Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 20870-20881

  Peng, Lu ^a   Liang, Dongyu ^a   Tong, Wenyan ^a   Li, Jianhua ^a   Yuan, Zhenghong ^a,b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC; CASPASE-3; CELL SURVIVAL; CELLULAR PROTEINS; CO-IMMUNOPRECIPITATIONS; FK506-BINDING PROTEINS; GLUTATHIONE-S-TRANSFERASE; HEPATITIS C VIRUS; HUMAN HEPATOMA CELL LINES; LY294002; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); NONSTRUCTURAL PROTEINS; OVER-EXPRESSION; PERSISTENT INFECTION; PHOSPHATIDYLINOSITOL 3-KINASE; POLY POLYMERASE; RAPAMYCIN;

ASSOCIATION REACTIONS; CELL CULTURE; CELL DEATH; MAMMALS; PHOSPHORYLATION; PROTEINS; TUMORS; VIRUSES;

ANTIBIOTICS;

2 MORPHOLINO 8 PHENYLCHROMONE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 38; GLUTATHIONE TRANSFERASE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 5A; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PATHOGENESIS; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REPLICON; VIRUS CELL INTERACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIBODIES, VIRAL; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL LINE; CELL SURVIVAL; CHROMONES; ENZYME ACTIVATION; HEPACIVIRUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MORPHOLINES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE DELETION; TACROLIMUS BINDING PROTEINS; TRANSFECTION; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS; MAMMALIA;

EID: 77954227028     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.112045     Document Type: Article

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