2010. http://www.R-project.Org
24. Davis S, Du P, Bilke S. methylumi: Handle Illumina methylation data. 2010; R package version 1.6.1.
25. Fox J, Weisberg S. An R Companion to Applied Regression. Thousand Oaks, CA: Sage 2010; 2; http://socserv.socsci.mcmaster.ca/jfox/Books/Companion
26. Pinheiro J, Bates D, DebRoy S, Sarkar D and R Core team. Nlme: Linear and Nonlinear Mixed Effects Models. 2009; R package version 3.1-96.