메뉴 건너뛰기




Volumn 35, Issue 1, 2014, Pages 23-30

Strike a pose: Gαq complexes at the membrane

Author keywords

ARHGEF25; crystallography; G q; G protein coupled receptor; GRK2; heterotrimeric G protein signaling; membrane; p63RhoGEF; phospholipase C ; phospholipids; protein structure; second messengers

Indexed keywords

CALCIUM ION; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PHOSPHOLIPASE C BETA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84891633242     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2013.10.008     Document Type: Review
Times cited : (28)

References (70)
  • 1
    • 0037205055 scopus 로고    scopus 로고
    • G protein pathways
    • DOI 10.1126/science.1071550
    • S.R. Neves et al. G protein pathways Science 296 2002 1636 1639 (Pubitemid 34579147)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1636-1639
    • Neves, S.R.1    Ram, P.T.2    Iyengar, R.3
  • 2
    • 80051658642 scopus 로고    scopus 로고
    • s protein complex
    • s protein complex Nature 477 2011 549 555
    • (2011) Nature , vol.477 , pp. 549-555
    • Rasmussen, S.G.1
  • 3
    • 34548443356 scopus 로고    scopus 로고
    • Structural Basis of Effector Regulation and Signal Termination in Heterotrimeric Gα Proteins
    • DOI 10.1016/S0065-3233(07)74001-9, PII S0065323307740019, Mechanisms and Pathways of Heterotrimeric G Protein Signaling
    • S.R. Sprang et al. Structural basis of effector regulation and signal termination in heterotrimeric Gα proteins Adv. Protein Chem. 74 2007 1 65 (Pubitemid 47369746)
    • (2007) Advances in Protein Chemistry , vol.74 , pp. 1-65
    • Sprang, S.R.1    Chen, Z.2    Du, X.3
  • 4
    • 0029664589 scopus 로고    scopus 로고
    • The 2.0 Å crystal structure of a heterotrimeric G protein
    • D.G. Lambright et al. The 2.0 Å crystal structure of a heterotrimeric G protein Nature 379 1996 311 319
    • (1996) Nature , vol.379 , pp. 311-319
    • Lambright, D.G.1
  • 5
    • 0029593456 scopus 로고
    • 2
    • 2 Cell 83 1995 1047 1058
    • (1995) Cell , vol.83 , pp. 1047-1058
    • Wall, M.A.1
  • 6
    • 84875210368 scopus 로고    scopus 로고
    • q-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain
    • q-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain Nat. Struct. Mol. Biol. 20 2013 355 362
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 355-362
    • Lyon, A.M.1
  • 7
    • 27444440633 scopus 로고    scopus 로고
    • Cell signalling diversity of the Gqα family of heterotrimeric G proteins
    • DOI 10.1016/j.cellsig.2005.08.004, PII S0898656805002226
    • qα family of heterotrimeric G proteins Cell. Signal. 18 2006 135 150 (Pubitemid 41528793)
    • (2006) Cellular Signalling , vol.18 , Issue.2 , pp. 135-150
    • Hubbard, K.B.1    Hepler, J.R.2
  • 8
    • 84930210536 scopus 로고    scopus 로고
    • The phospholipase C isozymes and their regulation
    • A. Gresset et al. The phospholipase C isozymes and their regulation Subcell. Biochem. 58 2012 61 94
    • (2012) Subcell. Biochem. , vol.58 , pp. 61-94
    • Gresset, A.1
  • 9
    • 84884692712 scopus 로고    scopus 로고
    • Structural insights into phospholipase C-β function
    • A.M. Lyon, and J.J. Tesmer Structural insights into phospholipase C-β function Mol. Pharmacol. 84 2013 488 500
    • (2013) Mol. Pharmacol. , vol.84 , pp. 488-500
    • Lyon, A.M.1    Tesmer, J.J.2
  • 11
    • 35948968634 scopus 로고    scopus 로고
    • q-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
    • q-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs Science 318 2007 1923 1927
    • (2007) Science , vol.318 , pp. 1923-1927
    • Lutz, S.1
  • 13
    • 35748983198 scopus 로고    scopus 로고
    • q directly activates p63RhoGEF and trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain
    • DOI 10.1074/jbc.M703458200
    • q directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain J. Biol. Chem. 282 2007 29201 29210 (Pubitemid 350043381)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.40 , pp. 29201-29210
    • Rojas, R.J.1    Yohe, M.E.2    Gershburg, S.3    Kawano, T.4    Kozasa, T.5    Sondek, J.6
