Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction

Endocrinology

Volumn 153, Issue 7, 2012, Pages 2985-2996

  Taguchi, Kumiko ^a   Matsumoto, Takayuki ^a   Kamata, Katsuo ^a   Kobayashi, Tsuneo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

[METHYL([5 NITRO 2 FURYL]VINYL) 2 FUROATE; BETA ARRESTIN 2; CLONIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; G PROTEIN COUPLED RECEPTOR KINASE 2; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DRUG EFFICACY; ENDOTHELIAL DYSFUNCTION; GENE TRANSLOCATION; GLUCOSE INTOLERANCE; ISOMETRICS; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; VASCULAR ENDOTHELIAL FUNCTION; WESTERN BLOTTING;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; ARRESTINS; BLOOD PRESSURE; CLONIDINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GLUCOSE TOLERANCE TEST; MALE; MICE; MICE, OBESE; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84862745056     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1101     Document Type: Article

References (46)

1. Reaven GM, Chen YD 1996 Insulin resistance, its consequences, and coronary heart disease. Must we choose one culprit? Circulation 93:1780-1783 (Pubitemid 26154026)
2. Zanella MT, Kohlmann Jr O, Ribeiro AB 2001 Treatment of obesity hypertension and diabetes syndrome. Hypertension 38:705-708
3. Kahn SE, Hull RL, Utzschneider KM 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-846 (Pubitemid 46024990)
4. Van Gaal LF, Mertens IL, De Block CE 2006 Mechanisms linking obesity with cardiovascular disease. Nature 444:875-880 (Pubitemid 46028447)
5. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes Jr DR, Lerman A 2000 Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101:948-954 (Pubitemid 30131694)
6. Verdecchia P, Reboldi G, Angeli F, Borgioni C, Gattobigio R, Filippucci L, Norgiolini S, Bracco C, Porcellati C 2004 Adverse prognostic significance of new diabetes in treated hypertensive subjects. Hypertension 43:963-969 (Pubitemid 38579899)
7. Alderman MH, Cohen H, Madhavan S 1999 Diabetes and cardiovascular events in hypertensive patients. Hypertension 33:1130-1134 (Pubitemid 29230961)
8. Sowers JR, Epstein M, Frohlich ED 2001 Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 37:1053-1059 (Pubitemid 32304003)
9. Taguchi K, Kobayashi T, Takenouchi Y, Matsumoto T, Kamata K 2011 Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model. Pharmacol Res 64:535-546
10. Taguchi K, Kobayashi T, Matsumoto T, Kamata K 2011 Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice. Am J Physiol Heart Circ Physiol 301:H571-H583
11. Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, Sessa WC, Groszmann RJ 1999 Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 117:1222-1228 (Pubitemid 29512682)
12. Garacía-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC 1998 Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 392:821-824 (Pubitemid 28225323)
13. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM 1999 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
14. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC 1999 Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597-601
15. Kobayashi T, Taguchi K, Yasuhiro T, Matsumoto T, Kamata K 2004 Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model. Hypertension 44:956-962 (Pubitemid 39577428)
16. Kobayashi T, Taguchi K, Nemoto S, Nogami T, Matsumoto T, Kamata K 2009 Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats. Am J Physiol Heart Circ Physiol 297:H1767-H1775
17. Kobayashi T, Taguchi K, Takenouchi Y, Matsumoto T, Kamata K 2007 Insulin-induced impairment via peroxynitrite production of endothelium-dependent relaxation and sarco/endoplasmic reticulum Ca2+-ATPase function in aortas from diabetic rats. Free Radic Biol Med 43:431-443 (Pubitemid 46977627)
18. Lee JH, Palaia T, Ragolia L 2009 Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation. Am J Physiol Cell Physiol 296:C327-C338
19. Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ 2007 Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med 13:315-323 (Pubitemid 46376685)
20. Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC 2005 A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 11:952-958 (Pubitemid 41294440)
