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Volumn 7, Issue 10, 2012, Pages

Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; STAT3 PROTEIN;

EID: 84867692347     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046631     Document Type: Article
Times cited : (47)

References (49)
  • 1
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Lauer GM, Walker BD, (2001) Hepatitis C virus infection. N Engl J Med 345: 41-52.
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 2
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • Shepard CW, Finelli L, Alter MJ, (2005) Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5: 558-567.
    • (2005) Lancet Infect Dis , vol.5 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 3
    • 0035453089 scopus 로고    scopus 로고
    • Hepatitis C infection in liver transplantation
    • Charlton M, (2001) Hepatitis C infection in liver transplantation. Am J Transplant 1: 197-203.
    • (2001) Am J Transplant , vol.1 , pp. 197-203
    • Charlton, M.1
  • 4
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, et al. (2000) LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 480: 147-150.
    • (2000) FEBS Lett , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.J.3    Schulz, A.4    Forssmann, W.G.5
  • 5
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T, (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276: 7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 6
    • 20144369874 scopus 로고    scopus 로고
    • Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections
    • Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, et al. (2005) Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem 280: 9272-9282.
    • (2005) J Biol Chem , vol.280 , pp. 9272-9282
    • Lauth, X.1    Babon, J.J.2    Stannard, J.A.3    Singh, S.4    Nizet, V.5
  • 7
    • 27944441799 scopus 로고    scopus 로고
    • Purification and partial characterisation of recombinant human hepcidin
    • Wallace DF, Jones MD, Pedersen P, Rivas L, Sly LI, et al. (2006) Purification and partial characterisation of recombinant human hepcidin. Biochimie 88: 31-37.
    • (2006) Biochimie , vol.88 , pp. 31-37
    • Wallace, D.F.1    Jones, M.D.2    Pedersen, P.3    Rivas, L.4    Sly, L.I.5
  • 8
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5
  • 10
    • 0036775797 scopus 로고    scopus 로고
    • Effect of free iron on collagen synthesis, cell proliferation and MMP-2 expression in rat hepatic stellate cells
    • Gardi C, Arezzini B, Fortino V, Comporti M, (2002) Effect of free iron on collagen synthesis, cell proliferation and MMP-2 expression in rat hepatic stellate cells. Biochem Pharmacol 64: 1139-1145.
    • (2002) Biochem Pharmacol , vol.64 , pp. 1139-1145
    • Gardi, C.1    Arezzini, B.2    Fortino, V.3    Comporti, M.4
  • 11
    • 28444435827 scopus 로고    scopus 로고
    • Iron in nonhemochromatotic liver disorders
    • Alla V, Bonkovsky HL, (2005) Iron in nonhemochromatotic liver disorders. Semin Liver Dis 25: 461-472.
    • (2005) Semin Liver Dis , vol.25 , pp. 461-472
    • Alla, V.1    Bonkovsky, H.L.2
  • 12
    • 36849075284 scopus 로고    scopus 로고
    • Iron chelation beyond transfusion iron overload
    • Pietrangelo A, (2007) Iron chelation beyond transfusion iron overload. Am J Hematol 82: 1142-1146.
    • (2007) Am J Hematol , vol.82 , pp. 1142-1146
    • Pietrangelo, A.1
  • 13
    • 33847609799 scopus 로고    scopus 로고
    • Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C
    • Fujita N, Sugimoto R, Takeo M, Urawa N, Mifuji R, et al. (2007) Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 13: 97-104.
    • (2007) Mol Med , vol.13 , pp. 97-104
    • Fujita, N.1    Sugimoto, R.2    Takeo, M.3    Urawa, N.4    Mifuji, R.5
  • 14
    • 33747359666 scopus 로고    scopus 로고
    • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    • Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, et al. (2006) Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 281: 22974-22982.
    • (2006) J Biol Chem , vol.281 , pp. 22974-22982
    • Harrison-Findik, D.D.1    Schafer, D.2    Klein, E.3    Timchenko, N.A.4    Kulaksiz, H.5
  • 15
    • 33947095427 scopus 로고    scopus 로고
    • ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3
    • Choi SO, Cho YS, Kim HL, Park JW, (2007) ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochem Biophys Res Commun 356: 312-317.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 312-317
    • Choi, S.O.1    Cho, Y.S.2    Kim, H.L.3    Park, J.W.4
  • 16
    • 56149115918 scopus 로고    scopus 로고
    • Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    • Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA, (2008) Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 48: 1420-1429.
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3    Schnabl, B.4    Brenner, D.A.5
  • 17
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531-539.
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5
  • 18
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC, (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108: 3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 19
    • 33846212344 scopus 로고    scopus 로고
    • STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    • Pietrangelo A, Dierssen U, Valli L, Garuti C, Rump A, et al. (2007) STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology 132: 294-300.
