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Volumn 2, Issue 1, 2013, Pages 304-316

Hepatitis C virus and hepatocellular carcinoma

Author keywords

Androgen receptor; Apoptosis; Gender difference; Hepatitis; Hepatocellular carcinoma; Inflammation; Virus

Indexed keywords


EID: 84900547406     PISSN: None     EISSN: 20797737     Source Type: Journal    
DOI: 10.3390/biology2010304     Document Type: Review
Times cited : (16)

References (113)
  • 1
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to hepatitis C virus seroprevalence
    • doi:10.1002/hep.26141
    • Hanafiah, K.M.; Groegar, J.; Flaxman, A.D.; Wiersma, S.T. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to hepatitis C virus seroprevalence. Hepatology 2012, doi:10.1002/hep.26141.
    • (2012) Hepatology
    • Hanafiah, K.M.1    Groegar, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 2
    • 0030931156 scopus 로고    scopus 로고
    • Hepatitis C and hepatocellular carcinoma
    • Di Bisceglie, A.M. Hepatitis C and hepatocellular carcinoma. Hepatology 2012, 26, 34S-38S.
    • (2012) Hepatology , vol.26
    • Di Bisceglie, A.M.1
  • 3
    • 77958105927 scopus 로고    scopus 로고
    • New antiviral therapies for chronic hepatitis C
    • Kanda, T.; Imazeki, F.; Yokosuka, O. New antiviral therapies for chronic hepatitis C. Hepatol. Int. 2010, 4, 548-561.
    • (2010) Hepatol. Int. , vol.4 , pp. 548-561
    • Kanda, T.1    Imazeki, F.2    Yokosuka, O.3
  • 5
    • 0029927642 scopus 로고    scopus 로고
    • Structure of the 3' terminus of the hepatitis C virus genome
    • Tanaka, T.; Kato, N.; Cho, M.J.; Sugiyama, K.; Shimotohno, K. Structure of the 3' terminus of the hepatitis C virus genome. J. Virol. 1996, 70, 3307-3312.
    • (1996) J. Virol. , vol.70 , pp. 3307-3312
    • Tanaka, T.1    Kato, N.2    Cho, M.J.3    Sugiyama, K.4    Shimotohno, K.5
  • 6
    • 69249208681 scopus 로고    scopus 로고
    • Inhibition of intrahepatic gamma interferon production by hepatitis C virus nonstructural protein 5A in transgenic mice
    • Kanda, T.; Steele, R.; Ray, R.; Ray, R.B. Inhibition of intrahepatic gamma interferon production by hepatitis C virus nonstructural protein 5A in transgenic mice. J. Virol. 2009, 83, 8463-8469.
    • (2009) J. Virol. , vol.83 , pp. 8463-8469
    • Kanda, T.1    Steele, R.2    Ray, R.3    Ray, R.B.4
  • 7
    • 0029949695 scopus 로고    scopus 로고
    • Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA
    • Honda, M.; Brown, E.A.; Lemon, S.M. Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA. RNA 1996, 2, 955-968.
    • (1996) RNA , vol.2 , pp. 955-968
    • Honda, M.1    Brown, E.A.2    Lemon, S.M.3
  • 8
    • 79952126737 scopus 로고    scopus 로고
    • Oncogenic potential of hepatitis C virus proteins
    • Banerjee, A.; Ray, R.B.; Ray, R. Oncogenic potential of hepatitis C virus proteins. Viruses 2010, 2, 2108-2133.
    • (2010) Viruses , vol.2 , pp. 2108-2133
    • Banerjee, A.1    Ray, R.B.2    Ray, R.3
  • 9
    • 0028961434 scopus 로고
    • Incidence of hepatocellular carcinoma in chronic hepatitis B and C: A prospective study of 251 patients
    • Takano, S.; Yokosuka O.; Imazeki, F.; Tagawa, M.; Omata, M. Incidence of hepatocellular carcinoma in chronic hepatitis B and C: A prospective study of 251 patients. Hepatology 1995, 21, 650-655.
    • (1995) Hepatology , vol.21 , pp. 650-655
    • Takano, S.1    Yokosuka, O.2    Imazeki, F.3    Tagawa, M.4    Omata, M.5
  • 10
    • 0033566684 scopus 로고    scopus 로고
    • Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis
    • Tarao, K.; Rino, Y.; Ohkawa, S.; Shimizu, A.; Tamai, S.; Miyakawa, K.; Aoki, H.; Imada, T.; Shindo, K.; Okamoto, N.; Totsuka, S. Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis. Cancer 1999, 86, 589-595.
    • (1999) Cancer , vol.86 , pp. 589-595
    • Tarao, K.1    Rino, Y.2    Ohkawa, S.3    Shimizu, A.4    Tamai, S.5    Miyakawa, K.6    Aoki, H.7    Imada, T.8    Shindo, K.9    Okamoto, N.10    Totsuka, S.11
  • 11
    • 84882602729 scopus 로고    scopus 로고
    • Signaling pathways involved in molecular carcinogenesis of hepatocellular carcinoma
    • In, Qiao, L., George, J., Li, Y., Yan, X., Eds.; Bentham Science: Oak Park, IL, USA
    • Kanda, T.; Imazeki, F.; Kanai, F.; Tada, M.; Yokosuka, O.; Omata, M. Signaling pathways involved in molecular carcinogenesis of hepatocellular carcinoma. In Molecular Aspects of Hepatocellular Carcinoma; Qiao, L., George, J., Li, Y., Yan, X., Eds.; Bentham Science: Oak Park, IL, USA, 2012; pp. 39-55.
    • (2012) Molecular Aspects of Hepatocellular Carcinoma , pp. 39-55
    • Kanda, T.1    Imazeki, F.2    Kanai, F.3    Tada, M.4    Yokosuka, O.5    Omata, M.6
  • 12
    • 77951622187 scopus 로고    scopus 로고
    • Viral hepatocarcinogenesis
    • Tsai, W.L.; Chung, R.T. Viral hepatocarcinogenesis. Oncogene 2010, 29, 2309-2324.
