Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors

Journal of Hepatology

Volumn 57, Issue 5, 2012, Pages 1021-1028

  Akkari, Leila ^a,b,d   Grégoire, Damien ^a,b   Floc'H, Nicolas ^a,b,e   Moreau, Marie ^a,b   Hernandez, Céline ^c   Simonin, Yannick ^a,b   Rosenberg, Arielle R ^c   Lassus, Patrice ^a,b   Hibner, Urszula ^a,b  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^b UNIV MONTPELLIER   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e Genetics Department ^*  (United States)

Author keywords

Epithelial to mesenchymal transition; Hepatitis C virus; Hepatocellular carcinoma; Invasion; Motility; NS5A; Twist

Indexed keywords

ACTIN; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; NONSTRUCTURAL PROTEIN 5A; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST2; TRANSFORMING GROWTH FACTOR BETA; TUBULIN; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CARCINOGENESIS; CELL IMMORTALIZATION; CELL POLARITY; CELL STRUCTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HEPATITIS C; HEPATITIS C VIRUS; HEPATOCYTE PRECURSOR; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL; LIVER CELL CARCINOMA; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL LINE; CELL POLARITY; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATITIS C; HEPATOCYTES; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; PROTO-ONCOGENE PROTEINS P21(RAS); REPRESSOR PROTEINS; RISK FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HETEROLOGOUS; TWIST TRANSCRIPTION FACTOR; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84867580125     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.06.027     Document Type: Article

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