    • (2007) Gastroenterology , vol.132 , pp. 294-300
    • Pietrangelo, A.1    Dierssen, U.2    Valli, L.3    Garuti, C.4    Rump, A.5
  • 20
    • 5144222035 scopus 로고    scopus 로고
    • STAT3 induces anti-hepatitis C viral activity in liver cells
    • Zhu H, Shang X, Terada N, Liu C, (2004) STAT3 induces anti-hepatitis C viral activity in liver cells. Biochem Biophys Res Commun 324: 518-528.
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 518-528
    • Zhu, H.1    Shang, X.2    Terada, N.3    Liu, C.4
  • 21
    • 0032510805 scopus 로고    scopus 로고
    • STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activities
    • Yang CH, Murti A, Pfeffer LM, (1998) STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activities. Proc Natl Acad Sci U S A 95: 5568-5572.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5568-5572
    • Yang, C.H.1    Murti, A.2    Pfeffer, L.M.3
  • 22
    • 0034888396 scopus 로고    scopus 로고
    • Effect of alpha interferon on the hepatitis C virus replicon
    • Guo JT, Bichko VV, Seeger C, (2001) Effect of alpha interferon on the hepatitis C virus replicon. J Virol 75: 8516-8523.
    • (2001) J Virol , vol.75 , pp. 8516-8523
    • Guo, J.T.1    Bichko, V.V.2    Seeger, C.3
  • 23
    • 0036893332 scopus 로고    scopus 로고
    • Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication
    • Blight KJ, McKeating JA, Rice CM, (2002) Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J Virol 76: 13001-13014.
    • (2002) J Virol , vol.76 , pp. 13001-13014
    • Blight, K.J.1    McKeating, J.A.2    Rice, C.M.3
  • 24
    • 34247172187 scopus 로고    scopus 로고
    • Superinfection exclusion in cells infected with hepatitis C virus
    • Tscherne DM, Evans MJ, von Hahn T, Jones CT, Stamataki Z, et al. (2007) Superinfection exclusion in cells infected with hepatitis C virus. J Virol 81: 3693-3703.
    • (2007) J Virol , vol.81 , pp. 3693-3703
    • Tscherne, D.M.1    Evans, M.J.2    von Hahn, T.3    Jones, C.T.4    Stamataki, Z.5
  • 25
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, et al. (2005) Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11: 791-796.
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3    Date, T.4    Miyamoto, M.5
  • 26
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M, Vecchi C, Pietrangelo A, et al. (2008) Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 134: 226-238.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3    Vecchi, C.4    Pietrangelo, A.5
  • 27
    • 66449085883 scopus 로고    scopus 로고
    • Impaired regulation of serum hepcidin during phlebotomy in patients with chronic hepatitis C
    • Sugimoto R, Fujita N, Tomosugi N, Hara N, Miyachi H, et al. (2009) Impaired regulation of serum hepcidin during phlebotomy in patients with chronic hepatitis C. Hepatol Res 39: 619-624.
    • (2009) Hepatol Res , vol.39 , pp. 619-624
    • Sugimoto, R.1    Fujita, N.2    Tomosugi, N.3    Hara, N.4    Miyachi, H.5
  • 28
  • 29
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T, (2003) Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102: 783-788.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 30
    • 18944366215 scopus 로고    scopus 로고
    • Mechanisms of disease: The role of hepcidin in iron homeostasis-implications for hemochromatosis and other disorders
    • Pietrangelo A, Trautwein C, (2004) Mechanisms of disease: The role of hepcidin in iron homeostasis-implications for hemochromatosis and other disorders. Nat Clin Pract Gastroenterol Hepatol 1: 39-45.
    • (2004) Nat Clin Pract Gastroenterol Hepatol , vol.1 , pp. 39-45
    • Pietrangelo, A.1    Trautwein, C.2
  • 31
    • 45849140833 scopus 로고    scopus 로고
    • Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma
    • Kijima H, Sawada T, Tomosugi N, Kubota K, (2008) Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma. BMC Cancer 8: 167.
    • (2008) BMC Cancer , vol.8 , pp. 167
    • Kijima, H.1    Sawada, T.2    Tomosugi, N.3    Kubota, K.4
  • 32
    • 0029999597 scopus 로고    scopus 로고
    • Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals
    • Okada S, (1996) Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals. Pathol Int 46: 311-332.
    • (1996) Pathol Int , vol.46 , pp. 311-332
    • Okada, S.1
  • 33
    • 2542560427 scopus 로고    scopus 로고
    • Hereditary hemochromatosis-a new look at an old disease
    • Pietrangelo A, (2004) Hereditary hemochromatosis-a new look at an old disease. N Engl J Med 350: 2383-2397.
    • (2004) N Engl J Med , vol.350 , pp. 2383-2397
    • Pietrangelo, A.1
  • 34
    • 0037009846 scopus 로고    scopus 로고
    • The role of iron in cell cycle progression and the proliferation of neoplastic cells
    • Le NT, Richardson DR, (2002) The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta 1603: 31-46.
