Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 8, 2013, Pages

  Xing, Wenjuan ^a   Li, Youyou ^a   Zhang, Haifeng ^a   Mi, Chunjuan ^a   Hou, Zuoxu ^a   Quon, Michael J ^b   Gao, Feng ^a,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Exercise; GRK2; Hypertension; Vascular insulin resistance

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; G PROTEIN COUPLED RECEPTOR KINASE 2; INSULIN; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; EXERCISE; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MESENTERIC ARTERY; NONHUMAN; PREHYPERTENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESISTANCE BLOOD VESSEL; SWIMMING; SYSTOLIC BLOOD PRESSURE; UPREGULATION; VASODILATATION;

EXERCISE; GRK2; HYPERTENSION; VASCULAR INSULIN RESISTANCE;

ANIMALS; ARTERIOLES; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOWN-REGULATION; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HYPERTENSION; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; MESENTERIC ARTERIES; NITRIC OXIDE SYNTHASE TYPE III; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VASODILATION;

EID: 84885575620     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00290.2013     Document Type: Article

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