    • (2010) Oncogene , vol.29 , pp. 2309-2324
    • Tsai, W.L.1    Chung, R.T.2
  • 13
    • 8944262349 scopus 로고    scopus 로고
    • Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype
    • Ray, R.B.; Lagging, L.M.; Meyer, K.; Ray, R. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J. Virol. 1996, 70, 4438-4443.
    • (1996) J. Virol. , vol.70 , pp. 4438-4443
    • Ray, R.B.1    Lagging, L.M.2    Meyer, K.3    Ray, R.4
  • 14
    • 0033945531 scopus 로고    scopus 로고
    • Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1
    • Aoki, H.; Hayashi, J.; Moriyama, M.; Arakawa, Y.; Hino, O. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. J. Virol. 2000, 74, 1736-1741.
    • (2000) J. Virol. , vol.74 , pp. 1736-1741
    • Aoki, H.1    Hayashi, J.2    Moriyama, M.3    Arakawa, Y.4    Hino, O.5
  • 15
    • 0033755010 scopus 로고    scopus 로고
    • Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha
    • Hayashi, J.; Aoki, H.; Kajino, K.; Moriyama, M.; Arakawa, Y.; Hino, O. Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. Hepatology 2000, 32, 958-961.
    • (2000) Hepatology , vol.32 , pp. 958-961
    • Hayashi, J.1    Aoki, H.2    Kajino, K.3    Moriyama, M.4    Arakawa, Y.5    Hino, O.6
  • 16
    • 0035799529 scopus 로고    scopus 로고
    • Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein
    • Giambartolomei, S.; Covone, F.; Levrero, M.; Balsano, C. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein. Oncogene 2001, 20, 2606-2610.
    • (2001) Oncogene , vol.20 , pp. 2606-2610
    • Giambartolomei, S.1    Covone, F.2    Levrero, M.3    Balsano, C.4
  • 17
    • 33744958372 scopus 로고    scopus 로고
    • Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1
    • Spaziani, A.; Alisi, A.; Sanna, D.; Balsano, C. Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1. J. Biol. Chem. 2006, 281, 10983-10989.
    • (2006) J. Biol. Chem. , vol.281 , pp. 10983-10989
    • Spaziani, A.1    Alisi, A.2    Sanna, D.3    Balsano, C.4
  • 18
    • 33845436329 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB
    • Sato, Y.; Kato, J.; Takimoto, R.; Takada, K.; Kawano, Y.; Miyanishi, K.; Kobune, M.; Takayama, T.; Matunaga, T.; Niitsu, Y. Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB. Gut 2006, 55, 1801-1808.
    • (2006) Gut , vol.55 , pp. 1801-1808
    • Sato, Y.1    Kato, J.2    Takimoto, R.3    Takada, K.4    Kawano, Y.5    Miyanishi, K.6    Kobune, M.7    Takayama, T.8    Matunaga, T.9    Niitsu, Y.10
  • 19
    • 17844372967 scopus 로고    scopus 로고
    • Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression
    • Fukutomi, T.; Zhou, Y.; Kawai, S.; Eguchi, H.; Wands, J.R.; Li, J. Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression. Hepatology 2005, 41, 1096-1105.
    • (2005) Hepatology , vol.41 , pp. 1096-1105
    • Fukutomi, T.1    Zhou, Y.2    Kawai, S.3    Eguchi, H.4    Wands, J.R.5    Li, J.6
  • 20
    • 0031892177 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein
    • Ray, R.B.; Meyer, K.; Steele, R.; Shrivastava, A.; Aggarwal, B.B.; Ray, R. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein. J. Biol. Chem. 1998, 273, 2256-2259.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2256-2259
    • Ray, R.B.1    Meyer, K.2    Steele, R.3    Shrivastava, A.4    Aggarwal, B.B.5    Ray, R.6
  • 21
    • 0033061215 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits Fas-and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation
    • Marusawa, H.; Hijikata, M.; Chiba, T.; Shimotohno, K. Hepatitis C virus core protein inhibits Fas-and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation. J. Virol. 1999, 73, 4713-4720.
    • (1999) J. Virol. , vol.73 , pp. 4713-4720
    • Marusawa, H.1    Hijikata, M.2    Chiba, T.3    Shimotohno, K.4
  • 22
    • 33646166625 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein
    • Saito, K.; Meyer, K.; Warner, R.; Basu, A.; Ray, R.B.; Ray, R. Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein. J. Virol. 2006, 80, 4372-4379.
    • (2006) J. Virol. , vol.80 , pp. 4372-4379
    • Saito, K.1    Meyer, K.2    Warner, R.3    Basu, A.4    Ray, R.B.5    Ray, R.6
  • 23
    • 0344012537 scopus 로고    scopus 로고
    • Hepatitis C virus core protein upregulates transforming growth factor-beta 1 transcription
    • Taniguchi, H.; Kato, N.; Otsuka, M.; Goto, T.; Yoshida, H.; Shiratori, Y.; Omata, M. Hepatitis C virus core protein upregulates transforming growth factor-beta 1 transcription. J. Med. Virol. 2004, 72, 52-59.
    • (2004) J. Med. Virol. , vol.72 , pp. 52-59
    • Taniguchi, H.1    Kato, N.2    Otsuka, M.3    Goto, T.4    Yoshida, H.5    Shiratori, Y.6    Omata, M.7
  • 24
    • 26944444737 scopus 로고    scopus 로고
    • Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
    • Pavio, N.; Battaglia, S.; Boucreux, D.; Arnulf, B.; Sobesky, R.; Hermine, O.; Brechot, C. Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway. Oncogene 2005, 24, 6119-6132.
    • (2005) Oncogene , vol.24 , pp. 6119-6132
    • Pavio, N.1    Battaglia, S.2    Boucreux, D.3    Arnulf, B.4    Sobesky, R.5    Hermine, O.6    Brechot, C.7
  • 25
    • 34547097746 scopus 로고    scopus 로고
    • Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • Waris, G.; Felmlee, D.J.; Negro, F.; Siddiqui, A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J. Virol. 2007, 81, 8122-8130.