    • (2002) Biochim Biophys Acta , vol.1603 , pp. 31-46
    • Le, N.T.1    Richardson, D.R.2
  • 35
    • 50549086197 scopus 로고    scopus 로고
    • Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium
    • Nairz M, Fritsche G, Brunner P, Talasz H, Hantke K, et al. (2008) Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium. Eur J Immunol 38: 1923-1936.
    • (2008) Eur J Immunol , vol.38 , pp. 1923-1936
    • Nairz, M.1    Fritsche, G.2    Brunner, P.3    Talasz, H.4    Hantke, K.5
  • 36
    • 34848888911 scopus 로고    scopus 로고
    • Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis
    • Sow FB, Florence WC, Satoskar AR, Schlesinger LS, Zwilling BS, et al. (2007) Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis. J Leukoc Biol 82: 934-945.
    • (2007) J Leukoc Biol , vol.82 , pp. 934-945
    • Sow, F.B.1    Florence, W.C.2    Satoskar, A.R.3    Schlesinger, L.S.4    Zwilling, B.S.5
  • 37
    • 84877007665 scopus 로고    scopus 로고
    • Hepcidin mRNA level as a parameter of disease progression in chronic hepatitis C and hepatocellular carcinoma
    • Abd Elmonem E, Tharwa el S, Farag MA, Fawzy A, El Shinnawy SF, et al. (2009) Hepcidin mRNA level as a parameter of disease progression in chronic hepatitis C and hepatocellular carcinoma. J Egypt Natl Canc Inst 21: 333-342.
    • (2009) J Egypt Natl Canc Inst , vol.21 , pp. 333-342
    • Abd Elmonem, E.1    el Tharwa, S.2    Farag, M.A.3    Fawzy, A.4    El Shinnawy, S.F.5
  • 38
    • 53249142510 scopus 로고    scopus 로고
    • Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion
    • Fujita N, Sugimoto R, Motonishi S, Tomosugi N, Tanaka H, et al. (2008) Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. J Hepatol 49: 702-710.
    • (2008) J Hepatol , vol.49 , pp. 702-710
    • Fujita, N.1    Sugimoto, R.2    Motonishi, S.3    Tomosugi, N.4    Tanaka, H.5
  • 40
    • 61849160363 scopus 로고    scopus 로고
    • A functional genomic screen identifies cellular cofactors of hepatitis C virus replication
    • Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, et al. (2009) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 5: 298-307.
    • (2009) Cell Host Microbe , vol.5 , pp. 298-307
    • Tai, A.W.1    Benita, Y.2    Peng, L.F.3    Kim, S.S.4    Sakamoto, N.5
  • 41
    • 80051739560 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus replication by iron and hepcidin in Huh7 hepatocytes
    • Bartolomei G, Cevik RE, Marcello A, (2011) Modulation of hepatitis C virus replication by iron and hepcidin in Huh7 hepatocytes. J Gen Virol 92: 2072-2081.
    • (2011) J Gen Virol , vol.92 , pp. 2072-2081
    • Bartolomei, G.1    Cevik, R.E.2    Marcello, A.3
  • 43
    • 2442705429 scopus 로고    scopus 로고
    • Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
    • Kariko K, Bhuyan P, Capodici J, Weissman D, (2004) Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J Immunol 172: 6545-6549.
    • (2004) J Immunol , vol.172 , pp. 6545-6549
    • Kariko, K.1    Bhuyan, P.2    Capodici, J.3    Weissman, D.4
  • 44
    • 1542306855 scopus 로고    scopus 로고
    • Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
    • Kim DH, Longo M, Han Y, Lundberg P, Cantin E, et al. (2004) Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat Biotechnol 22: 321-325.
    • (2004) Nat Biotechnol , vol.22 , pp. 321-325
    • Kim, D.H.1    Longo, M.2    Han, Y.3    Lundberg, P.4    Cantin, E.5
  • 45
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, et al. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11: 263-270.
    • (2005) Nat Med , vol.11 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3    Ablasser, A.4    Schlee, M.5
  • 46
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge AD, Sood V, Shaw JR, Fang D, McClintock K, et al. (2005) Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23: 457-462.
    • (2005) Nat Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5
  • 47
    • 0037405824 scopus 로고    scopus 로고
    • Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway
    • Zhu H, Liu C, (2003) Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway. J Virol 77: 5493-5498.
    • (2003) J Virol , vol.77 , pp. 5493-5498
    • Zhu, H.1    Liu, C.2
  • 48
    • 59749085225 scopus 로고    scopus 로고
    • Structure and function of HCV IRES domains
    • Lukavsky PJ, (2009) Structure and function of HCV IRES domains. Virus Res 139: 166-171.
    • (2009) Virus Res , vol.139 , pp. 166-171
    • Lukavsky, P.J.1
  • 49
    • 78651473245 scopus 로고    scopus 로고
    • Sen GC The ISG56/IFIT1 gene family
    • Fensterl V, Sen GC The ISG56/IFIT1 gene family. J Interferon Cytokine Res 31: 71-78.
    • J Interferon Cytokine Res , vol.31 , pp. 71-78
    • Fensterl, V.1


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