SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 305, Issue 9, 2013, Pages

  Yao, Hongwei ^a   Hwang, Jae Woong ^a   Sundar, Isaac K ^a   Friedman, Alan E ^a   McBurney, Michael W ^b   Guarente, Leonard ^c   Gu, Wei ^d   Kinnula, Vuokko L ^e   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d College of Physicians and Surgeons Columbia University ^*  (United States)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cigarette smoke; COPD; Emphysema; MMPs; SIRT1; TIMPs

Indexed keywords

CIGARETTE SMOKE; GELATINASE A; GELATINASE B; LYSINE; MACROPHAGE ELASTASE; SIRTUIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

ANIMAL TISSUE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; LUNG EMPHYSEMA; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REDUCTION; SMOKING; TANDEM MASS SPECTROMETRY; WILD TYPE;

CIGARETTE SMOKE; COPD; EMPHYSEMA; MMPS; SIRT1; TIMPS;

AMINO ACID SEQUENCE; ANIMALS; EMPHYSEMA; HUMANS; LUNG; MATRIX METALLOPROTEINASE 9; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIRTUIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TOBACCO SMOKE POLLUTION;

EID: 84886997569     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00249.2012     Document Type: Article

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