    • (2007) J. Virol. , vol.81 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.J.2    Negro, F.3    Siddiqui, A.4
  • 26
  • 27
    • 40149089262 scopus 로고    scopus 로고
    • Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance
    • Banerjee, S.; Saito, K.; Ait-Goughoulte, M.; Meyer, K.; Ray, R.B.; Ray, R. Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. J. Virol. 2008, 82, 2606-2612.
    • (2008) J. Virol. , vol.82 , pp. 2606-2612
    • Banerjee, S.1    Saito, K.2    Ait-Goughoulte, M.3    Meyer, K.4    Ray, R.B.5    Ray, R.6
  • 28
    • 79955164804 scopus 로고    scopus 로고
    • HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt
    • Nakamura, H.; Aoki, H.; Hino, O.; Moriyama, M. HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt. Hepatol. Res. 2011, 41, 455-462.
    • (2011) Hepatol. Res. , vol.41 , pp. 455-462
    • Nakamura, H.1    Aoki, H.2    Hino, O.3    Moriyama, M.4
  • 29
    • 84863590701 scopus 로고    scopus 로고
    • Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance
    • Bose, S.K.; Shrivastava, S.; Meyer, K.; Ray, R.B.; Ray, R. Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance. J. Virol. 2012, 86, 6315-6322.
    • (2012) J. Virol. , vol.86 , pp. 6315-6322
    • Bose, S.K.1    Shrivastava, S.2    Meyer, K.3    Ray, R.B.4    Ray, R.5
  • 30
    • 0031797725 scopus 로고    scopus 로고
    • Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors
    • Shrivastava, A.; Manna, S.K.; Ray, R.; Aggarwal, B.B. Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J. Virol. 1998, 72, 9722-9728.
    • (1998) J. Virol. , vol.72 , pp. 9722-9728
    • Shrivastava, A.1    Manna, S.K.2    Ray, R.3    Aggarwal, B.B.4
  • 31
    • 0035844148 scopus 로고    scopus 로고
    • Hepatitis C virus core protein activates nuclear factor kappa B-dependent signaling through tumor necrosis factor receptor-associated factor
    • Yoshida, H.; Kato, N.; Shiratori, Y.; Otsuka, M.; Maeda, S.; Kato, J.; Omata, M. Hepatitis C virus core protein activates nuclear factor kappa B-dependent signaling through tumor necrosis factor receptor-associated factor. J. Biol. Chem. 2001, 276, 16399-16405.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16399-16405
    • Yoshida, H.1    Kato, N.2    Shiratori, Y.3    Otsuka, M.4    Maeda, S.5    Kato, J.6    Omata, M.7
  • 32
    • 0036064441 scopus 로고    scopus 로고
    • Distinct functional role of Hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variation
    • Ray, R.B.; Steele, R.; Basu, A.; Meyer, K.; Majumder, M.; Ghosh, A.K.; Ray, R. Distinct functional role of Hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variation. Virus Res. 2002, 87, 21-29.
    • (2002) Virus Res. , vol.87 , pp. 21-29
    • Ray, R.B.1    Steele, R.2    Basu, A.3    Meyer, K.4    Majumder, M.5    Ghosh, A.K.6    Ray, R.7
  • 33
    • 0030891710 scopus 로고    scopus 로고
    • Transcriptional repression of p53 promoter by hepatitis C virus core protein
    • Ray, R.B.; Steele, R.; Meyer, K.; Ray, R. Transcriptional repression of p53 promoter by hepatitis C virus core protein. J. Biol. Chem. 1997, 272, 10983-10986.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10983-10986
    • Ray, R.B.1    Steele, R.2    Meyer, K.3    Ray, R.4
  • 34
    • 0032570876 scopus 로고    scopus 로고
    • Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity
    • Ray, R.B.; Steele, R.; Meyer, K.; Ray, R. Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity. Gene 1998, 208, 331-336.
    • (1998) Gene , vol.208 , pp. 331-336
    • Ray, R.B.1    Steele, R.2    Meyer, K.3    Ray, R.4
  • 35
    • 0034602420 scopus 로고    scopus 로고
    • Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability
    • Otsuka, M.; Kato, N.; Lan, K.; Yoshida, H.; Kato, J.; Goto, T.; Shiratori, Y.; Omata, M. Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. J. Biol. Chem. 2000, 275, 34122-34130.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34122-34130
    • Otsuka, M.1    Kato, N.2    Lan, K.3    Yoshida, H.4    Kato, J.5    Goto, T.6    Shiratori, Y.7    Omata, M.8
  • 36
    • 0036717295 scopus 로고    scopus 로고
    • Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
    • Yoshida, T.; Hanada, T.; Tokuhisa, T.; Kosai, K.; Sata, M.; Kohara, M.; Yoshimura, A. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J. Exp. Med. 2002, 196, 641-653.
    • (2002) J. Exp. Med. , vol.196 , pp. 641-653
    • Yoshida, T.1    Hanada, T.2    Tokuhisa, T.3    Kosai, K.4    Sata, M.5    Kohara, M.6    Yoshimura, A.7
  • 37
    • 33646887378 scopus 로고    scopus 로고
    • Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes
    • Basu, A.; Meyer, K.; Lai, K.K.; Saito, K.; di Bisceglie, A.M.; Grosso, L.E.; Ray, R.B.; Ray, R. Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes. Virology 2006, 349, 347-358.
    • (2006) Virology , vol.349 , pp. 347-358
    • Basu, A.1    Meyer, K.2    Lai, K.K.3    Saito, K.4    Di Bisceglie, A.M.5    Grosso, L.E.6    Ray, R.B.7    Ray, R.8
  • 38
    • 79953178933 scopus 로고    scopus 로고
    • Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway
    • Tacke, R.S.; Tosello-Trampont, A.; Nguyen, V.; Mullins, D.W.; Hahn, Y.S. Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. J. Biol. Chem. 2011, 286, 10847-10855.
