Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

Journal of Virology

Volumn 70, Issue 7, 1996, Pages 4438-4443

  Ray, Ratna B ^a,b   Martin Lagging, L ^a   Meyer, Keith ^a   Ray, Ranjit ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA TRANSFECTION; EMBRYO; FEMALE; FIBROBLAST; HEPATITIS C VIRUS; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE C MYC; ONCOGENE H RAS; PRIORITY JOURNAL; RAT; VIRUS CELL TRANSFORMATION;

EID: 8944262349     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.7.4438-4443.1996     Document Type: Article

References (51)

1. Alter, H. J., R. Purcell, J. Shin, J. Melpolder, M. Houghton, Q. L. Choo, and G. Kuo. 1989. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N. Engl. J. Med. 321:1494.
2. Birrer, M. J., S. Shegal, J. S. DeGreve, F. Kaye, E. A. Sausville, and J. D. Minna. 1988. L-myc cooperates with ras to transform primary rat embryo fibroblasts. Mol. Cell. Biol. 8:2668-2673.
3. Bishop, J. M. 1987. The molecular genetics of cancer. Science 235:305-311.
4. Brough, D. E., T. J. Hofmann, K. B. Elwood, R. A. Townley, and M. D. Cole. 1995. An essential domain of the c-Myc protein interacts with a nuclear factor that is also required for E1A-mediated transformation. Mol. Cell. Biol. 15:1536-1544.
5. Bruix, J., J. M. Barrera, X. Calvet, G. Ercilla, J. Costa, J. M. Sanchez-Tapias, M. Ventura, M. Vall, M. Bruguera, and C. Bru. 1989. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet ii:1004-1006.
6. Bukh, J., R. H. Purcell, and R. H. Miller. 1994. Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc. Natl. Acad. Sci. USA 91:8239-8243.
7. Cerni, C., B. Binetruy, J. T. Schiller, D. R. Lowy, G. Meneguzzi, and F. Cuzin. 1989. Successive steps in the process of immortalization identified by transfer of separate bovine papillomavirus genes into rat fibroblasts. Proc. Natl. Acad. Sci. USA 86:3266-3270.
8. Cerny, A., and F. V. Chisari. 1994. Immunological aspects of HCV infection. Intervirology 37:119-125.
9. Chien, D. Y., Q. L. Choo, R. Ralston, R. Spaete, M. Tong, M. Houghton, and G. Kuo. 1993. Persistence of HCV despite antibodies to both putative envelope glycoproteins. Lancet 342:933.
10. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
11. Choo, Q.-L., K. H. Richman, J. H. Han, K. Berger, C. Lee, C. Dong, C. Gallegos, D. Coit, A. Medina-Selby, P. J. Barr, A. J. Weiner, D. W. Bradley, G. Kuo, and M. Houghton. 1991. Genetic organization and diversity of the hepatitis C virus. Proc. Natl. Acad. Sci. USA 88:2451-2455.
12. Colombo, M., G. Kuo, Q. L. Choo, M. F. Donato, E. Del Ninno, M. Tonnasini, N. Dioguardi, and M. Houghton. 1989. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet ii:1006-1008.
13. Crook, T., A. Storey, N. Almond, K. Osborn, and L. Crawford. 1988. Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells. Proc. Natl. Acad. Sci. USA 85:8820-8824.
14. Farci, P., H. J. Alter, D. C. Wong, R. H. Miller, S. Govindarajan, R. Engle, M. Shapiro, and R. H. Purcell. 1994. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc. Natl. Acad. Sci. USA 91:7792-7796.
15. Hamburger, A. W., and S. E. Salmon. 1980. Development of a bioassay for human myeloma colony-forming cells. Prog. Clin. Biol. Res. 48:23-41.
16. Hawley-Nelson, P., K. H. Vousden, N. L. Hubbert, D. R. Lowy, and J. T. Schiller. 1989. HPV 16 E6 and E7 protein cooperate to immortalize human foreskin keratinocytes. EMBO J. 8:3905-3910.
17. Jewers, R. J., P. Hildebrandt, J. W. Ludlow, B. Kell, and D. J. McCance. 1992. Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes. J. Virol. 66:1329-1335.
18. Kelekar, A., and M. D. Cole. 1987. Immortalization by c-myc, H-ras, and E1a oncogenes induces differential cellular gene expression and growth factor responses. Mol. Cell. Biol. 7:3899-3907.
19. Kew, M. C. 1992. Tumors of the liver. Scand. J. Gastroenterol. 192:39-42.
20. Kew, M. C., M. Houghton, Q. L. Choo, and G. Kuo. 1990. Hepatitis C virus antibodies in southern Africa blacks with hepatocellular carcinoma. Lancet 335:873-874.
21. Khanna, A., and R. Ray. 1995. Hepatitis C virus core protein: synthesis, affinity purification, and immunoreactivity with infected human sera. Gene 153:185-189.
22. Lagging, L. M., K. Meyer, D. Hoft, M. Houghton, R. B. Belshe, and R. Ray. 1995. Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J. Virol. 69:5859-5863.
23. Land, H., A. C. Chen, J. P. Morgenstern, L. F. Parada, and R. A. Weinberg. 1986. Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts. Mol. Cell. Biol. 6:1917-1925.
24. Land, H., L. F. Parada, and R. A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least 2 cooperating oncogenes. Nature (London) 304:596-602.