  • 15
    • 83555168220 scopus 로고    scopus 로고
    • G protein-coupled receptor kinases: More than just kinases and not only for GPCRs
    • E.V. Gurevich et al. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs Pharmacol. Ther. 133 2012 40 69
    • (2012) Pharmacol. Ther. , vol.133 , pp. 40-69
    • Gurevich, E.V.1
  • 16
    • 12544256442 scopus 로고    scopus 로고
    • Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2
    • K. Iwata et al. Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2 J. Biol. Chem. 280 2005 2197 2204
    • (2005) J. Biol. Chem. , vol.280 , pp. 2197-2204
    • Iwata, K.1
  • 17
    • 47849128759 scopus 로고    scopus 로고
    • M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms
    • J. Luo et al. M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms Mol. Pharmacol. 74 2008 338 347
    • (2008) Mol. Pharmacol. , vol.74 , pp. 338-347
    • Luo, J.1
  • 18
    • 69949181911 scopus 로고    scopus 로고
    • Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons
    • F.M. Ribeiro et al. Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons J. Biol. Chem. 284 2009 23444 23453
    • (2009) J. Biol. Chem. , vol.284 , pp. 23444-23453
    • Ribeiro, F.M.1
  • 19
    • 79957624874 scopus 로고    scopus 로고
    • + channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Gαq/11
    • + channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Gαq/11 J. Biol. Chem. 286 2011 19259 19269
    • (2011) J. Biol. Chem. , vol.286 , pp. 19259-19269
    • Lee, I.H.1
  • 21
    • 65549119793 scopus 로고    scopus 로고
    • 16 and inhibits the canonical phospholipase Cβ pathway
    • 16 and inhibits the canonical phospholipase Cβ pathway Cell. Signal. 21 2009 1317 1325
    • (2009) Cell. Signal. , vol.21 , pp. 1317-1325
    • Yeung, W.W.1    Wong, Y.H.2
  • 22
    • 78149410867 scopus 로고    scopus 로고
    • q signaling complex
    • q signaling complex Science 330 2010 974 980
    • (2010) Science , vol.330 , pp. 974-980
    • Waldo, G.L.1
  • 24
    • 48349120928 scopus 로고    scopus 로고
    • General and versatile autoinhibition of PLC isozymes
    • S.N. Hicks et al. General and versatile autoinhibition of PLC isozymes Mol. Cell 31 2008 383 394
    • (2008) Mol. Cell , vol.31 , pp. 383-394
    • Hicks, S.N.1
  • 25
    • 0031016185 scopus 로고    scopus 로고
    • Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C
    • L.O. Essen et al. Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C Biochemistry 36 1997 1704 1718
    • (1997) Biochemistry , vol.36 , pp. 1704-1718
    • Essen, L.O.1
  • 28
    • 0029841118 scopus 로고    scopus 로고
    • The role of carboxyl-terminal basic amino acids in G(q)α-dependent activation, particulate association, and nuclear localization of phospholipase C-β1
    • DOI 10.1074/jbc.271.35.21187
    • qα-dependent activation, particulate association, and nuclear localization of phospholipase C-β1 J. Biol. Chem. 271 1996 21187 21192 (Pubitemid 26292971)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.35 , pp. 21187-21192
    • Kim, C.G.1    Park, D.2    Rhee, S.G.3
  • 32
    • 0027465720 scopus 로고
    • Identification of critical regions on phospholipase C-β1 required for activation by G-proteins
    • D. Wu et al. Identification of critical regions on phospholipase C-β1 required for activation by G-proteins J. Biol. Chem. 268 1993 3704 3709 (Pubitemid 23071017)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.5 , pp. 3704-3709
    • Wu, D.1    Jiang, H.2    Katz, A.3    Simon, M.I.4
  • 34
    • 77950473766 scopus 로고    scopus 로고
    • 2, and Rac2
    • 2, and Rac2 J. Biol. Chem. 285 2010 3905 3915
    • (2010) J. Biol. Chem. , vol.285 , pp. 3905-3915
    • Gutman, O.1
  • 35
    • 0037424517 scopus 로고    scopus 로고
    • Rac2 regulation of phospholipase C-β 2 activity and mode of membrane interactions in intact cells
    • D. llenberger et al. Rac2 regulation of phospholipase C-β 2 activity and mode of membrane interactions in intact cells J. Biol. Chem. 278 2003 8645 8652
    • (2003) J. Biol. Chem. , vol.278 , pp. 8645-8652
    • Llenberger, D.1