    • (2011) J. Biol. Chem. , vol.286 , pp. 10847-10855
    • Tacke, R.S.1    Tosello-Trampont, A.2    Nguyen, V.3    Mullins, D.W.4    Hahn, Y.S.5
  • 39
    • 55549090712 scopus 로고    scopus 로고
    • Hepatitis C virus core protein augments androgen receptor-mediated signaling
    • Kanda, T.; Steele, R.; Ray, R.; Ray, R.B. Hepatitis C virus core protein augments androgen receptor-mediated signaling. J. Virol. 2008, 82, 11066-11072.
    • (2008) J. Virol. , vol.82 , pp. 11066-11072
    • Kanda, T.1    Steele, R.2    Ray, R.3    Ray, R.B.4
  • 42
    • 0031957325 scopus 로고    scopus 로고
    • Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis
    • Zhu, N.; Khoshnan, A.; Schneider, R.; Matsumoto, M.; Dennert, G.; Ware, C.; Lai, M.M. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J. Virol. 1998, 72, 3691-3697.
    • (1998) J. Virol. , vol.72 , pp. 3691-3697
    • Zhu, N.1    Khoshnan, A.2    Schneider, R.3    Matsumoto, M.4    Dennert, G.5    Ware, C.6    Lai, M.M.7
  • 43
    • 0035111296 scopus 로고    scopus 로고
    • Hepatitis C virus core protein potentiates c-Jun N-terminal kinase activation through a signaling complex involving TRADD and TRAF2
    • Park, K.J.; Choi, S.H.; Koh, M.S.; Kim, D.J.; Yie, S.W.; Lee, S.Y.; Hwang, S.B. Hepatitis C virus core protein potentiates c-Jun N-terminal kinase activation through a signaling complex involving TRADD and TRAF2. Virus Res. 2001, 74, 89-98.
    • (2001) Virus Res. , vol.74 , pp. 89-98
    • Park, K.J.1    Choi, S.H.2    Koh, M.S.3    Kim, D.J.4    Yie, S.W.5    Lee, S.Y.6    Hwang, S.B.7
  • 44
    • 0035809057 scopus 로고    scopus 로고
    • HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation
    • Cho, J.; Baek, W.; Yang, S.; Chang, J.; Sung, Y.C.; Suh, M. HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation. Biochim. Biophys. Acta. 2001, 1538, 59-66.
    • (2001) Biochim. Biophys. Acta. , vol.1538 , pp. 59-66
    • Cho, J.1    Baek, W.2    Yang, S.3    Chang, J.4    Sung, Y.C.5    Suh, M.6
  • 45
    • 33845341103 scopus 로고    scopus 로고
    • Interaction of HCV core protein with 14-3-3epsilon protein releases Bax to activate apoptosis
    • Lee, S.K.; Park, S.O.; Joe, C.O.; Kim, Y.S. Interaction of HCV core protein with 14-3-3epsilon protein releases Bax to activate apoptosis. Biochem. Biophys. Res. Commun. 2007, 352, 756-762.
    • (2007) Biochem. Biophys. Res. Commun. , vol.352 , pp. 756-762
    • Lee, S.K.1    Park, S.O.2    Joe, C.O.3    Kim, Y.S.4
  • 46
    • 67349125450 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis
    • Kang, S.M.; Kim, S.J.; Kim, J.H.; Lee, W.; Kim, G.W.; Lee, K.H.; Choi, K.Y.; Oh, J.W. Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis. Cancer Lett. 2009, 279, 230-237.
    • (2009) Cancer Lett. , vol.279 , pp. 230-237
    • Kang, S.M.1    Kim, S.J.2    Kim, J.H.3    Lee, W.4    Kim, G.W.5    Lee, K.H.6    Choi, K.Y.7    Oh, J.W.8
  • 47
    • 70349295222 scopus 로고    scopus 로고
    • The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1
    • Mohd-Ismail, N.K.; Deng, L.; Sukumaran, S.K.; Yu, V.C.; Hotta, H.; Tan, Y.J. The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1. J. Virol. 2009, 83, 9993-10006.
    • (2009) J. Virol. , vol.83 , pp. 9993-10006
    • Mohd-Ismail, N.K.1    Deng, L.2    Sukumaran, S.K.3    Yu, V.C.4    Hotta, H.5    Tan, Y.J.6
  • 48
    • 17544383005 scopus 로고    scopus 로고
    • Activation of nuclear factor kappaB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis
    • Tai, D.I.; Tsai, S.L.; Chen, Y.M.; Chuang, Y.L.; Peng, C.Y.; Sheen, I.S.; Yeh, C.T.; Chang, K.S.; Huang, S.N.; Kuo, G.C.; et al. Activation of nuclear factor kappaB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis. Hepatology 2000, 31, 656-664.
    • (2000) Hepatology , vol.31 , pp. 656-664
    • Tai, D.I.1    Tsai, S.L.2    Chen, Y.M.3    Chuang, Y.L.4    Peng, C.Y.5    Sheen, I.S.6    Yeh, C.T.7    Chang, K.S.8    Huang, S.N.9    Kuo, G.C.10
  • 49
    • 0034798319 scopus 로고    scopus 로고
    • Suppression of serum starvation-induced apoptosis by hepatitis C virus core protein
    • Takamatsu, M.; Fujita, T.; Hotta, H. Suppression of serum starvation-induced apoptosis by hepatitis C virus core protein. Kobe J. Med. Sci. 2001, 47, 97-112.
    • (2001) Kobe J. Med. Sci. , vol.47 , pp. 97-112
    • Takamatsu, M.1    Fujita, T.2    Hotta, H.3
  • 50
    • 0036343156 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits apoptosis via enhanced Bcl-xL expression
    • Otsuka, M.; Kato, N.; Taniguchi, H.; Yoshida, H.; Goto, T.; Shiratori, Y.; Omata, M. Hepatitis C virus core protein inhibits apoptosis via enhanced Bcl-xL expression. Virology 2002, 296, 84-93.