25. Lanford, R. E., D. Chavez, F. V. Chisari, and C. Sureau. 1995. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J. Virol. 69:8079-8083.
26. Liu, Z., J. Ghai, R. S. Ostrow, R. C. McGlennen, and A. J. Faras. 1994. The E6 gene of human papilloma virus type 16 is sufficient for transformation of baby rat kidney cells in cotransfection with activated Ha-ras. Virology 201:388-396.
27. Lo, S.-Y., F. Masiara, S. B. Hwang, M. M. C. Lai, and J.-H. Ou. 1995. Differential subcellular localization of hepatitis C virus core gene products. Virology 213:455-461.
28. Matlashewski, G., J. Schneider, L. Banks, N. Jones, A. Murray, and L. Crawford. 1987. Human papillomavirus type 16 DNA cooperate with activated ras in transforming primary cells. EMBO J. 6:1741-1746.
29. Münger, K., W. C. Phelps, V. Bubb, P. M. Howley, and R. Schlegel. 1989. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63:4417-4421.
30. Purcell, R. H. 1994. Hepatitis viruses: changing patterns of human disease. Proc. Natl. Acad. Sci. USA 91:2401-2406.
31. Ray, R., A. Khanna, L. M. Lagging, K. Meyer, Q.-L. Choo, R. Ralston, M. Houghton, and P. R. Becherer. 1994. Peptide immimogen mimicry of putative E1 glycoprotein-specitic epitopes in hepatitis C virus. J. Virol. 68:4420-4426.
32. Ray, R., and D. M. Miller. 1991. Cloning and characterization of a human c-myc promoter-binding protein. Mol. Cell. Biol. 11:2154-2161.
33. Ray, R., S. Thomas, and D. M. Miller. 1989. Mouse fibroblasts transformed with the human c-myc gene express a high level of mRNA but a low level of c-myc protein and are non-tumorigenic in nude mice. Oncogene 4:593-600.
34. Ray, R. B. 1995. Induction of cell death in murine fibroblasts by a c-myc promoter binding protein. Cell Growth Differ. 6:1089-1096.
35. Ray, R. B., L. M. Lagging, K. Meyer, R. Steele, and R. Ray. 1995. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res. 37:209-220.
36. Ray, R. B., R. Steele, E. Seftor, and M. Hendrix. 1995. Human breast carcinoma cells transfected with the gene encoding a c-myc promoter-binding protein (MBP-1) inhibits tumors in nude mice. Cancer Res. 55:3747-3751.
37. Ragler, C. E., and F. V. Chisari. 1992. Cellular and molecular mechanisms of hepatocarcinogenesis. Semin. Liver Dis. 12:265-278.
38. Rovinski, B., and S. Benchimol. 1988. Immortalization of rat embryo fibroblasts by the cellular p53 oncogene. Oncogene 2:445-452.
39. Ruley, H. E. 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (London) 304:602-606.
40. Saito, I., T. Miyamura, A. Ohbayashi, H. Harada, T. Katayama, S. Kikuchi, Y. Watanabe, S. Koi, M. Onji, V. Ohta, Q. L. Choo, M. Houghton, and G. Kuo. 1990. Hepatitis C virus infection is associated with development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87:6547-6549.
41. Sakamuro, D., T. Furukawa, and T. Takegami. 1995. Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J. Virol. 69:3893-3896.
42. Santolini, E., G. Migliaccio, and N. L. Monica. 1994. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol. 68:3631-3641.
43. Selby, M. J., Q.-L. Choo, K. Berger, G. Kuo, E. Glazer, M. Eckart, C. Lee, D. Chien, C. Kuo, and M. Houghton. 1993. Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J. Gen. Virol. 74:1103-1113.
44. Shenk, T., and J. Flint. 1991. Transcriptional and transforming activities of the adenovirus E1A proteins. Adv. Cancer Res. 57:47-85.
45. Shih, C.-M., C.-M. Chen, S.-Y. Chen, and Y.-H. W. Lee. 1995. Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation. J. Virol. 69:1160-1171.
46. Shih, C. M., S. J. Lo, T. Miyamura, S. Y. Chen, and Y. W. Lee. 1993. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J. Virol. 67:5823-5832.
47. Smotkin, D., and F. O. Wettstein. 1987. The major human papillomavirus protein in cervical cancers in a cytoplasmic phosphoprotein. J. Virol. 61:1686-1689.
48. Suzuki, R., Y. Matsuura, T. Suzuki, A. Ando, J. Chiba, S. Harada, I. Saito, and T. Miyamura. 1995. Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted. J. Gen. Virol. 76:53-61.
49. Tappero, G., G. Natoli, G. Anfossi, F. Rosina, F. Negro, A. Smedile, F. Bonino, A. Angeli, R. H. Purcell, M. Rizzetto, and M. Levrero. 1994. Expression of the c-myc protooncogene product in cells infected with the hepatitis delta virus. Hepatology 20:1109-1114.
50. Teramoto, T., K. Satonaka, S. Kitazawa, T. Fujimori, K. Hayashi, and S. Maeda. 1994. p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis. Cancer Res. 54:231-235.
51. Werness, B.A., A. J. Levine, and P. M. Howley. 1990. Association of human papilloma virus type 16 and 18E6 proteins with p53. Science 248:76-79.