  • 36
    • 80054027590 scopus 로고    scopus 로고
    • q and phospholipase Cβ in a signalling complex
    • q and phospholipase Cβ in a signalling complex J. Cell Sci. 124 2011 3292 3304
    • (2011) J. Cell Sci. , vol.124 , pp. 3292-3304
    • Cartier, A.1
  • 37
    • 70450263435 scopus 로고    scopus 로고
    • Fine-tuning of GPCR activity by receptor-interacting proteins
    • S.L. Ritter, and R.A. Hall Fine-tuning of GPCR activity by receptor-interacting proteins Nat. Rev. Mol. Cell Biol. 10 2009 819 830
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 819-830
    • Ritter, S.L.1    Hall, R.A.2
  • 38
    • 0035805607 scopus 로고    scopus 로고
    • q with Rho and its exchange factors
    • q with Rho and its exchange factors J. Biol. Chem. 276 2001 15445 15452
    • (2001) J. Biol. Chem. , vol.276 , pp. 15445-15452
    • Sagi, S.A.1
  • 39
    • 0036261720 scopus 로고    scopus 로고
    • Leukemia-associated Rho guanine nucleotide exchange factor promotes Gαq-coupled activation of RhoA
    • DOI 10.1128/MCB.22.12.4053-4061.2002
    • q-coupled activation of RhoA Mol. Cell. Biol. 22 2002 4053 4061 (Pubitemid 34556576)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.12 , pp. 4053-4061
    • Booden, M.A.1    Siderovski, D.P.2    Der, C.J.3
  • 40
    • 84855586361 scopus 로고    scopus 로고
    • LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways
    • M. Pfreimer et al. LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways Cell. Signal. 24 2012 652 663
    • (2012) Cell. Signal. , vol.24 , pp. 652-663
    • Pfreimer, M.1
  • 41
    • 8544267258 scopus 로고    scopus 로고
    • GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation
    • DOI 10.1074/jbc.M406216200
    • B. Bryan et al. GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation J. Biol. Chem. 279 2004 45824 45832 (Pubitemid 39491575)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.44 , pp. 45824-45832
    • Bryan, B.1    Kumar, V.2    Stafford, L.J.3    Cai, Y.4    Wu, G.5    Liu, M.6
  • 42
    • 33646375965 scopus 로고    scopus 로고
    • The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth
    • DOI 10.1002/jnr.20814
    • B.A. Bryan et al. The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth J. Neurosci. Res. 83 2006 1151 1159 (Pubitemid 43667998)
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.7 , pp. 1151-1159
    • Bryan, B.A.1    Cai, Y.2    Liu, M.3
  • 43
    • 78649736583 scopus 로고    scopus 로고
    • P63RhoGEF - A key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells
    • C.M. Wuertz et al. p63RhoGEF - a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells FASEB J. 24 2010 4865 4876
    • (2010) FASEB J. , vol.24 , pp. 4865-4876
    • Wuertz, C.M.1
  • 44
    • 80055009632 scopus 로고    scopus 로고
    • 2+ sensitization of vascular smooth muscle contractility
    • 2+ sensitization of vascular smooth muscle contractility Circ. Res. 109 2011 993 1002
    • (2011) Circ. Res. , vol.109 , pp. 993-1002
    • Momotani, K.1
  • 46
    • 84875215211 scopus 로고    scopus 로고
    • P63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells
    • A. Hayashi et al. p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells FEBS Lett. 587 2013 698 705
    • (2013) FEBS Lett. , vol.587 , pp. 698-705
    • Hayashi, A.1
  • 47
    • 84886066175 scopus 로고    scopus 로고
    • q-p63RhoGEF-Rho GTPase pathway
    • 10.1158/0008-5472.CAN-13-1049
    • q-p63RhoGEF-Rho GTPase pathway Cancer Res. 2013 10.1158/0008-5472.CAN-13-1049
    • (2013) Cancer Res.
    • Tang, X.1
  • 48
    • 84878505226 scopus 로고    scopus 로고
    • q/11-p63RhoGEF-RhoA axis
    • q/11-p63RhoGEF-RhoA axis PLoS Pathog. 9 2013 e1003385
    • (2013) PLoS Pathog. , vol.9 , pp. 1003385
    • Siegert, P.1
  • 49
    • 77952293250 scopus 로고    scopus 로고
    • q allosterically activates and relieves autoinhibition of p63RhoGEF
    • q allosterically activates and relieves autoinhibition of p63RhoGEF Cell. Signal. 22 2010 1114 1123
    • (2010) Cell. Signal. , vol.22 , pp. 1114-1123
    • Shankaranarayanan, A.1
  • 50