    • (2002) Virology , vol.296 , pp. 84-93
    • Otsuka, M.1    Kato, N.2    Taniguchi, H.3    Yoshida, H.4    Goto, T.5    Shiratori, Y.6    Omata, M.7
  • 51
    • 0036301977 scopus 로고    scopus 로고
    • Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes
    • Basu, A.; Meyer, K.; Ray, R.B.; Ray, R. Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes. Virology 2002, 298, 53-62.
    • (2002) Virology , vol.298 , pp. 53-62
    • Basu, A.1    Meyer, K.2    Ray, R.B.3    Ray, R.4
  • 52
  • 53
    • 2342638820 scopus 로고    scopus 로고
    • Suppression of ceramide-induced cell death by hepatitis C virus core protein
    • Kim, J.S.; Ryu, J.; Hwang, S.B.; Lee, S.Y.; Choi, S.Y.; Park, J. Suppression of ceramide-induced cell death by hepatitis C virus core protein. J. Biochem. Mol. Biol. 2004, 37, 192-198.
    • (2004) J. Biochem. Mol. Biol. , vol.37 , pp. 192-198
    • Kim, J.S.1    Ryu, J.2    Hwang, S.B.3    Lee, S.Y.4    Choi, S.Y.5    Park, J.6
  • 54
    • 18844416914 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c-independent increase in Apaf-1 and caspase-9 activation for cell death
    • Meyer, K.; Basu, A.; Saito, K.; Ray, R.B.; Ray, R. Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c-independent increase in Apaf-1 and caspase-9 activation for cell death. Virology 2005, 336, 198-207.
    • (2005) Virology , vol.336 , pp. 198-207
    • Meyer, K.1    Basu, A.2    Saito, K.3    Ray, R.B.4    Ray, R.5
  • 56
    • 28244483929 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells
    • Herzer, K.; Weyer, S.; Krammer, P.H.; Galle, P.R.; Hofmann, T.G. Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells. Cancer Res. 2005, 65, 10830-10837.
    • (2005) Cancer Res. , vol.65 , pp. 10830-10837
    • Herzer, K.1    Weyer, S.2    Krammer, P.H.3    Galle, P.R.4    Hofmann, T.G.5
  • 57
    • 58249123434 scopus 로고    scopus 로고
    • Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression
    • Du, J.; Liang, X.; Liu, Y.; Qu, Z.; Gao, L.; Han, L.; Liu, S.; Cui, M.; Shi, Y.; Zhang, Z.; et al. Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression. Cell Death Differ. 2009, 16, 219-229.
    • (2009) Cell Death Differ. , vol.16 , pp. 219-229
    • Du, J.1    Liang, X.2    Liu, Y.3    Qu, Z.4    Gao, L.5    Han, L.6    Liu, S.7    Cui, M.8    Shi, Y.9    Zhang, Z.10
  • 58
    • 0041914260 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
    • Chung, Y.L.; Sheu, M.L.; Yen, S.H. Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma. Int. J. Cancer 2003, 107, 65-73.
    • (2003) Int. J. Cancer , vol.107 , pp. 65-73
    • Chung, Y.L.1    Sheu, M.L.2    Yen, S.H.3
  • 59
    • 0345004984 scopus 로고    scopus 로고
    • Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase
    • Gale, M., Jr.; Kwieciszewski, B.; Dossett, M.; Nakao, H.; Katze, M.G. Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J. Virol. 1999, 73, 6506-6516.
    • (1999) J. Virol. , vol.73 , pp. 6506-6516
    • Gale Jr., M.1    Kwieciszewski, B.2    Dossett, M.3    Nakao, H.4    Katze, M.G.5
  • 60
    • 0036063623 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice
    • Majumder, M.; Ghosh, A.K.; Steele, R.; Zhou, X.Y.; Phillips, N.J.; Ray, R.; Ray, R.B. Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice. Virology 2002, 294, 94-105.
    • (2002) Virology , vol.294 , pp. 94-105
    • Majumder, M.1    Ghosh, A.K.2    Steele, R.3    Zhou, X.Y.4    Phillips, N.J.5    Ray, R.6    Ray, R.B.7
  • 62
    • 80955139377 scopus 로고    scopus 로고
    • The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-kappaB pathways
    • Jiang, Y.F.; He, B.; Li, N.P.; Ma, J.; Gong, G.Z.; Zhang, M. The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-kappaB pathways. Cell Biol. Int. 2011, 35, 1225-1232.
    • (2011) Cell Biol. Int. , vol.35 , pp. 1225-1232
    • Jiang, Y.F.1    He, B.2    Li, N.P.3    Ma, J.4    Gong, G.Z.5    Zhang, M.6
  • 63
    • 0036721468 scopus 로고    scopus 로고
    • Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase
    • He, Y.; Nakao, H.; Tan, S.L.; Polyak, S.J.; Neddermann, P.; Vijaysri, S.; Jacobs, B.L.; Katze, M.G. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J. Virol. 2002, 76, 9207-9217.
    • (2002) J. Virol. , vol.76 , pp. 9207-9217
    • He, Y.1    Nakao, H.2    Tan, S.L.3    Polyak, S.J.4    Neddermann, P.5    Vijaysri, S.6    Jacobs, B.L.7    Katze, M.G.8
  • 64
    • 1842478144 scopus 로고    scopus 로고
    • The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade
    • Street, A.; Macdonald, A.; Crowder, K.; Harris, M. The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 2004, 279, 12232-12241.
    • (2004) J. Biol. Chem. , vol.279 , pp. 12232-12241
    • Street, A.1    McDonald, A.2    Crowder, K.3    Harris, M.4
  • 66
    • 33644856599 scopus 로고    scopus 로고
    • The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity
    • Nanda S.K.; Herion, D.; Liang, T.J. The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity. Gastroenterology 2006, 130, 794-809.
