Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C

Journal of Gastroenterology

Volumn 42, Issue 10, 2007, Pages 830-836

  Kato, Junji ^a   Miyanishi, Koji ^a   Kobune, Masayoshi ^a   Nakamura, Tokiko ^a   Takada, Kohichi ^a   Takimoto, Rishu ^a   Kawano, Yutaka ^a   Takahashi, Sho ^a   Takahashi, Minoru ^a   Sato, Yasushi ^a   Takayama, Tetsuji ^a   Niitsu, Yoshiro ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic hepatitis C; Iron depletion therapy; Low iron diet therapy; Phlebotomy

Indexed keywords

ALANINE AMINOTRANSFERASE; FERRITIN; HEMOGLOBIN; INTERFERON;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CANCER RISK; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IRON DEFICIENCY; IRON DEPLETION; IRON RESTRICTION; LIVER BIOPSY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER FIBROSIS; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PHLEBOTOMY; PRIORITY JOURNAL; RISK FACTOR; RISK REDUCTION;

ADULT; AGED; ALANINE TRANSAMINASE; CARCINOMA, HEPATOCELLULAR; COHORT STUDIES; DIET; FEMALE; FOLLOW-UP STUDIES; HEPATITIS C, CHRONIC; HUMANS; IRON; IRON, DIETARY; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHLEBOTOMY; RISK FACTORS;

EID: 35448952080     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-007-2095-z     Document Type: Article

References (20)

1. SL Chen TR Morgan 2006 The natural history of hepatitis C virus (HCV) infection Int J Med 3 47-52
2. MJ Alter 1997 The epidemiology of acute and chronic hepatitis C Clin Liver Dis 1 559-68 15560058 10.1016/S1089-3261(05)70321-4 1:STN:280:DC%2BD2cros1yisg%3D%3D
3. A Wasley MJ Alter 2000 Epidemiology of hepatitis C: Geographic differences and temporal trends Semin Liver Dis 20 1-16 10895428 10.1055/ s-2000-9506 1:STN:280:DC%2BD3M%2Fit12ltg%3D%3D
4. LB Seeff 1997 Natural history of hepatitis C Hepatology 26 S21-8 10.1002/ hep.510260704
5. AM Di Bisceglie JH Hoofnagel 2002 Optimal therapy of hepatitis C Hepatology 36 S121-7 12407585 10.1002/hep.1840360716
6. MP Manns JG McHutchison SC Gordon VK Rustgi M Shiffman R Reindollar 2001 Peginterferon alpha-2b plus ribavirin compared with interferon alpha-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial Lancet 358 958-65 11583749 10.1016/ S0140-6736(01)06102-5 1:CAS:528:DC%2BD3MXntF2qtb8%3D
7. KL Lindsay 2002 Introduction to therapy of hepatitis C Hepatology 36 S114-20 12407584 10.1002/hep.1840360715
8. H Hayashi T Takikawa N Nishimura M Yano T Isomura N Sakamoto 1994 Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron Am J Gastroenterol 89 986-8 8017395 1:STN:280:ByuB1cfgtF0%3D
9. SE Bassett AM Di Bisceglie BR Bacon RM Sharp S Govindarajan GB Hubbard 1999 Effects of iron loading on pathogenicity in hepatitis C virus-infected chimpanzees Hepatology 29 1884-92 10347134 10.1002/ hep.510290623 1:CAS:528:DyaK1MXjvFOmsb0%3D
10. J Kato M Kobune T Nakamura G Kuroiwa K Takada R Takimoto 2001 Normalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet Cancer Res 61 8697-702 11751387 1:CAS:528:DC%2BD38Xht1Ogug%3D%3D
11. G Poli M Parola 1997 Oxidative damage and fibrogenesis Free Radic Biol Med 22 287-305 8958154 10.1016/S0891-5849(96)00327-9 1:CAS:528:DyaK28XnsVGju7o%3D
12. KC Cheng DS Cahill H Kasai S Nishimura LA Loeb 1992 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions J Biol Chem 267 166-72 1730583 1:CAS:528:DyaK38XjvFWlug%3D%3D
13. R Floyd 1990 The role of 8-hydroxyguanine in carcinogenesis Carcinogenesis (Lond) 11 1147-50
14. L Benvegnu A Alberti 1996 Risk factors and prevention of hepatocellular carcinoma in HCV infection Dig Dis Sci 41 Suppl 49S-55S 9011476 10.1007/ BF02087876 1:STN:280:ByiC2cfnvV0%3D
15. D Liu J Liu J Wen 1999 Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction Free Radic Biol Med 27 478-82 10468225 10.1016/S0891-5849(99)00073-8 1:CAS:528:DyaK1MXltlKrtr8%3D
16. J Kato M Kobune Y Kohgo N Sugawara H Hisai T Nakamura 1996 Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats J Clin Invest 98 923-9 8770863 1:CAS:528:DyaK28XlsFOgtr8%3D
17. RG Knodell KG Ishak WC Black TS Chen R Craig N Kaplowitz 1981 Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis Hepatology 1 431-5 7308988 10.1002/hep.1840010511 1:STN:280:Bi2D2svitlY%3D
18. AL Barton BF Banner EE Cable HL Bonkovsky 1995 Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy Am J Clin Pathol 103 419-24 7537017 1:STN:280:ByqB2czhvFw%3D
19. RB Perni SJ Almquist RA Byrn G Chandorkar PR Chaturvedi LF Courtney 2006 Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease Antimicrob Agents Chemother 50 899-909 16495249 10.1128/ AAC.50.3.899-909.2006 1:CAS:528:DC%2BD28XisFamt70%3D
20. JA Wilson CD Richardson 2006 Future promise of siRNA and other nucleic acid based therapeutics for the treatment of chronic HCV Infect Disord Drug Targets 6 43-56 16787303 1:CAS:528:DC%2BD28Xkt1Gnsr4%3D