    • 80053186768 scopus 로고    scopus 로고
    • Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells
    • M. Aittaleb et al. Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells J. Biol. Chem. 286 2011 34448 34456
    • (2011) J. Biol. Chem. , vol.286 , pp. 34448-34456
    • Aittaleb, M.1
  • 51
    • 84891632925 scopus 로고    scopus 로고
    • q through its effectors p63RhoGEF and GEFT depends on their subcellular location
    • q through its effectors p63RhoGEF and GEFT depends on their subcellular location Sci. Rep. 3 2013 2284
    • (2013) Sci. Rep. , vol.3 , pp. 2284
    • Goedhart, J.1
  • 53
    • 0037799206 scopus 로고    scopus 로고
    • Keeping G proteins at bay: A complex between G protein-coupled receptor kinase 2 and Gβγ
    • DOI 10.1126/science.1082348
    • D.T. Lodowski et al. Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gβγ Science 300 2003 1256 1262 (Pubitemid 36618232)
    • (2003) Science , vol.300 , Issue.5623 , pp. 1256-1262
    • Lodowski, D.T.1    Pitcher, J.A.2    Capel, W.D.3    Lefkowitz, R.J.4    Tesmer, J.J.G.5
  • 58
    • 0026803164 scopus 로고
    • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors
    • J.A. Pitcher et al. Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors Science 257 1992 1264 1267
    • (1992) Science , vol.257 , pp. 1264-1267
    • Pitcher, J.A.1
  • 60
    • 77957778459 scopus 로고    scopus 로고
    • Molecular basis for activation of G protein-coupled receptor kinases
    • C.A. Boguth et al. Molecular basis for activation of G protein-coupled receptor kinases EMBO J. 29 2010 3249 3259
    • (2010) EMBO J. , vol.29 , pp. 3249-3259
    • Boguth, C.A.1
  • 62
    • 80053089071 scopus 로고    scopus 로고
    • Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane
    • A.P. Boughton et al. Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane Proc. Natl. Acad. Sci. U.S.A. 108 2011 E667 E673
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108
    • Boughton, A.P.1
  • 63
    • 36348958940 scopus 로고    scopus 로고
    • Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members
    • DOI 10.1074/jbc.M702685200
    • S. Gu et al. Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members J. Biol. Chem. 282 2007 33064 33075 (Pubitemid 350159325)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.45 , pp. 33064-33075
    • Gu, S.1    He, J.2    Ho, W.-T.3    Ramineni, S.4    Thal, D.M.5    Natesh, R.6    Tesmer, J.J.G.7    Hepler, J.R.8    Heximer, S.P.9
  • 64
    • 58049192385 scopus 로고    scopus 로고
    • q-effector complexes with RGS proteins
    • q- effector complexes with RGS proteins J. Biol. Chem. 283 2008 34923 34934
    • (2008) J. Biol. Chem. , vol.283 , pp. 34923-34934
    • Shankaranarayanan, A.1
  • 65
    • 0035931919 scopus 로고    scopus 로고
    • Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å
    • DOI 10.1038/35059138
    • K.C. Slep et al. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å Nature 409 2001 1071 1077 (Pubitemid 32204063)
    • (2001) Nature , vol.409 , Issue.6823 , pp. 1071-1077
    • Slep, K.C.1    Kercher, M.A.2    He, W.3    Cowan, C.W.4    Wensel, T.G.5    Sigler, P.B.6
  • 67
    • 84874888362 scopus 로고    scopus 로고
    • q complex
    • q complex Structure 21 2013 438 448
    • (2013) Structure , vol.21 , pp. 438-448
    • Nance, M.R.1
  • 68
    • 0141541343 scopus 로고    scopus 로고
    • Isoforms of mammalian adenylyl cyclase: Multiplicities of signaling
    • R.K. Sunahara, and R. Taussig Isoforms of mammalian adenylyl cyclase: multiplicities of signaling Mol. Interv. 2 2002 168 184
    • (2002) Mol. Interv. , vol.2 , pp. 168-184
    • Sunahara, R.K.1    Taussig, R.2
  • 69
  • 70
    • 2642689663 scopus 로고    scopus 로고
    • Crystal structure of the catalytic domains of adenylyl cyclase in a complex with G(sα)·GTPγΣ
    • DOI 10.1126/science.278.5345.1907
    • sα·GTPγS Science 278 1997 1907 1916 (Pubitemid 28013225)
    • (1997) Science , vol.278 , Issue.5345 , pp. 1907-1916
    • Tesmer, J.J.G.1    Sunahara, R.K.2    Gilman, A.G.3    Sprang, S.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.