    • (2006) Gastroenterology , vol.130 , pp. 794-809
    • Nanda, S.K.1    Herion, D.2    Liang, T.J.3
  • 67
    • 33746367134 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells
    • Wang, J.; Tong, W.; Zhang, X.; Chen, L.; Yi, Z.; Pan, T.; Hu, Y.; Xiang, L.; Yuan, Z. Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells. FEBS Lett. 2006, 580, 4392-4400.
    • (2006) FEBS Lett. , vol.580 , pp. 4392-4400
    • Wang, J.1    Tong, W.2    Zhang, X.3    Chen, L.4    Yi, Z.5    Pan, T.6    Hu, Y.7    Xiang, L.8    Yuan, Z.9
  • 68
    • 77954227028 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR
    • Peng, L.; Liang, D.; Tong, W.; Li, J.; Yuan, Z. Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR. J. Biol. Chem. 2010, 285, 20870-20881.
    • (2010) J. Biol. Chem. , vol.285 , pp. 20870-20881
    • Peng, L.1    Liang, D.2    Tong, W.3    Li, J.4    Yuan, Z.5
  • 70
    • 84862839698 scopus 로고    scopus 로고
    • Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A
    • Norris, C.A.; He, K.; Springer, M.G.; Hartnett, K.A.; Horn, J.P.; Aizenman, E. Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A. J. Neurosci. 2012, 32, 8865-8870.
    • (2012) J. Neurosci. , vol.32 , pp. 8865-8870
    • Norris, C.A.1    He, K.2    Springer, M.G.3    Hartnett, K.A.4    Horn, J.P.5    Aizenman, E.6
  • 71
    • 80051712972 scopus 로고    scopus 로고
    • Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4
    • Tamura, R.; Kanda, T.; Imazeki, F.; Wu, S.; Nakamoto, S.; Tanaka, T.; Arai, M.; Fujiwara, K.; Saito, K.; Roger, T.; et al. Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4. J. Infect. Dis. 2011, 204, 793-801.
    • (2011) J. Infect. Dis. , vol.204 , pp. 793-801
    • Tamura, R.1    Kanda, T.2    Imazeki, F.3    Wu, S.4    Nakamoto, S.5    Tanaka, T.6    Arai, M.7    Fujiwara, K.8    Saito, K.9    Roger, T.10
  • 72
    • 0028978937 scopus 로고
    • Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A
    • Tanji, Y.; Kaneko, T.; Satoh, S.; Shimotohno, K. Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J. Virol. 1995, 69, 3980-3986.
    • (1995) J. Virol. , vol.69 , pp. 3980-3986
    • Tanji, Y.1    Kaneko, T.2    Satoh, S.3    Shimotohno, K.4
  • 73
    • 0038719743 scopus 로고    scopus 로고
    • The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling
    • Macdonald, A.; Crowder, K.; Street, A.; McCormick, C.; Saksela, K.; Harris, M. The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling. J. Biol. Chem. 2003, 278, 17775-17784.
    • (2003) J. Biol. Chem. , vol.278 , pp. 17775-17784
    • McDonald, A.1    Crowder, K.2    Street, A.3    McCormick, C.4    Saksela, K.5    Harris, M.6
  • 74
    • 76249125464 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion
    • Milward, A.; Mankouri, J.; Harris, M. Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion. J. Gen. Virol. 2010, 91, 373-381.
    • (2010) J. Gen. Virol. , vol.91 , pp. 373-381
    • Milward, A.1    Mankouri, J.2    Harris, M.3
  • 75
    • 70349735843 scopus 로고    scopus 로고
    • Nonstructural 5A protein activates beta-catenin signaling cascades: Implication of hepatitis C virus-induced liver pathogenesis
    • Park, C.Y.; Choi, S.H.; Kang, S.M.; Kang, J.I.; Ahn, B.Y.; Kim, H.; Jung, G.; Choi, K.Y.; Hwang, S.B. Nonstructural 5A protein activates beta-catenin signaling cascades: Implication of hepatitis C virus-induced liver pathogenesis. J. Hepatol. 2009, 51, 853-864.
    • (2009) J. Hepatol. , vol.51 , pp. 853-864
    • Park, C.Y.1    Choi, S.H.2    Kang, S.M.3    Kang, J.I.4    Ahn, B.Y.5    Kim, H.6    Jung, G.7    Choi, K.Y.8    Hwang, S.B.9
  • 76
    • 16244364798 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription
    • Street, A.; Macdonald, A.; McCormick, C.; Harris, M. Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription. J. Virol. 2005, 79, 5006-5016.
    • (2005) J. Virol. , vol.79 , pp. 5006-5016
    • Street, A.1    McDonald, A.2    McCormick, C.3    Harris, M.4
  • 77
    • 0034084529 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein protects against TNF-alpha mediated apoptotic cell death
    • Ghosh, A.K.; Majumder, M.; Steele, R.; Meyer, K.; Ray, R.; Ray, R.B. Hepatitis C virus NS5A protein protects against TNF-alpha mediated apoptotic cell death. Virus Res. 2000, 67, 173-178.
    • (2000) Virus Res. , vol.67 , pp. 173-178
    • Ghosh, A.K.1    Majumder, M.2    Steele, R.3    Meyer, K.4    Ray, R.5    Ray, R.B.6
  • 78
    • 33646348166 scopus 로고    scopus 로고
    • Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein
    • Choi, S.H.; Hwang, S.B. Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein. J. Biol. Chem. 2006, 281, 7468-7478.
    • (2006) J. Biol. Chem. , vol.281 , pp. 7468-7478
    • Choi, S.H.1    Hwang, S.B.2
  • 79
    • 79952616582 scopus 로고    scopus 로고
    • Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-beta1: Role of TGF-beta1 in HCV replication
    • Presser, L.D.; Haskett, A.; Waris, G. Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-beta1: Role of TGF-beta1 in HCV replication. Virology 2011, 412, 284-296.
