Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA

RNA

Volumn 2, Issue 10, 1996, Pages 955-968

  Honda, Masao ^a   Brown, Edwin A ^a,b   Lemon, Stanley M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

cap independent translation; GB virus B; internal ribosomal entry site; pathogenesis; RNA structure; viral persistence

Indexed keywords

VIRUS RNA;

ARTICLE; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; RNA ANALYSIS; RNA STRUCTURE; RNA TRANSCRIPTION; RNA TRANSLATION; TRANSLATION INITIATION;

ANTIGENS, VIRAL; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CODON, INITIATOR; FLAVIVIRIDAE; HEPACIVIRUS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; RIBOSOMES; RNA, VIRAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; TUMOR CELLS, CULTURED;

HEPATITIS C VIRUS; HEPATITIS GB VIRUS B;

EID: 0029949695     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Alter MJ, Margolis HS, Krawczynski K, et al. 1992. The natural history of community-acquired hepatitis C in the United States. N Engt J Med 327:1899-1905.
2. Andino R, Rieckhof GE, Baltimore D. 1990. A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA. Cell 63:369-380.
3. Andrake M, Guild N, Hsu T, Gold L, Tuerk C, Karam J. 1988. DNA polymerase of bacteriophage T4 is an autogenous translational repressor. Proc Natl Acad Sci USA 85:7942-7946.
4. Bernardi A, Shaphr P. 1972. Nucleotide sequence at the binding site for coat protein on RNA of bacteriophage R17. Proc Natl Acad Sci USA 59:3033-3037.
5. Brown EA, Day SP, Jansen RW, Lemon SM. 1991. The 5' nontranslated region of hepatitis A virus: Secondary structure and elements required for translation in vitro. J Virol 65:5828-5838.
6. Brown EA, Zajac AJ, Lemon SM. 1994. In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: Comparison with the IRES of encephalomyocarditis virus. J Virol 63:1066-1074.
7. Brown EA, Zhang H, Ping LH, Lemon SM. 1992. Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res 20:5041-5045.
8. Bukh J, Purcell RH, Miller RH. 1994. Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc Natl Acad Sci USA 91:8239-8243.
9. Cerny A, Chisari FV. 1994. Immunological aspects of HCV infection. Intervirology 37:119-125.
10. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
11. Farci P, Alter HJ, Wong D, et al. 1991. A long-term study of hepatitis C virus replication in non-A, non-B hepatitis. N Engl J Med 325:98-104.
12. Frank J, Zhu J, Penczek P, et al. 1995. A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome. Nature 376:441-444.
13. Fuerst TR, Niles EG, Studier FW, Moss B. 1986. Eukaryotic transientexpression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci USA 83:8122-8126.
14. Hayashi N, Higashi H, Kaminaka K, et al. 1993. Molecular cloning and heterogeneity of the human hepatitis C virus (HCV) genome. J Hepatol 77:S94-107.
15. Hijikata M, Kalo N, Ootsuyama Y, Nakagawa M, Shimotohno K. 1991. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci USA 88:5547-5551.
16. Holmberg L, Melander Y, Nygard O. 1994. Probing the structure of the mouse Ehrlich ascites 5.8S, 18S and 28S ribosomal RNA in situ. Nucleic Acids Res 22:1374-1382.
17. Honda M, Kaneko S, Sakai A, Unoura M, Murakami S, Kobayashi K. 1994. Degree of diversity of hepatitis C virus quasispecies and progression of liver disease. Hepatology 20:1144-1151.
18. Honda M, Ping LH, Rijnbrand RCA, et al. 1996. Structural requirements for initiation of translation by internal ribosomal entry within genome-length hepatitis C virus RNA. Virology 222:31-42.
19. Houghton M, Weiner A, Han J, Kuo G, Choo QL. 1991. Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease. Hepatology 74:381-388.
20. Jackson RJ, Hunt SL, Gibbs CL, Kaminski A. 1994. Internal initiation of translation of picornavirus RNAs. Mol Biol Rep 19:147-159.
21. Jang SK, Krausslich HG, Nicklin MJH, Duke GM, Palmenberg AC, Wimmer EC. 1988. A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol 62:2636-2643.