21. Moore CA, Milano SK, Benovic JL 2007 Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69:451-482 (Pubitemid 46457651)
22. Jewell-Motz EA, Liggett SB 1996Gprotein-coupled receptor kinase specificity for phosphorylation and desensitization of α2-adrenergic receptor subtypes. J Biol Chem 271:18082-18087 (Pubitemid 26250795)
23. Marwaha A, Lokhandwala MF 2006 Tempol reduces oxidative stress and restores renal dopamine D1-like receptor-G protein coupling and function in hyperglycemic rats. Am J Physiol Renal Physiol 291:F58-F66 (Pubitemid 43945936)
24. Murata T, Hori M, Lee S, Nakamura A, Kohama K, Karaki H, Ozaki H 2005 Vascular endothelium has a local anti-adenovirus vector system and glucocorticoid optimizes its gene transduction. Arterioscler Thromb Vasc Biol 25:1796-1803 (Pubitemid 41243445)
25. Chen S, Feng B, George B, Chakrabarti R, Chen M, Chakrabarti S 2010 Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells. Am J Physiol Endocrinol Metab 298:E127-E137
26. Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H 2000 High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49:1939-1945
27. Cosentino F, Eto M, De Paolis P, van der Loo B, Bachschmid M, Ullrich V, Kouroedov A, Delli Gatti C, Joch H, Volpe M, Lüscher TF 2003 High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation 107:1017-1023 (Pubitemid 36258726)
28. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T 2001 Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88:E14-E22
29. Molnar J, Yu S, Mzhavia N, Pau C, Chereshnev I, Dansky HM 2005 Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice. Circ Res 96:1178-1184 (Pubitemid 40827693)
30. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD 1996 Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97:2601-2610
31. Cai H, Harrison DG 2000 Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840-844
32. Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hudaihed A, Yasskiy A 2005 Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation 111:310-314 (Pubitemid 40165337)
33. Lerman A, Zeiher AM 2005 Endothelial function: cardiac events. Circulation 111:363-368 (Pubitemid 40165345)
34. Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire- Buys D, Novelli M, Ribes G 1998 Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 47:224-229
35. Förstermann U, Münzel T 2006 Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113:1708-1714
36. Luo Z, Fujio Y, Kureishi Y, Rudic RD, Daumerie G, Fulton D, Sessa WC, Walsh K 2000 Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest 106:493-499 (Pubitemid 30666382)
37. Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR 2003 The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest 111:1373-1380 (Pubitemid 36554708)
38. Iino M, Furugori T, Mori T, Moriyama S, Fukuzawa A, Shibano T 2002 Rational design and evaluation of new lead compound structures for selective βARK1 inhibitors. J Med Chem 45:2150-2159 (Pubitemid 34525795)
39. Eckhart AD, Koch WJ 2001 Transgenic studies of cardiac adrenergic receptor regulation. J Pharmacol Exp Ther 299:1-5 (Pubitemid 32905111)
40. Levy D, Kenchaiah S, Larson MG, Benjamin EJ, Kupka MJ, Ho KK, Murabito JM, Vasan RS 2002 Long-term trends in the incidence of and survival with heart failure. N Engl J Med 347:1397-1402 (Pubitemid 35239711)
41. Willets JM, Challiss RA, Nahorski SR 2003 Non-visual GRKs: are we seeing the whole picture? Trends Pharmacol Sci 24:626-633 (Pubitemid 37494784)
42. Gros R, Benovic JL, Tan CM, Feldman RD 1997 G-protein-coupled receptor kinase activity is increased in hypertension. J Clin Invest 99:2087-2093 (Pubitemid 27203764)
43. Williams ML, Hata JA, Schroder J, Rampersaud E, Petrofski J, Jakoi A, Milano CA, Koch WJ 2004 Targeted β-adrenergic receptor kinase (βARK1) inhibition by gene transfer in failing human hearts. Circulation 109:1590-1593 (Pubitemid 38451713)
44. Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ 2005 Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J 26:1752-1758 (Pubitemid 41219848)
45. Lipton SA, Kim WK, Choi YB, Kumar S, D'Emilia DM, Rayudu PV, Arnelle DR, Stamler JS 1997 Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA 94:5923-5928
46. Luan B, Zhao J, Wu H, Duan B, Shu G, Wang X, Li D, Jia W, Kang J, Pei G 2009 Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance. Nature 457:1146-1149