    • (2011) Virology , vol.412 , pp. 284-296
    • Presser, L.D.1    Haskett, A.2    Waris, G.3
  • 80
    • 84867580125 scopus 로고    scopus 로고
    • Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors
    • Akkari, L.; Gregoire, D.; Floc'h, N.; Moreau, M.; Hernandez, C.; Simonin, Y.; Rosenberg, A.R.; Lassus, P.; Hibner, U. Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors. J. Hepatol. 2012, 57, 1021-1028.
    • (2012) J. Hepatol. , vol.57 , pp. 1021-1028
    • Akkari, L.1    Gregoire, D.2    Floc'H, N.3    Moreau, M.4    Hernandez, C.5    Simonin, Y.6    Rosenberg, A.R.7    Lassus, P.8    Hibner, U.9
  • 81
    • 84872443890 scopus 로고    scopus 로고
    • P53 controls hepatitis C virus nonstructural protein 5A-mediated down-regulation of GADD45α expression via the NF-κB and PI3K-Akt pathways
    • doi:10.1099/vir.0.046052-0
    • Cheng, D.; Zhao, L.; Zhang, L.; Jiang, Y.; Tian, Y.; Xiao, X.; Gong, G. P53 controls hepatitis C virus nonstructural protein 5A-mediated down-regulation of GADD45α expression via the NF-κB and PI3K-Akt pathways. J. Gen. Virol. 2012, doi:10.1099/vir.0.046052-0.
    • (2012) J. Gen. Virol.
    • Cheng, D.1    Zhao, L.2    Zhang, L.3    Jiang, Y.4    Tian, Y.5    Xiao, X.6    Gong, G.7
  • 82
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong, G.; Waris, G.; Tanveer, R.; Siddiqui, A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc. Natl. Acad. Sci. USA 2001, 98, 9599-9604.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 83
    • 0037066713 scopus 로고    scopus 로고
    • Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation
    • Park, K.J.; Choi, S.H.; Lee, S.Y.; Hwang, S.B.; Lai, M.M. Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation. J. Biol. Chem. 2002, 277, 13122-13128.
    • (2002) J. Biol. Chem. , vol.277 , pp. 13122-13128
    • Park, K.J.1    Choi, S.H.2    Lee, S.Y.3    Hwang, S.B.4    Lai, M.M.5
  • 84
    • 0037111954 scopus 로고    scopus 로고
    • Endoplasmic reticulum (ER) stress: Hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3
    • Waris, G.; Tardif, K.D.; Siddiqui, A. Endoplasmic reticulum (ER) stress: Hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3. Biochem. Pharmacol. 2002, 64, 1425-1430.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1425-1430
    • Waris, G.1    Tardif, K.D.2    Siddiqui, A.3
  • 85
    • 0142039960 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease
    • Waris, G.; Livolsi, A.; Imbert, V.; Peyron, J.F.; Siddiqui, A. Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease. J. Biol. Chem. 2003, 278, 40778-40787.
    • (2003) J. Biol. Chem. , vol.278 , pp. 40778-40787
    • Waris, G.1    Livolsi, A.2    Imbert, V.3    Peyron, J.F.4    Siddiqui, A.5
  • 86
    • 0032938224 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth
    • Ghosh, A.K.; Steele, R.; Meyer, K.; Ray, R.; Ray, R.B. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J. Gen. Virol. 1999, 80, 1179-1183.
    • (1999) J. Gen. Virol. , vol.80 , pp. 1179-1183
    • Ghosh, A.K.1    Steele, R.2    Meyer, K.3    Ray, R.4    Ray, R.B.5
  • 87
    • 0034629092 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP
    • Ghosh, A.K.; Majumder, M.; Steele, R.; Yaciuk, P.; Chrivia, J.; Ray, R.; Ray, R.B. Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. J. Biol. Chem. 2000, 275, 7184-7188.
    • (2000) J. Biol. Chem. , vol.275 , pp. 7184-7188
    • Ghosh, A.K.1    Majumder, M.2    Steele, R.3    Yaciuk, P.4    Chrivia, J.5    Ray, R.6    Ray, R.B.7
  • 88
    • 0035148645 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner
    • Majumder, M.; Ghosh, A.K.; Steele, R.; Ray, R.; Ray, R.B. Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner. J. Virol. 2001, 75, 1401-1407.
    • (2001) J. Virol. , vol.75 , pp. 1401-1407
    • Majumder, M.1    Ghosh, A.K.2    Steele, R.3    Ray, R.4    Ray, R.B.5
  • 89
    • 1942518231 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase
    • Sarcar, B.; Ghosh, A.K.; Steele, R.; Ray, R.; Ray, R.B. Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. Virology 2004, 322, 51-60.
    • (2004) Virology , vol.322 , pp. 51-60
    • Sarcar, B.1    Ghosh, A.K.2    Steele, R.3    Ray, R.4    Ray, R.B.5
  • 93
    • 0029063640 scopus 로고
    • Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells
    • Sakamuro, D.; Furukawa, T.; Takegami, T. Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J. Virol. 1995, 69, 3893-3896.
    • (1995) J. Virol. , vol.69 , pp. 3893-3896
    • Sakamuro, D.1    Furukawa, T.2    Takegami, T.3
  • 95
    • 13844265988 scopus 로고    scopus 로고
    • Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth
    • Hassan, M.; Ghozlan, H.; Abdel-Kader, O. Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth. Virology 2005, 333, 324-336.
    • (2005) Virology , vol.333 , pp. 324-336
    • Hassan, M.1    Ghozlan, H.2    Abdel-Kader, O.3
  • 96
    • 30144437078 scopus 로고    scopus 로고
    • Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3
    • Tanaka, M.; Nagano-Fujii, M.; Deng, L.; Ishido, S.; Sada, K.; Hotta, H. Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3. Biochem. Biophys. Res. Commun. 2006, 340, 792-799.
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 792-799
    • Tanaka, M.1    Nagano-Fujii, M.2    Deng, L.3    Ishido, S.4    Sada, K.5    Hotta, H.6
  • 98
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy, E.; Li, K.; Wang, C.; Sumpter, R., Jr.; Ikeda, M.; Lemon, S.M.; Gale, M., Jr. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003, 300, 1145-1148.
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3    Sumpter Jr., R.4    Ikeda, M.5    Lemon, S.M.6    Gale Jr., M.7
  • 99
    • 44949154435 scopus 로고    scopus 로고
    • Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A
    • Moriyama, M.; Kato, N.; Otsuka, M.; Shao, R.X.; Taniguchi, H.; Kawabe, T.; Omata, M. Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A. Hepatol. Int. 2007, 1, 302-310.
    • (2007) Hepatol. Int. , vol.1 , pp. 302-310
    • Moriyama, M.1    Kato, N.2    Otsuka, M.3    Shao, R.X.4    Taniguchi, H.5    Kawabe, T.6    Omata, M.7
  • 100
    • 68949107512 scopus 로고    scopus 로고
    • Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography
    • Masuzaki, R.; Tateishi, R.; Yoshida, H.; Goto, E.; Sato, T.; Ohki, T.; Imamura, J.; Goto, T.; Kanai, F.; Kato, N.; et al. Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography. Hepatology 2009, 49, 1954-1961.
    • (2009) Hepatology , vol.49 , pp. 1954-1961
    • Masuzaki, R.1    Tateishi, R.2    Yoshida, H.3    Goto, E.4    Sato, T.5    Ohki, T.6    Imamura, J.7    Goto, T.8    Kanai, F.9    Kato, N.10
  • 102
    • 0038216621 scopus 로고    scopus 로고
    • Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis
    • Shuda, M.; Kondoh, N.; Imazeki, N.; Tanaka, K.; Okada, T.; Mori, K.; Hada, A.; Arai, M.; Wakatsuki, T.; Matsubara, O.; et al. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 2003, 38, 605-614.
    • (2003) J. Hepatol. , vol.38 , pp. 605-614
    • Shuda, M.1    Kondoh, N.2    Imazeki, N.3    Tanaka, K.4    Okada, T.5    Mori, K.6    Hada, A.7    Arai, M.8    Wakatsuki, T.9    Matsubara, O.10
  • 104
    • 80052899192 scopus 로고    scopus 로고
    • HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response
    • Merquiol, E.; Uzi, D.; Mueller, T.; Goldenberg, D.; Nahmias, Y.; Xavier, R.J.; Tirosh, B.; Shibolet, O. HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS One 2011, 6, e24660.
    • (2011) PLoS One , vol.6
    • Merquiol, E.1    Uzi, D.2    Mueller, T.3    Goldenberg, D.4    Nahmias, Y.5    Xavier, R.J.6    Tirosh, B.7    Shibolet, O.8
  • 105
    • 84868119125 scopus 로고    scopus 로고
    • Hepatitis C virus and cellular stress response: Implications to molecular pathogenesis of liver diseases
    • Ke, P.Y.; Chen, S.S. Hepatitis C virus and cellular stress response: Implications to molecular pathogenesis of liver diseases. Viruses 2012, 4, 2251-2290.
    • (2012) Viruses , vol.4 , pp. 2251-2290
    • Ke, P.Y.1    Chen, S.S.2
  • 106
    • 84873669841 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy
    • Huang, H.; Kang, R.; Wang, J.; Luo, G.; Yang, W.; Zhao, Z. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy. Autophagy 2012, 9, 175-195.
    • (2012) Autophagy , vol.9 , pp. 175-195
    • Huang, H.1    Kang, R.2    Wang, J.3    Luo, G.4    Yang, W.5    Zhao, Z.6
  • 107
    • 84870705848 scopus 로고    scopus 로고
    • Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus
    • Tsukiyama-Kohara, K. Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus. Int. J. Mol. Sci. 2012, 13, 15271-15278.
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 15271-15278
    • Tsukiyama-Kohara, K.1
  • 108
    • 0035893552 scopus 로고    scopus 로고
    • Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet
    • Kato, J.; Kobune, M.; Nakamura, T.; Kuroiwa, G.; Takada, K.; Takimoto, R.; Sato, Y.; Fujikawa, K.; Takahashi, M.; Takayama, T.; et al. Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet. Cancer Res. 2001, 61, 8697-8702.
    • (2001) Cancer Res. , vol.61 , pp. 8697-8702
    • Kato, J.1    Kobune, M.2    Nakamura, T.3    Kuroiwa, G.4    Takada, K.5    Takimoto, R.6    Sato, Y.7    Fujikawa, K.8    Takahashi, M.9    Takayama, T.10
  • 110
    • 84867692347 scopus 로고    scopus 로고
    • Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus
    • Liu, H.; Trinh, T.L.; Dong, H.; Keith, R.; Nelson, D.; Liu, C. Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus. PLoS One 2012, 7, e46631.
    • (2012) PLoS One , vol.7
    • Liu, H.1    Trinh, T.L.2    Dong, H.3    Keith, R.4    Nelson, D.5    Liu, C.6
  • 111
  • 112
    • 58149518683 scopus 로고    scopus 로고
    • Effect of steatosis and inflammation on liver fibrosis in chronic hepatitis C
    • Nieminen, U.; Arkkila, P.E.; Karkkainen, P.; Farkkila, M.A. Effect of steatosis and inflammation on liver fibrosis in chronic hepatitis C. Liver Int. 2009, 29,153-158.
    • (2009) Liver Int. , vol.29 , pp. 153-158
    • Nieminen, U.1    Arkkila, P.E.2    Karkkainen, P.3    Farkkila, M.A.4
  • 113
    • 84858718448 scopus 로고    scopus 로고
    • NF-kappaB and the link between inflammation and cancer
    • DiDonato, J.A.; Mercurio, F.; Karin, M. NF-kappaB and the link between inflammation and cancer. Immunol. Rev. 2012, 246, 379-400.
    • (2012) Immunol. Rev. , vol.246 , pp. 379-400
    • DiDonato, J.A.1    Mercurio, F.2    Karin, M.3


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